Galip Akaydın | Hacettepe University (original) (raw)

Papers by Galip Akaydın

Hacettepe Universitesi Egitim Fakultesi Dergisi, 1992

Hacettepe Universitesi Egitim Fakultesi Dergisi, 2000

OZIET: Bu çalışmada liselerdeki biyoloji laboratuvarıannın araç ve gereçler açısından yeterli olu... more OZIET: Bu çalışmada liselerdeki biyoloji laboratuvarıannın araç ve gereçler açısından yeterli olup olmadı~ı araştınlmıştır. Biyoloji ö~etiminde uyıı;ulamalarm amacına ulaşahilmesi. biyoloji laboratuvarlannın bu açıdan yeterlili~i ile yakından ilişkilidir. Konuyla ba~lantılı olarak, liselerimizdeki durumun araştırılması amacıyla hazırlanan anket formları Ankara' da bulunan "eşitli liselerdeki biyoloji ö~retmenlerine uygulanmıştır. Anket sonuçlarının de~erlendirilmesiyle elde edilen veriler, liselerdeki biyoloji laboratuvarlarmın araçlar ve kimyasallar bakımından orta ve iyi durumda. ancak donanımlar ve modeller bakımından yeterli olmadı~ını ortaya koymuştur. ANAHTAR söZCÜKLER:

Asian Journal of Pharmaceutical and Clinical Research, Dec 29, 2013

Objective: In developing countries, population explosion is one of the most important causes of p... more Objective: In developing countries, population explosion is one of the most important causes of poverty and pollution. Therefore, severa l approaches have been investigated to decrease fertility, including hormonal, chemical and immunological approaches. However, no suitable method has been found to be effective and free from side effects. Thus, the aim of this study was to investigate the effect of B. sulphureum and C. intybus extracts on various parameters of male fertility using a rat model. Methods: Ethanolic extracts of both plants at doses of 125, 250 and 500 mg/kg, were each given orally to male Wistar rats for 7 weeks. Sperm characters and serum levels of sex hormones were assessed. Mating success %, fertility success % and fertility index were also calculated. The testes, liver and kidney were processed for histological examination. The effect on some biochemical and hematological parameters were quantified. Results: Results showed significant decrease in the weight of testes, epididymis, seminal vesicle and ventral prostate in the 250 and 500 mg/kg groups after 7 weeks of treatment. Both extracts reduced the motility, count and viability of sperms. Significant reduction in serum levels of testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) with hyperprolactinemia were observed. Both extracts did not significantly alter any of the biochemical and hematologic parameters studied. Conclusion: These data suggest that administration of B. sulphureum and C. intybus extracts for 7 weeks contribute to reduce testicular and epididymal function in exposed rats.

Israel Journal of Plant Sciences, 2002

A new species, Acantholimon avanosicum Dogan & Akaydin in the Plumbaginaceae is described and ill... more A new species, Acantholimon avanosicum Dogan & Akaydin in the Plumbaginaceae is described and illustrated. The species grows on argillaceous slopes in Central Anatolia, Turkey. The diagnostic morphological characters that distinguish it from closely related taxa are discussed. A revised key to Acantholimon species in Turkey with densely distichous simple spikes is presented.

Dietary, therapeutical, and other ethnobotanical utilizations of the wild plants grown in Haymana... more Dietary, therapeutical, and other ethnobotanical utilizations of the wild plants grown in Haymana district of Ankara were investigated. Information was collected by face-to-face interviews with 160 individuals in 9 selected sites. The demographic characteristics of the informants were evaluated and cross-relationships with the recorded data were also analyzed by SPSS statistical software. Results of the study show that 83.8% of

Turkish Journal of Botany, Oct 1, 2003

Bot J Linn Soc, 2004

Three new species, Acantholimon bashkaleicum sp. nov. , Acantholimon artosense sp. nov. and Acant... more Three new species, Acantholimon bashkaleicum sp. nov. , Acantholimon artosense sp. nov. and Acantholimon hoshapicum sp. nov. (Plumbaginaceae) are described and illustrated. The species are all confined to B9/B10 Van Province in East Anatolia where they grow either on calcareous mountain slopes or on mountain steppes. Diagnostic morphological characteristics from the closely related species are given, along with a discussion dealing with their taxonomic relationships, and their conservation statuses are pointed out. A revised key to the Acantholimon species with heterophyllous leaves, two or more flowered and four or more bracteated spikelets is also provided.

