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Number of items: 101.

2025

Pala, L. et al. (2025)Mitochondrial succinate transport is required for cardiac ischemia/reperfusion injury. Cardiovascular Research, (Accepted for Publication)

Eaglesfield, Ross, Fernandez-Vizarra, Erika, Lacko, Erik, Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Sloan, Nikki L., Siciarz, Daniel, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 and Tokatlidis, Kostas ORCID: https://orcid.org/0000-0001-6295-8183(2025)Sub-organellar mitochondrial hydrogen peroxide observed using a SNAP tag targeted coumarin-based fluorescent reporter. Redox Biology, 80, 103502. (doi: 10.1016/j.redox.2025.103502) (PMID:39864323) (PMCID:PMC11802384)

Luk, C. et al. (2025)Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice. Nature Communications, 16(1), 170. (doi: 10.1038/s41467-024-54669-1) (PMID:39747815) (PMCID:PMC11696296)

Miljkovic, J. L. et al. (2025)Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H2S in biological samples. Nature Communications, 17(1), 85. (doi: 10.1038/s41467-025-66795-5) (PMID:41345365)

2024

Faragher, Richard G. A. and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2024)Drug discovery for ageing: SIMPs, NEDs and screening challenges. Nature Reviews Drug Discovery, 23, pp. 725-726. (doi: 10.1038/d41573-024-00087-3) (PMID:38811795)

Cardwell, Patrick A., Del Moro, Carlo, Murphy, Michael P., Lapthorn, Adrian J. ORCID: https://orcid.org/0000-0002-2197-8134 and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2024)Human mitochondrial glutathione transferases: Kinetic parameters and accommodation of a mitochondria-targeting group in substrates. Bioorganic and Medicinal Chemistry, 104, 117712. (doi: 10.1016/j.bmc.2024.117712) (PMID:38593670)

2023

Uno, Shinpei, Harkiss, Alexander H., Chowdhury, Roy, Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Prime, Tracy A., James, Andrew M., Gallagher, Brendan, Prudent, Julien, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 and Murphy, Michael P.(2023)Incorporating a polyethyleneglycol linker to enhance the hydrophilicity of mitochondria‐targeted triphenylphosphonium constructs. ChemBioChem, 24(11), e202200774. (doi: 10.1002/cbic.202200774) (PMID:36917207) (PMCID:PMC10946768)

2022

Miljkovic, J. L. et al. (2022)Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury. Redox Biology, 55, 102429. (doi: 10.1016/j.redox.2022.102429) (PMID:35961099) (PMCID:PMC9382561)

James, Andrew M., Norman, Abigail A. I., Houghton, Jack W., Prag, Hiran A., Logan, Angela, Antrobus, Robin, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 and Murphy, Michael P.(2022)Native chemical ligation approach to sensitively probe tissue acyl-CoA pools. Cell Chemical Biology, 29(7), 1232-1244.e5. (doi: 10.1016/j.chembiol.2022.04.005) (PMID:35868236) (PMCID:PMC9586882)

Burger, N. et al. (2022)ND3 Cys39 in complex I is exposed during mitochondrial respiration. Cell Chemical Biology, 29(4), 636-649.e14. (doi: 10.1016/j.chembiol.2021.10.010) (PMID:34739852)

Camargo, L. L. et al. (2022)Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research, 118(5), pp. 1359-1373. (doi: 10.1093/cvr/cvab171) (PMID:34320175) (PMCID:PMC8953456)

Ryan, D. G. et al. (2022)Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response. iScience, 25(2), 103827. (doi: 10.1016/j.isci.2022.103827)

Prag, H. A. et al. (2022)Ester prodrugs of malonate with enhanced intracellular delivery protect against cardiac ischemia-reperfusion injury in vivo. Cardiovascular Drugs and Therapy, 36(1), pp. 1-13. (doi: 10.1007/s10557-020-07033-6) (PMID:32648168) (PMCID:PMC8770414)

2021

Carter, R. N. et al. (2021)The hepatic compensatory response to elevated systemic sulfide promotes diabetes. Cell Reports, 37(6), 109958. (doi: 10.1016/j.celrep.2021.109958) (PMID:34758301) (PMCID:PMC8595646)

