Role of Neuro-Immunological Factors in the Pathophysiology of Mood Disorders: Implications for Novel Therapeutics for Treatment Resistant Depression (original) (raw)

References

  1. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS, National Comorbidity Survey Replication (2003) The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 289:3095–3105
    Article PubMed Google Scholar
  2. O’Leary OF, Dinan TG, Cryan JF (2015) Faster, better, stronger: towards new antidepressant therapeutic strategies. Eur J Pharmacol 753:32–50
    Article PubMed CAS Google Scholar
  3. Papakostas GI, Ionescu DF (2015) Towards new mechanisms: an update on therapeutics for treatment-resistant major depressive disorder. Mol Psychiatry 20:1142–1150
    Article CAS PubMed Google Scholar
  4. Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, Niederehe G, Thase ME, Lavori PW, Lebowitz BD, McGrath PJ, Rosenbaum JF, Sackeim HA, Kupfer DJ, Luther J, Fava M (2006) Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry 163:1905–1917
    Article PubMed Google Scholar
  5. Carvalho LA, Torre JP, Papadopoulos AS, Poon L, Juruena MF, Markopoulou K, Cleare AJ, Pariante CM (2013) Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system. J Affect Disord 148:136–140
    Article CAS PubMed Google Scholar
  6. Cattaneo A, Gennarelli M, Uher R, Breen G, Farmer A, Aitchison KJ, Craig IW, Anacker C, Zunsztain PA, McGuffin P, Pariante CM (2013) Candidate genes expression profile associated with antidepressants response in the GENDEP study: differentiating between baseline ‘predictors’ and longitudinal ‘targets’. Neuropsychopharmacology 38:377–385
    Article CAS PubMed Google Scholar
  7. O’Brien SM, Scully P, Fitzgerald P, Scott LV, Dinan TG (2007) Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. J Psychiatric Res 41:326–331
    Article Google Scholar
  8. Uher R, Tansey KE, Dew T, Maier W, Mors O, Hauser J, Dernovsek MZ, Henigsberg N, Souery D, Farmer A, McGuffin P (2014) An inflammatory biomarker as a differential predictor of outcome of depression treatment with escitalopram and nortriptyline. Am J Psychiatry 171:1278–1286
    Article PubMed Google Scholar
  9. Yoshimura R, Hori H, Ikenouchi-Sugita A, Umene-Nakano W, Ueda N, Nakamura J (2009) Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression. Prog Neuropsychopharmacol Biol Psychiatry 33:722–726
    Article CAS PubMed Google Scholar
  10. Pariante CM (2016) Neuroscience, mental health and the immune system: overcoming the brain-mind-body trichotomy. Epidemiol Psychiatr Sci 25(2):101–105
    Article CAS PubMed Google Scholar
  11. Wohleb ES, Franklin T, Iwata M, Duman RS (2016) Integrating neuroimmune systems in the neurobiology of depression. Nat Rev Neurosci 17:497–511
    Article CAS PubMed Google Scholar
  12. Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O’Connor KC, Huang Y, Carson RE, Hannestad J, Cosgrove KP (2015) Imaging robust microglial activation after lipopolysaccharide administration in humans with PET. Proc Natl Acad Sci U S A 112:12468–12473
    Article CAS PubMed PubMed Central Google Scholar
  13. Haapakoski R, Ebmeier KP, Alenius H, Kivimaki M (2016) Innate and adaptive immunity in the development of depression: an update on current knowledge and technological advances. Prog Neuropsychopharmacol Biol Psychiatry 66:63–72
    Article CAS PubMed PubMed Central Google Scholar
  14. Morris G, Berk M (2015) The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. BMC Med 13:68
    Article PubMed PubMed Central CAS Google Scholar