Records of Natural Products, 2011

Kappa Opioid Peptide Receptor (KOPr) activation produces analgesic, psychotomimetic, diuretic and... more Kappa Opioid Peptide Receptor (KOPr) activation produces analgesic, psychotomimetic, diuretic and antipruritic effects. KOPr ligands are investigated for their potential roles in the treatment of addiction, depression, feeding behavior, psychosis and schizophrenia. In this study the methanolic extracts of a number of Salvia species which are native to Turkey (S. tomentosa, S. tchihatcheffii, S. rosifolia, S. dichroantha and S. sclarea) were tested for their potential binding to opioid receptors in rat brain membranes and Chinese Hamster Ovary Cells expressing human KOPr (CHO-KOPh). [ 3 H]Diprenorphine, an unselective opioid antagonist, was utilized in the radioligand receptor binding assays. All extracts (0.11 mg/mL) inhibited the [ 3 H]Diprenorphine binding with ranging KOPr binding affinities. More than 50% inhibition of diprenorphine binding was shown only with Salvia dichroantha and Salvia sclarea both in rat brain membranes and CHO-KOPh membranes. Among them Salvia sclarea deserves further investigation for its active component(s) and its pharmacological characterization. This study clearly demonstrates the potential opioid receptor binding activities of several Turkish Salvia species. This work constitutes the first study on in vitro opioid receptor binding activities of Salvia species from the Turkish flora.

Food Chemistry, Jun 1, 2012

Pharmaceutical Biology, 2016

Context Some Ajuga L. (Lamiaceae) species are traditionally used for the treatment of malaria, as... more Context Some Ajuga L. (Lamiaceae) species are traditionally used for the treatment of malaria, as well as fever, which is a common symptom of many parasitic diseases. Objective In the continuation of our studies on the identification of antiprotozoal secondary metabolites of Turkish Lamiaceae species, we have investigated the aerial parts of Ajuga laxmannii. Materials and methods The aerial parts of A. laxmannii were extracted with MeOH. The H2O subextract was subjected to polyamide, C18-MPLC and SiO2 CCs to yield eight metabolites. The structures of the isolates were elucidated by NMR spectroscopy and MS analyses. The extract, subextracts as well as the isolates were tested for their in vitro antiprotozoal activities against Plasmodium falciparum, Trypanasoma brucei rhodesiense, T. cruzi and Leishmania donovani at concentrations of 90-0.123 μg/mL. Results Two iridoid glycosides harpagide (1) and 8-O-acetylharpagide (2), three o-coumaric acid derivatives cis-melilotoside (3), trans-melilotoside (4) and dihydromelilotoside (5), two phenylethanoid glycosides verbascoside (6) and galactosylmartynoside (7) and a flavone-C-glycoside, isoorientin (8) were isolated. Many compounds showed moderate to good antiparasitic activity, with isoorientin (8) displaying the most significant antimalarial potential (an IC50 value of 9.7 μg/mL). Discussion and conclusion This is the first report on the antiprotozoal evaluation of A. laxmannii extracts and isolates. Furthermore, isoorientin and dihydromelilotoside are being reported for the first time from the genus Ajuga.

Bangladesh Journal of …, Jan 1, 2011

The present study aims to evaluate the anatomy of leaf and stem as well as pollen morphology in t... more The present study aims to evaluate the anatomy of leaf and stem as well as pollen morphology in two taxa, namely L. racemosus (Lam.) Tzvelev subsp. sabulosus (Bieb.) Tzvelev and L. cappadocicus (Boiss. & Bal.) Melderis. Also, it is targeted to contribute to the morphology of these two taxa. The results have revealed varying anatomical characters in the types of stomata, wall appearance of the long cells, indumentum densities, dispositions of sclerenchyma around the vascular bundles, girders and strand shapes of the sclerenchymatic cells in the leaves, epidermal cell arrangements and epidermal cell sizes in the attachment points with sclerenchyma in the stems. Moreover, alternation in the pollen morphology concerning pollen size, operculum, undulation and the number of scabrae has also been demonstrated.

