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Number of items: 131.

2018

Ritchie, Neil D., Ritchie, Ryan, Bayes, Hannah K., Mitchell, Tim J. and Evans, Tom J. ORCID logo ORCID: https://orcid.org/0000-0002-4140-6352(2018)IL-17 can be protective or deleterious in murine pneumococcal pneumonia. PLoS Pathogens, 14(5), e1007099. (doi: 10.1371/journal.ppat.1007099) (PMID:29813133) (PMCID:PMC5993294)

Herbert, Jenny A., Mitchell, Andrea M., Ritchie, Ryan, Ma, Jiangtao, Ross-Hutchinson, Kirsty and Mitchell, Timothy J.(2018)Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence. PLoS ONE, 13(1), e0189426. (doi: 10.1371/journal.pone.0189426) (PMID:29342160) (PMCID:PMC5771582)

2017

Lizcano, A. et al. (2017)Transcriptional organization of pneumococcal psrP-secY2A2 and impact of GtfA and GtfB deletion on PsrP-associated virulence properties. Microbes and Infection, 19(6), pp. 323-333. (doi: 10.1016/j.micinf.2017.04.001) (PMID:28408270)

2014

Cockeran, Riana, Herbert, Jenny A., Mitchell, Timothy J., Dix-Peek, Thérèse, Dickens, Caroline, Anderson, Ronald and Feldman, Charles(2014)Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11). BioMed Research International, 2014, p. 976347. (doi: 10.1155/2014/976347)

2013

Hupp, S., Förtsch, C., Wippel, C., Ma, J., Mitchell, T.J. and Iliev, A.I.(2013)Direct transmembrane interaction between actin and the pore-competent, cholesterol-dependent cytolysin pneumolysin. Journal of Molecular Biology, 425(3), pp. 636-646. (doi: 10.1016/j.jmb.2012.11.034)

2012

van den Biggelaar, A.H.J. et al. (2012)Effect of early carriage of streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancy. Pediatric Infectious Disease Journal, 31(3), pp. 243-248. (doi: 10.1097/INF.0b013e318245a5a8)

Hupp, S., Heimeroth, V., Wippel, C., Förtsch, C., Ma, J., Mitchell, T.J. and Iliev, A.I.(2012)Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema. Glia, 60(1), pp. 137-146. (doi: 10.1002/glia.21256)

Chimalapati, S., Cohen, J.M., Camberlein, E., MacDonald, N., Durmort, C., Vernet, T., Hermans, P.W.M., Mitchell, T. and Brown, J.S.(2012)Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo. PLoS ONE, 7(7), e41393. (doi: 10.1371/journal.pone.0041393) (PMID:22911788) (PMCID:PMC3404074)

Lüttge, M. et al. (2012)Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells. Cellular Microbiology, 14(2), pp. 210-225. (doi: 10.1111/j.1462-5822.2011.01712.x)

Marriott, H.M. et al. (2012)Interleukin-1 regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages. Infection and Immunity, 80(3), pp. 1140-1149. (doi: 10.1128/IAI.05697-11)

Ritchie, N.D., Mitchell, T.J. and Evans, T.J. ORCID logo ORCID: https://orcid.org/0000-0002-4140-6352(2012)What is different about serotype 1 pneumococci? Future Microbiology, 7(1), pp. 33-46. (doi: 10.2217/FMB.11.146)

Schmidt, E.E., Holmes, A., Lindestam Arlehamn, C.S., Wang, D., Mitchell, T.J., Evans, T.J. ORCID logo ORCID: https://orcid.org/0000-0002-4140-6352 and Roe, A.J. ORCID: https://orcid.org/0000-0003-3698-6134(2012)Expression and regulation of the Escherichia coli O157:H7 effector proteins NleH1 and NleH2. PLoS ONE, 7(3), e33408. (doi: 10.1371/journal.pone.0033408) (PMID:22428045) (PMCID:PMC3299786)

2011

Wang, D. et al. (2011)Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds. Journal of Biological Chemistry, 286(34), pp. 29922-29931. (doi: 10.1074/jbc.M111.233858) (PMID:21724850) (PMCID:PMC3191033)

Inverarity, D., Diggle, M., Ure, R., Johnson, P.C.D. ORCID logo ORCID: https://orcid.org/0000-0001-6663-7520, Altstadt, P., Mitchell, T.J., Edwards, G. and Santana-Hernandez, D.(2011)Molecular epidemiology and genetic diversity of pneumococcal carriage among children in Beni State, Bolivia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 105(8), pp. 445-451. (doi: 10.1016/j.trstmh.2011.04.013)

Witzenrath, M. et al. (2011)The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. Journal of Immunology, 187(1), pp. 434-440. (doi: 10.4049/jimmunol.1003143)

Inverarity, D. et al. (2011)Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types. Journal of Medical Microbiology, 60(6), pp. 793-802. (doi: 10.1099/jmm.0.028803-0)

Lebon, A. et al. (2011)Natural antibodies against several pneumococcal virulence proteins in children during the pre-pneumococcal-vaccine Era: the Generation R Study. Infection and Immunity, 79(4), pp. 1680-1687. (doi: 10.1128/IAI.01379-10)

Förtsch, C., Hupp, S., Ma, J., Mitchell, T.J., Maier, E., Benz, R. and Iliev, A.I.(2011)Changes in astrocyte shape induced by sublytic concentrations of the cholesterol-dependent cytolysin pneumolysin still require pore-forming capacity. Toxins, 3(1), pp. 43-62.