  15. Hodes GE, Pfau ML, Leboeuf M, Golden SA, Christoffel DJ, Bregman D, Rebusi N, Heshmati M, Aleyasin H, Warren BL, Lebonte B, Horn S, Lapidus KA, Stelzhammer V, Wong EH, Bahn S, Krishnan V, Bolanos-Guzman CA, Murrough JW, Merad M, Russo SJ (2014) Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc Natl Acad Sci U S A 111:16136–16141
    Article CAS PubMed PubMed Central Google Scholar
  16. Kohler O, Benros ME, Krogh J (2015) Anti-inflammatory intervention in depression--reply. JAMA Psychiatry 72:512–513
    Article PubMed Google Scholar
  17. Najjar S, Pearlman DM, Alper K, Najjar A, Devinsky O (2013) Neuroinflammation and psychiatric illness. J Neuroinflammation 10:43
    CAS PubMed PubMed Central Google Scholar
  18. Ben-Shaanan TL, Azulay-Debby H, Dubovik T, Starosvetsky E, Korin B, Schiller M, Green NL, Admon Y, Hakim F, Shen-Orr SS, Rolls A (2016) Activation of the reward system boosts innate and adaptive immunity. Nat Med 22:940–944
    Article CAS PubMed Google Scholar
  19. Louveau A, Harris TH, Kipnis J (2015) Revisiting the mechanisms of CNS immune privilege. Trends Immunol 36:569–577
    Article CAS PubMed PubMed Central Google Scholar
  20. Yirmiya R, Goshen I (2011) Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun 25:181–213
    Article CAS PubMed Google Scholar
  21. Bhattacharya A, Derecki NC, Lovenberg TW, Drevets WC (2016) Role of neuro-immunological factors in the pathophysiology of mood disorders. Psychopharmacology (Berl) 233:1623–1636
    Article CAS Google Scholar
  22. Savitz J, Frank MB, Victor T, Bebak M, Marino JH, Bellgowan PS, McKinney BA, Bodurka J, Kent Teague T, Drevets WC (2013) Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain Behav Immun 31:161–171
    Article CAS PubMed Google Scholar
  23. Savitz J, Drevets WC (2009) Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide. Neurosci Biobehav Rev 33:699–771
    Article PubMed PubMed Central Google Scholar
  24. Craddock N, Sklar P (2013) Genetics of bipolar disorder. Lancet 381:1654–1662
    Article CAS PubMed Google Scholar
  25. Edvardsen J, Torgersen S, Roysamb E, Lygren S, Skre I, Onstad S, Oien PA (2009) Unipolar depressive disorders have a common genotype. J Affect Disord 117:30–41
    Article PubMed Google Scholar
  26. Milaneschi Y, Lamers F, Peyrot WJ, Abdellaoui A, Willemsen G, Hottenga JJ, Jansen R, Mbarek H, Dehghan A, Lu C, Group Ciw, Boomsma DI, Penninx BW (2016) Polygenic dissection of major depression clinical heterogeneity. Mol Psychiatry 21:516–522
    Article CAS PubMed Google Scholar
  27. Capuron L, Miller AH (2011) Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther 130:226–238
    Article CAS PubMed PubMed Central Google Scholar
  28. Wohleb ES, McKim DB, Sheridan JF, Godbout JP (2014) Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior. Front Neurosci 8:447
    PubMed Google Scholar
  29. Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J (2015) Structural and functional features of central nervous system lymphatic vessels. Nature 523:337–341
    Article CAS PubMed PubMed Central Google Scholar
  30. Raper D, Louveau A, Kipnis J (2016) How do meningeal lymphatic vessels drain the CNS? Trends Neurosci
    Google Scholar
  31. Wu Y, Dissing-Olesen L, MacVicar BA, Stevens B (2015) Microglia: dynamic mediators of synapse development and plasticity. Trends Immunol 36:605–613
    Article PubMed PubMed Central CAS Google Scholar
  32. Ben Achour S, Pascual O (2010) Glia: the many ways to modulate synaptic plasticity. Neurochem Int 57:440–445
    Article CAS PubMed Google Scholar
  33. Orihuela R, McPherson CA, Harry GJ (2016) Microglial M1/M2 polarization and metabolic states. Br J Pharmacol 173(4):649–665
