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Number of items: 39.

2022

Marsango, S. et al. (2022)The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Proceedings of the National Academy of Sciences of the United States of America, 119(24), e220110311. (doi: 10.1073/pnas.2201103119) (PMID:35671422) (PMCID:PMC9214538)

2021

Ward, Richard J., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Marsango, Sara, Jolly, Richard, Stoneman, Michael R., Biener, Gabriel, Handel, Tracy M., Raicu, Valerica and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2021)Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t. Journal of Biological Chemistry, 296, 100139. (doi: 10.1074/jbc.RA120.016612) (PMID:33268380)

2019

Stoneman, Michael R., Biener, Gabriel, Ward, Richard J., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Badu, Dammar, Eis, Annie, Popa, Ionel, Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519 and Raicu, Valerică(2019)A general method to quantify ligand-driven oligomerization from fluorescence-based images. Nature Methods, 16(6), pp. 493-496. (doi: 10.1038/s41592-019-0408-9) (PMID:31110281)

2018

Liu, Y. et al. (2018)Visualization of the activation of the histamine H3 receptor (H3R) using novel fluorescence resonance energy transfer biosensors and their potential application to the study of H3R pharmacology. FEBS Journal, 285(12), pp. 2319-2336. (doi: 10.1111/febs.14484) (PMID:29701013)

Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Ward, Richard J., Marsango, Sara and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2018)Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization. Trends in Pharmacological Sciences, 39(2), pp. 175-186. (doi: 10.1016/j.tips.2017.09.001) (PMID:29032835) (PMCID:PMC5783713)

2017

Ward, Richard J., Marsango, Sara, Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2017)The use of spatial intensity distribution analysis to examine G protein-coupled receptor oligomerization. In: Herrick-Davis, Katharine, Milligan, Graeme and Di Giovanni, Giuseppe (eds.)G-Protein-Coupled Receptor Dimers. Series: Receptors (33). Humana Press: Cham, pp. 15-38. ISBN 9783319601724(doi: 10.1007/978-3-319-60174-8_2)

Shaw, Andy, Jeromson, Stewart, Watterson, Kenneth R. ORCID: https://orcid.org/0000-0003-3819-4026, Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Gallagher, Iain, Whalley, Tim, Dreczkowski, Gillian, Brooks, Naomi, Galloway, Stuart and Hamilton, D. Lee(2017)Multiple AMPK activators inhibit L-Carnitine uptake in C2C12 skeletal muscle myotubes. American Journal of Physiology: Cell Physiology, 312(6), C689-C696. (doi: 10.1152/ajpcell.00026.2016) (PMID:28298333)

Ward, Richard J., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Harikumar, Kaleeckal G., Miller, Laurence J. and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2017)Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor. Biochemical Journal, 474(11), pp. 1879-1895. (doi: 10.1042/BCJ20170184) (PMID:28424368) (PMCID:PMC5442643)

Marsango, Sara, Caltabiano, Gianluigi, Jiménez-Rosés, Mireia, Millan, Mark J., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Ward, Richard J. and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2017)A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization. Scientific Reports, 7, 2134. (doi: 10.1038/s41598-017-02249-3) (PMID:28522847) (PMCID:PMC5437050)

2016

Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Ward, Richard J., Godin, Antoine G., Marsango, Sara and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2016)Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs. Journal of Biological Chemistry, 291, pp. 13132-13146. (doi: 10.1074/jbc.M115.712562) (PMID:27080256) (PMCID:PMC4933229)

2015

Ward, Richard J., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Godin, Antoine G. and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2015)Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis. Journal of Biological Chemistry, 290(20), pp. 12844-12857. (doi: 10.1074/jbc.M115.644724) (PMID:25825490) (PMCID:PMC4432300)

2014

Zakrys, Linas, Ward, Richard J., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Godin, Antoine G., Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2014)Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2. Biochemical Journal, 461(1), pp. 61-73. (doi: 10.1042/BJ20140190)

2013

Horobin, R.W. ORCID: https://orcid.org/0000-0002-6612-6664, Rashid-Doubell, F., Pediani, J.D. ORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2013)Predicting small molecule fluorescent probe localization in living cells using QSAR modeling. 1. Overview and models for probes of structure, properties and function in single cells. Biotechnic and Histochemistry, 88(8), pp. 440-460. (doi: 10.3109/10520295.2013.780634)

Hudson, B.D. ORCID: https://orcid.org/0000-0001-7059-0091, Shimpukade, B., Mackenzie, A.E., Butcher, A.J., Pediani, J.D. ORCID: https://orcid.org/0000-0001-6615-537X, Christiansen, E., Heathcote, H., Tobin, A.B., Ulven, T. and Milligan, G. ORCID: https://orcid.org/0000-0002-6946-3519(2013)The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Molecular Pharmacology, 84(5), pp. 710-725. (doi: 10.1124/mol.113.087783)