Cockeran, R., Steel, H.C., Theron, A.J., Mitchell, T.J., Feldman, C. and Anderson, R.(2011)Characterization of the interactions of the pneumolysoid, Δ6 PLY, with human neutrophils in vitro. Vaccine, 29(48), pp. 8780-8782. (doi: 10.1016/j.vaccine.2011.09.080)

Croucher, N. J. et al. (2011)Rapid Pneumococcal Evolution in Response to Clinical Interventions. Science, 331(6016), pp. 430-434. (doi: 10.1126/science.1198545)

Deretic, V. et al. (2011)A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci. PLoS Pathogens, 7(1), e1001262. (doi: 10.1371/journal.ppat.1001262)

Pido-Lopez, J., Kwok, W.W., Mitchell, T.J., Heyderman, R.S. and Williams, N.A.(2011)Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue. PLoS Pathogens, 7(12), e1002396. (doi: 10.1371/journal.ppat.1002396)

Tse, H. et al. (2011)Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone. PLoS ONE, 6(12), e28850. (doi: 10.1371/journal.pone.0028850) (PMID:22205975) (PMCID:PMC3242761)

Wippel, C., Fortsch, C., Hupp, S., Maier, E., Benz, R., Ma, J., Mitchell, T.J. and Iliev, A. I.(2011)Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue. Journal of Infectious Diseases, 204(6), pp. 930-936. (doi: 10.1093/infdis/jir434)

2010

Banerjee, Anirban, Van Sorge, Nina M., Sheen, Tamsin R., Uchiyama, Satoshi, Mitchell, Tim J. and Doran, Kelly S.(2010)Activation of brain endothelium by pneumococcal neuraminidase NanA promotes bacterial internalization. Cellular Microbiology, 12(11), pp. 1576-1588. (doi: 10.1111/j.1462-5822.2010.01490.x)

Donati, C. et al. (2010)Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species. Genome Biology, 11(10), R107--. (doi: 10.1186/gb-2010-11-10-r107)

11/568802 (2010)Mutant Pneumolysin Proteins. .

Johnston, C., Hinds, J., Smith, A. ORCID logo ORCID: https://orcid.org/0000-0003-0580-4078, van der Linden, M., Van Eldere, J. and Mitchell, T.J.(2010)Detection of large numbers of pneumococcal virulence genes in Streptococci of the Mitis group. Journal of Clinical Microbiology, 48(8), pp. 2762-2769. (doi: 10.1128/JCM.01746-09)

Mitchell, A.M. and Mitchell, T.J.(2010)Streptococcus pneumoniae: virulence factors and variation. Clinical Microbiology and Infection, 16(5), pp. 411-418. (doi: 10.1111/j.1469-0691.2010.03183.x)

Rush, C.M., Mitchell, T.J. and Garside, P.(2010)A detailed characterisation of the distribution and presentation of DNA vaccine encoded antigen. Vaccine, 28(6), pp. 1620-1634. (doi: 10.1016/j.vaccine.2009.11.014)

Jefferies, J.M., Smith, A.J., Edwards, G.F.S., McMenamin, J., Mitchell, T.J. and Clarke, S.C.(2010)Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine. Journal of Clinical Microbiology, 48(1), pp. 87-96. (doi: 10.1128/JCM.01485-09)

Cooke, B. et al. (2010)Antibiotic resistance in invasive Streptococcus pneumoniae isolates identified in Scotland between 1999 and 2007. Journal of Medical Microbiology, 59(10), p. 1212. (doi: 10.1099/jmm.0.022954-0)

Dogan, Semih, Zhang, Qibo, Pridmore, Alison C., Mitchell, Timothy J., Finn, Adam and Murdoch, Craig(2010)Pneumolysin-induced CXCL8 production by nasopharyngeal epithelial cells is dependent on calcium flux and MAPK activation via Toll-like receptor 4. Microbes and Infection, 13(5), pp. 65-75. (doi: 10.1016/j.micinf.2010.10.003)

Douce, G., Ross, K., Cowan, G., Ma, J. and Mitchell, T.J.(2010)Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae. Vaccine, 28(18), pp. 3231-3237. (doi: 10.1016/j.vaccine.2010.02.014)

