James Smoliga | High Point University (original) (raw)

Papers by James Smoliga

Research paper thumbnail of The Effects of Pre-Exercise Ginger Supplementation on Muscle Damage and Delayed Onset Muscle Soreness

Phytotherapy Research, 2015

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Research paper thumbnail of Potential Benefits of Resveratrol Supplementation for Optimizing Health and Preventing Chronic Disease

... Keywords: Anti-inflammatory, Antioxidant, Nutraceuticals, Polyphenols, Resveratrol,Supplement... more ... Keywords: Anti-inflammatory, Antioxidant, Nutraceuticals, Polyphenols, Resveratrol,Supplements ... Therefore, a number of resveratrol supplements have been developed, with capsules containing anywhere from 1mg through to as much as 1g per dose. ...

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Research paper thumbnail of Kinematic And Electromyographic Analysis Of The Legs, Torso, And Arms During An Exhaustive Run

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Research paper thumbnail of MINIMIZING OXYGEN CONSUMPTION DURING ULTRAMARATHONS: BEYOND RUNNING ECONOMY

Journal of Applied Physiology

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Research paper thumbnail of A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations

Aging

In recent years, the wealth of basic science research supporting resveratrol's potential to t... more In recent years, the wealth of basic science research supporting resveratrol's potential to treat, delay, and even prevent age-related chronic diseases has led to a number of human clinical trials. While such translational research has yielded promising results in clinical populations, recently published conflicting results from studies evaluating resveratrol's potential for primary prevention of chronic disease in healthy / asymptomatic individuals have generated considerable controversy and do not initially appear consistent with findings from animal models. We argue that trials targeting healthy humans are often fundamentally flawed owing to inappropriate use of paradigms only applicable to populations with overt clinical disease and the consequent misleading (typically negative) results can severely retard advancement of drug development. To appropriately perform translational research centered on resveratrol as a primary prevention agent in non-clinical populations, it ...

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Research paper thumbnail of If an animal looks obese, precise estimation of body composition is of limited clinical value

Journal of the American Veterinary Medical Association

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Research paper thumbnail of Oxidative stress: friend and foe of the elite marathoner

Journal of Applied Physiology

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Research paper thumbnail of Risk factors associated with lower extremity stress fractures in runners: a systematic review with meta-analysis

British Journal of Sports Medicine, 2015

Stress fractures are common overuse injuries with up to 95% occurring in the lower extremities. A... more Stress fractures are common overuse injuries with up to 95% occurring in the lower extremities. Among runners, stress fractures account for 15-20% of all musculoskeletal injuries. We systematically reviewed and critiqued the evidence regarding risk factors associated with increased risk of lower extremity stress fractures in runners. Systematic review. A systematic, computerised literature search of Medline, Embase, PubMed, SPORTDiscus, and CINAHL databases (from database inception through 9 January 2014) using keywords related to risk factors and stress fractures. This systematic review with meta-analysis utilised the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for the search and reporting phases of the study. Inverse variance meta-analyses, using a random effects model were used to summarise ORs. 8 articles met the inclusion criteria; 7 were considered low risk. 4 articles qualified for meta-analysis. Results of the meta-analysis identified previous history of stress fracture and female sex as the primary risk factors for future stress fracture with a pooled OR of 4.99 (95% CI 2.91 to 8.56; p<0.001; I(2)=0%) and 2.31 (95% CI 1.24 to 4.29; p<0.01; I(2)=0%), respectively. Currently, only previous history of stress fracture and female sex are risk factors for lower extremity stress fractures strongly supported by the data.

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Research paper thumbnail of Effects of unweighting and speed on in-shoe regional loading during running on a lower body positive pressure treadmill

Journal of Biomechanics, 2015

The purpose of this study was to determine how unweighted running on a lower body positive pressu... more The purpose of this study was to determine how unweighted running on a lower body positive pressure treadmill (LBPPT) modifies in-shoe regional loading. Ten experienced runners were fit with pressure distribution measurement insoles and ran at 100%, 120%, and 140% of self-reported easy training pace on a LBPPT at 20%, 40%, 60%, 80%, and 100% body weight percentage settings (BWSet). Speeds and BWSet were in random order. A linear mixed effect model (p<0.05 significance level) was used to compare differences in whole foot and regional maximum in-shoe plantar force (FMAX), impulse, and relative load distribution across speeds and BWSet. There were significant main effects (p<0.001) for running speed and BWSet for whole foot Fmax and impulse. The model revealed 1.4% and 0.24% increases in whole foot FMAX (times body weight) and impulse, respectively, for every unit increase in body weight percentage. There was a significant main effect for BWSet on Fmax and relative load (p<0.05) for each of the nine foot regions examined, though four regions were not different between 80% and 100% BWSet. There was a significant (p<0.001) main effect for BWSet on forefoot to rear foot relative load. Linear relationships were found between increases in BWSet and increases in-shoe Fmax and impulse, resulting from regional changes in foot pressure which represent a shift towards forefoot loading, most evident <80% BWSet. Estimating in-shoe regional loading parameters may be useful during rehabilitation and training to appropriately prescribe specific speed and body weight levels, without exceeding certain critical peak force levels while running.