Cairns, Andrew G., McQuaker, Stephen J., Murphy, Michael P. and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2021)Insights on targeting small molecules to the mitochondrial matrix and the preparation of MitoB and MitoP as exomarkers of mitochondrial hydrogen peroxide. In: Weissig, Volkmar and Edeas, Marvin (eds.)Mitochondrial Medicine: Volume 1: Targeting Mitochondria. Series: Methods in molecular biology (2275). Humana: New York, NY, pp. 87-117. ISBN 9781071612613(doi: 10.1007/978-1-0716-1262-0_6)

Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, O'Byrne, Sean, Wilson, Calum, Cvetko, Filip, Murphy, Michael P., McCarron, John G. and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2021)Photoactivated release of membrane impermeant sulfonates inside cells. Chemical Communications, 57(32), pp. 3917-3920. (doi: 10.1039/D0CC07713E) (PMID:33871501) (PMCID:PMC7611313)

Gaddale Devanna, K. K. et al. (2021)Tetra-arylborate lipophilic anions as targeting groups. Chemical Communications, 57(25), pp. 3147-3150. (doi: 10.1039/D0CC07924C) (PMID:33634803) (PMCID:PMC8062962)

Cvetko, Filip, Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Higgins, Maureen, Suzuki, Takafumi, Yamamoto, Masayuki, Prag, Hiran A., Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405, Dinkova-Kostova, Albena and Murphy, Michael P.(2021)Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production. Journal of Biological Chemistry, 296, 100169. (doi: 10.1074/jbc.RA120.016551) (PMID:33298526) (PMCID:PMC7948991)

Tan, S. M. et al. (2021)Targeting methylglyoxal in diabetic kidney disease using the mitochondria-targeted compound MitoGamide. Nutrients, 13(5), 1457. (doi: 10.3390/nu13051457) (PMID:33922959) (PMCID:PMC8145135)

2020

Park, M. et al. (2020)Confirmation of the cardioprotective effect of MitoGamide in the diabetic heart. Cardiovascular Drugs and Therapy, 34, pp. 823-834. (doi: 10.1007/s10557-020-07086-7) (PMID:32979176)

Aggarwal, V. K. et al. (2020)Stuart Warren (24 Dec 1938–22 Mar 2020). Organic and Biomolecular Chemistry, 18(37), pp. 7236-7237. (doi: 10.1039/D0OB90121K) (PMID:32936190)

Pala, Laura, Senn, Hans M. ORCID: https://orcid.org/0000-0001-8232-5957, Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Prime, Tracey A., Warrington, Stefan, Bright, Thomas P., Prag, Hiran A., Wilson, Claire ORCID: https://orcid.org/0000-0002-0090-5374, Murphy, Michael and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2020)Enhancing the mitochondrial uptake of phosphonium cations by carboxylic acid incorporation. Frontiers in Chemistry, 8, 783. (doi: 10.3389/fchem.2020.00783)

Prag, Hiran A., Kula-Alwar, Duvaraka, Pala, Laura, Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Beach, Timothy E., James, Andrew M., Saeb-Parsy, Kourosh, Krieg, Thomas, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 and Murphy, Michael P.(2020)Selective delivery of dicarboxylates to mitochondria by conjugation to a lipophilic cation via a cleavable linker. Molecular Pharmaceutics, 17(9), pp. 3526-3540. (doi: 10.1021/acs.molpharmaceut.0c00533) (PMID:32692564) (PMCID:PMC7482397)

Beach, T. E. et al. (2020)Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury. Redox Biology, 36, 101640. (doi: 10.1016/j.redox.2020.101640)

Chowdhury, Anindya Roy, Zielonka, Jacek, Kalyanaraman, Balaraman, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405, Murphy, Michael P. and Avadhani, Narayan G.(2020)Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: a dose-dependent phenomenon. Redox Biology, 36, 101606. (doi: 10.1016/j.redox.2020.101606)

