Philippe Guillet | EPHE - Academia.edu (original) (raw)
Papers by Philippe Guillet
Histoire Des Sciences Medicales, 2017
The history of the publication of A Translation of Galen’s Hygiene (De Sanitate Tuenda) by R.M. G... more The history of the publication of A Translation of Galen’s Hygiene (De Sanitate Tuenda) by
R.M. Green, the first English translation of Galen’s De sanitate tuenda, published in 1951 in North America, highlights the perils looming over the adaptation of ancient medical texts to modern readers, and underscores the need for a tight collaboration between experts across various disci- plines in order to achieve success. It also gives us the opportunity to reminisce about several great medical historians from the first half of last century.
Histoire Des Sciences Medicales, 2016
The main objective of this research was, for the first time, to partially edit an anatomical text... more The main objective of this research was, for the first time, to partially edit an anatomical text in
middle french, the ms FR 19.991, a 15th century manuscript held by the Bibliothèque Nationale de France. After restitution of the text (transcription, expansion of abbreviations and identification of rubricated sections) a glossary of all terms was compiled. The analysis of this anatomical treatise following the arabic galenic tradition revealed that it results from the assembly of at least three previous texts, the largest part of it (18 / 22 sections) following very closely the anatomia ricardi salertinani, translated from arabic to latin in the 12th century in the Salernitan school of medicine. The use of this treatise remains to be elucidated.
Histoire Des Sciences Médicales, 2018
Codex 432 kept at the Bibliothèque Inter-Universitaire de Santé in Paris contains two heavily com... more Codex 432 kept at the Bibliothèque Inter-Universitaire de Santé in Paris contains two heavily
commented copies of Cælius Aurelianus’ Treatise on Chronic Diseases, published in Basel in 1529 by Petrus Henricus. The study of this document allowed to establish that it contains two states of the comments made by Jacques Dalechamps, a physician and humanist from the 16th century, esta- blished in Lyons and collaborating with the librarian-printer Guillaume Rouillé. This document was made in preparation of a new complete version of Cælius’s Treatise on Acute and Chronic Diseases, published by Rouillé in 1566. The study confirms the conclusions of the work of Anna- Maria Urso who demonstrated on philological arguments that the marginal annotations on the rovillian edition are from Jacques Dalechamps’ hand. This document also allows to look into some aspects of the activities involved in editing and printing medical texts in the 16th century.
En 1951, le Docteur Sidney Licht fait publier la première traduction en langue moderne de l'Hygiè... more En 1951, le Docteur Sidney Licht fait publier la première traduction en langue moderne de l'Hygiène (De sanitate tuenda libri VI) rédigé par Galien entre 175 et 190 de notre ère. C'est le docteur Robert Montraville Green, professeur d'anatomie à la Harvard Medical School et gynécologueobstétricien à la retraite, ayant été formé aux Classiques à la Boston Latin School, qui est chargé de cette traduction. L'historien de la médecine Henry Ernest Sigerist en écrit l'introduction. Ce premier volume s'inscrit dans un programme plus vaste prévoyant la traduction en anglais de vingt autres textes de Galien, qui ne seront pas publiés. Malgré ses limites, cette traduction reste à l'heure actuelle la seule permettant aux non hellénistes et non latinistes d'approcher la pensée de Galien sur les mesures à prendre pour conserver la santé tout au long de la vie et ainsi permettre à chacun de vieillir confortablement. Á la lecture de cette oeuvre on mesure la finesse d'observation et l'actualité de ce grand médecin de l'Antiquité ; la gérontologie moderne, apparue à la fin du XIX e siècle avec l'accroissement de la longévité, a corroboré les observations qu'il avait déjà faites il y a près de deux mille ans.