Segura, V., Pérez-Aso, M., Montó, F., Carceller, E., Noguera, M.A., Pediani, J. ORCID: https://orcid.org/0000-0001-6615-537X, Milligan, G. ORCID: https://orcid.org/0000-0002-6946-3519, McGrath, I.C. ORCID: https://orcid.org/0000-0002-5276-0381 and D’Ocon, P.(2013)Differences in the signaling pathways of α1A- and α1B-adrenoceptors are related to different endosomal targeting. PLoS ONE, 8(5), e64996. (doi: 10.1371/journal.pone.0064996) (PMID:23717684) (PMCID:PMC3663791)

2012

Wiejak, Jolanta, Dunlop, Julia ORCID: https://orcid.org/0000-0003-3180-6763, Stoyle, Chloe, Lappin, Gillian, McIlroy, Anna, Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Gao, Shan and Yarwood, Stephen J.(2012)The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun. Cellular Signalling, 24(8), pp. 1690-1699. (doi: 10.1016/j.cellsig.2012.04.016)

Cunningham, Margaret R., McIntosh, Kathryn A., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Robben, Joris, Cooke, Alexandra E., Nilsson, Mary, Gould, Gwyn W. ORCID: https://orcid.org/0000-0001-6571-2875, Mundell, Stuart, Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519 and Plevin, Robin(2012)Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4). Journal of Biological Chemistry, 287(20), pp. 16656-16669. (doi: 10.1074/jbc.M111.315911)

Xu, Tian-Rui, Ward, Richard J., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2012)Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. Journal of Biological Chemistry, 287, pp. 14937-14949. (doi: 10.1074/jbc.M111.334300)

Fewou, Simon N., Rupp, Angie, Nickolay, Lauren E., Carrick, Kathryn, Greenshields, Kay N., Pediani, John ORCID: https://orcid.org/0000-0001-6615-537X, Plomp, Jaap J. and Willison, Hugh J. ORCID: https://orcid.org/0000-0002-5997-1683(2012)Anti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy. Journal of Clinical Investigation, 122(3), pp. 1037-1051. (doi: 10.1172/JCI59110) (PMID:22307327) (PMCID:PMC3287221)

2011

Alvarez-Curto, Elisa ORCID: https://orcid.org/0000-0003-4004-4545, Prihandoko, Rudi, Tautermann, Christofer S., Zwier, Jurriaan M., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X, Lohse, Martin J., Hoffmann, Carsten, Tobin, Andrew B. and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2011)Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a Receptor Activated Solely by Synthetic Ligand (RASSL). Molecular Pharmacology, 80(6), pp. 1033-1046. (doi: 10.1124/mol.111.074674) (PMID:21880827) (PMCID:PMC3228535)

Ward, Richard J., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2011)Heteromultimerization of cannabinoid CB1 receptor and orexin OX1 receptor generates a unique complex in which both protomers are regulated by orexin A. Journal of Biological Chemistry, 286(43), pp. 37414-37428. (doi: 10.1074/jbc.M111.287649)

Xu, Tian‑Rui, Ward, Richard J., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2011)The orexin OX1 receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands. Biochemical Journal, 439(1), pp. 171-183. (doi: 10.1042/BJ20110230)

Van Lith, Marcel, Tiwari, Shweta, Pediani, John ORCID: https://orcid.org/0000-0001-6615-537X, Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519 and Bulleid, Neil J. ORCID: https://orcid.org/0000-0002-9839-5279(2011)Real-time monitoring of redox changes in the mammalian endoplasmic reticulum. Journal of Cell Science, 124(14), pp. 2349-2356. (doi: 10.1242/jcs.085530)

Ward, Richard J., Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2011)Ligand-induced internalisation of the orexin OX1 and cannabinoid CB1 receptors assessed via N-terminal SNAP and CLIP-tagging. British Journal of Pharmacology, 162(6), pp. 1439-1452. (doi: 10.1111/j.1476-5381.2010.01156.x)

2010

Alvarez-Curto, Elisa ORCID: https://orcid.org/0000-0003-4004-4545, Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2010)Applications of fluorescence and bioluminescence resonance energy transfer to drug discovery at G protein coupled receptors. Analytical and Bioanalytical Chemistry, 398(1), pp. 167-180. (doi: 10.1007/s00216-010-3823-4) (PMID:20517598)

Alvarez-Curto, Elisa, Ward, Richard J., Pediani, John D. and Milligan, Graeme(2010)Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET. Journal of Biological Chemistry, 285(30), pp. 23318-23330. (doi: 10.1074/jbc.M110.122184) (PMID:20489201) (PMCID:PMC2906324)

2009

Greenshields, K.N. et al. (2009)The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice. Journal of Clinical Investigation, 119(3), pp. 595-610. (doi: 10.1172/JCI37338)

2007

Lopez-Gimenez, Juan F., Canals Buj, Meritxell, Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519(2007)The 1b-adrenoceptor exists as a higher-order oligomer: effective oligomerization is required for receptor maturation, surface delivery, and function. Molecular Pharmacology, 71(4), pp. 1015-1029. (doi: 10.1124/mol.106.033035)

McGrath, I., Pediani, J.D. ORCID: https://orcid.org/0000-0001-6615-537X, Methven, L., MacMillan, J. and Daly, C.J. ORCID: https://orcid.org/0000-0002-0410-7548(2007)Visualisation of Receptors in Native Tissue. Life Sciences 2007, 2007.