2 Abstract: This study examines whether a satisfactory infrageneric grouping of Turkish Acantholi... more 2 Abstract: This study examines whether a satisfactory infrageneric grouping of Turkish Acantholimon can be obtained from phenetic clustering based on external vegetative and floral morphological characters. Forty-one morphological characters were selected and scored for the 52 species of Acantholimon found in Turkey and the data subjected to numerical taxonomic analyses. The results of this study suggest that there are

Nordic Journal of Botany, 2001

ABSTRACT

Nordic Journal of Botany, 2002

Israel Journal of Plant Sciences, 2003

ABSTRACT

Hacettepe Universitesi Egitim Fakultesi Dergisi, 1992

Hacettepe Universitesi Egitim Fakultesi Dergisi, 2000

OZIET: Bu çalışmada liselerdeki biyoloji laboratuvarıannın araç ve gereçler açısından yeterli olu... more OZIET: Bu çalışmada liselerdeki biyoloji laboratuvarıannın araç ve gereçler açısından yeterli olup olmadı~ı araştınlmıştır. Biyoloji ö~etiminde uyıı;ulamalarm amacına ulaşahilmesi. biyoloji laboratuvarlannın bu açıdan yeterlili~i ile yakından ilişkilidir. Konuyla ba~lantılı olarak, liselerimizdeki durumun araştırılması amacıyla hazırlanan anket formları Ankara' da bulunan "eşitli liselerdeki biyoloji ö~retmenlerine uygulanmıştır. Anket sonuçlarının de~erlendirilmesiyle elde edilen veriler, liselerdeki biyoloji laboratuvarlarmın araçlar ve kimyasallar bakımından orta ve iyi durumda. ancak donanımlar ve modeller bakımından yeterli olmadı~ını ortaya koymuştur. ANAHTAR söZCÜKLER:

Asian Journal of Pharmaceutical and Clinical Research, Dec 29, 2013

Objective: In developing countries, population explosion is one of the most important causes of p... more Objective: In developing countries, population explosion is one of the most important causes of poverty and pollution. Therefore, severa l approaches have been investigated to decrease fertility, including hormonal, chemical and immunological approaches. However, no suitable method has been found to be effective and free from side effects. Thus, the aim of this study was to investigate the effect of B. sulphureum and C. intybus extracts on various parameters of male fertility using a rat model. Methods: Ethanolic extracts of both plants at doses of 125, 250 and 500 mg/kg, were each given orally to male Wistar rats for 7 weeks. Sperm characters and serum levels of sex hormones were assessed. Mating success %, fertility success % and fertility index were also calculated. The testes, liver and kidney were processed for histological examination. The effect on some biochemical and hematological parameters were quantified. Results: Results showed significant decrease in the weight of testes, epididymis, seminal vesicle and ventral prostate in the 250 and 500 mg/kg groups after 7 weeks of treatment. Both extracts reduced the motility, count and viability of sperms. Significant reduction in serum levels of testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) with hyperprolactinemia were observed. Both extracts did not significantly alter any of the biochemical and hematologic parameters studied. Conclusion: These data suggest that administration of B. sulphureum and C. intybus extracts for 7 weeks contribute to reduce testicular and epididymal function in exposed rats.

Israel Journal of Plant Sciences, 2002

A new species, Acantholimon avanosicum Dogan & Akaydin in the Plumbaginaceae is described and ill... more A new species, Acantholimon avanosicum Dogan & Akaydin in the Plumbaginaceae is described and illustrated. The species grows on argillaceous slopes in Central Anatolia, Turkey. The diagnostic morphological characters that distinguish it from closely related taxa are discussed. A revised key to Acantholimon species in Turkey with densely distichous simple spikes is presented.

Dietary, therapeutical, and other ethnobotanical utilizations of the wild plants grown in Haymana... more Dietary, therapeutical, and other ethnobotanical utilizations of the wild plants grown in Haymana district of Ankara were investigated. Information was collected by face-to-face interviews with 160 individuals in 9 selected sites. The demographic characteristics of the informants were evaluated and cross-relationships with the recorded data were also analyzed by SPSS statistical software. Results of the study show that 83.8% of

Turkish Journal of Botany, Oct 1, 2003

Bot J Linn Soc, 2004

Three new species, Acantholimon bashkaleicum sp. nov. , Acantholimon artosense sp. nov. and Acant... more Three new species, Acantholimon bashkaleicum sp. nov. , Acantholimon artosense sp. nov. and Acantholimon hoshapicum sp. nov. (Plumbaginaceae) are described and illustrated. The species are all confined to B9/B10 Van Province in East Anatolia where they grow either on calcareous mountain slopes or on mountain steppes. Diagnostic morphological characteristics from the closely related species are given, along with a discussion dealing with their taxonomic relationships, and their conservation statuses are pointed out. A revised key to the Acantholimon species with heterophyllous leaves, two or more flowered and four or more bracteated spikelets is also provided.