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Research paper thumbnail of Diagnostic Accuracy of Various Imaging Modalities for Suspected Lower Extremity Stress Fractures: A Systematic Review With Evidence-Based Recommendations for Clinical Practice

The American Journal of Sports Medicine, 2015

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Research paper thumbnail of The Effects of Pre-Exercise Ginger Supplementation on Muscle Damage and Delayed Onset Muscle Soreness

Phytotherapy Research, 2015

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Research paper thumbnail of Controlled-frequency breath swimming improves swimming performance and running economy

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Research paper thumbnail of Increased physiologic intensity during walking and running on a non-motorized, curved treadmill

Physical Therapy in Sport, 2014

To determine whether exercise performed on a non-motorized, curved treadmill (NMCT) provides grea... more To determine whether exercise performed on a non-motorized, curved treadmill (NMCT) provides greater physiologic stimulus compared to a standard motorized treadmill (SMT). Crossover. Clinical research laboratory. 10 healthy athletic adults. Participants walked (1.34 m s(-1)) for 3 min and ran (2.24 m s(-1)) for 4 min on NMCT and SMT (randomized order) while metabolic data and rating of perceived exertion (RPE) were collected. Participants then identified preferred easy and moderate intensity training paces on each treadmill while blinded to speed. Repeated-measures ANOVA and Wilcoxon Signed-Rank tests were used to compare responses between treadmills. Intensity was significantly greater (P < 0.001) for NMCT than SMT [mean (95% confidence interval): Walking = 5.9(5.3,6.4) vs. 3.4(3.0,3.7) METs; Running = 10.7(9,6,11.7) vs. 7.3(6.8,7.8) METs]. Overall RPE was significantly greater (P < 0.01) on NMCT than SMT for walking [median (inter-quartile range): 7(1) vs. 6(0.8)] and running [11.5(3) vs. 8(2.5)]. Preferred speed was significantly slower on NMCT than SMT for easy [2.5(2.3,2.7) vs. 2.8(2.5,3.1) m s(-1)] and moderate [3.2(3.0,3.4) vs. 3.5(3.1,3.9) m s(-1)] intensities. NMCT elicits greater physiological stimulus than SMT with small, though statistically significant, changes in RPE at matched speeds. Clinicians must be aware of differences in intensity and RPE when prescribing exercise on NMCT.

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Research paper thumbnail of Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is the Solution?

Molecules, 2014

Resveratrol has emerged as a leading candidate for improving healthspan through potentially slowi... more Resveratrol has emerged as a leading candidate for improving healthspan through potentially slowing the aging process and preventing chronic diseases. The poor bioavailability of resveratrol in humans has been a major concern for translating basic science findings into clinical utility. Although a number of positive findings have emerged from human clinical trials, there remain many conflicting results, which may partially be attributed to the dosing protocols used. A number of theoretical solutions have been developed to improve the bioavailability of resveratrol, including consumption with various foods, micronized powders, combining it with additional phytochemicals, controlled release devices, and nanotechnological formulations. While laboratory models indicate these approaches all have potential to improve bioavailability of resveratrol and optimize its clinical utility, there is surprisingly very little data regarding the bioavailability of resveratrol in humans. If bioavailability is indeed a limitation in the clinical utility of resveratrol, there is a need to further explore methods to optimize bioavailability in humans. This review summarizes the current bioavailability data, focusing on data from humans, and provides suggested directions for future research in this realm.