Horsham, M., Saxby, H., Blake, J., Isaacs, N., Mitchell, T.J. and Riboldi-Tunnicliffe, A.(2010)Expression, purification, crystallization and preliminary X-ray crystallographic data from TktA, a transketolase from the lactic acid bacteriumLactobacillus salivarius. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 66(8), pp. 899-901. (doi: 10.1107/S1744309110012157)

Jefferies, J. M. C., Tocheva, A. S., Rubery, H., Bennett, J., Garland, J., Christodoulides, M., Faust, S. N., Smith, A. ORCID logo ORCID: https://orcid.org/0000-0003-0580-4078, Mitchell, T.J. and Clarke, S. C.(2010)Identification of novel pneumolysin alleles from paediatric carriage isolates of Streptococcus pneumoniae. Journal of Medical Microbiology, 59(7), pp. 808-814. (doi: 10.1099/jmm.0.018663-0)

Lebon, A. et al. (2010)The inverse correlation between staphylococcus aureus and streptococcus pneumoniae colonization in infants is not explained by differences in serum antibody levels. the generation r study. Clinical and Vaccine Immunology, 18(1), pp. 180-183. (doi: 10.1128/CVI.00357-10)

Yuste, J., Khandavilli, S., Ansari, N., Muttardi, K., Ismail, L., Hyams, C., Weiser, J., Mitchell, T.J. and Brown, J. S.(2010)The Effects of PspC on Complement-Mediated Immunity to Streptococcus pneumoniae Vary with Strain Background and Capsular Serotype. Infection and Immunity, 78(1), pp. 283-292. (doi: 10.1128/IAI.00541-09)

2009

Cockeran, R., Mitchell, T. J., Feldman, C. and Anderson, R.(2009)Pneumolysin induces release of matrix metalloproteinase-8 and -9 from human neutrophils. European Respiratory Journal, 34(5), pp. 1167-1170. (doi: 10.1183/09031936.00007109)

Mureithi, M.W., Finn, A., Ota, M.O., Zhang, Q., Davenport, V., Mitchell, T.J., Williams, N.A., Adegbola, R.A. and Heyderman, R.S.(2009)T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease. Journal of Infectious Diseases, 200(5), pp. 783-793. (doi: 10.1086/605023)

Uchiyama, S., Carlin, A. F., Khosravi, A., Weiman, S., Banerjee, A., Quach, D., Hightower, G., Mitchell, T. J., Doran, K. S. and Nizet, V.(2009)The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. Journal of Experimental Medicine, 206(9), pp. 1845-1852. (doi: 10.1084/jem.20090386)

Romero Fernandez, P., Croucher, N.J., Hiller, N.L., Hu, F.Z., Ehrlich, G.D., Bentley, S.D., Garcia, E. and Mitchell, T.J.(2009)Comparative genomic analysis of 10 Streptococcus pneumoniae temperate bacteriophages. Journal of Bacteriology, 191(15), pp. 4854-4862. (doi: 10.1128/JB.01272-08) (PMID:19502408) (PMCID:PMC2715734)

Croucher, N.J. et al. (2009)Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81. Journal of Bacteriology, 191(5), pp. 1480-1489. (doi: 10.1128/JB.01343-08)

Iliev, A.I., Djannatian, J.R., Opazo, F., Gerber, J.P., Nau, R., Mitchell, T.J. and Wouters, F.S.(2009)Rapid microtubule bundling and stabilization by the Streptococcus pneumoniae neurotoxin pneumolysin in a cholesterol-dependent, non-lytic and Src-kinase dependent manner inhibits intracellular trafficking. Molecular Microbiology, 71(2), pp. 461-477. (doi: 10.1111/j.1365-2958.2008.06538.x)

Hughes, T.R., Ross, K.S., Cowan, G.J.M., Sivasankar, B., Harris, C.L., Mitchell, T.J. and Morgan, B.P.(2009)Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59. Molecular Immunology, 46(7), pp. 1561-1567. (doi: 10.1016/j.molimm.2009.01.003)

Romero Fernandez, P., Garcia, E. and Mitchell, T.J.(2009)Development of a Prophage Typing System and Analysis of Prophage Carriage in Streptococcus pneumoniae. Applied and Environmental Microbiology, 75(6), pp. 1642-1649. (doi: 10.1128/AEM.02155-08)

Witzenrath, M. et al. (2009)Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia*. Critical Care Medicine, 37(2), pp. 584-590. (doi: 10.1097/CCM.0b013e3181959814)

2008

Marriott, H.M., Mitchell, T.J. and Dockrell, D.H.(2008)Pneumolysin: A double-edged sword during the host-pathogen interaction. Current Molecular Medicine, 8(6), 497 -509.