Burger, Nils, Logan, Angela, Prime, Tracy A., Mottahedin, Amin, Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Krieg, Thomas, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405, James, Andrew M. and Murphy, Michael P.(2020)A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo. Free Radical Biology and Medicine, 147, pp. 37-47. (doi: 10.1016/j.freeradbiomed.2019.11.028) (PMID:31811922) (PMCID:PMC6975167)

2019

Tate, M. et al. (2019)The mitochondria-targeted methylglyoxal sequestering compound, MitoGamide, is cardioprotective in the diabetic heart. Cardiovascular Drugs and Therapy, 33(6), pp. 669-674. (doi: 10.1007/s10557-019-06914-9) (PMID:31654171) (PMCID:PMC6994445)

Martin, J. et al. (2019)Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation. Nature Metabolism, 1(10), pp. 966-974. (doi: 10.1038/s42255-019-0115-y)

Lim, P. J. et al. (2019)Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin. Nature Metabolism, 1, pp. 519-531. (doi: 10.1038/s42255-019-0063-6) (PMID:31276102)

Antonucci, S. et al. (2019)Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis. Free Radical Biology and Medicine, 134, pp. 678-687. (doi: 10.1016/j.freeradbiomed.2019.01.034) (PMID:30731114)

Booty, L. M. et al. (2019)Selective disruption of mitochondrial thiol redox state in cells and in vivo. Cell Chemical Biology, 26(3), 449-461.e8. (doi: 10.1016/j.chembiol.2018.12.002) (PMID:30713096) (PMCID:PMC6436940)

Pinho, Brígida R., Reis, Sara D., Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405, Murphy, Michael P. and Oliveira, Jorge M.A.(2019)Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. Free Radical Biology and Medicine, 130, pp. 318-327. (doi: 10.1016/j.freeradbiomed.2018.10.446) (PMID:30389496) (PMCID:PMC6340810)

Lau, Gigi Y., Barts, Nicholas, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405, Tobler, Michael, Richards, Jeffrey G., Murphy, Michael P. and Arndt, Sabine(2019)Detection of changes in mitochondrial hydrogen sulfide (H2S) in vivo in the fish model Poecilia mexicana (Poeciliidae). Biology Open, 8, bio041467. (doi: 10.1242/bio.041467) (PMID:31072908) (PMCID:PMC6550084)

2018

Murphy, Michael P. and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2018)Mitochondria as a therapeutic target for common pathologies. Nature Reviews Drug Discovery, 17, pp. 865-886. (doi: 10.1038/nrd.2018.174) (PMID:30393373)

Salin, Karine, Villasevil, Eugenia M., Anderson, Graeme J., Auer, Sonya K., Selman, Colin ORCID: https://orcid.org/0000-0002-8727-0593, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Chinopoulos, Christos and Metcalfe, Neil B. ORCID: https://orcid.org/0000-0002-1970-9349(2018)Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost. Functional Ecology, 32(9), pp. 2149-2157. (doi: 10.1111/1365-2435.13125) (PMID:30333678) (PMCID:PMC6175143)

De Lucca Camargo, L. et al. (2018)Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144) (PMCID:PMC6004120)

Guthrie, Stuart, Jensen, Thomas, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405, Ramaesh, Kanna and Lockington, David(2018)Assessing the accuracy of intracameral phenylephrine preparation in cataract surgery. Eye, 32, pp. 1615-1620. (doi: 10.1038/s41433-018-0143-y) (PMID:29907787)

Fazakerley, D. J. et al. (2018)Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation. Journal of Biological Chemistry, 293(19), pp. 7315-7328. (doi: 10.1074/jbc.RA117.001254) (PMID:29599292) (PMCID:PMC5950018)

Mills, E. L. et al. (2018)Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 5556, pp. 113-117. (doi: 10.1038/nature25986) (PMID:29590092) (PMCID:PMC6047741)

Cao, Zhenbo, Mitchell, Lorna, Hsia, Oliver, Scarpa, Miriam, Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Alfred, Arina D., Gennaris, Alexandra, Collet, Jean-Francois, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 and Bulleid, Neil J. ORCID: https://orcid.org/0000-0002-9839-5279(2018)Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase. Biochemical Journal, 475, pp. 827-838. (doi: 10.1042/BCJ20170929) (PMID:29420254) (PMCID:PMC6488974)

