Applications of miRNA Technology for Atherosclerosis (original) (raw)

Abstract

MicroRNAs (miRNAs) are a class of post-transcriptional regulators that provide a mechanism of gene silencing by translational repression or degradation of the targeted gene. Gene expression regulation by miRNAs is involved in most if not all physiological and pathophysiological processes. Atherosclerosis is a major cardiovascular disease pathology regulated by miRNAs. Recent miRNA profiling studies have implicated the potential use of miRNAs as biomarkers in patients with atherosclerosis, as both diagnostic and prognostic indicators. This review will discuss the clinical and basic science research information that has been gleaned regarding miRNA roles in dyslipidemia, diabetes, obesity, and insulin resistance which are the major stimulators for the development of atherosclerosis.

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Acknowledgments

We acknowledge funding support from the National Institutes of Health NHLBI HHSN 268201000036C (N01-HV-00244) for the San Antonio Cardiovascular Proteomics Center, HL075360 and HL051971, and the Veteran’s Administration (Merit) to MLL.

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Conflict of Interest

Hiroe Toba, Dolores Cortez, and Merry L. Lindsey declare that they have no conflict of interest.

Robert J. Chilton received honoraria from Takada and Pfizer and received payment for the development of educational presentations from Lilly and BMS.

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan
    Hiroe Toba
  2. Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, MS, USA
    Hiroe Toba & Merry L. Lindsey
  3. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA
    Hiroe Toba & Merry L. Lindsey
  4. Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, MS, USA
    Merry L. Lindsey
  5. San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Hiroe Toba, Dolores Cortez, Merry L. Lindsey & Robert J. Chilton
  6. Cardiology Division, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA
    Dolores Cortez & Robert J. Chilton

Authors

  1. Hiroe Toba
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  2. Dolores Cortez
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  3. Merry L. Lindsey
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  4. Robert J. Chilton
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Corresponding author

Correspondence toRobert J. Chilton.

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This article is part of the Topical Collection on Coronary Heart Disease

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Toba, H., Cortez, D., Lindsey, M.L. et al. Applications of miRNA Technology for Atherosclerosis.Curr Atheroscler Rep 16, 386 (2014). https://doi.org/10.1007/s11883-013-0386-9

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