Marriott, H. M. et al. (2008)Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia. American Journal of Respiratory and Critical Care Medicine, 177(8), pp. 887-895. (doi: 10.1164/rccm.200707-990OC)

Khandavilli, S., Homer, K.A., Yuste, J., Basavanna, S., Mitchell, T.J. and Brown, J.S.(2008)Maturation of Streptococcus pneumoniae lipoproteins by a type II signal peptidase is required for ABC transporter function and full virulence. Molecular Microbiology, 67(3), pp. 541-557. (doi: 10.1111/j.1365-2958.2007.06065.x)

Bernatoniene, J., Zhang, Q., Dogan, S., Mitchell, T. J., Paton, J. C. and Finn, A.(2008)Induction of CC and CXC chemokines in human antigen-presenting dendritic cells by the pneumococcal proteins pneumolysin and CbpA, and the role played by toll-like receptor 4, NF-kappaB, and mitogen-activated protein kinases. Journal of Infectious Diseases, 198(12), pp. 1823-1833. (doi: 10.1086/593177)

Paterson, Gavin K., Nieminen, Leena, Jefferies, Johanna M.C. and Mitchell, T.J.(2008)PclA, a pneumococcal collagen-like protein with selected strain distribution, contributes to adherence and invasion of host cells. FEMS Microbiology Letters, 285(2), pp. 170-176. (doi: 10.1111/j.1574-6968.2008.01217.x)

2007

Braun, Johann S., Hoffmann, Olaf, Schickhaus, Miriam, Freyer, Dorette, Dagand, Emilie, Bermpohl, Daniela, Mitchell, Tim J., Bechmann, Ingo and Weber, Joerg R.(2007)Pneumolysin causes neuronal cell death through mitochondrial damage. Infection and Immunity, 75(9), pp. 4245-4254. (doi: 10.1128/IAI.00031-07)

Anderson, R, Steel, H.C., Cockeran, R, Smith, A.M., von Gottberg, A, de Gouveia, L, Brink, A, Klugman, K.P., Mitchell, T.J. and Feldman, C(2007)Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae. Journal of Antimicrobial Chemotherapy, 59, pp. 224-229. (doi: 10.1093/jac/dkl479)

Anderson, R, Steel, HC, Cockeran, R, Von Gottberg, A, de Gouveia, L, Klugman, KP, Mitchell, TJ and Feldman, C(2007)Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro. Journal of Antimicrobial Chemotherapy, 60, pp. 1155-1158. (doi: 10.1093/jac/dkm338)

Bagrade, L, Bernatoniene, J, Clarke, E, Finn, A, Mitchell, TJ, Nunez, DA, Paton, JC and Zhang, QB(2007)Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children. Journal of Infectious Diseases, 195, pp. 1194-1202. (doi: 10.1086/512617)

Cowan, GJM, Atkins, HS, Johnson, LK, Titball, RW and Mitchell, TJ(2007)Immunisation with anthrolysin O or a genetic toxoid protects against challenge with the toxin but not against Bacillus anthracis. Vaccine, 25, pp. 7197-7205. (doi: 10.1016/j.vaccine.2007.07.040)

Feldman, C, Cockeran, R, Jedrzejas, MJ, Mitchell, TJ and Anderson, R(2007)Hyaluronidase augments pneumolysin-mediated injury to human ciliated epithelium. International Journal of Infectious Diseases, 11, pp. 11-15. (doi: 10.1016/j.ijid.2005.09.002)

Jefferies, J, Nieminen, L, Kirkham, LA, Johnston, C, Smith, A and Mitchell, TJ(2007)Identification of a secreted cholesterol-dependent cytolysin (Mitilysin) from Streptococcus mitis. Journal of Bacteriology, 189, pp. 627-632. (doi: 10.1128/JB.01092-06)

Jefferies, J. et al. (2007)Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae associated with disease outbreaks. Journal of Infectious Diseases, 196, pp. 936-944. (doi: 10.1086/520091)

Mitchell, T(2007)Isolation and characterization of a new plasmid pSpnP1 from a multidrug-resistant clone of Streptococcus pneumoniae. Plasmid, 58(1), pp. 51-60. (doi: 10.1016/j.plasmid.2006.12.006)

Spreer, A, von Rueden, C, Mitchell, TJ, Eiffert, H and Nau, R(2007)Influence of subinhibitory concentrations of protein-synthesis-inhibiting antibiotics on production and release of the pneumococcal virulence factor pneumolysin in vitro. Chemotherapy, 53, pp. 327-331. (doi: 10.1159/000107691)

Witzenrath, M. et al. (2007)Role of platelet-activating factor in pneumolysin-induced acute lung injury. Critical Care Medicine, 35, pp. 1756-1762. (doi: 10.1097/01.CCM.0000269212.84709.23)

2006

Kerr, A., Paterson, G.K., McCluskey, J., Lannelli, F, Oggioni, M.R., Pozzi, G. and Mitchell, T.(2006)The contribution of PspC to pneumococcal virulence varies between strains and is accomplished by both complement evasion and complement-independent mechanisms. Infection and Immunity, 74(9), pp. 5319-5324. (doi: 10.1128%2FIAI.00543-06)

Zhang, Q., Bernatoniene, J., Bagrade, L., Paton, J.C., Mitchell, T.J., Hammerschmidt, S., Nunez, D.A. and Finn, A.(2006)Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children. Infection and Immunity, 74(8), pp. 4735-4743.