2017

Shchepinova, M. M. et al. (2017)MitoNeoD: a mitochondria-targeted superoxide probe. Cell Chemical Biology, 24(10), 1285-1298.e12. (doi: 10.1016/j.chembiol.2017.08.003) (PMID:28890317) (PMCID:PMC6278870)

Pawellek, Andrea, Ryder, Ursula, Tammsalu, Triin, King, Lewis J., Kreinin, Helmi, Ly, Tony, Hay, Ronald T., Hartley, Richard ORCID: https://orcid.org/0000-0003-1033-5405 and Lamond, Angus I.(2017)Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. eLife, 6, e27402. (doi: 10.7554/eLife.27402) (PMID:28884683)

Arndt, S. et al. (2017)Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA. Journal of Biological Chemistry, 292(19), pp. 7761-7773. (doi: 10.1074/jbc.M117.784678) (PMID:28320864) (PMCID:PMC5427258)

Salin, Karine, Auer, Sonya K., Villasevil, Eugenia M., Anderson, Graeme J., Cairns, Andrew G., Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 and Metcalfe, Neil B. ORCID: https://orcid.org/0000-0002-1970-9349(2017)Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress. Scientific Reports, 7, 41228. (doi: 10.1038/srep41228) (PMID:28117373) (PMCID:PMC5259740)

2016

Buskiewicz, I. A. et al. (2016)Reactive oxygen species induce virus-independent MAVS-oligomerization in systemic lupus erythematosus. Science Signaling, 9(456), ra115. (doi: 10.1126/scisignal.aaf1933) (PMID:27899525)

McGarry, David J., Shchepinova, Maria M., Lillla, Sergio, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 and Olson, Michael F. ORCID: https://orcid.org/0000-0003-3428-3507(2016)A cell-permeable biscyclooctyne as a novel probe for the identification of protein sulfenic acids. ACS Chemical Biology, 11(12), pp. 3300-3304. (doi: 10.1021/acschembio.6b00742) (PMID:27792307)

2015

Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Cairns, Andrew G., Olson, Marnie, Chalmers, Susan, Sandison, Mairi, Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, McCarron, John G. and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2015)Synthesis of an azido-tagged low affinity ratiometric calcium sensor. Tetrahedron, 71(51), pp. 9571-9578. (doi: 10.1016/j.tet.2015.10.052) (PMID:26709317) (PMCID:PMC4660056)

Robb, E. L. et al. (2015)Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology and Medicine, 89, pp. 883-894. (doi: 10.1016/j.freeradbiomed.2015.08.021) (PMID:26454075)

Salin, Karine, Auer, Sonya k., Rudolf, Agata M., Anderson, Graeme J., Cairns, Andrew G., Mullen, William ORCID: https://orcid.org/0000-0002-5685-1563, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405, Selman, Colin ORCID: https://orcid.org/0000-0002-8727-0593 and Metcalfe, Neil B. ORCID: https://orcid.org/0000-0002-1970-9349(2015)Individuals with higher metabolic rates have lower levels of reactive oxygen species in vivo. Biology Letters, 11(9), 20150538. (doi: 10.1098/rsbl.2015.0538) (PMID:26382073)

Cairns, Andrew G., McQuaker, Stephen J., Murphy, Michael P. and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2015)Targeting mitochondria with small molecules: the preparation of MitoB and MitoP as exomarkers of mitochondrial hydrogen peroxide. In: Weissig, Volkmar and Edeas, Marvin (eds.)Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function. Series: Methods in Molecular Biology, 1265. Springer New York, pp. 25-50. ISBN 9781493922871(doi: 10.1007/978-1-4939-2288-8_3)

2014

Chouchani, E. T. et al. (2014)Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature, 515(7527), pp. 431-435. (doi: 10.1038/nature13909) (PMID:25383517) (PMCID:PMC4255242)

