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Papers by Ming-chang Chiang
Proceedings of the 17th International Conference on Pattern Recognition, 2004. ICPR 2004., 2004
This paper deals with the matching of geometric objects including points, curves, surfaces, and s... more This paper deals with the matching of geometric objects including points, curves, surfaces, and subvolumes using implicit object representations in both linear and non-linear settings. This framework can be applied to feature-based non-linear image warping in biomedical imaging with the deformation constrained to be one-to-one, onto, and diffeomorphic. Moreover, a theoretical connection is established between the well known Hausdorff metric and the framework proposed in this paper. A general strategy for matching geometric objects in both 2D and 3D is discussed. The corresponding Euler-Lagrange equations are presented and gradient descent method is employed to solve the time dependent partial differential equations.
2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, 2010
We have developed a new electronic nose based on a gas sensor array to detect organic vapors. The... more We have developed a new electronic nose based on a gas sensor array to detect organic vapors. The gas sensor array is based on 2×2 non-continuously working oscillators equipped with differently polymer-coated surface acoustic wave (SAW) sensors. The SAW detection system which is employed to detect various organic molecules in a static system was prepared using 99.8 MHz two-port SAW
Human molecular genetics, 2007
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG ... more Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. Using two mouse models of HD, we demonstrate that the urea cycle deficiency characterized by hyperammonemia, high blood citrulline and suppression of urea cycle enzymes is a prominent feature of HD. The resultant ammonia toxicity might exacerbate the neurological deficits of HD. Suppression of C/EBPalpha, a crucial transcription factor for the transcription of urea cycle enzymes, appears to mediate the urea cycle deficiency in HD. We found that in the presence of mutant Htt, C/EBPalpha loses its ability to interact with an important cofactor (CREB-binding protein). Moreover, mutant Htt recruited C/EBPalpha into aggregates, as well as suppressed expression of the C/EBPalpha gene. Consumption of protein-restricted diets not only led to the restoration of C/EBPalpha's activity, and repair of the urea cycle deficiency and hyperammonem...
The Journal of biological chemistry, Jan 8, 2005
Huntington's disease is a neurodegenerative disease resulting from a CAG (glutamine) trinucle... more Huntington's disease is a neurodegenerative disease resulting from a CAG (glutamine) trinucleotide expansion in exon 1 of the Huntingtin (Htt) gene. The role of the striatum-enriched A2A adenosine receptor (A2A-R) in Huntington's disease has attracted much attention lately. In the present study, we found that expression of mutant Htt with expanded poly(Q) significantly reduced the transcript levels of the endogenous A2A-R in PC12 cells and primary striatal neurons. Cotransfection of various promoter constructs of the A2A-R gene and an expression construct of poly(Q)-expanded Htt revealed that the Htt mutant suppressed the core promoter activity of the A2A-R gene. Stimulation of the A2A-R using CGS21680, forskolin, and a constitutively active cAMP-response element-binding protein (CREB) mutant elevated the reduced promoter activity of the A2A-R gene by mutant Htt. Moreover, the effect of CGS was blocked by an A2A-R-selective antagonist (CSC), two inhibitors of protein kinase ...