John Wiley & Sons, Ltd eBooks, Jan 12, 2016
In addition to the sites referenced above, there are also the following resources for free books:... more In addition to the sites referenced above, there are also the following resources for free books: WorldeBookFair: for a limited time, you can have access to over a million free ebooks. WorldLibrary:More than 330,000+ unabridged original single file PDF eBooks by the original authors. FreeTechBooks: just like the name of the site, you can get free technology-related books here. FullBooks.com: organized alphabetically; there are a TON of books here. Bartleby eBooks: a huge array of classic literature, all available for free download.
Clinical Neuropharmacology, 1992
Fundamental & Clinical Pharmacology, May 6, 1994
BACKGROUND: This study evaluated the correlation between the pharmacokinetics and pharmacodynamic... more BACKGROUND: This study evaluated the correlation between the pharmacokinetics and pharmacodynamics of granulocyte colony-stimulating factor (lenograstim) and the impact of initiation time of apheresis on stem cell mobilization in patients with multiple myeloma. STUDY DESIGN AND METHODS: Twenty-four patients with multiple myeloma were randomized into one of the two groups (early vs. late). Lenograstim at 10 μg/kg/day once daily was injected for at least 4 consecutive days. Apheresis was initiated 2 hours after the fourth dose of lenograstim in the early collection group and 16 hours after the fourth dose of lenograstim in the late collection group. Blood sampling for pharmacokinetics was performed within 30 minutes before, and 1, 2, 6, and 24 hours after the fourth dose of lenograstim.
The pharmacological treatment of the elderly patient represents a therapeutic problem which, over... more The pharmacological treatment of the elderly patient represents a therapeutic problem which, over the last decade, has reached a totally unexpected dimension with important social, medical and economic implications [1,2]. A better understanding of various aetiopathogenic factors and the improvement of therapeutic possibilities are factors which have contributed to a better quality of life and an increase in life expectancy. However, at the same time there has been an increase in the ‘institutionalization’ of the elderly, as well as in the use of agents capable not only of curing illnesses but also of modifying behaviour in ways not always acceptable to the family and/or the community.
Alzheimers & Dementia, Jul 1, 2014
Histoire des sciences medicales, 2016
The main objective of this research was,for the first time, to partially edit an anatomical text ... more The main objective of this research was,for the first time, to partially edit an anatomical text in middle french, the ms FR 19.991, a 15th century manuscript held by the Bibliotheque Nationale de France. After restitution of the text (transcription, expansion of abbreviations and identification of rubricated sections) a glossary of all terms was compiled. The analysis of this anatomical treatise following the arabic galenic tradition revealed that it results from the assembly of at least three previous texts, the largest part of it (18 / 22 sections) following very closely the anatomia ricardi salertinani, translated from arabic to latin in the 12th century in the Salernitan school of medicine. The use of this treatise remains to be elucidated.
En 1951, le Docteur Sidney Licht fait publier la premiere traduction en langue moderne de l’Hygie... more En 1951, le Docteur Sidney Licht fait publier la premiere traduction en langue moderne de l’Hygiene (De sanitate tuenda libri VI) redige par Galien entre 175 et 190 de notre ere. C’est le docteur Robert Montraville Green, professeur d’anatomie a la Harvard Medical School et gynecologue-obstetricien a la retraite, ayant ete forme aux Classiques a la Boston Latin School, qui est charge de cette traduction. L’historien de la medecine Henry Ernest Sigerist en ecrit l’introduction. Ce premier volume s’inscrit dans un programme plus vaste prevoyant la traduction en anglais de vingt autres textes de Galien, qui ne seront pas publies. Malgre ses limites, cette traduction reste a l’heure actuelle la seule permettant aux non hellenistes et non latinistes d’approcher la pensee de Galien sur les mesures a prendre pour conserver la sante tout au long de la vie et ainsi permettre a chacun de vieillir confortablement. A la lecture de cette oeuvre, on mesure la finesse d’observation et l’actualite ...