    Article CAS PubMed Google Scholar
  34. Ransohoff RM (2016) A polarizing question: do M1 and M2 microglia exist? Nat Neurosci 19:987–991
    Article CAS PubMed Google Scholar
  35. Tang Y, Le W (2015) Differential roles of M1 and M2 microglia in neurodegenerative diseases. Mol Neurobiol 53(2):1181–1194
    Article PubMed CAS Google Scholar
  36. Cherry JD, Olschowka JA, O’Banion MK (2014) Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J Neuroinflammation 11:98
    Article PubMed PubMed Central CAS Google Scholar
  37. Prinz M, Priller J (2014) Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat Rev Neurosci 15:300–312
    Article CAS PubMed Google Scholar
  38. Steiner J, Walter M, Gos T, Guillemin GJ, Bernstein HG, Sarnyai Z, Mawrin C, Brisch R, Bielau H, Meyer zu Schwabedissen L, Bogerts B, Myint AM (2011) Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J Neuroinflammation 8:94
    Article CAS PubMed PubMed Central Google Scholar
  39. Aguzzi A, Barres BA, Bennett ML (2013) Microglia: scapegoat, saboteur, or something else? Science 339:156–161
    Article CAS PubMed PubMed Central Google Scholar
  40. Chung WS, Barres BA (2012) The role of glial cells in synapse elimination. Curr Opin Neurobiol 22:438–445
    Article CAS PubMed Google Scholar
  41. Zhan Y, Paolicelli RC, Sforazzini F, Weinhard L, Bolasco G, Pagani F, Vyssotski AL, Bifone A, Gozzi A, Ragozzino D, Gross CT (2014) Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat Neurosci 17:400–406
    Article CAS PubMed Google Scholar
  42. Yirmiya R, Rimmerman N, Reshef R (2015) Depression as a microglial disease. Trends Neurosci 38:637–658
    Article CAS PubMed Google Scholar
  43. Brynskikh A, Warren T, Zhu J, Kipnis J (2008) Adaptive immunity affects learning behavior in mice. Brain Behav Immun 22:861–869
    Article CAS PubMed Google Scholar
  44. Derecki NC, Cardani AN, Yang CH, Quinnies KM, Crihfield A, Lynch KR, Kipnis J (2010) Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med 207:1067–1080
    Article CAS PubMed PubMed Central Google Scholar
  45. Jiang NM, Tofail F, Moonah SN, Scharf RJ, Taniuchi M, Ma JZ, Hamadani JD, Gurley ES, Houpt ER, Azziz-Baumgartner E, Haque R, Petri WA Jr (2014) Febrile illness and pro-inflammatory cytokines are associated with lower neurodevelopmental scores in Bangladeshi infants living in poverty. BMC Pediatr 14:50
    Article PubMed PubMed Central CAS Google Scholar
  46. Kipnis J, Cohen H, Cardon M, Ziv Y, Schwartz M (2004) T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. Proc Natl Acad Sci U S A 101:8180–8185
    Article CAS PubMed PubMed Central Google Scholar
  47. Wolf SA, Steiner B, Akpinarli A, Kammertoens T, Nassenstein C, Braun A, Blankenstein T, Kempermann G (2009) CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis. J Immunol 182:3979–3984
    Article CAS PubMed Google Scholar
  48. Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, Greenberg N, Cohen H, Kipnis J, Schwartz M (2006) Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci 9:268–275
    Article CAS PubMed Google Scholar
  49. Yarovinsky F (2014) Innate immunity to Toxoplasma gondii infection. Nat Rev Immunol 14:109–121
    Article CAS PubMed Google Scholar
  50. Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M (1999) Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 5:49–55
    Article CAS PubMed Google Scholar
  51. Hofstetter HH, Sewell DL, Liu F, Sandor M, Forsthuber T, Lehmann PV, Fabry Z (2003) Autoreactive T cells promote post-traumatic healing in the central nervous system. J Neuroimmunol 134:25–34
    Article CAS PubMed Google Scholar