Fragile X syndrome (FraX), a genetic neurodevelopmental disorder, results in impaired cognition w... more Fragile X syndrome (FraX), a genetic neurodevelopmental disorder, results in impaired cognition with particular deficits in executive function and visuo-spatial skills. Here we report the first detailed 3D maps of the effects of the Fragile X mutation on brain structure, using tensor-based morphometry. TBM visualizes structural brain deficits automatically, without time-consuming specification of regions-of-interest. We compared 36 subjects with FraX (age: 14.66+/−1.58SD, 18 females/18 males), and 33 age-matched healthy controls (age: 14.67+/−2.2SD, 17 females/16 males), using highdimensional elastic image registration. All 69 subjects' 3D T1-weighted brain MRIs were spatially deformed to match a high-resolution single-subject average MRI scan in ICBM space, whose geometry was optimized to produce a minimal deformation target. Maps of the local Jacobian determinant (expansion factor) were computed from the deformation fields. Statistical maps showed increased caudate (10% higher; p=0.001) and lateral ventricle volumes (19% higher; p=0.003), and trend-level parietal and temporal white matter excesses (10% higher locally; p=0.04). In affected females, volume abnormalities correlated with reduction in systemically measured levels of the fragile X mental retardation protein (FMRP; Spearman's r<−0.5 locally). Decreased FMRP correlated with ventricular expansion (p=0.042; permutation test), and anterior cingulate tissue reductions (p=0.0026; permutation test) supporting theories that FMRP is required for normal dendritic pruning in fronto-striatal-limbic pathways. No sex differences were found; findings were confirmed using traditional volumetric measures in regions of interest. Deficit patterns were replicated using Lie group statistics optimized for tensor-valued data. Investigation of how these anomalies emerge over time will accelerate our understanding of FraX and its treatment.
Expert review of neurotherapeutics, 2015
Small fiber neuropathy is a syndrome of diverse disease etiology because of multiple pathophysiol... more Small fiber neuropathy is a syndrome of diverse disease etiology because of multiple pathophysiologic mechanisms with major presentations of neuropathic pain and autonomic symptoms. Over the past decade, there has been substantial progress in the treatments for neuropathic pain, dysautonomia and disease-modifying strategy. In particular, anticonvulsants and antidepressants alleviate neuropathic pain based on randomized clinical trials.
ABSTRACT Group buying is emerging as a new online buying model, in which an initiator takes the i... more ABSTRACT Group buying is emerging as a new online buying model, in which an initiator takes the initiative and other users participate through a virtual community. A group of people who have the same need buy products online together, taking advantage of numbers to get bargains. Website stickiness, the website's ability to retain online customers and prolong the duration of each stay, is one of the key factors to e-commerce success. How to maintain members' stickiness becomes a critical issue in Information Systems (IS) study. Therefore, we aim to explore members' stickiness intention by linking justice theory and trust. The research model is based on Social cognition theory (SCT) and trust related literature. This study posits trust in marketplace, trust in initiator, and conformity as environmental influences, while collective efficacy is viewed as personal influences. We validate that member perceived distributive justice, procedure justice, and interactional justice have impact on their trust in marketplace and trust in initiator. Besides, member's perceived trust, conformity, and collective efficacy have influence on their stickiness intention.
Two-tier testing questions are gradually becoming commonly-used conception diagnostic tools, and ... more Two-tier testing questions are gradually becoming commonly-used conception diagnostic tools, and the application domain of Dynamic Assessment (DA) is extending from special education to general education. This study adopts the Computerized Two-tier Testing Question (CTTQ) as pretest tool and combines CTTQ with the standardized graduate prompting mode of DA. It encourages teachers to explore the student's concept-cognition situation individually, and according to the misconceptions arrange individualized remedial instruction. The process of this study was designed with the nonequivalent-control group design model. The teaching materials are on fifth-grade fraction problems. Based on review of numerous studies on fraction misconceptions, it organizes a two-tier examination. The purpose is to prove the effectiveness of CTTQ as a conception diagnostic tool. The experiment involves four groups: one-tier control group (OTCG), two-tier control group (TTCG), one-tier experiment group (OTEG), and two-tier experiment group (TTEG). The samples came from three primary schools in Taipei County, including 176 fifth-grade pupils, who were assigned to the four groups randomly. After analyzing the experiment data, we found: 1. The result of the fraction conception posttest of the experiment group is better than that the control group, and there are significant difference between the two. 2. The result of the fraction conception posttest of TTCG is better than that of OTCG, and there is a significant difference between the two. 3. The result of the fraction conception posttest of TTEG is better than that of OTEG, and there is a significant difference between them.