Psychopharmacology, 1991
The anxiolytic activity and tolerance of four doses of suriclone (0.1, 0.2, 0.3 and 0.4 mg tid), ... more The anxiolytic activity and tolerance of four doses of suriclone (0.1, 0.2, 0.3 and 0.4 mg tid), diazepam (5 mg tid), and placebo were compared in six parallel groups of 54-59 outpatients with generalized anxiety disorder (DSM III-R). After a 1-week placebo run-in period, the patients were treated for 4 weeks, with assessments at baseline and after 1, 2, and 4 weeks by the Hamilton anxiety scale and the Clinical Global Impressions. Results showed better improvement with active drugs as compared to placebo, without significant differences among the four different doses of suriclone and diazepam. The number of adverse events, particularly drowsiness, was significantly higher with diazepam than with suriclone, particularly 0.1 and 0.2 mg tid which did not differ from placebo. These results demonstrate that suriclone at daily doses ranging from 0.1 to 0.4 mg tid is an effective anxiolytic, better tolerated than diazepam.
Drugs & Aging, 1993
Healthy elderly people aged 70 or more should receive a starting dosage of the anxiolytic drug su... more Healthy elderly people aged 70 or more should receive a starting dosage of the anxiolytic drug suriclone half that recommended for younger people; frail or ill elderly people may require further dosage reduction. These conclusions were based on a study of the pharmacokinetics and tolerability of orally administered suriclone after a single dose of 0.2mg and after multiple doses of 0.2mg 3-times daily in 8 male and 8 female healthy elderly volunteers. Informal comparisons of the pharmacokinetic data from this study with studies in younger volunteers showed a 53% decrease in clearance and an 84% increase in elimination half-life. Area under the plasma concentration-time curve (AUC) for suriclone and total antigenic products in the elderly were twice the values in younger volunteers when adjusted for different dosage. There were no significant changes in pulse rate or blood pressure during the study. One person showed a change from sinus rhythm to atrial fibrillation. Six people had transient adverse events including unsteadiness, vomiting, difficulty in reaching for objects, urinary incontinence and sedation.
La Revue De Geriatrie, 1983
Clinical Neuropharmacology, 1992
Clinical Neuropharmacology, 1992
Cherubini/Clinical trials in older adults, 2016
Guide Pratique du Vieillissement, 2016
Histoire Des Sciences Medicales, 2017
The history of the publication of A Translation of Galen’s Hygiene (De Sanitate Tuenda) by R.M. G... more The history of the publication of A Translation of Galen’s Hygiene (De Sanitate Tuenda) by
R.M. Green, the first English translation of Galen’s De sanitate tuenda, published in 1951 in North America, highlights the perils looming over the adaptation of ancient medical texts to modern readers, and underscores the need for a tight collaboration between experts across various disci- plines in order to achieve success. It also gives us the opportunity to reminisce about several great medical historians from the first half of last century.
Histoire Des Sciences Medicales, 2016
The main objective of this research was, for the first time, to partially edit an anatomical text... more The main objective of this research was, for the first time, to partially edit an anatomical text in
middle french, the ms FR 19.991, a 15th century manuscript held by the Bibliothèque Nationale de France. After restitution of the text (transcription, expansion of abbreviations and identification of rubricated sections) a glossary of all terms was compiled. The analysis of this anatomical treatise following the arabic galenic tradition revealed that it results from the assembly of at least three previous texts, the largest part of it (18 / 22 sections) following very closely the anatomia ricardi salertinani, translated from arabic to latin in the 12th century in the Salernitan school of medicine. The use of this treatise remains to be elucidated.
Histoire Des Sciences Médicales, 2018
Codex 432 kept at the Bibliothèque Inter-Universitaire de Santé in Paris contains two heavily com... more Codex 432 kept at the Bibliothèque Inter-Universitaire de Santé in Paris contains two heavily
commented copies of Cælius Aurelianus’ Treatise on Chronic Diseases, published in Basel in 1529 by Petrus Henricus. The study of this document allowed to establish that it contains two states of the comments made by Jacques Dalechamps, a physician and humanist from the 16th century, esta- blished in Lyons and collaborating with the librarian-printer Guillaume Rouillé. This document was made in preparation of a new complete version of Cælius’s Treatise on Acute and Chronic Diseases, published by Rouillé in 1566. The study confirms the conclusions of the work of Anna- Maria Urso who demonstrated on philological arguments that the marginal annotations on the rovillian edition are from Jacques Dalechamps’ hand. This document also allows to look into some aspects of the activities involved in editing and printing medical texts in the 16th century.
