Murat Kanbur | Erciyes University (original) (raw)

Papers by Murat Kanbur

The purpose of this study is to investigate the effectiveness of the application of colostrum in ... more The purpose of this study is to investigate the effectiveness of the application of colostrum in aflatoxin toxication. For this aim, a total of 48, 3-4 month old Balb C female mice were used, and 4 groups were established. The animals of group 1 were the control group used. Groups 2, 3 and 4 were given 500 mg/kg bw/day bovine colostrum, 750 mu g/kg bw/day aflatoxin (approximately 77% AFB(1), 15% AFB(2), 5% AFG(1) and 3% AFG(2)) and 500 mg/kg bw/day bovine colostrum plus 750 mu g/kg bw/day aflatoxin, respectively, for 21 days by gavage. The MDA levels and the activities of CAT, SOD and GSH-Px were measured in the blood. Furthermore, levels/activities of the glucose, triglyceride, cholesterol, total protein, albumin, BUN, bilirubin, AST and ALP were performed in serum. These results showed that AF caused negative changes in all the oxidative stress parameters and in some biochemical parameters (triglyceride, total protein, AST and ALP), and applications of colostrum alleviated AF toxicity. It was concluded that colostrum is one of the compounds that can be used as a supportive agent in case of aflatoxin intoxication

Human & Experimental Toxicology, 2017

A total of 66 male Wistar rats were used and six groups (control: 10 animals and experimental: 12... more A total of 66 male Wistar rats were used and six groups (control: 10 animals and experimental: 12 animals) were formed. While a separate control group was established for each study period, mad honey application to the animals in the experimental group was carried out with a single dose (12.5 g kg−1 body weight (b.w.); acute stage), at a dose of 7.5 g kg−1 b.w. for 21 days (subacute stage), and at a dose of 5 g kg−1 b.w. for 60 days (chronic stage). Tissue and blood oxidative stress markers (malondialdehyde (MDA), nitric oxide (NO), 4-hydroxynonenal (HNE), superoxide dismutase, catalase, glutathione (GSH) peroxidase, and glucose-6-phosphate dehydrogenase), hepatic chemical metabolizing parameters in the liver (cytochrome P450 2E1, nicotinamide adenine dinucleotide (NADH)-cytochrome b5 reductase, nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome c reductase (CYTC), GSH S-transferase (GST), and GSH), and micronucleus and comet test in some samples were examined. Findings ...

Environmental Science and Pollution Research, 2018

In the current study, the possible prophylactic and therapeutic effects of colostrum (COL) on acu... more In the current study, the possible prophylactic and therapeutic effects of colostrum (COL) on acute organ injury caused by paracetamol (PAR) in rats were evaluated. Within the scope of this study, a 2-month-old male (150-200 g) 70 Wistar Albino rat was used and a total of seven groups were designed. The first group (CNT) was maintained for control purposes. The second group (COL-1) was given COL for 1 day, at a dose of 500 mg/kg at 6-h intervals, and blood and tissue sampling was performed at 24 h. The third group (COL-7) received COL for 7 days, at a dose of 500 mg/kg at 6-h intervals on day 1 and at a daily dose of 500 mg/kg on the following days, and blood and tissue samples were taken at the end of seventh day. The fourth group (PAR-1) was administered with PAR at a dose of 1.0 g/kg bw and was blood and tissue sampled at 24 h. The fifth group (PAR-7) received PAR at a dose of 1.0 g/kg bw on day 1 and was blood and tissue was removed at the end of day 7. The sixth group (PAR+COL-1) was administered with a combination of PAR (1 g/kg bw) and COL (500 mg/kg at 6-h intervals), and blood and tissue samples were collected at 24 h. The seventh group (PAR+COL-7) received 1.0 g/kg bw of PAR on day 1 and was given COL throughout the 7-day study period (at a dose of 500 mg/kg at 6-h intervals on day 1 and at a daily dose of 500 mg/kg on the following days). In the seventh group, blood and tissue samples were taken at the end of seventh day. Alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), glucose, creatinine, triglyceride, total bilirubin, total protein and albumin levels/activities were analysed in the serum samples. The malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) levels/activities, known as oxidative stress parameters, were assayed for tissue homogenates and blood (erythrocytes/plasma); in addition, enzyme activities of GSH S-transferase (GST), cytochrome P4502E1 (CYP2E1), NADH-cytochrome b5 reductase (CYTB5), glucose-6phosphate dehydrogenase (G6PD), NADPH-cytochrome P450 C reductase (CYTC) and glutathione (GSH) levels/activities defined as drug metabolising parameters were measured in liver homogenates. In result, it was determined that PAR caused significant alterations in some biochemical and lipid peroxidation parameters and the activities/levels of drug metabolising parameters in the liver and that COL normalised some of these parameters and reduced PAR-induced tissue damage.

... Murat KANBUR1, Ali BİLGİLİ2, Erdal Dinç3 1 Erciyes Üniversitesi, Veteriner Fakültesi, Farmako... more ... Murat KANBUR1, Ali BİLGİLİ2, Erdal Dinç3 1 Erciyes Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Kayseri -TÜRKİYE 2 Ankara Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı ... 4. Dinç E, Baydan E, Kanbur M, Onur F, 2002. ...