Silva, N.A., McCluskey, J., Jefferies, J.M.C., Hinds, J., Smith, A., Clarke, S.C., Mitchell, T.J. and Paterson, G.K.(2006)Genomic diversity between strains of the same serotype and multilocus sequence type among pneumococcal clinical isolates. Infection and Immunity, 74(6), pp. 3513-3518.

Clarke, S.C., Jefferies, J.M., Smith, A.J., McMenamin, J., Mitchell, T.J. and Edwards, G.F.S.(2006)Potential impact of conjugate vaccine on the incidence of invasive pneumococcal disease among children in Scotland. Journal of Clinical Microbiology, 44(4), pp. 1224-1228.

Kirkham, L., Jefferies, J.M.C., Kerr, A., Jing, Y., Clarke, S.C., Smith, A. and Mitchell, T.J.(2006)Identification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin. Journal of Clinical Microbiology, 44(1), pp. 151-159. (doi: 10.1128/JCM.44.1.151-159.2006)

Bogaert, D., Sluijter, M., Lemmens-den Toom, N., Mitchell, T.J., Goessens, W.H.F., Clarke, S.C., de Groot, R. and Hermans, P.W.M.(2006)Dynamics of pneumococcal colonization in healthy Dutch children. Microbiology: SGM, 152, pp. 377-385. (doi: 10.1099/mic.0.28394-0)

Clarke, SC, Edwards, GFS, Jefferies, JMC, McMenamin, J, Mitchell, TJ and Smith, AJ(2006)Pneumococci causing invasive disease in children prior to the introduction of pneumococcal conjugate vaccine in Scotland. Journal of Medical Microbiology, 55, pp. 1079-1084. (doi: 10.1099/jmm.0.46550-0)

Mitchell, T.J.(2006)Streptococcus pneumoniae: Infection, inflammation and disease. Hot Topics in Infection and Immunity in Children III, 582, pp. 111-124.

Paterson, G.K. and Mitchell, T.J.(2006)Innate immunity and the pneumococcus. Microbiology: SGM, 152, pp. 285-293. (doi: 10.1099/mic.0.28551-0)

Paterson, GK, Blue, CE and Mitchell, TJ(2006)An operon in Streptococcus pneumoniae containing a putative alkylhydroperoxidase D homologue contributes to virulence and the response to oxidative stress. Microbial Pathogenesis, 40, pp. 152-160. (doi: 10.1016/j.micpath.2005.12.003)

Paterson, GK, Blue, CE and Mitchell, TJ(2006)Role of two-component systems in the virulence of Streptococcus pneumoniae. Journal of Medical Microbiology, 55, pp. 355-363. (doi: 10.1099/jmm.0.46423-0)

Paterson, GK and Mitchell, TJ(2006)The role of Streptococcus pneumoniae sortase A in colonisation and pathogenesis. Microbes and Infection, 8, pp. 145-153. (doi: 10.1016/j.micinf.2005.06.009)

Rush, CM, Mitchell, TJ, Burke, B and Garside, P(2006)Dissecting the components of the humoral immune response elicited by DNA vaccines. Vaccine, 24, pp. 776-784. (doi: 10.1016/j.vaccine.2005.08.080)

Schmeck, B. et al. (2006)Pneumococci induced TLR- and Rac1-dependent NF-kappa B-recruitment to the IL-8 promoter in lung epithelial cells. American Journal of Physiology: Lung Cellular and Molecular Physiology, 290, L730-L737. (doi: 10.1152/ajplung.00271.2005)

Witzenrath, M. et al. (2006)Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia. Critical Care Medicine, 34, pp. 1947-1954. (doi: 10.1097/01.CCM.0000220496.48295.A9)

2005

Chen, Shu, Paterson, Gavin K., Tong, Hua Hua, Mitchell, Timothy J. and DeMaria, Thomas F.(2005)Sortase A contributes to pneumococcal nasopharyngeal colonization in the chinchilla model. FEMS Microbiology Letters, 253(1), pp. 151-154. (doi: 10.1016/j.femsle.2005.09.052)

Beurg, M., Hafidi, A., Skinner, L.A., Cowan, G., Hondarrague, Y., Mitchell, T.J. and Dulon, D.(2005)The mechanism of pneumolysin-induced cochlear hair cell death in the rat. Journal of Physiology, 568, pp. 211-227. (doi: 10.1113/jphysiol.2005.092478)

Bogaert, D. et al. (2005)Molecular epidemiology of pneumococcal colonization in response to pneumococcal conjugate vaccination in children with recurrent acute otitis media. Journal of Clinical Microbiology, 43, pp. 74-83. (doi: 10.1128/JCM.43.1.74-83.2005)