  52. Kipnis J, Mizrahi T, Yoles E, Ben-Nun A, Schwartz M (2002) Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity. J Neuroimmunol 130:78–85
    Article CAS PubMed Google Scholar
  53. Kelley KW, Bluthe RM, Dantzer R, Zhou JH, Shen WH, Johnson RW, Broussard SR (2003) Cytokine-induced sickness behavior. Brain Behav Immun 17(Suppl 1):S112–S118
    Article CAS PubMed Google Scholar
  54. Dantzer R (2016) Role of the Kynurenine metabolism pathway in inflammation-induced depression: preclinical approaches. Curr Top Behav Neurosci. doi:10.1007/7854_2016_6
    Google Scholar
  55. Breen MS, Maihofer AX, Glatt SJ, Tylee DS, Chandler SD, Tsuang MT, Risbrough VB, Baker DG, O’Connor DT, Nievergelt CM, Woelk CH (2015) Gene networks specific for innate immunity define post-traumatic stress disorder. Mol Psychiatry 20(12):1538–1545
    Article CAS PubMed PubMed Central Google Scholar
  56. Glabinski AR, Balasingam V, Tani M, Kunkel SL, Strieter RM, Yong VW, Ransohoff RM (1996) Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. J Immunol 156:4363–4368
    CAS PubMed Google Scholar
  57. Andjelkovic AV, Pachter JS (2000) Characterization of binding sites for chemokines MCP-1 and MIP-1alpha on human brain microvessels. J Neurochem 75:1898–1906
    Article CAS PubMed Google Scholar
  58. Lamers F, Bot M, Jansen R, Chan MK, Cooper JD, Bahn S, Penninx BW (2016) Serum proteomic profiles of depressive subtypes. Transl Psychiatry 6:e851
    Article CAS PubMed Google Scholar
  59. Noto C, Rizzo LB, Mansur RB, McIntyre RS, Maes M, Brietzke E (2014) Targeting the inflammatory pathway as a therapeutic tool for major depression. Neuroimmunomodulation 21:131–139
    Article CAS PubMed Google Scholar
  60. Rosenblat JD, Cha DS, Mansur RB, McIntyre RS (2014) Inflamed moods: a review of the interactions between inflammation and mood disorders. Prog Neuropsychopharmacol Biol Psychiatry 53:23–34
    Article CAS PubMed Google Scholar
  61. Walker AK, Kavelaars A, Heijnen CJ, Dantzer R (2014) Neuroinflammation and comorbidity of pain and depression. Pharmacol Rev 66:80–101
    Article CAS PubMed PubMed Central Google Scholar
  62. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctot KL (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67:446–457
    Article CAS PubMed Google Scholar
  63. Jones KA, Thomsen C (2013) The role of the innate immune system in psychiatric disorders. Mol Cell Neurosci 53:52–62
    Article CAS PubMed Google Scholar
  64. Pace TW, Miller AH (2009) Cytokines and glucocorticoid receptor signaling. Relevance to major depression. Ann N Y Acad Sci 1179:86–105
    Article CAS PubMed PubMed Central Google Scholar
  65. Soderlund J, Olsson SK, Samuelsson M, Walther-Jallow L, Johansson C, Erhardt S, Landen M, Engberg G (2011) Elevation of cerebrospinal fluid interleukin-1ss in bipolar disorder. J Psychiatry Neurosci 36:114–118
    Article PubMed PubMed Central Google Scholar
  66. Young JJ, Bruno D, Pomara N (2014) A review of the relationship between proinflammatory cytokines and major depressive disorder. J Affect Disord 169:15–20
    Article CAS PubMed Google Scholar
  67. Carvalho LA, Bergink V, Sumaski L, Wijkhuijs J, Hoogendijk WJ, Birkenhager TK, Drexhage HA (2014) Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder. Transl Psychiatry 4:e344
    Article CAS PubMed PubMed Central Google Scholar
  68. Jansen R, Penninx BW, Madar V, Xia K, Milaneschi Y, Hottenga JJ, Hammerschlag AR, Beekman A, van der Wee N, Smit JH, Brooks AI, Tischfield J, Posthuma D, Schoevers R, van Grootheest G, Willemsen G, de Geus EJ, Boomsma DI, Wright FA, Zou F, Sun W, Sullivan PF (2016) Gene expression in major depressive disorder. Mol Psychiatry 21(3):339–347
