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Number of items: 85.

2025

McAleese, C. ORCID: https://orcid.org/0000-0003-2756-4941, Joudah, G., Salt, I.P. ORCID: https://orcid.org/0000-0003-0055-3724, Petrie, J.R. ORCID: https://orcid.org/0000-0002-4894-9819, Leiper, J.M. ORCID: https://orcid.org/0000-0003-4656-519X and Dowsett, Laura B. ORCID: https://orcid.org/0000-0002-3356-8183(2025)Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin. Journal of Physiology, (doi: 10.1113/JP288006) (PMID:39998029) (Early Online Publication)

2024

Hanson Ng, Y. Y. et al. (2024)Asymmetric dimethylarginine enables depolarizing spikes and vasospasm in mesenteric and coronary resistance arteries. Hypertension, 81(4), pp. 764-775. (doi: 10.1161/HYPERTENSIONAHA.123.22454) (PMID:38226470) (PMCID:PMC10956675)

2023

Sri, S. et al. (2023)A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia. Cerebral Circulation - Cognition and Behavior, 5, 100189. (doi: 10.1016/j.cccb.2023.100189) (PMID:37941765) (PMCID:PMC10628644)

Dowsett, Laura ORCID: https://orcid.org/0000-0002-3356-8183, Duluc, Lucie, Higgins, Erin, Alghamdi, Fatmah, Fast, Walter, Salt, Ian P. ORCID: https://orcid.org/0000-0003-0055-3724 and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2023)Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, 110676. (doi: 10.1016/j.cellsig.2023.110676) (PMID:37028778)

2021

Boder, Philipp, Mary, Sheon ORCID: https://orcid.org/0000-0001-9392-3020, Mark, Patrick B. ORCID: https://orcid.org/0000-0003-3387-2123, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X, Dominiczak, Anna F. ORCID: https://orcid.org/0000-0003-4913-3608, Padmanabhan, Sandosh ORCID: https://orcid.org/0000-0003-3869-5808, Rampold, Luca and Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612(2021)Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension. Journal of Hypertension, 39(8), pp. 1490-1504. (doi: 10.1097/HJH.0000000000002861) (PMID:34187999) (PMCID:PMC7611110)

2020

Dowsett, Laura ORCID: https://orcid.org/0000-0002-3356-8183, Higgins, Erin, Alanazi, Sarah, Alshuwayer, Noha A., Leiper, Fiona C. ORCID: https://orcid.org/0000-0001-6681-681X and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2020)ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9(9), 3026. (doi: 10.3390/jcm9093026) (PMID:32962225) (PMCID:PMC7563400)

2019

Zöllner, Julia, Lambden, Simon, Nasri, Noor Mohd, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X and Johnson, Mark R.(2019)Rapid onset of severe septic shock in the pregnant mouse. Biology of Reproduction, 100(2), pp. 505-513. (doi: 10.1093/biolre/ioy193) (PMID:30184059)

Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2019)Nitric oxide. In: Touyz, Rhian M. and Delles, Christian (eds.)Textbook of Vascular Medicine. Springer: Cham, pp. 117-126. ISBN 9783030164805(doi: 10.1007/978-3-030-16481-2_11)

2018

Lambden, Simon, Tomlinson, James, Piper, Sophie, Gordon, Anthony C. and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2018)Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity. Critical Care, 22(1), 336. (doi: 10.1186/s13054-018-2277-5) (PMID:30538005) (PMCID:PMC6288902)

Bell, Tracy, Araujo, Magali, Luo, Zaiming, Tomlinson, James, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X, Welch, William J. and Wilcox, Christopher S.(2018)Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase 1. American Journal of Physiology: Renal Physiology, 315(1), F74-F78. (doi: 10.1152/ajprenal.00560.2017) (PMID:29513072) (PMCID:PMC6087787)

Wang, Cheng, Luo, Zaiming, Carter, Gabriella, Wellstein, Anton, Jose, Pedro A., Tomlinson, James, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X, Welch, William J., Wilcox, Christopher S. and Wang, Dan(2018)NRF2 prevents hypertension, increased ADMA, microvascular oxidative stress, and dysfunction in mice with two weeks of ANG II infusion. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 314(3), R399-R406. (doi: 10.1152/ajpregu.00122.2017) (PMID:29167164)