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Research paper thumbnail of Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus-systematic review and meta-analysis

Molecular Nutrition & Food Research, 2014

The red wine polyphenol, resveratrol, is highly effective in treating type 2 diabetes mellitus (T... more The red wine polyphenol, resveratrol, is highly effective in treating type 2 diabetes mellitus (T2DM) in animal models, but there is no consensus regarding its efficacy in humans. We conducted a systematic review, which included searches in nine scholarly databases and six clinical trial registries, and identified randomized controlled clinical trials whereby resveratrol was used as an adjunct to pharmaceutical interventions in T2DM. Meta-analysis on clinical parameters was performed for available data. Of 764 articles originally identified, data from six unique datasets, examining a total of 196 T2DM patients (104 resveratrol, 92 control/placebo) ultimately met inclusion criteria. Statistically significant (p < 0.05) positive effects, indicating that resveratrol supplementation was more effective than placebo/control, were identified for systolic blood pressure, hemoglobin A1c, and creatinine, but not for fasting glucose, homeostatic model assessment of insulin resistance, diastolic blood pressure, insulin, triglycerides, LDL, or HDL cholesterol. No major adverse events were reported and side effects of resveratrol were not different than placebo/control. Though limitations in sample size and treatment duration preclude definitive changes in clinical practice, significant improvements in multiple cardiometabolic biomarkers and an excellent safety profile support resveratrol as a leading candidate as an adjunct to pharmacological management of T2DM.

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Research paper thumbnail of Translating dosages from animal models to human clinical trials--revisiting body surface area scaling

The FASEB Journal, 2015

Body surface area (BSA) scaling has been used for prescribing individualized dosages of various d... more Body surface area (BSA) scaling has been used for prescribing individualized dosages of various drugs and has also been recommended by the U.S. Food and Drug Administration as one method for using data from animal model species to establish safe starting dosages for first-in-human clinical trials. Although BSA conversion equations have been used in certain clinical applications for decades, recent recommendations to use BSA to derive interspecies equivalents for therapeutic dosages of drug and natural products are inappropriate. A thorough review of the literature reveals that BSA conversions are based on antiquated science and have little justification in current translational medicine compared to more advanced allometric and physiologically based pharmacokinetic modeling. Misunderstood and misinterpreted use of BSA conversions may have disastrous consequences, including underdosing leading to abandonment of potentially efficacious investigational drugs, and unexpected deadly adverse events. We aim to demonstrate that recent recommendations for BSA are not appropriate for animal-to-human dosage conversions and use pharmacokinetic data from resveratrol studies to demonstrate how confusion between the "human equivalent dose" and "pharmacologically active dose" can lead to inappropriate dose recommendations. To optimize drug development, future recommendations for interspecies scaling must be scientifically justified using physiologic, pharmacokinetic, and toxicology data rather than simple BSA conversion.-Blanchard, O. L., Smoliga, J. M. Translating dosages from animal models to human clinical trials-revisiting body surface area scaling.

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Research paper thumbnail of Resveratrol: Nutraceutical believed to counteract the detrimental effects of high-fat diet

Lipid Technology, 2014

ABSTRACT Resveratrol is a polyphenol found in red wine which has received considerable attention ... more ABSTRACT Resveratrol is a polyphenol found in red wine which has received considerable attention in recent years for its many beneficial effects on health. There is a wealth of evidence from laboratory models that resveratrol has anti oxidant, anti-inflammatory, anti-obesity, and anticancer effects which contribute to improved health. In the past five years, a number of human clinical trials have emerged, which generally support the data from animal models. While resveratrol may ultimately be useful in the prevention and treatment of chronic disease, considerable research is required before it can become incorporated into mainstream clinical use across multiple disciplines of medicine.

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Research paper thumbnail of The Effect of Passive Versus Active Recovery on Power Output Over Six Repeated Wingate Sprints

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Research paper thumbnail of Supplemental Tables Flaherty et al 2014

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Research paper thumbnail of Upper Extremity Physical Performance Tests in Collegiate Athletes

Journal of sport rehabilitation, Jan 22, 2015

Physical performance tests (PPTs) are commonly utilized in rehabilitation and injury prevention s... more Physical performance tests (PPTs) are commonly utilized in rehabilitation and injury prevention settings, yet normative values of upper extremity PPTs have not been established in high-level athletes. To 1) establish normative data values for the Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) and Upper Quarter Y-Balance Test™ (UQYBT) in collegiate athletes and compare results between sports, and 2) analyze the relationship between the two tests. Observational. Laboratory/ Athletic Facility. 257 (male=118, female=139) Division-1 athletes participating in basketball, soccer, baseball, lacrosse, volleyball, track and field and cross country. CKCUEST and UQYBT scores were recorded as part of a comprehensive injury-risk screening battery. Pearson correlations assessed the relationship between all measures of the CKCUEST and UQYBT scores. A factorial ANOVA and repeated measures ANOVA (arm dominance) were used to assess interactions between sex, year in school, and sport for...