Ebert, S, Dietz, GPH, Mitchell, TJ, Michel, U, Bahr, M and Nau, R(2005)Limited protection of TAT-Bcl-X-L against pneumolysin-induced neuronal cell death. Neuroscience Letters, 384, pp. 349-353. (doi: 10.1016/j.neulet.2005.05.027)

Ebert, S, Gerber, J, Bader, S, Muhlhauser, F, Brechtel, K, Mitchell, TJ and Nau, R(2005)Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination. Journal of Neuroimmunology, 159, pp. 87-96. (doi: 10.1016/j.jneuroim.2004.10.005)

Fickl, H, Cockeran, R, Steel, HC, Feldman, C, Cowan, G, Mitchell, TJ and Anderson, R(2005)Pneumolysin-mediated activation of NF kappa B in human neutrophils is antagonized by docosahexaenoic acid. Clinical and Experimental Immunology, 140, pp. 274-281. (doi: 10.1111/j.1365-2249.2005.02757.x)

Guiral, S, Mitchell, TJ, Martin, B and Claverys, JP(2005)Competence-programmed predation of noncompletent cells in the human pathogen Streptococcus pneumoniae: Genetic requirements. Proceedings of the National Academy of Sciences of the United States of America, 102(24), pp. 8710-8715. (doi: 10.1073/pnas.0500879102)

Harraghy, N and Mitchell, TJ(2005)Isolation and characterization of the promoter and partial enhancer region of the porcine inter-alpha-trypsin inhibitor heavy chain 4 gene. Clinical and Diagnostic Laboratory Immunology, 12, pp. 1336-1339. (doi: 10.1128/CDLI.12.11.1336-1339.2005)

Ibrahim, YM, Kerr, AR, Silva, NA and Mitchell, TJ(2005)Contribution of the ATP-dependent protease ClpCP to the autolysis and virulence of Streptococcus pneumoniae. Infection and Immunity, 73, pp. 730-740. (doi: 10.1128/IAI.73.2.730-740.2005)

Kerr, AR, Kirkham, LAS, Kadioglu, A, Andrew, PW, Garside, P, Thompson, H and Mitchell, TJ(2005)Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts. Microbes and Infection, 7, pp. 845-852. (doi: 10.1016/j.mincinf.2005.02.011)

Kerr, AR, Paterson, GK, Riboldi-Tunnicliffe, A and Mitchell, TJ(2005)Innate immune defense against pneumococcal pneumonia requires pulmonary complement component C3. Infection and Immunity, 73, pp. 4245-4252. (doi: 10.1128/IAI.73.7.4245-4252.2005)

Paterson, GK, Bluet, CE and Mitchell, TJ(2005)Role of interleukin-18 in experimental infections with Streptococcus pneumoniae. Journal of Medical Microbiology, 54, pp. 323-326. (doi: 10.1099/JMM.0.45873-0)

2004

Nöllmann, Marcelo, Gilbert, Robert, Mitchell, Timothy, Sferrazza, Michelle and Byron, Olwyn ORCID logo ORCID: https://orcid.org/0000-0001-7857-4520(2004)The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin. Biophysical Journal, 86(5), pp. 3141-3151. (doi: 10.1016/S0006-3495(04)74362-3) (PMID:15111427) (PMCID:PMC1304179)

Burke, B, Pridmore, A, Harraghy, N, Collick, A, Brown, J and Mitchell, T(2004)Transgenic mice showing inflammation-inducible overexpression of granulocyte macrophage colony-stimulating factor. Clinical and Diagnostic Laboratory Immunology, 11, pp. 588-598. (doi: 10.1128/CDLI.11.3.588-598.2004)

Cockeran, R, Theron, AJ, Feldman, C, Mitchell, TJ and Anderson, R(2004)Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils. Infection and Immunity, 72, pp. 4327-4329. (doi: 10.1128/IAI.72.7.4327-4329.2004)

Cockeran, R, Theron, AJ, Feldman, C, Mitchell, TJ and Anderson, R(2004)Pneumolysin potentiates oxidative inactivation of alpha-1-proteinase inhibitor by activated human neutrophils. Respiratory Medicine, 98, pp. 865-871. (doi: 10.1016/j.rmed.2004.02.014)

Ibrahim, YM, Kerr, AR, McCluskey, J and Mitchell, TJ(2004)Control of virulence by the two-component system CiaR/H is mediated via HtrA, a major virulence factor of Streptococcus pneumoniae. Journal of Bacteriology, 186, pp. 5258-5266. (doi: 10.1128/JB.186.16.5258-5266.2004)

Ibrahim, YM, Kerr, AR, McCluskey, J and Mitchell, TJ(2004)Role of HtrA in the virulence and competence of Streptococcus pneumoniae. Infection and Immunity, 72, pp. 3584-3591. (doi: 10.1128/IAI.72.6.3584-3591.2004)