Paul, Eleanor J., Kalk, Eliza, Tossell, Kyoko, Irvine, Elaine E., Franks, Nicholas P., Wisden, William, Withers, Dominic J., Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X and Ungless, Mark A.(2018)nNOS-expressing neurons in the ventral tegmental area and substantia nigra pars compacta. eNeuro, 5(5), ENEURO.0381-18.2018. (doi: 10.1523/ENEURO.0381-18.2018) (PMID:30456293) (PMCID:PMC6240015)

2017

Tesfai, A. et al. (2017)Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways. PLoS ONE, 12(8), e0183025. (doi: 10.1371/journal.pone.0183025) (PMID:28813479) (PMCID:PMC5557592)

Zöllner, Julia, Howe, Laura G., Edey, Lydia F., O’Dea, Kieran P., Takata, Masao, Gordon, Fabiana, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X and Johnson, Mark R.(2017)The response of the innate immune and cardiovascular systems to LPS in pregnant and nonpregnant mice. Biology of Reproduction, 97(2), pp. 258-272. (doi: 10.1093/biolre/iox076) (PMID:29044422)

2016

Rodionov, R. N. et al. (2016)A novel pathway for metabolism of the cardiovascular risk factor homoarginine by alanine:glyoxylate aminotransferase 2. Scientific Reports, 6, 35277. (doi: 10.1038/srep35277) (PMID:27752063) (PMCID:PMC5082758)

Lange, C. et al. (2016)Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis. Experimental Eye Research, 147, pp. 148-155. (doi: 10.1016/j.exer.2016.05.007) (PMID:27181226) (PMCID:PMC4912010)

Lambden, S., Martin, D., Vanezis, K., Lee, B., Tomlinson, J., Piper, S., Boruc, O., Mythen, M. and Leiper, J. ORCID: https://orcid.org/0000-0003-4656-519X(2016)Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia. Nitric Oxide, 58, pp. 59-66. (doi: 10.1016/j.niox.2016.06.003) (PMID:27319282)

2015

Tomlinson, J. A.P. et al. (2015)Reduced renal methylarginine metabolism protects against progressive kidney damage. Journal of the American Society of Nephrology, 26(12), pp. 3045-3059. (doi: 10.1681/ASN.2014030280) (PMID:25855779) (PMCID:PMC4657823)

DʼMello, Richard, Sand, Claire A., Pezet, Sophie, Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X, Gaurilcikaite, Egle, McMahon, Stephen B., Dickenson, Anthony H. and Nandi, Manasi(2015)Dimethylarginine dimethylaminohydrolase 1 is involved in spinal nociceptive plasticity. Pain, 156(10), pp. 2052-2060. (doi: 10.1097/j.pain.0000000000000269) (PMID:2609843) (PMCID:PMC4770343)

Dowsett, L. et al. (2015)Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis. Circulation, 131(25), pp. 2217-2225. (doi: 10.1161/CIRCULATIONAHA.114.015064) (PMID:25910799)

Lambden, S. et al. (2015)Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), pp. 1382-1392. (doi: 10.1161/ATVBAHA.115.305278) (PMID:25857313)

Ahmetaj-Shala, B. et al. (2015)Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs. Circulation, 131(7), pp. 633-642. (doi: 10.1161/CIRCULATIONAHA.114.011591) (PMID:25492024) (PMCID:PMC4768634)

2014

Starr, Anna, Sand, Claire A., Heikal, Lamia, Kelly, Peter D., Spina, Domenico, Crabtree, Mark, Channon, Keith M., Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X and Nandi, Manasi(2014)Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock. Shock, 42(5), pp. 432-439. (doi: 10.1097/SHK.0000000000000235) (PMID:25046538) (PMCID:PMC4851220)

Libri, V. et al. (2014)Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study. Lancet, 384(9942), pp. 504-513. (doi: 10.1016/S0140-6736(14)60382-2) (PMID:24794816)

Iannone, Lucio, Zhao, Lan, Dubois, Olivier, Duluc, Lucie, Rhodes, Christopher J., Wharton, John, Wilkins, Martin R., Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X and Wojciak-Stothard, Beata(2014)miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia. Biochemical Journal, 462(1), pp. 103-112. (doi: 10.1042/BJ20140486) (PMID:24895913)

Wang, Z. et al. (2014)Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock. Biochemical Journal, 460(2), pp. 309-316. (doi: 10.1042/BJ20131666) (PMID:24611830)