    Article CAS PubMed Google Scholar
  69. Padmos RC, Hillegers MH, Knijff EM, Vonk R, Bouvy A, Staal FJ, de Ridder D, Kupka RW, Nolen WA, Drexhage HA (2008) A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch Gen Psychiatry 65:395–407
    Article CAS PubMed Google Scholar
  70. Powell TR, McGuffin P, D’Souza UM, Cohen-Woods S, Hosang GM, Martin C, Matthews K, Day RK, Farmer AE, Tansey KE, Schalkwyk LC (2014) Putative transcriptomic biomarkers in the inflammatory cytokine pathway differentiate major depressive disorder patients from control subjects and bipolar disorder patients. PLoS One 9:e91076
    Article PubMed PubMed Central CAS Google Scholar
  71. Hannestad J, DellaGioia N, Bloch M (2011) The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsychopharmacology 36:2452–2459
    Article CAS PubMed PubMed Central Google Scholar
  72. Baraldi S, Hepgul N, Mondelli V, Pariante CM (2012) Symptomatic treatment of interferon-alpha-induced depression in hepatitis C: a systematic review. J Clin Psychopharmacol 32:531–543
    Article CAS PubMed Google Scholar
  73. Dantzer R, Bluthe RM, Laye S, Bret-Dibat JL, Parnet P, Kelley KW (1998) Cytokines and sickness behavior. Ann N Y Acad Sci 840:586–590
    Article CAS PubMed Google Scholar
  74. Miller AH, Maletic V, Raison CL (2009) Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 65:732–741
    Article CAS PubMed PubMed Central Google Scholar
  75. Capuron L, Fornwalt FB, Knight BT, Harvey PD, Ninan PT, Miller AH (2009) Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals? J Affect Disord 119:181–185
    Article CAS PubMed PubMed Central Google Scholar
  76. Pasquini M, Speca A, Mastroeni S, Delle Chiaie R, Sternberg CN, Biondi M (2008) Differences in depressive thoughts between major depressive disorder, IFN-alpha-induced depression, and depressive disorders among cancer patients. J Psychosom Res 65:153–156
    Article PubMed Google Scholar
  77. Bull SJ, Huezo-Diaz P, Binder EB, Cubells JF, Ranjith G, Maddock C, Miyazaki C, Alexander N, Hotopf M, Cleare AJ, Norris S, Cassidy E, Aitchison KJ, Miller AH, Pariante CM (2009) Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. Mol Psychiatry 14:1095–1104
    Article CAS PubMed Google Scholar
  78. Udina M, Hidalgo D, Navines R, Forns X, Sola R, Farre M, Capuron L, Vieta E, Martin-Santos R (2014) Prophylactic antidepressant treatment of interferon-induced depression in chronic hepatitis C: a systematic review and meta-analysis. J Clin Psychiatry 75:e1113–e1121
    Article PubMed Google Scholar
  79. McNutt MD, Liu S, Manatunga A, Royster EB, Raison CL, Woolwine BJ, Demetrashvili MF, Miller AH, Musselman DL (2012) Neurobehavioral effects of interferon-alpha in patients with hepatitis-C: symptom dimensions and responsiveness to paroxetine. Neuropsychopharmacology 37:1444–1454
    Article CAS PubMed PubMed Central Google Scholar
  80. Tyring S, Gottlieb A, Papp K, Gordon K, Leonardi C, Wang A, Lalla D, Woolley M, Jahreis A, Zitnik R, Cella D, Krishnan R (2006) Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial. Lancet 367:29–35
    Article CAS PubMed Google Scholar
  81. Lamers F, Rhebergen D, Merikangas KR, de Jonge P, Beekman AT, Penninx BW (2012) Stability and transitions of depressive subtypes over a 2-year follow-up. Psychol Med 42:2083–2093
    Article CAS PubMed Google Scholar
  82. Grosse L, Carvalho LA, Wijkhuijs AJ, Bellingrath S, Ruland T, Ambree O, Alferink J, Ehring T, Drexhage HA, Arolt V (2015) Clinical characteristics of inflammation-associated depression: monocyte gene expression is age-related in major depressive disorder. Brain Behav Immun 44:48–56