En 1951, le Docteur Sidney Licht fait publier la première traduction en langue moderne de l'Hygiè... more En 1951, le Docteur Sidney Licht fait publier la première traduction en langue moderne de l'Hygiène (De sanitate tuenda libri VI) rédigé par Galien entre 175 et 190 de notre ère. C'est le docteur Robert Montraville Green, professeur d'anatomie à la Harvard Medical School et gynécologueobstétricien à la retraite, ayant été formé aux Classiques à la Boston Latin School, qui est chargé de cette traduction. L'historien de la médecine Henry Ernest Sigerist en écrit l'introduction. Ce premier volume s'inscrit dans un programme plus vaste prévoyant la traduction en anglais de vingt autres textes de Galien, qui ne seront pas publiés. Malgré ses limites, cette traduction reste à l'heure actuelle la seule permettant aux non hellénistes et non latinistes d'approcher la pensée de Galien sur les mesures à prendre pour conserver la santé tout au long de la vie et ainsi permettre à chacun de vieillir confortablement. Á la lecture de cette oeuvre on mesure la finesse d'observation et l'actualité de ce grand médecin de l'Antiquité ; la gérontologie moderne, apparue à la fin du XIX e siècle avec l'accroissement de la longévité, a corroboré les observations qu'il avait déjà faites il y a près de deux mille ans.
John Wiley & Sons, Ltd eBooks, Jan 12, 2016
In addition to the sites referenced above, there are also the following resources for free books:... more In addition to the sites referenced above, there are also the following resources for free books: WorldeBookFair: for a limited time, you can have access to over a million free ebooks. WorldLibrary:More than 330,000+ unabridged original single file PDF eBooks by the original authors. FreeTechBooks: just like the name of the site, you can get free technology-related books here. FullBooks.com: organized alphabetically; there are a TON of books here. Bartleby eBooks: a huge array of classic literature, all available for free download.
Clinical Neuropharmacology, 1992
Fundamental & Clinical Pharmacology, May 6, 1994
BACKGROUND: This study evaluated the correlation between the pharmacokinetics and pharmacodynamic... more BACKGROUND: This study evaluated the correlation between the pharmacokinetics and pharmacodynamics of granulocyte colony-stimulating factor (lenograstim) and the impact of initiation time of apheresis on stem cell mobilization in patients with multiple myeloma. STUDY DESIGN AND METHODS: Twenty-four patients with multiple myeloma were randomized into one of the two groups (early vs. late). Lenograstim at 10 μg/kg/day once daily was injected for at least 4 consecutive days. Apheresis was initiated 2 hours after the fourth dose of lenograstim in the early collection group and 16 hours after the fourth dose of lenograstim in the late collection group. Blood sampling for pharmacokinetics was performed within 30 minutes before, and 1, 2, 6, and 24 hours after the fourth dose of lenograstim.
The pharmacological treatment of the elderly patient represents a therapeutic problem which, over... more The pharmacological treatment of the elderly patient represents a therapeutic problem which, over the last decade, has reached a totally unexpected dimension with important social, medical and economic implications [1,2]. A better understanding of various aetiopathogenic factors and the improvement of therapeutic possibilities are factors which have contributed to a better quality of life and an increase in life expectancy. However, at the same time there has been an increase in the ‘institutionalization’ of the elderly, as well as in the use of agents capable not only of curing illnesses but also of modifying behaviour in ways not always acceptable to the family and/or the community.