Ghebremariam, Yohannes T., LePendu, Paea, Lee, Jerry C., Erlanson, Daniel A., Slaviero, Anna, Shah, Nigam H., Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X and Cooke, John P.(2014)Response to letters regarding article, "Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine". Circulation, 129(13), e428-e428. (doi: 10.1161/CIRCULATIONAHA.114.009343) (PMID:24687654) (PMCID:PMC4105215)

2013

Tsang, H. et al. (2013)Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function. Pulmonary Circulation, 3(3), pp. 675-691. (doi: 10.1086/674440) (PMID:24618552) (PMCID:PMC4070793)

Ghebremariam, Yohannes T., LePendu, Paea, Lee, Jerry C., Erlanson, Daniel A., Slaviero, Anna, Shah, Nigam H., Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X and Cooke, John P.(2013)Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine. Circulation, 128(8), pp. 845-853. (doi: 10.1161/CIRCULATIONAHA.113.003602) (PMID:23825361) (PMCID:PMC3838201)

2012

Caplin, Ben, Wang, Zhen, Slaviero, Anna, Tomlinson, James, Dowsett, Laura ORCID: https://orcid.org/0000-0002-3356-8183, Delahaye, Mathew, Salama, Alan, Wheeler, David C. and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2012)Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(12), pp. 2892-2900. (doi: 10.1161/ATVBAHA.112.254078) (PMID:23023372)

Nandi, Manasi, Kelly, Peter, Torondel, Belen, Wang, Zhen, Starr, Anna, Ma, Yue, Cunningham, Philip, Stidwill, Raymond and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2012)Genetic and pharmacological inhibition of dimethylarginine dimethylaminohydrolase 1 is protective in endotoxic shock. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2589-97. (doi: 10.1161/ATVBAHA.112.300232) (PMID:22995517)

Caplin, Ben and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2012)Endogenous nitric oxide synthase inhibitors in the biology of disease: markers, mediators, and regulators? Arteriosclerosis, Thrombosis, and Vascular Biology, 32(6), pp. 1343-1353. (doi: 10.1161/ATVBAHA.112.247726) (PMID:22460557) (PMCID:PMC3975829)

Woods, Angela, Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X and Carling, David(2012)The role of ATM in response to metformin treatment and activation of AMPK [Letter]. Nature Genetics, 44(4), pp. 360-361. (doi: 10.1038/ng.2235) (PMID:22456733)

2011

Boult, Jessica K.R., Walker-Samuel, Simon, Jamin, Yann, Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X, Whitley, Guy St. J. and Robinson, Simon P.(2011)Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas. Journal of Pathology, 225(3), pp. 344-352. (doi: 10.1002/path.2904) (PMID:21590769)

Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X and Nandi, Manasi(2011)The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis. Nature Reviews Drug Discovery, 10(4), pp. 277-291. (doi: 10.1038/nrd3358) (PMID:21455237)

Pullamsetti, S. S. et al. (2011)cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases. Circulation, 123(11), pp. 1194-204. (doi: 10.1161/CIRCULATIONAHA.110.941484) (PMID:21382892)

Pullamsetti, S. S. et al. (2011)The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis. Science Translational Medicine, 3(87), 87ra53. (doi: 10.1126/scitranslmed.3001725) (PMID:21677199)

Lakhani, K., Kay, A. R., Leiper, J. ORCID: https://orcid.org/0000-0003-4656-519X, Barry, J. A. and Hardiman, P. J.(2011)Symmetric dimethylarginine (SDMA) is raised in women with polycystic ovary syndrome: A pilot study. Journal of Obstetrics and Gynaecology, 31(5), pp. 417-419. (doi: 10.3109/01443615.2011.569779) (PMID:21627426)

2010

Gray, Gillian A., Patrizio, Mark, Sherry, Lorcan, Miller, Alyson A. ORCID: https://orcid.org/0000-0001-7755-9046, Malaki, Mohammed, Wallace, Alison F., Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X and Vallance, Patrick(2010)Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarctioN. Acta Histochemica, 112(5), pp. 413-423. (doi: 10.1016/j.acthis.2009.02.009) (PMID:19481782)

Torondel, Belen, Nandi, Manasi, Kelly, Peter, Wojciak-Stothard, Beata, Fleming, Ingrid and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2010)Adenoviral-mediated overexpression of DDAH improves vascular tone regulation. Vascular Medicine, 15(3), pp. 205-213. (doi: 10.1177/1358863X09360264) (PMID:20219849)

Caplin, B. et al. (2010)Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms. Kidney International, 77(5), pp. 459-467. (doi: 10.1038/ki.2009.463) (PMID:20010544)