    Article CAS PubMed Google Scholar
  83. Drexhage RC, Knijff EM, Padmos RC, Heul-Nieuwenhuijzen L, Beumer W, Versnel MA, Drexhage HA (2010) The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder. Expert Rev Neurother 10:59–76
    Article CAS PubMed Google Scholar
  84. Hodes GE, Kana V, Menard C, Merad M, Russo SJ (2015) Neuroimmune mechanisms of depression. Nat Neurosci 18:1386–1393
    Article CAS PubMed PubMed Central Google Scholar
  85. Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–56
    Article CAS PubMed PubMed Central Google Scholar
  86. Krishnan R, Cella D, Leonardi C, Papp K, Gottlieb AB, Dunn M, Chiou CF, Patel V, Jahreis A (2007) Effects of etanercept therapy on fatigue and symptoms of depression in subjects treated for moderate to severe plaque psoriasis for up to 96 weeks. Br J Dermatol 157:1275–1277
    Article CAS PubMed Google Scholar
  87. Simen BB, Duman CH, Simen AA, Duman RS (2006) TNFalpha signaling in depression and anxiety: behavioral consequences of individual receptor targeting. Biol Psychiatry 59:775–785
    Article CAS PubMed Google Scholar
  88. Yamada K, Iida R, Miyamoto Y, Saito K, Sekikawa K, Seishima M, Nabeshima T (2000) Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-alpha gene: implications for emotional behavior. J Neuroimmunol 111:131–138
    Article CAS PubMed Google Scholar
  89. Karson A, Demirtas T, Bayramgurler D, Balci F, Utkan T (2013) Chronic administration of infliximab (TNF-alpha inhibitor) decreases depression and anxiety-like behaviour in rat model of chronic mild stress. Basic Clin Pharmacol Toxicol 112:335–340
    Article CAS PubMed Google Scholar
  90. Krugel U, Fischer J, Radicke S, Sack U, Himmerich H (2013) Antidepressant effects of TNF-alpha blockade in an animal model of depression. J Psychiatric Res 47:611–616
    Article Google Scholar
  91. Raison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P, Drake DF, Haroon E, Miller AH (2013) A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 70:31–41
    Article CAS PubMed PubMed Central Google Scholar
  92. Maes M, Anderson G, Kubera M, Berk M (2014) Targeting classical IL-6 signalling or IL-6 trans-signalling in depression? Expert Opin Ther Targets 18:495–512
    Article CAS PubMed Google Scholar
  93. Bay-Richter C, Linderholm KR, Lim CK, Samuelsson M, Traskman-Bendz L, Guillemin GJ, Erhardt S, Brundin L (2015) A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality. Brain Behav Immun 43:110–117
    Article CAS PubMed Google Scholar
  94. Anisman H, Ravindran AV, Griffiths J, Merali Z (1999) Interleukin-1 beta production in dysthymia before and after pharmacotherapy. Biol Psychiatry 46:1649–1655
    Article CAS PubMed Google Scholar
  95. Corwin EJ, Johnston N, Pugh L (2008) Symptoms of postpartum depression associated with elevated levels of interleukin-1 beta during the first month postpartum. Biol Res Nurs 10:128–133
    Article CAS PubMed Google Scholar
  96. Diniz BS, Teixeira AL, Talib L, Gattaz WF, Forlenza OV (2010) Interleukin-1beta serum levels is increased in antidepressant-free elderly depressed patients. Am J Geriatr Psychiatry 18:172–176
    Article PubMed Google Scholar
  97. Koo JW, Duman RS (2009) Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression. Curr Opin Investig Drugs 10:664–671
    CAS PubMed PubMed Central Google Scholar
  98. Maes M, Song C, Yirmiya R (2012) Targeting IL-1 in depression. Expert Opin Ther Targets 16:1097–1112
    Article CAS PubMed Google Scholar
  99. Koo JW, Duman RS (2008) IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci U S A 105:751–756