Logan, Angela, Shabalina, Irina G., Prime, Tracy A., Rogatti, Sebastian, Kalinovich, Anastasia V., Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405, Budd, Ralph C., Cannon, Barbara and Murphy, Michael P.(2014)In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice. Aging Cell, 13(4), pp. 765-768. (doi: 10.1111/acel.12212) (PMID:24621297) (PMCID:PMC4326952)

Cairns, Andrew G., Senn, Hans Martin ORCID: https://orcid.org/0000-0001-8232-5957, Murphy, Michael P. and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2014)Expanding the palette of phenanthridinium cations. Chemistry: A European Journal, 20(13), pp. 3742-3751. (doi: 10.1002/chem.201304241) (PMID:24677631) (PMCID:PMC4164275)

Li Pun, P. B. et al. (2014)A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes. Free Radical Biology and Medicine, 67, pp. 437-450. (doi: 10.1016/j.freeradbiomed.2013.11.025) (PMID:24316194) (PMCID:PMC3978666)

Logan, A. et al. (2014)Using exomarkers to assess mitochondrial reactive species in vivo. Biochimica et Biophysica Acta: General Subjects, 1840(2), pp. 923-930. (doi: 10.1016/j.bbagen.2013.05.026) (PMID:23726990)

2013

McQuaker, Stephen J., Quinlan, Casey L., Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Brand, Martin D. and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2013)A prototypical small-molecule modulator uncouples mitochondria in response to endogenous hydrogen peroxide production. ChemBioChem, 14(8), pp. 993-1000. (doi: 10.1002/cbic.201300115) (PMID:23640856) (PMCID:PMC3743171)

Chouchani, E. T. et al. (2013)Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine, 19(6), pp. 753-759. (doi: 10.1038/nm.3212) (PMID:23708290) (PMCID:PMC4019998)

Sikora, A., Zielonka, J., Adamus, J., Debski, D., Dybala-Defratyka, A., Michalowski, B., Joseph, J., Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405, Murphy, M.P. and Kalyanaraman, B.(2013)Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications. Chemical Research in Toxicology, 26(6), pp. 856-867. (doi: 10.1021/tx300499c) (PMID:23611338) (PMCID:PMC3700382)

2012

Harvey, Alan L., Young, Louise C., Kornisiuk, Edgar, Snitcofsky, Marina, Colettis, Natalia, Blanco, Carlos, Jerusalinsky, Diana, Jamieson, Andrew G. ORCID: https://orcid.org/0000-0003-1726-7353, Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 and Stone, Trevor W. ORCID: https://orcid.org/0000-0002-5532-0031(2012)A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A1 receptors and enhances consolidation of step-down avoidance. Behavioural Brain Research, 234(2), pp. 184-191. (doi: 10.1016/j.bbr.2012.06.023)

Smith, R.A.J., Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405, Cochemé, H.M. and Murphy, M.P.(2012)Mitochondrial pharmacology. Trends in Pharmacological Sciences, 33(6), pp. 341-352. (doi: 10.1016/j.tips.2012.03.010) (PMID:22521106)

Cochemé, H.M. et al. (2012)Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila. Nature Protocols, 7(5), pp. 946-958. (doi: 10.1038/nprot.2012.035) (PMID:22517261)

Caldwell, S.T. ORCID: https://orcid.org/0000-0003-1604-3462, McPhail, D.B., Duthie, G.D. and Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405(2012)Synthesis of polyhydroxylated flavonoids bearing a lipophilic decyl tail as potential therapeutic antioxidants. Canadian Journal of Chemistry = Journal canadien de chimie, 90(1), pp. 23-33. (doi: 10.1139/V11-087)

Chalmers, Susan, Caldwell, Stuart T ORCID: https://orcid.org/0000-0003-1604-3462, Quin, Caroline, Prime, Tracy A., James, Andrew M., Cairns, Andrew G., Murphy, Michael P, McCarron, John G. and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2012)Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. Journal of the American Chemical Society, 134(2), pp. 758-761. (doi: 10.1021/ja2077922) (PMID:22239373) (PMCID:PMC3260739)