Ivashchenko, Christine Y., Bradley, Benjamin T., Ao, Zhaohui, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X, Vallance, Patrick and Johns, Douglas J.(2010)Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2. American Journal of Physiology: Heart and Circulatory Physiology, 298(1), H251-H258. (doi: 10.1152/ajpheart.00195.2009) (PMID:19915177) (PMCID:PMC2806130)

Arrigoni, F., Ahmetaj, B. and Leiper, J. ORCID: https://orcid.org/0000-0003-4656-519X(2010)The Biology and therapeutic potential of the DDAH/ADMA pathway. Current Pharmaceutical Design, 16(37), pp. 4089-4102. (doi: 10.2174/138161210794519246) (PMID:21247398)

Breckenridge, Ross A., Kelly, Peter, Nandi, Manasi, Vallance, Patrick J., Ohun, Timothy J. and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2010)A role for Dimethylarginine Dimethylaminohydrolase 1 (DDAH1) in mammalian development. International Journal of Developmental Biology, 54(1), pp. 215-226. (doi: 10.1387/ijdb.072356rb) (PMID:19757398)

2009

Fiedler, Lorna R., Bachetti, Tiziana, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X, Zachary, Ian, Chen, Lihua, Renné, Thomas and Wojciak-Stothard, Beata(2009)The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(12), pp. 2117-2124. (doi: 10.1161/ATVBAHA.109.194035) (PMID:19778944)

Wojciak-Stothard, Beata, Torondel, Belen, Zhao, Lan, Renne, Thomas and Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X(2009)Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function. Molecular Biology of the Cell, 20(1), pp. 33-42. (doi: 10.1091/mbc.E08-04-0395) (PMID:18923147) (PMCID:PMC2613095)

2008

Nandi, Manasi, Kelly, Peter, Vallance, Patrick and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2008)Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production. Vascular Medicine, 13(1), pp. 29-36. (doi: 10.1177/1358863X07085916)

Onozato, Maristela L., Tojo, Akihiro, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X, Fujita, Toshiro, Palm, Fredrol and Wilcox, Christopher S.(2008)Expression of NG,NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockers. Diabetes, 57(1), pp. 172-180. (doi: 10.2337/db06-1772) (PMID:17909098)

Wojciak‐Stothard, Beata and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2008)Rho GTPases and hypoxia in pulmonary vascular endothelial cells. Methods in Enzymology, 439, pp. 267-283. (doi: 10.1016/S0076-6879(07)00420-X) (PMID:18374171)

2007

Wang, D. et al. (2007)Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO. Circulation Research, 101(6), pp. 627-35. (doi: 10.1161/CIRCRESAHA.107.158915) (PMID:17673667)

Hartzoulakis, B. et al. (2007)Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis. Bioorganic and Medicinal Chemistry Letters, 17(14), pp. 3953-3956. (doi: 10.1016/j.bmcl.2007.04.095) (PMID:17543521)

Wojciak-Stothard, Beata, Torondel, Belen, Tsang, Lillian Yen Fen, Fleming, Ingrid, Fisslthaler, Beate, Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X and Vallance, Patrick(2007)The ADMA/DDAH pathway is a critical regulator of endothelial cell motility. Journal of Cell Science, 120(6), pp. 929-942. (doi: 10.1242/jcs.002212) (PMID:17327280)

Leiper, J. et al. (2007)Disruption of methylarginine metabolism impairs vascular homeostasis. Nature Medicine, 13(2), pp. 198-203. (doi: 10.1038/nm1543) (PMID:17273169)

Bulau, Patrick, Zakrzewicz, Dariusz, Kitowska, Kamila, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X, Gunther, Andreas, Grimminger, Friedrich and Eickelberg, Oliver(2007)Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA. American Journal of Physiology: Lung Cellular and Molecular Physiology, 292(1), L18-L24. (doi: 10.1152/ajplung.00076.2006) (PMID:16891395)

Mookerjee, R. P. et al. (2007)Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis. Hepatology, 45(1), pp. 62-71. (doi: 10.1002/hep.21491) (PMID:17187433)

2006

Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X and Vallance, Patrick(2006)New tricks from an old dog: nitric oxide-independent effects of dimethylarginine dimethylaminohydrolase. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(7), pp. 1419-1420. (doi: 10.1161/01.ATV.0000229598.55602.17) (PMID:16794231)