Jefferies, JMC, Smith, A, Clarke, SC, Dowson, C and Mitchell, TJ(2004)Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching. Journal of Clinical Microbiology, 42, pp. 5681-5688. (doi: 10.1128/JCM.42.12.5681-5688.2004)

Kerr, AR, Adrian, PV, Estevao, S, de Groot, R, Alloing, G, Claverys, JP, Mitchell, TJ and Hermans, PWM(2004)The Ami-AliA/AliB permease of Streptococcus pneumoniae is involved in nasopharyngeal colonization but not in invasive disease. Infection and Immunity, 72, pp. 3902-3906. (doi: 10.1128/IAI.72.7.3902-3906.2004)

Kerr, AR, Wei, XQ, Andrew, PW and Mitchell, TJ(2004)Nitric oxide exerts distinct effects in local and systemic infections with Streptococcus pneumoniae. Microbial Pathogenesis, 36, pp. 303-310. (doi: 10.1016/j.micpath.2004.02.001)

Marriott, HM, Ali, F, Read, RC, Mitchell, TJ, Whyte, MKB and Dockrell, DH(2004)Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB Journal, 18, 1126-+. (doi: 10.1096/fj.03-1450fje)

McCluskey, J, Hinds, J, Husain, S, Witney, A and Mitchell, TJ(2004)A two-component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae. Molecular Microbiology, 51, pp. 1661-1675. (doi: 10.1046/j.1365-2958.2003.03917.x)

Mitchell, T(2004)Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody. Infection and Immunity, 72(11), pp. 6694-6698. (doi: 10.1128/IAI.72.11.6694-6698.2004)

Nagamune, H. et al. (2004)The human-specific action of intermedilysin, a homolog of streptolysin O, is dictated by domain 4 of the protein. Microbiology and Immunology, 48, pp. 677-692.

Paterson, GK and Mitchell, TJ(2004)The biology of Gram-positive sortase enzymes. Trends in Microbiology, 12, pp. 89-95. (doi: 10.1016/j.tim.2003.12.007)

Schmeck, B, Gross, R, NGuessan, PD, Hocke, AC, Hammerschmidt, S, Mitchell, TJ, Rosseau, S, Suttorp, N and Hippenstiel, S(2004)Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infection and Immunity, 72, pp. 4940-4947.

Skinner, L.J., Beurg, M., Mitchell, T.J., Darrouzet, V., Aran, J.M. and Dulon, D.(2004)Intracochlear perfusion of pneumolysin, a pneumococcal protein, rapidly abolishes auditory potentials in the guinea pig cochlea. Acta Oto-Laryngologica, 124, pp. 1000-1007. (doi: 10.1080/00016480410017125)

2003

Ali, F, Lee, ME, Iannelli, F, Pozzi, G, Mitchell, TJ, Read, RC and Dockrell, DH(2003)Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fc gamma receptors correlates with intracellular bacterial load. Journal of Infectious Diseases, 188, pp. 1119-1131.

Blue, CE and Mitchell, TJ(2003)Contribution of a response regulator to the virulence of Streptococcus pneumoniae is strain dependent. Infection and Immunity, 71, pp. 4405-4413. (doi: 10.1128/IAI.71.8.4405-4413.2003)

Blue, CE, Paterson, GK, Kerr, AR, Berge, M, Claverys, JP and Mitchell, TJ(2003)ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract. Infection and Immunity, 71, pp. 4925-4935. (doi: 10.1128/IAI.71.9.4925-4935.2003)

Bogaert, D, Hermans, PWM, Grivea, IN, Katopodis, GS, Mitchell, TJ, Sluijter, M, de Groot, R, Beratis, NG and Syrogiannopoulos, GA(2003)Molecular epidemiology of penicillin-susceptible non-beta-lactam-resistant Streptococcus pneumoniae isolates from Greek children. Journal of Clinical Microbiology, 41, pp. 5633-5639. (doi: 10.1128/JCM.41.12.5633-5639.2003)

Jefferies, J., Diggle, M., Clarke, S., Smith, A.J., Mitchell, T. and Dowson, C.(2003)Automated pneumococcal MLST using liquid-handling robotics and a capillary DNA sequencer. Molecular Biotechnology, 24(3), 303 -308.