    Article CAS PubMed PubMed Central Google Scholar
  100. Zhang Y, Liu L, Liu YZ, Shen XL, Wu TY, Zhang T, Wang W, Wang YX, Jiang CL (2015) NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation. Int J Neuropsychopharmacol 18(8):pyv006
    Article PubMed PubMed Central CAS Google Scholar
  101. Song C, Phillips AG, Leonard B (2003) Interleukin 1 beta enhances conditioned fear memory in rats: possible involvement of glucocorticoids. Eur J Neurosci 18:1739–1743
    Article PubMed Google Scholar
  102. Iwata M, Ota KT, Li XY, Sakaue F, Li N, Dutheil S, Banasr M, Duric V, Yamanashi T, Kaneko K, Rasmussen K, Glasebrook A, Koester A, Song D, Jones KA, Zorn S, Smagin G, Duman RS (2016) Psychological stress activates the inflammasome via release of adenosine triphosphate and stimulation of the purinergic type 2X7 receptor. Biol Psychiatry 80:12–22
    Article CAS PubMed Google Scholar
  103. Csolle C, Baranyi M, Zsilla G, Kittel A, Goloncser F, Illes P, Papp E, Vizi ES, Sperlagh B (2013) Neurochemical changes in the mouse hippocampus underlying the antidepressant effect of genetic deletion of P2X7 receptors. PLoS One 8:e66547
    Article CAS PubMed PubMed Central Google Scholar
  104. Solle M, Labasi J, Perregaux DG, Stam E, Petrushova N, Koller BH, Griffiths RJ, Gabel CA (2001) Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem 276:125–132
    Article CAS PubMed Google Scholar
  105. Caseley EA, Muench SP, Roger S, Mao HJ, Baldwin SA, Jiang LH (2014) Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers. Int J Mol Sci 15:13344–13371
    Article CAS PubMed PubMed Central Google Scholar
  106. Jiang LH, Baldwin JM, Roger S, Baldwin SA (2013) Insights into the molecular mechanisms underlying mammalian P2X7 receptor functions and contributions in diseases, revealed by structural modeling and single nucleotide polymorphisms. Front Pharmacol 4:55
    Article CAS PubMed PubMed Central Google Scholar
  107. Stokes L, Fuller SJ, Sluyter R, Skarratt KK, Gu BJ, Wiley JS (2010) Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion. FASEB J 24:2916–2927
    Article CAS PubMed Google Scholar
  108. Feng WP, Zhang B, Li W, Liu J (2014) Lack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: a meta-analysis. PLoS One 9:e88575
    Article PubMed PubMed Central CAS Google Scholar
  109. Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T, Yirmiya R (2008) Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry 13:717–728
    Article CAS PubMed Google Scholar
  110. Rao JS, Harry GJ, Rapoport SI, Kim HW (2010) Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry 15:384–392
    Article CAS PubMed Google Scholar
  111. Gubert C, Fries GR, Pfaffenseller B, Ferrari P, Coutinho-Silva R, Morrone FB, Kapczinski F, Battastini AM (2016) Role of P2X7 receptor in an animal model of mania induced by D-amphetamine. Mol Neurobiol 53(1):611–620
    Article CAS PubMed Google Scholar
  112. Bhattacharya A, Wang Q, Ao H, Shoblock JR, Lord B, Aluisio L, Fraser I, Nepomuceno D, Neff RA, Welty N, Lovenberg TW, Bonaventure P, Wickenden AD, Letavic MA (2013) Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. Br J Pharmacol 170:624–640
    Article CAS PubMed PubMed Central Google Scholar
  113. Lord B, Aluisio L, Shoblock JR, Neff RA, Varlinskaya EI, Ceusters M, Lovenberg TW, Carruthers N, Bonaventure P, Letavic MA, Deak T, Drinkenburg W, Bhattacharya A (2014) Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432. J Pharmacol Exp Ther 351:628–641
    Article PubMed CAS Google Scholar

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