Nandi, Manasi, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X, Arrigoni, Francesca, Hislop, Alison, Vallance, Patrick and Haworth, Sheila(2006)Developmental regulation of GTP-CH1 in the porcine lung and its relationship to pulmonary vascular relaxation. Pediatric Research, 59(6), pp. 767-772. (doi: 10.1203/01.pdr.0000219301.19958.a0) (PMID:16641207)

2005

Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X(2005)The DDAH-ADMA-NOS pathway. Therapeutic Drug Monitoring, 27(6), pp. 744-746. (doi: 10.1097/01.ftd.0000179849.42395.11) (PMID:16404814)

Smith, Caroline L., Anthony, Shelagh, Hubank, Mike, Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X and Vallance, Patrick(2005)Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA. PLoS Medicine, 2(10), e264. (doi: 10.1371/journal.pmed.0020264) (PMID:16190779) (PMCID:PMC1240048)

Vallance, Patrick and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2005)Asymmetric dimethylarginine and kidney disease: marker or mediator? Journal of the American Society of Nephrology, 16(8), pp. 2254-2256. (doi: 10.1681/ASN.2005050539) (PMID:15987745)

Rossiter, Sharon, Smith, Caroline L., Malaki, Mohammed, Nandi, Manasi, Gill, Herpreet, Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X, Vallance, Patrick and Selwood, David L.(2005)Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase. Journal of Medicinal Chemistry, 48(14), pp. 4670-4678. (doi: 10.1021/jm050187a) (PMID:16000003)

Anthony, Shelagh, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X and Vallance, Patrick(2005)Endogenous production of nitric oxide synthase inhibitors. Vascular Medicine, 10(2_supp), S3-S9. (doi: 10.1191/1358863x05vm595oa) (PMID:16444863)

2004

Vallance, Patrick and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2004)Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(6), pp. 1023-30. (doi: 10.1161/01.ATV.0000128897.54893.26) (PMID:15105281)

2003

Tran, Cam T.L., Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X and Vallance, Patrick(2003)The DDAH/ADMA/NOS pathway. Atherosclerosis Supplements, 4(4), pp. 33-40. (doi: 10.1016/S1567-5688(03)00032-1) (PMID:14664901)

Jones, L.C., Tran, C.T.L., Leiper, J.M. ORCID: https://orcid.org/0000-0003-4656-519X, Hingorani, A.D. and Vallance, P.(2003)Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells. Biochemical and Biophysical Research Communications, 310(3), pp. 836-843. (doi: 10.1016/j.bbrc.2003.09.097) (PMID:14550280)

Millatt, Lesley J., Whitley, Guy StJ., Li, Dechun, Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X, Siragy, Helmy M., Carey, Robert M. and Johns, Roger A.(2003)Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension. Circulation, 108(12), pp. 1493-1498. (doi: 10.1161/01.CIR.0000089087.25930.FF) (PMID:12952847)

Smith, Caroline L., Birdsey, Graeme M., Anthony, Shelagh, Arrigoni, Francesca I., Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X and Vallance, Patrick(2003)Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype. Biochemical and Biophysical Research Communications, 308(4), pp. 984-989. (doi: 10.1016/S0006-291X(03)01507-9) (PMID:12927816)

Achan, Vinod, Broadhead, Michael, Malaki, Mohammed, Whitley, Guy, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X, MacAllister, Raymond and Vallance, Patrick(2003)Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(8), pp. 1455-1459. (doi: 10.1161/01.ATV.0000081742.92006.59) (PMID:12805079)

Arrigoni, Francesca I., Vallance, Patrick, Haworth, Sheila G. and Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X(2003)Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia. Circulation, 107(8), pp. 1195-1201. (doi: 10.1161/01.CIR.0000051466.00227.13) (PMID:12615801)

2002

Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X, Murray-Rust, Judith, McDonald, Neil and Vallance, Patrick(2002)S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proceedings of the National Academy of Sciences of the United States of America, 99(21), pp. 13527-13532. (doi: 10.1073/pnas.212269799) (PMID:12370443) (PMCID:PMC129707)

Vallance, Patrick and Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X(2002)Blocking NO synthesis: how, where and why? Nature Reviews Drug Discovery, 1(12), pp. 939-950. (doi: 10.1038/nrd960) (PMID:12461516)

2001

Murray-Rust, Judith, Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X, McAlister, Mark, Phelan, John, Tilley, Sarah, Santa Maria, Jo, Vallance, Patrick and McDonald, Neil(2001)Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase. Nature Structural Biology, 8(8), pp. 679-683. (doi: 10.1038/90387) (PMID:11473257)

