Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth (original) (raw)

• Landen, C.N., Birrer, M.J. & Sood, A.K. Early events in the pathogenesis of epithelial ovarian cancer. J. Clin. Oncol. 26, 995–1005 (2008).
  Article PubMed Google Scholar
• Cho, K.R. & Shih, I.-M. Ovarian cancer. Annu. Rev. Pathol. 4, 287–313 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Folkins, A.K., Jarboe, E.A., Roh, M.H. & Crum, C.P. Precursor to pelvic serous carcinoma and their clinical implications. Gynecol. Oncol. 113, 391–396 (2009).
  Article PubMed Google Scholar
• Lengyel, E. Ovarian cancer development and metastasis. Am. J. Pathol. 177, 1053–1064 (2010).
  Article PubMed PubMed Central Google Scholar
• Rodbell, M. Metabolism of isolated fat cells. J. Biol. Chem. 239, 375–380 (1964).
  CAS PubMed Google Scholar
• Merritt, W.M. et al. Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth. J. Natl. Cancer Inst. 100, 359–372 (2008).
  Article CAS PubMed Google Scholar
• Nilsson, M.B., Langley, R.R. & Fidler, I.J. Interleukin-6 secreted by human ovarian carcinoma cells is a potent proangiogenic cytokine. Cancer Res. 65, 10794–10800 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Manabe, Y., Toda, S., Miyazaki, K. & Sugihara, H. Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions. J. Pathol. 201, 221–228 (2003).
  Article PubMed Google Scholar
• Tokuda, Y. et al. Prostate cancer cell growth is modulated by adipocyte–cancer cell interaction. BJU Int. 91, 716–720 (2003).
  Article CAS PubMed Google Scholar
• Dirat, B. et al. Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res. 71, 2455–2465 (2011).
  Article CAS PubMed Google Scholar
• Kaur, S. et al. β3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer. Am. J. Pathol. 175, 2184–2196 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Elliott, B.E., Tam, S.P., Dexter, D. & Chen, Z.Q. Capacity of adipose tissue to promote growth and metastasis of a murine mammary carcinoma: Effect of estrogen and progesterone. Int. J. Cancer 51, 416–424 (1992).
  Article CAS PubMed Google Scholar
• Wakil, S.J. & Abu-Elheiga, L.A. Fatty acid metabolism: target for metabolic syndrome. J. Lipid Res. 50, S138–S143 (2009).
  Article PubMed PubMed Central Google Scholar
• Gonzalez-Yanes, C. & Sanchez-Margalet, V. Signalling mechanisms regulating lipolysis. Cell. Signal. 18, 401–408 (2006).
  Article Google Scholar
• Sengenès, C. et al. Involvement of a cGMP pathway in the natriuretic peptide–mediated hormone sensitive lipase phosphorylation in human adipocytes. J. Biol. Chem. 278, 48617–48626 (2003).
  Article PubMed Google Scholar
• Brasaemle, D.L., Subramanian, V., Garcia, A., Marcinkiewicz, A. & Rothenberg, A. Perilipin A and the control of triacylglycerol metabolism. Mol. Cell. Biochem. 326, 15–21 (2009).
  Article CAS PubMed Google Scholar
• Gagnon, A. et al. Thyroid-stimulating hormose stimulates lipolysis in adipocytes in culture and raises serum free fatty acid levels in vivo. Metabolism 59, 547–553 (2010).
  Article CAS PubMed Google Scholar
• Wang, W. & Guan, K.-L. AMP-activated protein kinase and cancer. Acta Physiol. (Oxf.) 196, 55–63 (2009).
  Article CAS Google Scholar
• Munday, M.R., Campbell, D.G., Carling, D. & Hardie, D.G. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. Eur. J. Biochem. 175, 331–338 (1988).
  Article CAS PubMed Google Scholar
• Carey, M.S. et al. Functional proteomic analysis of advanced serous ovarian cancer using reverse phase protein array: TGF-β pathway signaling indicates response to primary chemotherapy. Clin. Cancer Res. 16, 2852–2860 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Hotamisligil, G.S. et al. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274, 1377–1379 (1996).
  Article CAS PubMed Google Scholar
• Furuhashi, M. & Hotamisligil, G.S. Fatty acid binding proteins: Role in metabolic diseases and potential as drug targets. Nat. Rev. Drug Discov. 7, 489–503 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Scheja, L. et al. Altered insulin secretion associated with reduced lipolytic efficiency in aP2−/− mice. Diabetes 48, 1987–1994 (1999).
  Article CAS PubMed Google Scholar
• Furuhashi, M. et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447, 959–965 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Hertzel, A.V. et al. Identification and characterization of a small molecule inhibitor of fatty acid binding proteins. J. Med. Chem. 52, 6024–6031 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Uysal, K.T., Scheja, L., Wiesbrock, S.M., Bonner-Wier, S. & Hotamisligil, G.S. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 141, 3388–3396 (2000).
  Article CAS PubMed Google Scholar
• Martinez-Outschoorn, U.E. et al. The autophagic tumor stroma model of cancer or “battery-operated tumor growth” a simple solution to the autophagy paradox. Cell Cycle 9, 4297–4306 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Pavlides, S. et al. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle 8, 3984–4001 (2009).
  Article CAS PubMed Google Scholar
• Levine, A.J. & Puzio-Kuter, A.M. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330, 1340–1344 (2010).
  Article CAS PubMed Google Scholar
• DeBerardinis, R.J., Lum, J.J., Hatzivassiliou, G. & Thompson, C.B. The biology of cancer: Metabolic programming fuels cell growth and proliferation. Cell Metab. 7, 11–20 (2008).
  Article CAS PubMed Google Scholar
• Liu, Y. Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer. Prostate Cancer Prostatic Dis. 9, 230–234 (2006).
  Article CAS PubMed Google Scholar
• Zaugg, K. et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev. 25, 1041–1051 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Pike, L.S., Smift, A.L., Croteau, N.J., Ferrick, D.A. & Wu, M. Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim. Biophys. Acta 1807, 726–734 (2011).
  Article CAS PubMed Google Scholar
• Hernlund, E. et al. Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. Int. J. Cancer 123, 476–483 (2008).
  Article CAS PubMed Google Scholar
• Moon, A. & Rhead, W.J. Complementation analysis of fatty acid oxidation disorders. J. Clin. Invest. 79, 59–64 (1987).
  Article CAS PubMed PubMed Central Google Scholar
• Hennessy, B.T. et al. A technical assessment of the utility of reverse phase protein arrays for the study of the functional proteome in non-microdissected human breast cancers. Clin. Proteomics 6, 129–151 (2010).
  Article CAS PubMed Google Scholar