Alzheimers & Dementia, Jul 1, 2014
Histoire des sciences medicales, 2016
The main objective of this research was,for the first time, to partially edit an anatomical text ... more The main objective of this research was,for the first time, to partially edit an anatomical text in middle french, the ms FR 19.991, a 15th century manuscript held by the Bibliotheque Nationale de France. After restitution of the text (transcription, expansion of abbreviations and identification of rubricated sections) a glossary of all terms was compiled. The analysis of this anatomical treatise following the arabic galenic tradition revealed that it results from the assembly of at least three previous texts, the largest part of it (18 / 22 sections) following very closely the anatomia ricardi salertinani, translated from arabic to latin in the 12th century in the Salernitan school of medicine. The use of this treatise remains to be elucidated.
En 1951, le Docteur Sidney Licht fait publier la premiere traduction en langue moderne de l’Hygie... more En 1951, le Docteur Sidney Licht fait publier la premiere traduction en langue moderne de l’Hygiene (De sanitate tuenda libri VI) redige par Galien entre 175 et 190 de notre ere. C’est le docteur Robert Montraville Green, professeur d’anatomie a la Harvard Medical School et gynecologue-obstetricien a la retraite, ayant ete forme aux Classiques a la Boston Latin School, qui est charge de cette traduction. L’historien de la medecine Henry Ernest Sigerist en ecrit l’introduction. Ce premier volume s’inscrit dans un programme plus vaste prevoyant la traduction en anglais de vingt autres textes de Galien, qui ne seront pas publies. Malgre ses limites, cette traduction reste a l’heure actuelle la seule permettant aux non hellenistes et non latinistes d’approcher la pensee de Galien sur les mesures a prendre pour conserver la sante tout au long de la vie et ainsi permettre a chacun de vieillir confortablement. A la lecture de cette oeuvre, on mesure la finesse d’observation et l’actualite ...
Psychopharmacology, 1991
The anxiolytic activity and tolerance of four doses of suriclone (0.1, 0.2, 0.3 and 0.4 mg tid), ... more The anxiolytic activity and tolerance of four doses of suriclone (0.1, 0.2, 0.3 and 0.4 mg tid), diazepam (5 mg tid), and placebo were compared in six parallel groups of 54-59 outpatients with generalized anxiety disorder (DSM III-R). After a 1-week placebo run-in period, the patients were treated for 4 weeks, with assessments at baseline and after 1, 2, and 4 weeks by the Hamilton anxiety scale and the Clinical Global Impressions. Results showed better improvement with active drugs as compared to placebo, without significant differences among the four different doses of suriclone and diazepam. The number of adverse events, particularly drowsiness, was significantly higher with diazepam than with suriclone, particularly 0.1 and 0.2 mg tid which did not differ from placebo. These results demonstrate that suriclone at daily doses ranging from 0.1 to 0.4 mg tid is an effective anxiolytic, better tolerated than diazepam.
Drugs & Aging, 1993
Healthy elderly people aged 70 or more should receive a starting dosage of the anxiolytic drug su... more Healthy elderly people aged 70 or more should receive a starting dosage of the anxiolytic drug suriclone half that recommended for younger people; frail or ill elderly people may require further dosage reduction. These conclusions were based on a study of the pharmacokinetics and tolerability of orally administered suriclone after a single dose of 0.2mg and after multiple doses of 0.2mg 3-times daily in 8 male and 8 female healthy elderly volunteers. Informal comparisons of the pharmacokinetic data from this study with studies in younger volunteers showed a 53% decrease in clearance and an 84% increase in elimination half-life. Area under the plasma concentration-time curve (AUC) for suriclone and total antigenic products in the elderly were twice the values in younger volunteers when adjusted for different dosage. There were no significant changes in pulse rate or blood pressure during the study. One person showed a change from sinus rhythm to atrial fibrillation. Six people had transient adverse events including unsteadiness, vomiting, difficulty in reaching for objects, urinary incontinence and sedation.
La Revue De Geriatrie, 1983
Clinical Neuropharmacology, 1992
Clinical Neuropharmacology, 1992
Cherubini/Clinical trials in older adults, 2016
Guide Pratique du Vieillissement, 2016