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Research paper thumbnail of The Effects of Pre-Exercise Ginger Supplementation on Muscle Damage and Delayed Onset Muscle Soreness

Phytotherapy Research, 2015

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Research paper thumbnail of Potential Benefits of Resveratrol Supplementation for Optimizing Health and Preventing Chronic Disease

... Keywords: Anti-inflammatory, Antioxidant, Nutraceuticals, Polyphenols, Resveratrol,Supplement... more ... Keywords: Anti-inflammatory, Antioxidant, Nutraceuticals, Polyphenols, Resveratrol,Supplements ... Therefore, a number of resveratrol supplements have been developed, with capsules containing anywhere from 1mg through to as much as 1g per dose. ...

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Research paper thumbnail of Kinematic And Electromyographic Analysis Of The Legs, Torso, And Arms During An Exhaustive Run

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Research paper thumbnail of MINIMIZING OXYGEN CONSUMPTION DURING ULTRAMARATHONS: BEYOND RUNNING ECONOMY

Journal of Applied Physiology

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Research paper thumbnail of A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations

Aging

In recent years, the wealth of basic science research supporting resveratrol's potential to t... more In recent years, the wealth of basic science research supporting resveratrol's potential to treat, delay, and even prevent age-related chronic diseases has led to a number of human clinical trials. While such translational research has yielded promising results in clinical populations, recently published conflicting results from studies evaluating resveratrol's potential for primary prevention of chronic disease in healthy / asymptomatic individuals have generated considerable controversy and do not initially appear consistent with findings from animal models. We argue that trials targeting healthy humans are often fundamentally flawed owing to inappropriate use of paradigms only applicable to populations with overt clinical disease and the consequent misleading (typically negative) results can severely retard advancement of drug development. To appropriately perform translational research centered on resveratrol as a primary prevention agent in non-clinical populations, it ...

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Research paper thumbnail of If an animal looks obese, precise estimation of body composition is of limited clinical value

Journal of the American Veterinary Medical Association

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Research paper thumbnail of Oxidative stress: friend and foe of the elite marathoner

Journal of Applied Physiology

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Research paper thumbnail of Risk factors associated with lower extremity stress fractures in runners: a systematic review with meta-analysis

British Journal of Sports Medicine, 2015

Stress fractures are common overuse injuries with up to 95% occurring in the lower extremities. A... more Stress fractures are common overuse injuries with up to 95% occurring in the lower extremities. Among runners, stress fractures account for 15-20% of all musculoskeletal injuries. We systematically reviewed and critiqued the evidence regarding risk factors associated with increased risk of lower extremity stress fractures in runners. Systematic review. A systematic, computerised literature search of Medline, Embase, PubMed, SPORTDiscus, and CINAHL databases (from database inception through 9 January 2014) using keywords related to risk factors and stress fractures. This systematic review with meta-analysis utilised the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for the search and reporting phases of the study. Inverse variance meta-analyses, using a random effects model were used to summarise ORs. 8 articles met the inclusion criteria; 7 were considered low risk. 4 articles qualified for meta-analysis. Results of the meta-analysis identified previous history of stress fracture and female sex as the primary risk factors for future stress fracture with a pooled OR of 4.99 (95% CI 2.91 to 8.56; p<0.001; I(2)=0%) and 2.31 (95% CI 1.24 to 4.29; p<0.01; I(2)=0%), respectively. Currently, only previous history of stress fracture and female sex are risk factors for lower extremity stress fractures strongly supported by the data.

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Research paper thumbnail of Effects of unweighting and speed on in-shoe regional loading during running on a lower body positive pressure treadmill

Journal of Biomechanics, 2015

The purpose of this study was to determine how unweighted running on a lower body positive pressu... more The purpose of this study was to determine how unweighted running on a lower body positive pressure treadmill (LBPPT) modifies in-shoe regional loading. Ten experienced runners were fit with pressure distribution measurement insoles and ran at 100%, 120%, and 140% of self-reported easy training pace on a LBPPT at 20%, 40%, 60%, 80%, and 100% body weight percentage settings (BWSet). Speeds and BWSet were in random order. A linear mixed effect model (p<0.05 significance level) was used to compare differences in whole foot and regional maximum in-shoe plantar force (FMAX), impulse, and relative load distribution across speeds and BWSet. There were significant main effects (p<0.001) for running speed and BWSet for whole foot Fmax and impulse. The model revealed 1.4% and 0.24% increases in whole foot FMAX (times body weight) and impulse, respectively, for every unit increase in body weight percentage. There was a significant main effect for BWSet on Fmax and relative load (p<0.05) for each of the nine foot regions examined, though four regions were not different between 80% and 100% BWSet. There was a significant (p<0.001) main effect for BWSet on forefoot to rear foot relative load. Linear relationships were found between increases in BWSet and increases in-shoe Fmax and impulse, resulting from regional changes in foot pressure which represent a shift towards forefoot loading, most evident <80% BWSet. Estimating in-shoe regional loading parameters may be useful during rehabilitation and training to appropriately prescribe specific speed and body weight levels, without exceeding certain critical peak force levels while running.