Proceedings of the 17th International Conference on Pattern Recognition, 2004. ICPR 2004., 2004
This paper deals with the matching of geometric objects including points, curves, surfaces, and s... more This paper deals with the matching of geometric objects including points, curves, surfaces, and subvolumes using implicit object representations in both linear and non-linear settings. This framework can be applied to feature-based non-linear image warping in biomedical imaging with the deformation constrained to be one-to-one, onto, and diffeomorphic. Moreover, a theoretical connection is established between the well known Hausdorff metric and the framework proposed in this paper. A general strategy for matching geometric objects in both 2D and 3D is discussed. The corresponding Euler-Lagrange equations are presented and gradient descent method is employed to solve the time dependent partial differential equations.
2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, 2010
We have developed a new electronic nose based on a gas sensor array to detect organic vapors. The... more We have developed a new electronic nose based on a gas sensor array to detect organic vapors. The gas sensor array is based on 2×2 non-continuously working oscillators equipped with differently polymer-coated surface acoustic wave (SAW) sensors. The SAW detection system which is employed to detect various organic molecules in a static system was prepared using 99.8 MHz two-port SAW
Human molecular genetics, 2007
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG ... more Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. Using two mouse models of HD, we demonstrate that the urea cycle deficiency characterized by hyperammonemia, high blood citrulline and suppression of urea cycle enzymes is a prominent feature of HD. The resultant ammonia toxicity might exacerbate the neurological deficits of HD. Suppression of C/EBPalpha, a crucial transcription factor for the transcription of urea cycle enzymes, appears to mediate the urea cycle deficiency in HD. We found that in the presence of mutant Htt, C/EBPalpha loses its ability to interact with an important cofactor (CREB-binding protein). Moreover, mutant Htt recruited C/EBPalpha into aggregates, as well as suppressed expression of the C/EBPalpha gene. Consumption of protein-restricted diets not only led to the restoration of C/EBPalpha's activity, and repair of the urea cycle deficiency and hyperammonem...
The Journal of biological chemistry, Jan 8, 2005
Huntington's disease is a neurodegenerative disease resulting from a CAG (glutamine) trinucle... more Huntington's disease is a neurodegenerative disease resulting from a CAG (glutamine) trinucleotide expansion in exon 1 of the Huntingtin (Htt) gene. The role of the striatum-enriched A2A adenosine receptor (A2A-R) in Huntington's disease has attracted much attention lately. In the present study, we found that expression of mutant Htt with expanded poly(Q) significantly reduced the transcript levels of the endogenous A2A-R in PC12 cells and primary striatal neurons. Cotransfection of various promoter constructs of the A2A-R gene and an expression construct of poly(Q)-expanded Htt revealed that the Htt mutant suppressed the core promoter activity of the A2A-R gene. Stimulation of the A2A-R using CGS21680, forskolin, and a constitutively active cAMP-response element-binding protein (CREB) mutant elevated the reduced promoter activity of the A2A-R gene by mutant Htt. Moreover, the effect of CGS was blocked by an A2A-R-selective antagonist (CSC), two inhibitors of protein kinase ...