Omar, M.H., Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Stalmach, A. ORCID: https://orcid.org/0000-0003-4491-654X, Auger, C., Rouanet, J.-M., Teissedre, P.-L., Caldwell, S.T. ORCID: https://orcid.org/0000-0003-1604-3462, Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405 and Crozier, A.(2012)Absorption, disposition, metabolism, and excretion of [3-14C]caffeic acid in rats. Journal of Agricultural and Food Chemistry, 60(20), pp. 5205-5214. (doi: 10.1021/jf3001185)

2011

Smith, Robin A.J., Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 and Murphy, Michael P.(2011)Mitochondria-targeted small molecule therapeutics and probes. Antioxidants and Redox Signaling, 15(12), pp. 3021-3038. (doi: 10.1089/ars.2011.3969) (PMID:21395490)

Figlus, M., Wellaway, N., Cooper, A.W.J., Sollis, S.L. and Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405(2011)Synthesis of arrays using low molecular weight MPEG-assisted Mitsunobu reaction. ACS Combinatorial Science, 13(3), pp. 280-285. (doi: 10.1021/co100091n)

Cochemé, H.M. et al. (2011)Measurement of H2O2 within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metabolism, 13(3), pp. 340-350. (doi: 10.1016/j.cmet.2011.02.003) (PMID:21356523) (PMCID:PMC4413513)

Haahr, A., Rankovic, Z. and Hartley, R. ORCID: https://orcid.org/0000-0003-1033-5405(2011)A one-pot procedure for methylenating carbonyl compounds using the Nysted reagent and titanocene dichloride. Tetrahedron Letters, 52(23), pp. 3020-3022. (doi: 10.1016/j.tetlet.2011.04.017)

2010

Quin, C., Robertson, L., McQuaker, S.J., Price, N.C., Brand, M.D. and Hartley, R.C.(2010)Caged mitochondrial uncouplers that are released in response to hydrogen peroxide. Tetrahedron, 66(13), pp. 2384-2389. (doi: 10.1016/j.tet.2010.01.103) (PMID:20418941) (PMCID:PMC2852674)

Figlus, M., Tarruella, A.C., Messer, A., Sollis, S.L. and Hartley, R.C.(2010)Low molecular weight MPEG-assisted organic synthesis. Chemical Communications, 46(24), pp. 4405-4407. (doi: 10.1039/c0cc00415d)

2009

Quin, C., Trnka, J., Hay, A., Murphy, M.P. and Hartley, R.C.(2009)Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization. Tetrahedron, 65(39), pp. 8154-8160. (doi: 10.1016/j.tet.2009.07.081) (PMID:19888470) (PMCID:PMC2767131)

Robertson, Linsey and Hartley, Richard C.(2009)Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants. Tetrahedron, 65(27), pp. 5284-5292. (doi: 10.1016/j.tet.2009.04.083) (PMID:19693262) (PMCID:PMC2722452)

El Fangour, S., Marini, M., Good, J., McQuaker, S.J., Shiels, P.G. ORCID: https://orcid.org/0000-0002-7577-9843 and Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405(2009)Nitrones for understanding and ameliorating the oxidative stress associated with aging. Age, 31(4), pp. 269-276. (doi: 10.1007/s11357-009-9098-z) (PMID:19479343) (PMCID:PMC2813050)

2008

Main, C.A., Rahman, S.S. and Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405(2008)Synthesis of spiroacetals using functionalised titanium carbenoids. Tetrahedron Letters, 49(32), pp. 4771-4774. (doi: 10.1016/j.tetlet.2008.05.094)

Main, C.A., Petersson, H.M., Rahman, S.S. and Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405(2008)High throughput synthesis of 2,5-substituted indoles using a titanium carbenoid bearing boronate functionality. Tetrahedron, 64(5), pp. 901-914. (doi: 10.1016/j.tet.2007.08.119)

