luis chorro | Ecole Polytechnique Federale de Lausanne (original) (raw)

Papers by luis chorro

The present study analyzes three aspects related to Ventricular Fibrillation (VF): 1) Stability o... more The present study analyzes three aspects related to Ventricular Fibrillation (VF): 1) Stability of the VF model using an isolated heart and maintaining perfusion; 2) Comparison among the information related to the spectral analysis of the VF signal given by different types and positioning of the electrodes during its stability; 3) Alterations in VF before its interruption provoked by administering ClK. The absolute (AAPM) and normalized (ANPM) amplitudes, the frequency for the maximum peak (FPM) and the energy contained in a band of ±1 Hz around the FPM are analyzed for a group of 25 registers. The conclusions are: 1) VF stability in isolated heart; 2) similar information respect to the FPM and the energy is obtained for unipolar and bipolar, endo- and epicardial electrodes during stable VF; 3) Progressive reduction in the FPM is appreciated following the administration of ClK

American Heart Journal, 1999

Resting ST-segment elevation on Q leads after an acute myocardial infarction has been related to ... more Resting ST-segment elevation on Q leads after an acute myocardial infarction has been related to a greater infarct size. Otherwise, the relation between exercise-induced ST-segment elevation and myocardial viability is controversial. We investigated the relation between ST-segment elevation on Q leads at rest and during exercise and regional dysfunction and its evolution, contractile reserve, left ventricular dilation, and coronary patency. Exercise testing and cardiac catheterization were performed at the first week after infarction in 51 patients. The study group was divided according to the existence (in 2 or more Q leads; n = 36) or not (n = 15) of resting ST-segment elevation and according to the existence (n = 28) or not (n = 23) of exercise-induced ST-segment elevation. Left ventricular end-diastolic and end-systolic volumes (mL/m2), regional wall motion (SD/chord), contractile reserve (wall motion percentage improvement with low-dose dobutamine), and coronary patency in the culprit artery were analyzed. Cardiac catheterization was repeated at the sixth month in 35 patients; systolic recovery (wall motion percentage improvement), left ventricular volumes, and coronary patency were again evaluated. Patients with resting ST-segment elevation showed poorer wall motion (2.1 +/- 0.8 SD/chord vs 1.2 +/- 1 SD/chord, P =.002), lesser contractile reserve (17% [0% to 39%] vs 41% [4% to 92%], P =.04), greater end-systolic volume (32 +/- 15 mL/m2 vs 23 +/- 11 mL/m2, P =.04), and higher percentage of occlusion (36% vs 7%, P =.04) than did patients without ST-segment elevation. Likewise, patients with exercise-induced ST-segment elevation showed lesser contractile reserve (8% [0% to 40%] vs 35% [12% to 86%], P =.03) than did patients without exercise-induced ST-segment elevation. The only independent predictors of contractile reserve were wall motion <2 SD/chord (odds ratio [OR] 7.1, confidence interval [CI] 6.3 to 7.9, P =.01) and the absence of exercise-induced ST-segment elevation (OR 5.7, CI 4.9 to 6.5, P =. 02). There were no significant differences between patients with and those without ST-segment elevation (at rest or during exercise) in systolic recovery or left ventricular volumes at the sixth month. ST-segment elevation on Q leads at rest is related to a poorer systolic function (more severe regional dysfunction, greater end-systolic volume, and less response to dobutamine). ST-segment elevation during exercise is independently related to a lesser contractile reserve. ST-segment elevation (at rest or during exercise) is not related to the evolution of volumes or regional dysfunction during the first 6 months after infarction.

Revista Espanola De Cardiologia, 2004

Introducción y objetivos. El mecanismo implicado en la elevación de la proteína C reactiva (PCR) ... more Introducción y objetivos. El mecanismo implicado en la elevación de la proteína C reactiva (PCR) en los síndromes coronarios agudos (inflamación en la placa de ateroma o necrosis miocárdica) es motivo de controversia. Se investigó la relación de la PCR con la complejidad angiográfica de la lesión causante y con la elevación de la troponina en el síndrome coronario agudo sin elevación del segmento ST.

Investigates the time course of the ECG parameters that are affected during pregnancy and after l... more Investigates the time course of the ECG parameters that are affected during pregnancy and after labour through the analysis of heart rate variability and ventricular repolarization. In 29 pregnant women, three stages have been studied: at 6 months pregnant (6MP), at 9 months (9MP) and one month after labour (1ML). Time- and frequency-domain parameters were evaluated on 24-hour Holter ECG recordings, for diurnal and nocturnal periods. The obtained results showed: (1) 9MP vs. 1ML provides significant differences between the parameters in the time- and frequency-domains in diurnal and nocturnal periods; (2) only ventricular repolarization parameters can distinguish 9MP from 6MP during nocturnal periods; (3) 6MP vs. 1ML only shows significant differences between the time- and frequency-domain parameters during nocturnal periods. In conclusion, the parasympathetic influence on heart rate variability decreases with time during pregnancy, reaching its minimum in the last month and recovering after labour