2000

Tran, Cam T.L., Fox, Margaret F. and ORCID: https://orcid.org/0000-0003-4656-519X(2000)Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. Genomics, 68(1), pp. 101-105. (doi: 10.1006/geno.2000.6262) (PMID:10950934)

Birdsey, G.M., Leiper, J.M. ORCID: https://orcid.org/0000-0003-4656-519X and Vallance, P.(2000)Intracellular localization of dimethylarginine dimethylaminohydrolase overexpressed in an endothelial cell line. Acta Physiologica Scandinavica, 168(1), pp. 73-79. (doi: 10.1046/j.1365-201x.2000.00672.x) (PMID:10691782)

1999

Santa Maria, Joanne, Vallance, Patrick, Charles, Ian G. and Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X(1999)Identification of microbial dimethylarginine dimethylaminohydrolase enzymes. Molecular Microbiology, 33(6), pp. 1278-1279. (doi: 10.1046/j.1365-2958.1999.01580.x) (PMID:10510241)

Leiper, James ORCID: https://orcid.org/0000-0003-4656-519X and Vallance, Patrick(1999)Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovascular Research, 43(3), pp. 542-548. (doi: 10.1016/S0008-6363(99)00162-5) (PMID:10690326)

1997

Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X and Danpure, Christopher J.(1997)A unique molecular basis for enzyme mistargeting in primary hyperoxaluria type 1. Clinica Chimica Acta, 266(1), pp. 39-50. (doi: 10.1016/S0009-8981(97)00165-4) (PMID:9435987)

1996

Danpure, Christopher J., Jennings, Patricia R., Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X, Lumb, Michael J. and Oatey, Paru B.(1996)Targeting of alanine: glyoxylate aminotransferase in normal individuals and its mistargeting in patients with primary hyperoxaluria type 1. Annals of the New York Academy of Sciences, 804, pp. 477-490. (doi: 10.1111/j.1749-6632.1996.tb18638.x) (PMID:8993566)

Leiper, J.M. ORCID: https://orcid.org/0000-0003-4656-519X and Danpure, C.J.(1996)The role of dimerization of alanine:glyoxylate aminotransferase 1 in its peroxisomal and mitochondrial import. Annals of the New York Academy of Sciences, 804, pp. 765-767. (PMID:8993617)

Leiper, J.M. ORCID: https://orcid.org/0000-0003-4656-519X, Harrison, G.B., Bayliss, J., Scott, J.D. and Pease, R.J.(1996)Systematic expression of the complete coding sequence of apoB-100 does not reveal transmembrane determinants. Journal of Lipid Research, 37(10), pp. 2215-2231. (PMID:8906598)

Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X, Oatey, Paru B. and Danpure, Christopher J.(1996)Inhibition of alanine:glyoxylate aminotransferase 1 dimerization is a prerequisite for its peroxisome-to-mitochondrion mistargeting in primary hyperoxaluria type 1. Journal of Cell Biology, 135(4), pp. 939-951. (PMID:8922378) (PMCID:PMC2133393)

Pease, R.J. and Leiper, J.M. ORCID: https://orcid.org/0000-0003-4656-519X(1996)Regulation of hepatic apolipoprotein-B-containing lipoprotein secretion. Current Opinion in Lipidology, 7(3), pp. 132-138. (PMID:8818509)

1995

Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X, Birdsey, Graeme M. and Oatey, Paru B.(1995)Peroxisomes proliferate. Trends in Cell Biology, 5(11), pp. 435-437. (doi: 10.1016/S0962-8924(00)89103-5) (PMID:14732049)

Pease, Richard J., Leiper, James M. ORCID: https://orcid.org/0000-0003-4656-519X, Harrison, Georgina B. and Scott, James(1995)Studies on the translocation of the amino terminus of apolipoprotein B into the endoplasmic reticulum. Journal of Biological Chemistry, 270(13), pp. 7261-7271. (doi: 10.1074/jbc.270.13.7261) (PMID:7706266)

1994

Leiper, J.M. ORCID: https://orcid.org/0000-0003-4656-519X, Bayliss, J.D., Pease, R.J., Brett, D.J., Scott, J. and Shoulders, C.C.(1994)Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells. Journal of Biological Chemistry, 269(35), pp. 21951-21954. (PMID:8071315)

This list was generated on Mon Feb 16 05:15:29 2026 GMT.