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Number of items: 45.

2026

Monaghan, L. et al. (2026)Selective small molecule targeting of KDM4 as a therapeutic strategy to reduce proliferation of acute myeloid leukemia. British Journal of Haematology, (doi: 10.1111/bjh.70351) (PMID:41622589) (Early Online Publication)

Patterson, S.D. et al. (2026)Sequential BCR::ABL1 evaluation during dose de-escalation in peripheral blood is more predictive of TFR success than single assessment at dose de-escalation in either peripheral blood or bone marrow. Leukemia, (Early Online Publication)

2025

Bubnova, Xenia, Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170 and Hope, Lauren(2025)Evaluation of current mouse in vivo models and advanced in vitro models for leukaemia research. Blood Reviews, 74, 101318. (doi: 10.1016/j.blre.2025.101318)

Cooke, S. F. et al. (2025)Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells. Molecular Therapy Oncology, 33(3), 201029. (doi: 10.1016/j.omton.2025.201029) (PMID:40896364) (PMCID:PMC12395054)

2024

Donnelly, H. et al. (2024)Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells. Nature Communications, 15, 5791. (doi: 10.1038/s41467-024-50054-0) (PMID:38987295) (PMCID:PMC11237034)

Busch, Caroline, Nyamondo, Kudzai and Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170(2024)Complexities of modelling the bone marrow microenvironment to facilitate haematopoietic research. Experimental Hematology, 135, 104233. (doi: 10.1016/j.exphem.2024.104233) (PMID:38740324)

Dawson, A. et al. (2024)Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, 1090. (doi: 10.1038/s41467-024-45471-0) (PMID:38316788) (PMCID:PMC10844594)

Nyamondo, Kudzai and Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170(2024)Microenvironment alterations through time leading to myeloid malignancies. British Journal of Pharmacology, 181(2), pp. 283-294. (doi: 10.1111/bph.15924) (PMID:35844165)

2023

Busch, Caroline, Mulholland, Theresa, Zagnoni, Michele, Dalby, Matthew ORCID: https://orcid.org/0000-0002-0528-3359, Berry, Catherine ORCID: https://orcid.org/0000-0002-6485-2187 and Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170(2023)Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach. Cell Communication and Signaling, 21, 342. (doi: 10.1186/s12964-023-01363-2) (PMID:38031192) (PMCID:PMC10685629)

Zarou, M. M. et al. (2023)Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. 65th ASH Annual Meeting and Exposition, San Diego, California, USA, 09-12 Dec 2023.(doi: 10.1182/blood-2023-181630)

2022

Parry, Narissa, Busch, Caroline, Aßmann, Victoria, Cassels, Jennifer ORCID: https://orcid.org/0009-0004-7138-9946, Hair, Alan, Helgason, G. Vignir ORCID: https://orcid.org/0000-0003-1616-132X, Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170 and Copland, Mhairi ORCID: https://orcid.org/0000-0002-7655-016X(2022)BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia. Cell Death Discovery, 8, 457. (doi: 10.1038/s41420-022-01211-1) (PMID:36379918) (PMCID:PMC9666353)

Pancheva, Alexandrina, Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170, Rogers, Simon ORCID: https://orcid.org/0000-0003-3578-4477 and Otto, Thomas D. ORCID: https://orcid.org/0000-0002-1246-7404(2022)Using topic modeling to detect cellular crosstalk in scRNA-seq. PLoS Computational Biology, 18(4), e1009975. (doi: 10.1371/journal.pcbi.1009975) (PMID:35395014) (PMCID:PMC9064087)

2021

Miari, Katerina E. ORCID: https://orcid.org/0000-0003-3008-966X, Guzman, Monica L., Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170 and Williams, Mark T. S.(2021)Macrophages in Acute Myeloid Leukaemia: significant players in therapy resistance and patient outcomes. Frontiers in Cell and Developmental Biology, 9, 692800. (doi: 10.3389/fcell.2021.692800) (PMID:34249942) (PMCID:PMC8264427)

Chantkran, Wittawat, Hsieh, Ya-Ching, Zheleva, Daniella, Frame, Sheelagh, Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170 and Copland, Mhairi ORCID: https://orcid.org/0000-0002-7655-016X(2021)Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML. Cell Death Discovery, 7, 137. (doi: 10.1038/s41420-021-00496-y) (PMID:34112754) (PMCID:PMC8192769)

