Hotamisligil, G.S. The role of TNFα and TNF receptors in obesity and insulin resistance. J. Intern. Med.245, 621–625 (1999). ArticleCAS Google Scholar
Shimomura, I. et al. Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity. Nature Med.2, 800–803 (1996). ArticleCAS Google Scholar
White, R.T. et al. Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J. Biol. Chem.267, 9210–9213 (1992). CASPubMed Google Scholar
Steppan, C.M. et al. The hormone resistin links obesity to diabetes. Nature409, 307–312 (2001). ArticleCAS Google Scholar
Matsuzawa, Y., Funahashi, T. & Nakamura, T. Molecular mechanism of metabolic syndrome X: Contribution of adipocytokines adipocyte-derived bioactive substances. Ann. NY Acad. Sci.892, 146–154 (1999). ArticleCAS Google Scholar
Maeda, K. et al. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem. Biophys. Res. Commun.221, 286–296 (1996). ArticleCAS Google Scholar
Scherer, P.E., Williams, S., Fogliano, M., Baldini, G. & Lodish, H.F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem.270, 26746–26749 (1995). ArticleCAS Google Scholar
Hu, E., Liang, P. & Spiegelman, B.M. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem.271, 10697–10703 (1996). ArticleCAS Google Scholar
Nakano, Y., Tobe, T., Choi-Miura, N.H., Mazda, T. & Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J. Biochem. (Tokyo)120, 802–812 (1996). Google Scholar
Arita, Y. et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun.257, 79–83 (1999). ArticleCAS Google Scholar
Fruebis, J. et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. USA98, 2005–2010 (2001). ArticleCAS Google Scholar
Vionnet, N. et al. Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome _3q27_-qter and independent replication of a type 2-diabetes locus on chromosome _1q21_-q24. Am. J. Hum. Genet.67, 1470–1480 (2000). ArticleCAS Google Scholar
Kissebah, A.H. et al. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc. Natl. Acad. Sci. USA97, 14478–14483 (2000). ArticleCAS Google Scholar
Kubota, N. et al. PPAR-γ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell4, 597–609 (1999). ArticleCAS Google Scholar
Miles, P.D., Barak, Y., He, W., Evans, R.M. & Olefsky, J.M. Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. J. Clin. Invest.105, 287–292 (2000). ArticleCAS Google Scholar
Ebisawa, M. et al. Retinoid X receptor-antagonistic diazepinylbenzoic acids. Chem. Pharm. Bull. (Tokyo)47, 1778–1786 (1999). ArticleCAS Google Scholar
Kersten, S., Desvergne, B. & Wahli, W. Roles of PPARs in health and disease. Nature405, 421–424 (2000). ArticleCAS Google Scholar
Spiegelman, B.M. & Flier, J.S. Adipogenesis and obesity: Rounding out the big picture. Cell87, 377–389 (1996). ArticleCAS Google Scholar
Schoonjans, K. et al. PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J.15, 5336–5348 (1996). ArticleCAS Google Scholar
Shimomura, I., Hammer, R.E., Ikemoto, S., Brown, M.S. & Goldstein, J.L. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature401, 73–76 (1999). ArticleCAS Google Scholar
Gavrilova, O. et al. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J. Clin. Invest.105, 271–278 (2000). ArticleCAS Google Scholar
Seip, M. & Trygstad, O. Generalized lipodystrophy, congenital and acquired (lipoatrophy). Acta Paediatr. Suppl.413, 2–28 (1996). ArticleCAS Google Scholar
Eggleton, P., Reid, K.B. & Tenner, A.J. C1q—how many functions? How many receptors? Trends Cell. Biol.8, 428–431 (1998). ArticleCAS Google Scholar
Shapiro, L. & Scherer, P.E. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol.8, 335–338 (1998). ArticleCAS Google Scholar
Motojima, K., Passilly, P., Peters, J.M., Gonzalez, F.J. & Latruffe, N. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor α and γ activators in a tissue- and inducer-specific manner. J. Biol. Chem.273, 16710–16714 (1998). ArticleCAS Google Scholar
Tontonoz, P., Nagy, L., Alvarez, J.G., Thomazy, V.A. & Evans, R.M. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell93, 241–252 (1998). ArticleCAS Google Scholar
Murakami, K. et al. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-α (PPAR-α) and PPAR-γ: Effect of PPAR-α activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes47, 1841–1847 (1998). ArticleCAS Google Scholar
Kersten, S. et al. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J. Clin. Invest.103, 1489–1498 (1999). ArticleCAS Google Scholar
Lowell, B.B. & Spiegelman, B.M. Towards a molecular understanding of adaptive thermogenesis. Nature404, 652–660 (2000). ArticleCAS Google Scholar
Kelly, L.J. et al. Peroxisome proliferator-activated receptors γ and α mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology139, 4920–4927 (1998). ArticleCAS Google Scholar
Shulman, G.I. Cellular mechanisms of insulin resistance. J. Clin. Invest.106, 171–176 (2000). ArticleCAS Google Scholar
Masuzaki, H. et al. Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: Usefulness of leptin for the treatment of obesity-associated diabetes. Diabetes48, 1615–1622 (1999). ArticleCAS Google Scholar
Kahn, C.R., Vicent, D. & Doria, A. Genetics of non-insulin-dependent (type-II) diabetes mellitus. Annu. Rev. Med.47, 509–31 (1996). ArticleCAS Google Scholar
Ouchi, N. et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-κB signaling through a cAMP-dependent pathway. Circulation102, 1296–301 (2000). ArticleCAS Google Scholar
Yamauchi, T. et al. Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol. Cell. Biol.16, 3074–3084 (1996). ArticleCAS Google Scholar
Mondon, C.E., Dolkas, C.B. & Oyama, J. Enhanced skeletal muscle insulin sensitivity in year-old rats adapted to hypergravity. Am. J. Physiol.240, E482–488 (1981). CASPubMed Google Scholar