Sartania, Nana ORCID: https://orcid.org/0000-0002-3196-2312, Appelbe, Shirley, Pediani, John D. ORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme(2007)Agonist occupancy of a single monomeric element is sufficient to cause internalization of the dimeric beta(2)-adrenoceptor. Cellular Signalling, 19, pp. 1928-1938. (doi: 10.1016/j.cellsig.2007.05.002)

2006

Ellis, J., Pediani, J.D. ORCID: https://orcid.org/0000-0001-6615-537X, Canals Buj, M., Milasta, S. and Milligan, G. ORCID: https://orcid.org/0000-0002-6946-3519(2006)Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. Journal of Biological Chemistry, 281(25), pp. 38812-38824. (doi: 10.1074/jbc.M602494200)

2003

Colston, J., Horobin, R.W. ORCID: https://orcid.org/0000-0002-6612-6664, Rashid-Doubell, F., Pediani, J. ORCID: https://orcid.org/0000-0001-6615-537X and Johal, K.K.(2003)Why fluorescent probes for endoplasmic reticulum are selective: an experimental and QSAR-modelling study. Biotechnic and Histochemistry, 78(6), pp. 323-332. (doi: 10.1080/10520290310001646659) (PMID:15473580)

2002

Daly, Craig ORCID: https://orcid.org/0000-0002-0410-7548, Pediani, John ORCID: https://orcid.org/0000-0001-6615-537X, Mackenzie, J.F. and McGrath, John ORCID: https://orcid.org/0000-0002-5276-0381(2002)Visualising agonist and antagonist interactions: the value of fluorescent ligands. Pharmacologist, 44(2), A73.

2000

Pediani, John Daniel ORCID: https://orcid.org/0000-0001-6615-537X, Mackenzie, Janet Fraser, Heeley, Robert Paul, Daly, Craig James ORCID: https://orcid.org/0000-0002-0410-7548 and McGrath, John Christie ORCID: https://orcid.org/0000-0002-5276-0381(2000)Single-cell recombinant pharmacology: bovine α1a-adrenoceptors in rat-1 fibroblasts release intracellular Ca2+, display subtype-characteristic agonism and antagonism, and exhibit an antagonist-reversible inverse concentration-response phase. Journal of Pharmacology and Experimental Therapeutics, 293(3), pp. 887-895.

Mackenzie, J.F., Pediani, John ORCID: https://orcid.org/0000-0001-6615-537X, Daly, Craig ORCID: https://orcid.org/0000-0002-0410-7548, Deighan, C. and McGrath, John ORCID: https://orcid.org/0000-0002-5276-0381(2000)Fluorescent ligand binding to alpha1-adrenoceptors in murine hepatocytes. In: 10th Porto Meeting on Adrenergic Mechanisms, Porto, Portugal, 25-27 Sept 2000, P2.

1999

McGrath, J.C. ORCID: https://orcid.org/0000-0002-5276-0381, Nagadeh, M.A., Pediani, J.D. ORCID: https://orcid.org/0000-0001-6615-537X, Mackenzie, J.F. and Daly, C.J. ORCID: https://orcid.org/0000-0002-0410-7548(1999)Importance of agonists in α-adrenoceptor classification and localisation of α1-adrenoceptors in human prostate. European Urology, 36(S1), pp. 80-88. (doi: 10.1159/000052326)

1998

Pediani, J.D. ORCID: https://orcid.org/0000-0001-6615-537X, Mackenzie, J.F., Daly, C.J. and McGrath, J.C. ORCID: https://orcid.org/0000-0002-5276-0381(1998)Functional pharmacological properties of the cloned bovine a 1a-adrenoceptor (a 1a-AR) stably expressed in rat-1 fibroblasts. Naunyn-Schmiedeberg's Archives of Pharmacology, 358(Supp.2), p. 646.

Pediani, John ORCID: https://orcid.org/0000-0001-6615-537X, Mackenzie, J.F., Daly, Craig ORCID: https://orcid.org/0000-0002-0410-7548 and McGrath, John ORCID: https://orcid.org/0000-0002-5276-0381(1998)Comparison of functional and binding pharmacological properties of the cloned bovine a 1a-adrenoceptor (a 1a-AR) stably expressed in rat-1 fibroblasts. Naunyn-Schmiedeberg's Archives of Pharmacology, 358(S2), P6.47.

1991

Wilson, S.M., Pediani, J. ORCID: https://orcid.org/0000-0001-6615-537X, Cockburn, F., Bovell, D.L., Jenkinson, D.M., Paton, J.Y. ORCID: https://orcid.org/0000-0002-9896-7855, Coutts, J., Davidson, R., Lambert, J. and Morris, G.(1991)The cholinergic regulation of potassium (86Rb ) permeability in sweat glands isolated from patients with cystic fibrosis. Experimental Physiology, 76(4), pp. 573-578.

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