PlasmaN-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome (original) (raw)
Hartmann, Daniel, von Figura, Guido, Song, Zhangfa, Harden, Sharon, Scott, Lucy C, Evans, TR Jeffry 
ORCID: https://orcid.org/0000-0002-4175-914X, Rudolph, Karl Lenhard, Bilsland, Alan E ORCID: https://orcid.org/0000-0003-0957-3908 and Keith, W Nicol ORCID: https://orcid.org/0000-0001-7862-3580(2015) PlasmaN-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome.Future Oncology, 11(2), pp. 193-203. (doi: 10.2217/fon.14.166)
Publisher's URL: http://dx.doi.org/10.2217/fon.14.166
Abstract
Background:N-acetyl-glucosaminidase (NAG) is a potential marker of genotoxicity. We retrospectively analyzed plasma NAG and clinico-pathologic features in advanced gastrointestinal adenocarcinoma patients. Methods: Plasma from 118 patients and 51 healthy volunteers was analyzed for associations between NAG levels and age, disease presence, stage, treatment responses and survival. Results:Pretreatment NAG correlated with age but was independently increased in metastatic versus locally advanced disease, particularly in gastric/esophageal patients. NAG was also associated with reduced overall survival. In subgroup analysis, increased NAG activity between day 1 and 2 of chemotherapy cycle 1 correlated with treatment response.Conclusion:We demonstrated that NAG correlates with gastrointestinal cancer outcomes. Further studies are required to determine if plasma markers of genotoxicity can be useful for disease monitoring.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Scott, Dr Lucy and Bilsland, Dr Alan and Evans, Professor Jeff and Keith, Professor Nicol and Harden, Ms Sharon |
| Authors: | Hartmann, D., von Figura, G., Song, Z., Harden, S., Scott, L. C., Evans, T. J., Rudolph, K. L., Bilsland, A. E., and Keith, W. N. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Future Oncology |
| Publisher: | Future Medicine Ltd. |
| ISSN: | 1479-6694 |
| ISSN (Online): | 1744-8301 |
| Copyright Holders: | Copyright © 2015 The Authors |
| First Published: | First published in Future Oncology 11(2):193-203 |
| Publisher Policy: | Reproduced under a Creative Commons License |
| Related URLs: | PubMed UK |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
| ID Code: | 102061 |
|---|---|
| Depositing User: | Ms Mary Anne Meyering |
| Datestamp: | 30 Jan 2015 11:47 |
| Last Modified: | 02 May 2025 04:42 |
| Date of first online publication: | 2015 |
| Date Deposited: | 15 December 2015 |
| Data Availability Statement: | No |