Mullen, W. ORCID: https://orcid.org/0000-0002-5685-1563, Rouanet, J.-M., Auger, C., Teissèdre, P.-L., Caldwell, S.T. ORCID: https://orcid.org/0000-0003-1604-3462, Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405, Lean, M.E.J. ORCID: https://orcid.org/0000-0003-2216-0083, Edwards, C.A. ORCID: https://orcid.org/0000-0003-0406-918X and Crozier, A.(2008)Bioavailability of [2-14C]Quercetin-4′-glucoside in rats. Journal of Agricultural and Food Chemistry, 56(24), pp. 12127-12137. (doi: 10.1021/jf802754s)

2007

Caldwell, Stuart T., Quin, Caroline, Edge, Ruth and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2007)A dual sensor spin trap for use with EPR spectroscopy. Organic Letters, 9(18), pp. 3499-3502. (doi: 10.1021/ol071285o)

Adriaenssens, L. V. and Hartley, R. C. ORCID: https://orcid.org/0000-0003-1033-5405(2007)beta-amino acids to piperidinones by petasis methylenation and acid-induced cyclization. Journal of Organic Chemistry, 72(26), pp. 10287-10290. (doi: 10.1021/jo7019948)

Austin, CA, Smith, D and Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405(2007)Solid-phase synthesis of cyclic imines - potential for radiolabelling. Journal of Labelled Compounds and Radiopharmaceuticals, 50, pp. 502-503. (doi: 10.1002/jlcr.1224)

Farrugia, LJ, Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405, Calver, AMA and Rahman, SS(2007)5-Bromoanthranil. Acta Crystallographica. Section E: Structure Reports Online, 63, O2540-O2541. (doi: 10.1107/S1600536807017278)

Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405, Li, JF, Main, CA and McKiernan, GJ(2007)Titanium carbenoid reagents for converting carbonyl groups into alkenes. Tetrahedron, 63, pp. 4825-4864. (doi: 10.1016/j.tet.2007.03.015)

2006

Adriaenssens, LV, Austin, CA, Gibson, M, Smith, D and Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405(2006)Stereodivergent diversity oriented synthesis of piperidine alkaloids. European Journal of Organic Chemistry, pp. 4998-5001. (doi: 10.1002/ejoc.200600744)

Caldwell, ST, Petersson, HM, Farrugia, LJ, Mullen, W, Crozier, A and Hartley, RC(2006)Isotopic labelling of quercetin 3-glucoside. Tetrahedron, 62, pp. 7257-7265. (doi: 10.1016/j.tet.2006.05.046)

Sklavounou, E., Hay, A., Ashraf, N., Lamb, K., Brown, E., Mac Intyre, A., George, W.D., Hartley, R.C. and Shiels, P.G. ORCID: https://orcid.org/0000-0002-7577-9843(2006)The use of telomere biology to identify and develop superior nitrone based anti-oxidants. Biochemical and Biophysical Research Communications, 347, pp. 420-427. (doi: 10.1016/j.bbrc.2006.06.087)

2005

Graf, BA, Mullen, W, Caldwell, ST, Hartley, RC, Duthie, GG, Lean, MEJ, Crozier, A and Edwards, CA(2005)Disposition and metabolism of [2-C-14]quercetin-4 '-glucoside in rats. Drug Metabolism and Disposition, 33, pp. 1036-1043. (doi: 10.1124/dmd.104.002691)

Hay, A, Burkitt, MJ, Jones, CM and Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405(2005)Development of a new EPR spin trap, DOD-8C (N-[4-dodecyloxy-2-(7'-carboxyhept-1'-yloxy) benzylidene]-N-tert-butylamine N-oxide), for the trapping of lipid radicals at a predetermined depth within biological membranes. Archives of Biochemistry and Biophysics, 435, pp. 336-346. (doi: 10.1016/j.abb.2004.12.030)

2004

Bennett, CJ, Caldwell, ST, McPhail, DB, Morrice, PC, Duthie, GG and Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405(2004)Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation. Bioorganic and Medicinal Chemistry, 12, pp. 2079-2098. (doi: 10.1016/j.bmc.2004.02.031)

Macleod, C, Austin, CA, Hamprecht, DW and Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405(2004)Preparation of quinolines from resin-bound esters using titanium reagents. Tetrahedron Letters, 45, pp. 8879-8882. (doi: 10.1016/j.tetlet.2004.09.170)