Jounblat, R, Kadioglu, A, Mitchell, TJ and Andrew, PW(2003)Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the ctolytic and complement-activating activities of pneumolysin. Infection and Immunity, 71, pp. 1813-1819. (doi: 10.1128/IAI.71.4.1813-1819.2003)

McCool, TL, Cate, TR, Tuomanen, EI, Adrian, P, Mitchell, TJ and Weiser, JN(2003)Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization. Infection and Immunity, 71, pp. 5724-5732. (doi: 10.1128/IAI.71.10.5724-5732.2003)

Mitchell, TJ(2003)The pathogenesis of streptococcal infections: From tooth decay to meningitis. Nature Reviews Microbiology, 1, pp. 219-230. (doi: 10.1038/nrmicro771)

Spreer, A, Kerstan, H, Bottcher, T, Gerber, J, Siemer, A, Zysk, G, Mitchell, TJ, Eiffert, H and Nau, R(2003)Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone. Antimicrobial Agents and Chemotherapy, 47, pp. 2649-2654. (doi: 10.1128/AAC.47.8.2649-2654.2003)

2002

Braun, JS, Sublett, JE, Freyer, D, Mitchell, TJ, Cleveland, JL, Tuomanen, EI and Weber, JR(2002)Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis. Journal of Clinical Investigation, 109, pp. 19-27.

Cockeran, R, Durandt, C, Feldman, C, Mitchell, TJ and Anderson, R(2002)Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro. Journal of Infectious Diseases, 186, pp. 562-565.

Feldman, C, Anderson, R, Cockeran, R, Mitchell, T, Cole, P and Wilson, R(2002)The effects of pneumolysin and hydrogen peroxide, alone and in combination, on human ciliated epithelium in vitro. Respiratory Medicine, 96, pp. 580-585. (doi: 10.1053/rmed.1316)

Hirst, RA, Yesilkaya, H, Clitheroe, E, Rutman, A, Dufty, N, Mitchell, TJ, OCallaghan, C and Andrew, PW(2002)Sensitivities of human monocytes and epithelial cells to pneumolysin are different. Infection and Immunity, 70, pp. 1017-1022.

Kadioglu, A, Taylor, S, Iannelli, F, Pozzi, G, Mitchell, TJ and Andrew, PW(2002)Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type. Infection and Immunity, 70, pp. 2886-2890. (doi: 10.1128/IAI.70.6.2886-2890.2002)

Kerr, AR, Irvine, JJ, Search, JJ, Gingles, NA, Kadioglu, A, Andrew, PW, McPheat, WL, Booth, CG and Mitchell, TJ(2002)Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection. Infection and Immunity, 70, pp. 1547-1557. (doi: 10.1128/IAI.70.3.1547-1557.2002)

McCluskey, J, Dowson, CG and Mitchell, TJ(2002)The use of microarray technology for the analysis of Streptococcus pneumoniae. Comparative and Functional Genomics, 3, pp. 366-368. (doi: 10.1002/cfg.190)

Rush, C, Mitchell, T and Garside, P(2002)Efficient priming of CD4(+) and CD8(+) T cells by DNA vaccination depends on appropriate targeting of sufficient levels of immunologically relevant antigen to appropriate processing pathways. Journal of Immunology, 169, pp. 4951-4960.

Stringaris, A. et al. (2002)Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. Neurobiology of Disease, 11, pp. 355-368. (doi: 10.1006/nbdi.2002.0561)

2001

Sullivan, Jeffrey H., Mitchell, Timothy J. and Steinhoff, Mark C.(2001)Antipneumolysin antibody titers in HIV-seropositive injection drug users before and after pneumococcal bacteremia. American Journal of Respiratory and Critical Care Medicine, 163(3), pp. 680-684. (doi: 10.1164/ajrccm.163.3.2002066)

Kadioglu, Aras, Sharpe, Jason A., Lazou, Irene, Svanborg, Catharina, Ockleford, Colin, Mitchell, Timothy J. and Andrew, Peter Andrew(2001)Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo. FEMS Microbiology Letters, 194(1), pp. 105-110. (doi: 10.1111/j.1574-6968.2001.tb09454.x)

Cockeran, R, Steel, HC, Mitchell, TJ, Feldman, C and Anderson, R(2001)Pneumolysin potentiates production of prostaglandin E-2 and leukotriene B-4 by human neutrophils. Infection and Immunity, 69, pp. 3494-3496.

Cockeran, R, Theron, AJ, Steel, HC, Matlola, NM, Mitchell, TJ, Feldman, C and Anderson, R(2001)Proinflammatory interactions of pneumolysin with human neutrophils. Journal of Infectious Diseases, 183, pp. 604-611.

Gingles, N. et al. (2001)Role of genetic resistance in invasive pneumococcal infection: Identification and study of susceptibility and resistance in inbred mouse strains. Infection and Immunity, 69, pp. 426-434.

Lappin, D.F., MacLeod, C.P., Kerr, A., Mitchell, T. and Kinane, D.F.(2001)Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue. Clinical and Experimental Immunology, 123(2), 294 -300. (doi: 10.1046/j.1365-2249.2001.01448.x)

Zysk, G, Schneider-Wald, BK, Hwang, JH, Bejo, L, Kim, KS, Mitchell, TJ, Hakenbeck, R and Heinz, HP(2001)Pneumolysin is the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniae. Infection and Immunity, 69, pp. 845-852.

This list was generated on Tue Feb 17 07:47:31 2026 GMT.