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Research paper thumbnail of Diagnostic Accuracy of Various Imaging Modalities for Suspected Lower Extremity Stress Fractures: A Systematic Review With Evidence-Based Recommendations for Clinical Practice

The American Journal of Sports Medicine, 2015

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Research paper thumbnail of The Effects of Pre-Exercise Ginger Supplementation on Muscle Damage and Delayed Onset Muscle Soreness

Phytotherapy Research, 2015

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Research paper thumbnail of Controlled-frequency breath swimming improves swimming performance and running economy

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Increased physiologic intensity during walking and running on a non-motorized, curved treadmill

Physical Therapy in Sport, 2014

To determine whether exercise performed on a non-motorized, curved treadmill (NMCT) provides grea... more To determine whether exercise performed on a non-motorized, curved treadmill (NMCT) provides greater physiologic stimulus compared to a standard motorized treadmill (SMT). Crossover. Clinical research laboratory. 10 healthy athletic adults. Participants walked (1.34 m s(-1)) for 3 min and ran (2.24 m s(-1)) for 4 min on NMCT and SMT (randomized order) while metabolic data and rating of perceived exertion (RPE) were collected. Participants then identified preferred easy and moderate intensity training paces on each treadmill while blinded to speed. Repeated-measures ANOVA and Wilcoxon Signed-Rank tests were used to compare responses between treadmills. Intensity was significantly greater (P < 0.001) for NMCT than SMT [mean (95% confidence interval): Walking = 5.9(5.3,6.4) vs. 3.4(3.0,3.7) METs; Running = 10.7(9,6,11.7) vs. 7.3(6.8,7.8) METs]. Overall RPE was significantly greater (P < 0.01) on NMCT than SMT for walking [median (inter-quartile range): 7(1) vs. 6(0.8)] and running [11.5(3) vs. 8(2.5)]. Preferred speed was significantly slower on NMCT than SMT for easy [2.5(2.3,2.7) vs. 2.8(2.5,3.1) m s(-1)] and moderate [3.2(3.0,3.4) vs. 3.5(3.1,3.9) m s(-1)] intensities. NMCT elicits greater physiological stimulus than SMT with small, though statistically significant, changes in RPE at matched speeds. Clinicians must be aware of differences in intensity and RPE when prescribing exercise on NMCT.

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Research paper thumbnail of Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is the Solution?

Molecules, 2014

Resveratrol has emerged as a leading candidate for improving healthspan through potentially slowi... more Resveratrol has emerged as a leading candidate for improving healthspan through potentially slowing the aging process and preventing chronic diseases. The poor bioavailability of resveratrol in humans has been a major concern for translating basic science findings into clinical utility. Although a number of positive findings have emerged from human clinical trials, there remain many conflicting results, which may partially be attributed to the dosing protocols used. A number of theoretical solutions have been developed to improve the bioavailability of resveratrol, including consumption with various foods, micronized powders, combining it with additional phytochemicals, controlled release devices, and nanotechnological formulations. While laboratory models indicate these approaches all have potential to improve bioavailability of resveratrol and optimize its clinical utility, there is surprisingly very little data regarding the bioavailability of resveratrol in humans. If bioavailability is indeed a limitation in the clinical utility of resveratrol, there is a need to further explore methods to optimize bioavailability in humans. This review summarizes the current bioavailability data, focusing on data from humans, and provides suggested directions for future research in this realm.

