Caged mitochondrial uncouplers that are released in response to hydrogen peroxide (original) (raw)
Quin, C., Robertson, L., McQuaker, S.J., Price, N.C., Brand, M.D. and Hartley, R.C.(2010) Caged mitochondrial uncouplers that are released in response to hydrogen peroxide.Tetrahedron, 66(13), pp. 2384-2389. (doi: 10.1016/j.tet.2010.01.103) (PMID:20418941) (PMCID:PMC2852674)
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Abstract
Caged versions of the most common mitochondrial uncouplers (proton translocators) have been prepared that sense the reactive oxygen species (ROS) hydrogen peroxide to release the uncouplers 2,4-dinitrophenol (DNP) and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) from caged states with second order rate constants of 10 (±0.8) M−1 s−1 and 64.8 (±0.6) M−1 s−1, respectively. The trigger mechanism involves conversion of an arylboronate into a phenol followed by fragmentation. Hydrogen peroxide-activated uncouplers may be useful for studying the biological process of ageing.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Price, Prof Nicholas and Hartley, Professor Richard and Robertson, Dr Linsey |
| Authors: | Quin, C., Robertson, L., McQuaker, S.J., Price, N.C., Brand, M.D., and Hartley, R.C. |
| Subjects: | Q Science > QH Natural history > QH345 Biochemistry |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life SciencesCollege of Science and Engineering > School of Chemistry |
| Journal Name: | Tetrahedron |
| Publisher: | Elsevier |
| ISSN: | 0040-4020 |
| ISSN (Online): | 1464-5416 |
| Published Online: | 02 February 2010 |
| Copyright Holders: | Copyright © 2010 Elsevier |
| First Published: | First published in Tetrahedron 66(13):2384-2389 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
| ID Code: | 32202 |
|---|---|
| Depositing User: | Mrs Alexis Stevenson |
| Datestamp: | 30 Jun 2010 09:48 |
| Last Modified: | 01 May 2025 14:10 |
| Date of first online publication: | 2 February 2010 |