Parry, Narissa, Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170 and Copland, Mhairi ORCID: https://orcid.org/0000-0002-7655-016X(2021)The application of BH3 mimetics in myeloid leukemias. Cell Death and Disease, 12, 222. (doi: 10.1038/s41419-021-03500-6) (PMID:33637708) (PMCID:PMC7908010)

2020

McAllister, Milly, Constancio, Vera, Patek, Samantha, Gan, Hao, Bailey, Peter ORCID: https://orcid.org/0000-0002-0857-2041, Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170, Underwood, Mark, Leung, Hing ORCID: https://orcid.org/0000-0002-3933-3975 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906(2020)Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer. Prostate, 80(15), pp. 1353-1364. (doi: 10.1002/pros.24064) (PMID:32846021)

Kinstrie, R. et al. (2020)CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia, 34(6), pp. 1613-1625. (doi: 10.1038/s41375-019-0684-5) (PMID:31896780) (PMCID:PMC7272220)

2019

Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170 and Busch, Caroline(2019)Bone marrow niche crosses paths with BMPs: a road to protection and persistence in CML. Biochemical Society Transactions, 47(5), pp. 1307-1325. (doi: 10.1042/BST20190221) (PMID:31551354)

2018

Toofan, Parto, Busch, Caroline, Morrison, Heather, O'Brien, Stephen, Jørgensen, Heather ORCID: https://orcid.org/0000-0003-4663-4191, Copland, Mhairi ORCID: https://orcid.org/0000-0002-7655-016X and Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170(2018)Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death and Disease, 9, 927. (doi: 10.1038/s41419-018-0905-2) (PMID:30206237) (PMCID:PMC6134087)

2017

Biggs, M. J.P. et al. (2017)The functional response of mesenchymal stem cells to electron-beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity. Advanced Materials, 29(39), 1702119. (doi: 10.1002/adma.201702119) (PMID:28861921)

Lewis, Natasha S., Lewis, Emily E.L., Mullin, Margaret, Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170, Dalby, Matthew J. ORCID: https://orcid.org/0000-0002-0528-3359 and Berry, Catherine C. ORCID: https://orcid.org/0000-0002-6485-2187(2017)Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence. Journal of Tissue Engineering, 8, pp. 1-11. (doi: 10.1177/2041731417704428) (PMID:28616152) (PMCID:PMC5460809)

2016

Horne, Gillian A. ORCID: https://orcid.org/0000-0001-9741-7352, Morrison, Heather, Campbell, Victoria, Kinstrie, Ross, Cassels, Jennifer ORCID: https://orcid.org/0009-0004-7138-9946, Hair, Alan, Vetrie, David ORCID: https://orcid.org/0000-0003-2075-4662, Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170, Holyoake, Tessa L. and Copland, Mhairi ORCID: https://orcid.org/0000-0002-7655-016X(2016)Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML). American Society of Hematology 58th Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Chaudhury, Shahzya S. ORCID: https://orcid.org/0000-0002-6732-9949, Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170, Gibson, Brenda and Keeshan, Karen ORCID: https://orcid.org/0000-0001-7266-0890(2016)The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Toofan, Parto and Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170(2016)Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis. Biochemical Society Transactions, 44(5), pp. 1455-1463. (doi: 10.1042/BST20160104) (PMID:27911727)

Lewis, Emily Elizabeth Louise, Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170, Lewis, Natasha, Yang, Jingli, Mullin, Margaret, Hursthouse, Andrew, Stirling, David, Dalby, Matthew John ORCID: https://orcid.org/0000-0002-0528-3359 and Berry, Catherine Cecilia ORCID: https://orcid.org/0000-0002-6485-2187(2016)A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation. ACS Nano, 10(9), pp. 8346-8354. (doi: 10.1021/acsnano.6b02841) (PMID:27602872)

Middleton, O., Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170 and Michie, A. ORCID: https://orcid.org/0000-0002-5404-475X(2016)Classical complement pathway. In: Ratcliffe, M.J.H. (ed.)Encyclopedia of Immunobiology, 1st Edition. Elsevier: New York, NY. ISBN 9780123742797(doi: 10.1016/B978-0-12-374279-7.02014-2)

Irvine, D. A. et al. (2016)Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Scientific Reports, 6, 25476. (doi: 10.1038/srep25476) (PMID:27157927) (PMCID:PMC4860619)

2015

Ford, C. A. et al. (2015)Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25(5), pp. 577-588. (doi: 10.1016/j.cub.2014.12.059) (PMID:25702581) (PMCID:PMC4353688)