Roberts, CF and Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405(2004)Titanium reagents for the synthesis of 2-substituted benzo[b]thiophenes on the solid phase. Journal of Organic Chemistry, 69, pp. 6145-6148. (doi: 10.1021/jo049344o)

Woodland, CA, Crawley, GC and Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405(2004)Stereoselectivity in the anionic oxy-Cope rearrangement of acyclic vinyl sulfides. Tetrahedron Letters, 45, pp. 1227-1231. (doi: 10.1016/j.tetlet.2003.11.132)

2003

Gibson, M, Goodman, JM, Farrugia, LJ and Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405(2003)Controlling neighbouring group participation from thioacetals. Tetrahedron Letters, 44, pp. 2841-2844. (doi: 10.1016/S0040-4039(03)00440-4)

Macleod, C, McKiernan, GJ, Guthrie, EJ, Farrugia, LJ, Hamprecht, DW, Macritchie, J and Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405(2003)Synthesis of 2-substituted benzofurans and Indoles using functionalized titanium benzylidene reagents on solid phase. Journal of Organic Chemistry, 68, pp. 387-401. (doi: 10.1021/jo026384o)

McKiernan, GJ and Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405(2003)Boronate titanium alkylidene reagents for diversity-based synthesis of benzofurans. Organic Letters, 5, pp. 4389-4392. (doi: 10.1021/ol035677g)

McPhail, DB, Hartley, RC ORCID: https://orcid.org/0000-0003-1033-5405, Gardner, PT and Duthie, GG(2003)Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy. Journal of Agricultural and Food Chemistry, 51, pp. 1684-1690. (doi: 10.1021/jf025922v)

Mullen, W, Hartley, RC and Crozier, A(2003)Detection and identification of C-14-labelled flavonol metabolites by high-performance liquid chromatography-radiocounting and tandem mass spectrometry. Journal of Chromatography A, 1007, pp. 21-29. (doi: 10.1016/S0021-9673(03)00882-3)

2002

Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405 and McKiernan, G.J.(2002)Titanium reagents for the alkylidenation of carboxylic acid and carbonic acid derivatives. Journal of the Chemical Society: Perkin Transactions 1, pp. 2763-2793. (doi: 10.1039/b009709h)

Macleod, C., Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405 and Hamprecht, D.W.(2002)Novel functionalized titanium(IV) benzylidenes for the traceless solid-phase synthesis of indoles. Organic Letters, 4, pp. 75-78. (doi: 10.1021/ol016924o)

Mullen, W, Graf, BA, Caldwell, ST, Hartley, RC, Duthie, GG, Edwards, CA, Lean, MEJ and Crozier, A(2002)Determination of flavonol metabolites in plasma and tissues of rats by HPLC-radiocounting and tandem mass spectrometry following oral ingestion of [2-C-14]quercetin-4' glucoside. Journal of Agricultural and Food Chemistry, 50, pp. 6902-6909. (doi: 10.1021/jf020598p)

2001

Rutherford, A.P., Gibb, C.S., Hartley, R.C. ORCID: https://orcid.org/0000-0003-1033-5405 and Goodman, J.M.(2001)Stereocontrol in a one-pot procedure for anionic oxy-Cope rearrangement followed by intramolecular aldol reaction. Journal of the Chemical Society: Perkin Transactions 1, pp. 1051-1061. (doi: 10.1039/b010138i)

2000

Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Crozier, Alan and Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405(2000)Isotopic labelling of quercetin 4 '-O-beta-D-glucoside. Tetrahedron, 56(24), pp. 4101-4106. (doi: 10.1016/s0040-4020(00)00325-2)

Hartley, Richard C. ORCID: https://orcid.org/0000-0003-1033-5405 and Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462(2000)Novel methods for the synthesis of three-, four-, five-, six- and seven-membered, saturated and partially unsaturated carbocycles. Journal of the Chemical Society: Perkin Transactions 1, 1(4), pp. 477-501. (doi: 10.1039/A804421J)

This list was generated on Mon Feb 16 15:59:57 2026 GMT.