Records of Natural Products, 2011

Kappa Opioid Peptide Receptor (KOPr) activation produces analgesic, psychotomimetic, diuretic and... more Kappa Opioid Peptide Receptor (KOPr) activation produces analgesic, psychotomimetic, diuretic and antipruritic effects. KOPr ligands are investigated for their potential roles in the treatment of addiction, depression, feeding behavior, psychosis and schizophrenia. In this study the methanolic extracts of a number of Salvia species which are native to Turkey (S. tomentosa, S. tchihatcheffii, S. rosifolia, S. dichroantha and S. sclarea) were tested for their potential binding to opioid receptors in rat brain membranes and Chinese Hamster Ovary Cells expressing human KOPr (CHO-KOPh). [ 3 H]Diprenorphine, an unselective opioid antagonist, was utilized in the radioligand receptor binding assays. All extracts (0.11 mg/mL) inhibited the [ 3 H]Diprenorphine binding with ranging KOPr binding affinities. More than 50% inhibition of diprenorphine binding was shown only with Salvia dichroantha and Salvia sclarea both in rat brain membranes and CHO-KOPh membranes. Among them Salvia sclarea deserves further investigation for its active component(s) and its pharmacological characterization. This study clearly demonstrates the potential opioid receptor binding activities of several Turkish Salvia species. This work constitutes the first study on in vitro opioid receptor binding activities of Salvia species from the Turkish flora.

Food Chemistry, Jun 1, 2012

Pharmaceutical Biology, 2016

Context Some Ajuga L. (Lamiaceae) species are traditionally used for the treatment of malaria, as... more Context Some Ajuga L. (Lamiaceae) species are traditionally used for the treatment of malaria, as well as fever, which is a common symptom of many parasitic diseases. Objective In the continuation of our studies on the identification of antiprotozoal secondary metabolites of Turkish Lamiaceae species, we have investigated the aerial parts of Ajuga laxmannii. Materials and methods The aerial parts of A. laxmannii were extracted with MeOH. The H2O subextract was subjected to polyamide, C18-MPLC and SiO2 CCs to yield eight metabolites. The structures of the isolates were elucidated by NMR spectroscopy and MS analyses. The extract, subextracts as well as the isolates were tested for their in vitro antiprotozoal activities against Plasmodium falciparum, Trypanasoma brucei rhodesiense, T. cruzi and Leishmania donovani at concentrations of 90-0.123 μg/mL. Results Two iridoid glycosides harpagide (1) and 8-O-acetylharpagide (2), three o-coumaric acid derivatives cis-melilotoside (3), trans-melilotoside (4) and dihydromelilotoside (5), two phenylethanoid glycosides verbascoside (6) and galactosylmartynoside (7) and a flavone-C-glycoside, isoorientin (8) were isolated. Many compounds showed moderate to good antiparasitic activity, with isoorientin (8) displaying the most significant antimalarial potential (an IC50 value of 9.7 μg/mL). Discussion and conclusion This is the first report on the antiprotozoal evaluation of A. laxmannii extracts and isolates. Furthermore, isoorientin and dihydromelilotoside are being reported for the first time from the genus Ajuga.

Bangladesh Journal of …, Jan 1, 2011

The present study aims to evaluate the anatomy of leaf and stem as well as pollen morphology in t... more The present study aims to evaluate the anatomy of leaf and stem as well as pollen morphology in two taxa, namely L. racemosus (Lam.) Tzvelev subsp. sabulosus (Bieb.) Tzvelev and L. cappadocicus (Boiss. & Bal.) Melderis. Also, it is targeted to contribute to the morphology of these two taxa. The results have revealed varying anatomical characters in the types of stomata, wall appearance of the long cells, indumentum densities, dispositions of sclerenchyma around the vascular bundles, girders and strand shapes of the sclerenchymatic cells in the leaves, epidermal cell arrangements and epidermal cell sizes in the attachment points with sclerenchyma in the stems. Moreover, alternation in the pollen morphology concerning pollen size, operculum, undulation and the number of scabrae has also been demonstrated.

2 Abstract: This study examines whether a satisfactory infrageneric grouping of Turkish Acantholi... more 2 Abstract: This study examines whether a satisfactory infrageneric grouping of Turkish Acantholimon can be obtained from phenetic clustering based on external vegetative and floral morphological characters. Forty-one morphological characters were selected and scored for the 52 species of Acantholimon found in Turkey and the data subjected to numerical taxonomic analyses. The results of this study suggest that there are

Nordic Journal of Botany, 2001

ABSTRACT

Nordic Journal of Botany, 2002

Israel Journal of Plant Sciences, 2003

ABSTRACT