Fresenius Environmental Bulletin

Export Date: 23 March 2014, Source: Scopus

Two chemometric methods were applied to the simultaneous determination of chlortetracycline (CTC)... more Two chemometric methods were applied to the simultaneous determination of chlortetracycline (CTC) andbenzocaine (BC) in their binary mixture. The methods involve multivariate calibration based on principalleast-squares (PCR) and partial least-squares (PLS) regressions. A concentration set consisting of binarymixtures of CTC and BC in 13 different combinations were randomly prepared in 0.011 M HCl. Bothmultivariate calibration models were constructed by using the relationship between the concentration setand its corresponding absorption data in the spectral region of 200-305 nm. The accuracy and the precisionof the methods were validated by analyzing synthetic mixtures containing investigated drugs. The recoveryresults obtained by applying PCR and PLS calibrations to artificial mixtures were found between 100.2 and101.0 %. Data treatments, regressions and statistical analysis were performed by using the Microsoft EXCELand PLS toolbox 3.5 in Matlab 7.0 software. Satisfactory results for both artificial and commercial veterinarysamples were obtained. The experimental results from two chemometric methods were compared witheach other.Keywords: PLS method; PCR method; chlortetracycline; benzocaine; veterinary powder product

Die Pharmazie, 2005

A comparison of two wavelet approaches, Daubechies and reverse Biorthogonal, is described for the... more A comparison of two wavelet approaches, Daubechies and reverse Biorthogonal, is described for the quantitative resolution of a binary mixture of diminazene aceturate (DIMA) and phenazone (PHE) in veterinary granules for injection without any chemical separation. These two approaches were specified as db4 (a = 180) and rbior3.7 (a = 125) respectively, after testing the signal analysis parameters for the overlapping absorption spectra and ratio spectra. In the first step db4 (a = 180) was applied to the original absorbance data vector of DIMA and PHE. In the second step rbio3.7 (a = 125) was applied to the ratio spectra data vectors of DIMA using the divisor PHE. The same approach was also subjected to the ratio spectra of PHE using the divisor DIMA. The db4 (a = 180) and rbior3.7 (a = 125) calibration graphs were constructed using the transformation values obtained in the wavelet domain. In the method validation, the wavelet calibration functions were tested using synthetic mixtures ...

Homeopathy, 2015

Aflatoxins are toxic fungal metabolites that have adverse effects on humans and animals. Tarantul... more Aflatoxins are toxic fungal metabolites that have adverse effects on humans and animals. Tarantula cubensis D6 is used as a homeopathic medicine for different purposes. The present study investigates the effects of Tarantula cubensis D6 on the oxidant-antioxidant balance and some biochemical parameters against exposure to aflatoxin. Thirty-two Sprague-Dawley female rats were used and evenly divided into four groups. Group 1 served as control. Groups 2, 3, and 4 received 200 μl/kg.bw/day Tarantula cubensis D6 (applied subcutaneously), 400 μg/kg.bw/day total aflatoxin (approximately 80% AF B1, 10% AF B2, 6 %AF G1, and 4% AF G2), and 200 μl/kg.bw/day Tarantula cubensis D6 plus 400 μg/kg.bw/day total aflatoxin, respectively, for 28 days. At the end of 28 days, blood samples and some organs (liver, kidney, brain, and spleen) were taken from all the animals. Oxidative stress markers (MDA, SOD, CAT, GSH-Px) and some biochemical parameters (glucose, triglyceride, cholesterol, BUN, creatinine, AST, ALT and ALP, total protein, albumin) were evaluated in blood samples and tissues. Aflatoxin caused negative changes in all oxidative stress parameters and some biochemical parameters (glucose, triglyceride, cholesterol, creatinine, AST, ALT, ALP, total protein, albumin). Administration of Tarantula cubensis D6 partly alleviated aflatoxin-induced negative changes. Our results indicated that Tarantula cubensis D6 partially neutralized the deleterious effects of aflatoxin.

Drug Research, 2014

In this study*, it was aimed to observe, genotoxic effects of antituberculosis drugs and combinat... more In this study*, it was aimed to observe, genotoxic effects of antituberculosis drugs and combinations on rats. Animals were treated with 31.5 mg/kg isoniazid (INH), 54 mg/kg rifampicin (RIF), 189 mg/kg pyrazinamide (PYR), 100 mg/kg etham-butol(ETA), INH+RIF+PYR (MIX1) and INH+RIF+PYR+ETA (MIX2) mixtures applied via gavage for 90 days. At the end of the study, blood, liver and kidney samples were taken and evaluated by Comet and Micronucleus techniques. Compared to control group, head intensity decreased, tail intensity and tail migration increased on experiment groups in blood samples. Head intensity of PYR and mixture groups decreased, tail intensity of PYR and mixture groups increased and tail migration of PYR, ETA and mixture groups increased in liver samples. Head intensity decreased and tail intensity increased of INH, RIF, ETA and MIX1 group; tail migration increased of MIX1 group in kidney samples. Compared to control group, micronucleus rate of ETA, RIF and MIX 2 groups increased in experiment groups. In conclusion antituberculosis drugs and their mixtures applied for 90 days causes to double strand break of DNA damage at different degrees in blood, kidney and liver cells in rats.

revmedvet.com

... Aflatoxin was produced according to DEMET et al. [8] mo-dified from SHATWELL et al. ... In: M... more ... Aflatoxin was produced according to DEMET et al. [8] mo-dified from SHATWELL et al. ... In: Methods in Molecular Biology, Ams-trong D. (ed.), Humana Press., 2009, pp.: 221-232. 8. -DEMET Ö., OĞUZ H., ADIGÜZEL H.: Pirinçte aflatoksin üretimi. Vet. Bil. ...