Kranc, K. R. et al. (2015)Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells, 33(3), pp. 699-712. (doi: 10.1002/stem.1889) (PMID:25377420)

Middleton, O., Cosimo, E., Dobbin, E., McCaig, A.M., Clarke, C., Brant, A.M., Leach, M.T., Michie, A.M. ORCID: https://orcid.org/0000-0002-5404-475X and Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170(2015)Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL. Leukemia, 29(1), pp. 107-114. (doi: 10.1038/leu.2014.146) (PMID:24787488)

2014

Gallipoli, Paolo, Cook, Amy, Rhodes, Susan ORCID: https://orcid.org/0000-0001-6676-890X, Hopcroft, Lisa ORCID: https://orcid.org/0000-0002-7022-1322, Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170, Whetton, Anthony D., Jorgensen, Heather G. ORCID: https://orcid.org/0000-0003-4663-4191, Bhatia, Ravi and Holyoake, Tessa L.(2014)JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood, 124(9), pp. 1492-1501. (doi: 10.1182/blood-2013-12-545640) (PMID:24957147) (PMCID:PMC4148771)

Toofan, Parto, Irvine, David, Hopcroft, Lisa ORCID: https://orcid.org/0000-0002-7022-1322, Copland, Mhairi ORCID: https://orcid.org/0000-0002-7655-016X and Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170(2014)The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi: 10.1042/BST20140037)

2013

Cosimo, E. et al. (2013)Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research, 19(9), pp. 2393-2405. (doi: 10.1158/1078-0432.CCR-12-2170)

Rhodes, Susan ORCID: https://orcid.org/0000-0001-6676-890X, Copland, Mhairi ORCID: https://orcid.org/0000-0002-7655-016X, Hopcroft, Lisa ORCID: https://orcid.org/0000-0002-7022-1322, Sayeski, Peter and Wheadon, Helen ORCID: https://orcid.org/0000-0001-9902-3170(2013)Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.

Sands, W.A., Copland, M. ORCID: https://orcid.org/0000-0002-7655-016X and Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170(2013)Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi: 10.1186/1478-811X-11-33)

Tarafdar, A., Dobbin, E., Corrigan, P., Freeburn, R. and Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170(2013)Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation. PLoS ONE, 8(11), e81030. (doi: 10.1371/journal.pone.0081030) (PMID:24324557) (PMCID:PMC3850021)

2011

Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170, Ramsey, J.M., Dobbin, E., Dickson, G.J., Corrigan, P.M., Freeburn, R.W. and Thompson, A.(2011)Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis. Stem Cells and Development, 20(8), pp. 1465-1476. (doi: 10.1089/scd.2010.0226)

2010

Dobbin, E., Graham, C., Freeburn, R.W., Unwin, R.D., Griffiths, J.R., Pierce, A., Whetton, A.D. and Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170(2010)Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), pp. 226-243. (doi: 10.1016/j.scr.2010.08.001)

2009

Dobbin, E., Graham, C., Corrigan, P., Thomas, K., Freeburn, R. and Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170(2009)Tel/PDGFRβ induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Experimental Hematology, 37(1), pp. 111-121. (doi: 10.1016/j.exphem.2008.09.012)

Corrigan, P.M., Dobbin, E., Freeburn, R.W. and Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170(2009)Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells and Development, 18(5), pp. 759-771. (doi: 10.1089/scd.2008.0270)

2008

Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W. and Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170(2008)Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32(10), pp. 1554-1564. (doi: 10.1016/j.leukres.2008.02.007)

2004

Paling, N.R.D., Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170, Bone, H.K. and Welham, M.J.(2004)Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Journal of Biological Chemistry, 279(46), pp. 48063-48070. (doi: 10.1074/jbc.M406467200)

2003

Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170, Edmead, C. and Welham, M.J.(2003)Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Biochemical Journal, 376(1), pp. 147-157. (doi: 10.1042/BJ20031160)

Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170 and Welham, M.J.(2003)The coupling of TEL/PDGF R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases. Blood, 102(4), pp. 1480-1489. (doi: 10.1182/blood-2002-09-2974)

2002

Wheadon, H. ORCID: https://orcid.org/0000-0001-9902-3170, Paling, N.R.D. and Welham, M.J.(2002)Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cellular Signalling, 14(3), pp. 219-229. (doi: 10.1016/S0898-6568(01)00241-8)

This list was generated on Tue Feb 17 08:58:33 2026 GMT.