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Research paper thumbnail of Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus-systematic review and meta-analysis

Molecular Nutrition & Food Research, 2014

The red wine polyphenol, resveratrol, is highly effective in treating type 2 diabetes mellitus (T... more The red wine polyphenol, resveratrol, is highly effective in treating type 2 diabetes mellitus (T2DM) in animal models, but there is no consensus regarding its efficacy in humans. We conducted a systematic review, which included searches in nine scholarly databases and six clinical trial registries, and identified randomized controlled clinical trials whereby resveratrol was used as an adjunct to pharmaceutical interventions in T2DM. Meta-analysis on clinical parameters was performed for available data. Of 764 articles originally identified, data from six unique datasets, examining a total of 196 T2DM patients (104 resveratrol, 92 control/placebo) ultimately met inclusion criteria. Statistically significant (p < 0.05) positive effects, indicating that resveratrol supplementation was more effective than placebo/control, were identified for systolic blood pressure, hemoglobin A1c, and creatinine, but not for fasting glucose, homeostatic model assessment of insulin resistance, diastolic blood pressure, insulin, triglycerides, LDL, or HDL cholesterol. No major adverse events were reported and side effects of resveratrol were not different than placebo/control. Though limitations in sample size and treatment duration preclude definitive changes in clinical practice, significant improvements in multiple cardiometabolic biomarkers and an excellent safety profile support resveratrol as a leading candidate as an adjunct to pharmacological management of T2DM.

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Research paper thumbnail of Translating dosages from animal models to human clinical trials--revisiting body surface area scaling

The FASEB Journal, 2015

Body surface area (BSA) scaling has been used for prescribing individualized dosages of various d... more Body surface area (BSA) scaling has been used for prescribing individualized dosages of various drugs and has also been recommended by the U.S. Food and Drug Administration as one method for using data from animal model species to establish safe starting dosages for first-in-human clinical trials. Although BSA conversion equations have been used in certain clinical applications for decades, recent recommendations to use BSA to derive interspecies equivalents for therapeutic dosages of drug and natural products are inappropriate. A thorough review of the literature reveals that BSA conversions are based on antiquated science and have little justification in current translational medicine compared to more advanced allometric and physiologically based pharmacokinetic modeling. Misunderstood and misinterpreted use of BSA conversions may have disastrous consequences, including underdosing leading to abandonment of potentially efficacious investigational drugs, and unexpected deadly adverse events. We aim to demonstrate that recent recommendations for BSA are not appropriate for animal-to-human dosage conversions and use pharmacokinetic data from resveratrol studies to demonstrate how confusion between the "human equivalent dose" and "pharmacologically active dose" can lead to inappropriate dose recommendations. To optimize drug development, future recommendations for interspecies scaling must be scientifically justified using physiologic, pharmacokinetic, and toxicology data rather than simple BSA conversion.-Blanchard, O. L., Smoliga, J. M. Translating dosages from animal models to human clinical trials-revisiting body surface area scaling.

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Research paper thumbnail of Resveratrol: Nutraceutical believed to counteract the detrimental effects of high-fat diet

Lipid Technology, 2014

ABSTRACT Resveratrol is a polyphenol found in red wine which has received considerable attention ... more ABSTRACT Resveratrol is a polyphenol found in red wine which has received considerable attention in recent years for its many beneficial effects on health. There is a wealth of evidence from laboratory models that resveratrol has anti oxidant, anti-inflammatory, anti-obesity, and anticancer effects which contribute to improved health. In the past five years, a number of human clinical trials have emerged, which generally support the data from animal models. While resveratrol may ultimately be useful in the prevention and treatment of chronic disease, considerable research is required before it can become incorporated into mainstream clinical use across multiple disciplines of medicine.

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Research paper thumbnail of The Effect of Passive Versus Active Recovery on Power Output Over Six Repeated Wingate Sprints

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Supplemental Tables Flaherty et al 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Upper Extremity Physical Performance Tests in Collegiate Athletes

Journal of sport rehabilitation, Jan 22, 2015

Physical performance tests (PPTs) are commonly utilized in rehabilitation and injury prevention s... more Physical performance tests (PPTs) are commonly utilized in rehabilitation and injury prevention settings, yet normative values of upper extremity PPTs have not been established in high-level athletes. To 1) establish normative data values for the Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) and Upper Quarter Y-Balance Test™ (UQYBT) in collegiate athletes and compare results between sports, and 2) analyze the relationship between the two tests. Observational. Laboratory/ Athletic Facility. 257 (male=118, female=139) Division-1 athletes participating in basketball, soccer, baseball, lacrosse, volleyball, track and field and cross country. CKCUEST and UQYBT scores were recorded as part of a comprehensive injury-risk screening battery. Pearson correlations assessed the relationship between all measures of the CKCUEST and UQYBT scores. A factorial ANOVA and repeated measures ANOVA (arm dominance) were used to assess interactions between sex, year in school, and sport for...

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