Fragile X syndrome (FraX), a genetic neurodevelopmental disorder, results in impaired cognition w... more Fragile X syndrome (FraX), a genetic neurodevelopmental disorder, results in impaired cognition with particular deficits in executive function and visuo-spatial skills. Here we report the first detailed 3D maps of the effects of the Fragile X mutation on brain structure, using tensor-based morphometry. TBM visualizes structural brain deficits automatically, without time-consuming specification of regions-of-interest. We compared 36 subjects with FraX (age: 14.66+/−1.58SD, 18 females/18 males), and 33 age-matched healthy controls (age: 14.67+/−2.2SD, 17 females/16 males), using highdimensional elastic image registration. All 69 subjects' 3D T1-weighted brain MRIs were spatially deformed to match a high-resolution single-subject average MRI scan in ICBM space, whose geometry was optimized to produce a minimal deformation target. Maps of the local Jacobian determinant (expansion factor) were computed from the deformation fields. Statistical maps showed increased caudate (10% higher; p=0.001) and lateral ventricle volumes (19% higher; p=0.003), and trend-level parietal and temporal white matter excesses (10% higher locally; p=0.04). In affected females, volume abnormalities correlated with reduction in systemically measured levels of the fragile X mental retardation protein (FMRP; Spearman's r<−0.5 locally). Decreased FMRP correlated with ventricular expansion (p=0.042; permutation test), and anterior cingulate tissue reductions (p=0.0026; permutation test) supporting theories that FMRP is required for normal dendritic pruning in fronto-striatal-limbic pathways. No sex differences were found; findings were confirmed using traditional volumetric measures in regions of interest. Deficit patterns were replicated using Lie group statistics optimized for tensor-valued data. Investigation of how these anomalies emerge over time will accelerate our understanding of FraX and its treatment.
Expert review of neurotherapeutics, 2015
Small fiber neuropathy is a syndrome of diverse disease etiology because of multiple pathophysiol... more Small fiber neuropathy is a syndrome of diverse disease etiology because of multiple pathophysiologic mechanisms with major presentations of neuropathic pain and autonomic symptoms. Over the past decade, there has been substantial progress in the treatments for neuropathic pain, dysautonomia and disease-modifying strategy. In particular, anticonvulsants and antidepressants alleviate neuropathic pain based on randomized clinical trials.
ABSTRACT Group buying is emerging as a new online buying model, in which an initiator takes the i... more ABSTRACT Group buying is emerging as a new online buying model, in which an initiator takes the initiative and other users participate through a virtual community. A group of people who have the same need buy products online together, taking advantage of numbers to get bargains. Website stickiness, the website's ability to retain online customers and prolong the duration of each stay, is one of the key factors to e-commerce success. How to maintain members' stickiness becomes a critical issue in Information Systems (IS) study. Therefore, we aim to explore members' stickiness intention by linking justice theory and trust. The research model is based on Social cognition theory (SCT) and trust related literature. This study posits trust in marketplace, trust in initiator, and conformity as environmental influences, while collective efficacy is viewed as personal influences. We validate that member perceived distributive justice, procedure justice, and interactional justice have impact on their trust in marketplace and trust in initiator. Besides, member's perceived trust, conformity, and collective efficacy have influence on their stickiness intention.
Two-tier testing questions are gradually becoming commonly-used conception diagnostic tools, and ... more Two-tier testing questions are gradually becoming commonly-used conception diagnostic tools, and the application domain of Dynamic Assessment (DA) is extending from special education to general education. This study adopts the Computerized Two-tier Testing Question (CTTQ) as pretest tool and combines CTTQ with the standardized graduate prompting mode of DA. It encourages teachers to explore the student's concept-cognition situation individually, and according to the misconceptions arrange individualized remedial instruction. The process of this study was designed with the nonequivalent-control group design model. The teaching materials are on fifth-grade fraction problems. Based on review of numerous studies on fraction misconceptions, it organizes a two-tier examination. The purpose is to prove the effectiveness of CTTQ as a conception diagnostic tool. The experiment involves four groups: one-tier control group (OTCG), two-tier control group (TTCG), one-tier experiment group (OTEG), and two-tier experiment group (TTEG). The samples came from three primary schools in Taipei County, including 176 fifth-grade pupils, who were assigned to the four groups randomly. After analyzing the experiment data, we found: 1. The result of the fraction conception posttest of the experiment group is better than that the control group, and there are significant difference between the two. 2. The result of the fraction conception posttest of TTCG is better than that of OTCG, and there is a significant difference between the two. 3. The result of the fraction conception posttest of TTEG is better than that of OTEG, and there is a significant difference between them.