Pace-pacing and Clinical Electrophysiology, 1989

SANJUAN, R., et al.: Transvenous ablation with high frequency energy for atrioventricular junctio... more SANJUAN, R., et al.: Transvenous ablation with high frequency energy for atrioventricular junctional (AV nodal) reentrant tachycardia We performed transcatheter AV junction ablation with high frequency energy in four patients with AV nodal reentrant tachycardia where extensive trials of several antiarrhythmic drugs failed to prevent further recurrences of tachycardia. Initially high frequency catheter ablation induced complete AV block in all patients. A recuperation of AV l:1 conduction followed some time later, persisting in follow-up. No complications have been encountered in either the acute phase or the follow-up (from 6 to 8 months; mean ± SD: 8.7 ± 2.5 months). The electrophysiological study was carried out 6 weeks following ablation, and all patients showed AV 1:1 conduction. No dual nodal pathway was encountered and no tachycardia could be triggered. With refinement of the method, the potential application of high frequency energy to interrupt intranodal or perinodal connections responsible for reentrant supraventricular tachycardia or to retard AV nodal conduction appears promising.

Revista Espanola De Cardiologia, 2008

Rev Esp Cardiol. 2008;61(2):161-9 161 INTRODUCCIÓN La cardiología es la disciplina o especialidad... more Rev Esp Cardiol. 2008;61(2):161-9 161 INTRODUCCIÓN La cardiología es la disciplina o especialidad médica encargada de la prevención, el diagnóstico y el tratamiento de las enfermedades cardiovasculares. Al constituir la principal causa de morbimortalidad en España y en la Unión Europea 1 , los profesionales de la cardiología tienen, respecto a otras especialidades médicas, una responsabilidad y autoridad morales añadidas, derivadas de la relevancia que tiene para la sociedad un ejercicio excelente de la lucha contra la enfermedad cardiovascular. De ahí la importancia de efectuar un seguimiento de las rápidas transiciones que en el momento actual se están dando en los órdenes sociales, administrativos, educativos, asistenciales y profesionales, transiciones que necesariamente condicionarán nuevos contextos para el ejercicio de la cardiología y para sus profesionales.

Inflammation, 2011

The evolution of white blood cells after ST elevation myocardial infarction (STEMI) and their ass... more The evolution of white blood cells after ST elevation myocardial infarction (STEMI) and their association with infarct size and major adverse cardiac events (MACE) remains unclear. Two hundred eleven patients underwent CMR after STEMI. Infarct mass (grams) was determined. Neutrophil, lymphocyte, and monocyte counts (×1,000 cells/ml) were measured upon arrival and at 12, 24, 48, 72, and 96 h. Patients with large infarctions (3rd tertile ≥ 28.5 g vs. 1st and 2nd tertiles < 28.5 g) showed a larger neutrophil count at 12 h (14.8 ± 4.8 vs. 11.4 ± 3.3, p < 0.0001) and an increased monocyte count (maximum at 24 h (0.65[0.50–0.91] vs. 0.55[0.42–0.71], p = 0.004)) but no difference in lymphocyte count. Neutrophil count at 12 h independently predicted large infarctions (OR 1.14, 95%CI [1.04–1.26], p = 0.008). During follow-up (median 504 days), 25 MACE occurred. Neutrophil count at 96 h independently predicted MACE (HR 1.2, 95%CI [1.1–1.4], p = 0.003). Large infarctions show a marked neutrophil peak and an increasing monocyte count. Neutrophil count independently predicts large infarctions and MACE.

Revista Espanola De Cardiologia, 2008

Pace-pacing and Clinical Electrophysiology, 2007

Background: Few experimental studies have analyzed the effects of selective radiofrequency (RF) l... more Background: Few experimental studies have analyzed the effects of selective radiofrequency (RF) lesions upon ventricular fibrillation (VF). The RF-induced isolation of selected zones would make it possible to determine whether these zones are essential for existence of the arrhythmia.Methods: In 31 Langendorff-perfused rabbit hearts, the characteristics and inducibility of VF were analyzed before and after the induction of RF lesions comprising: (1) the posterior zone of the septum and of the walls of both ventricles (n = 10); (2) the anterior zone of the septum and of the walls of both ventricles (n = 11); and (3) the midseptal zone (n = 10).Results: Complete isolation of the zone encompassed by the lesions was obtained in 5, 6, and 5 experiments of series 1, 2, and 3, respectively. In these experiments, the arrhythmia was only induced from within the zone encompassed by the lesions in one experiment belonging to series 2 (P < 0.05 with respect to baseline). In contrast, in all but one of the cases in series 2, VF could be induced from outside the isolated zone (ns vs baseline). Partial isolation was obtained in five experiments of each series. In these experiments, on pacing from within the partially isolated zone, sustained VF was not induced in any experiment (P < 0.05 with respect to baseline), while in all cases VF could be induced on pacing from the external zone (ns vs baseline).Conclusion: In the experimental model used, the three zones studied were not essential for maintaining VF. In most cases, their partial or total isolation avoided inducibility of the arrhythmia in those zones, though not in the remaining myocardium.

American Heart Journal, 1999

Revista Espanola De Cardiologia, 2004

Pace-pacing and Clinical Electrophysiology, 1989

Revista Espanola De Cardiologia, 2008

Inflammation, 2011

Revista Espanola De Cardiologia, 2008

Pace-pacing and Clinical Electrophysiology, 2007