Spondin 1 (original) (raw)

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Protein-coding gene in the species Homo sapiens

SPON1
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZOT, 2ZOU, 3COO, 3Q13
Identifiers
Aliases	SPON1, VSGP/F-spondin, f-spondin, Spondin 1
External IDs	OMIM: 604989; MGI: 2385287; HomoloGene: 4453; GeneCards: SPON1; OMA:SPON1 - orthologs
Gene location (Human)Chr.Chromosome 11 (human)[1]Band11p15.2Start13,962,723 bp[1]End14,268,133 bp[1]
Gene location (Mouse)Chr.Chromosome 7 (mouse)[2]Band7|7 F1Start113,365,235 bp[2]End113,642,605 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed ingallbladdermucosa of sigmoid colonpericardiumlower lobe of lungcardiamucosa of urinary bladderexternal globus pallidusright lungvisceral pleuraparietal pleuraTop expressed inepithelium of lensirisciliary bodyexternal carotid arterycervixinternal carotid arteryretinal pigment epitheliumatriumdeciduasuprachiasmatic nucleusMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function protein binding metal ion binding extracellular matrix structural constituent LBD domain binding Cellular component extracellular matrix extracellular region endoplasmic reticulum lumen extracellular space collagen-containing extracellular matrix Biological process cell adhesion protein O-linked fucosylation positive regulation of protein processing positive regulation of protein binding negative regulation of amyloid-beta formation positive regulation of amyloid precursor protein catabolic process Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez10418233744EnsemblENSG00000262655ENSMUSG00000038156UniProtQ9HCB6Q8VCC9RefSeq (mRNA)NM_006108NM_145584RefSeq (protein)NP_006099NP_663559Location (UCSC)Chr 11: 13.96 – 14.27 MbChr 7: 113.37 – 113.64 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene.[5] It is secreted by cells of the floor plate and may be involved in axon guidance[6] The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000262655 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038156 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
6. ^ "Entrez Gene: SPON1 spondin 1, extracellular matrix protein".

• Nakajima D, Okazaki N, Yamakawa H (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.

• Klar A, Baldassare M, Jessell TM (1992). "F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension". Cell. 69 (1): 95–110. doi:10.1016/0092-8674(92)90121-R. PMID 1555244. S2CID 14880785.

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

• Miyamoto K, Morishita Y, Yamazaki M (2001). "Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary". Arch. Biochem. Biophys. 390 (1): 93–100. doi:10.1006/abbi.2001.2367. PMID 11368520.

• Gonzalez de Peredo A, Klein D, Macek B (2002). "C-mannosylation and o-fucosylation of thrombospondin type 1 repeats". Mol. Cell. Proteomics. 1 (1): 11–8. doi:10.1074/mcp.M100011-MCP200. PMID 12096136.

• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

• Ho A, Südhof TC (2004). "Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2548–53. Bibcode:2004PNAS..101.2548H. doi:10.1073/pnas.0308655100. PMC 356987. PMID 14983046.

• Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

• Pyle-Chenault RA, Stolk JA, Molesh DA (2005). "VSGP/F-spondin: a new ovarian cancer marker". Tumour Biol. 26 (5): 245–57. doi:10.1159/000087379. PMID 16103746. S2CID 13409234.

• Otsuki T, Ota T, Nishikawa T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

• Kitagawa M, Kudo Y, Iizuka S (2006). "Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells" (PDF). Biochem. Biophys. Res. Commun. 349 (3): 1050–6. doi:10.1016/j.bbrc.2006.08.142. PMID 16965763.

• Overview of all the structural information available in the PDB for UniProt: Q9HCB6 (Spondin-1) at the PDBe-KB.