Mohammad Saberi | Shahre Rey Azad University (original) (raw)

Papers by Mohammad Saberi

Subsurface rocks and their fluid content along with their architecture affect reflected seismic w... more Subsurface rocks and their fluid content along with their architecture affect reflected seismic waves through variations in their travel time, reflection amplitude, and phase within the field of exploration seismology. The combined effects of these factors make subsurface interpretation by using reflection waves very difficult. Therefore, assistance from other subsurface disciplines is needed if we intend to make a more accurate image of the subsurface. In this regard, rock physics acts as an integrated tool to combine subsurface information from different disciplines in a set of relationships between engineering (petrophysical) properties and their relevant geophysical variations, or more specifically, elastic variations. As a matter of fact, rock physics is required for a better understanding of rock properties if we intend to have a full understanding of our reservoir properties and their fluid content. This paper reviews some of the most important rock physics models and their a...

who, together with my co-supervisor Professor Mike R. Talbot, made financing for my Ph.D. availab... more who, together with my co-supervisor Professor Mike R. Talbot, made financing for my Ph.D. available. I would specially like to thank Tor Arne for his continuous support, guidance and generosity. His motivating guidance, comments and inspiration was crucial during my Ph.D. project. I am also thankful to Dr. Philos. Bent Ole Ruud for sharing his knowledge and his great helps during all stages of my study. I would also like to thank the carbonate group in IRIS through Gunnar Saelen, Niels Bo Jensen and Ivar Grunnaleite, especially to Gunnar for sharing his experience and allowing me to join two amazing field trips on the Gorgano area, Italy. Special thanks also to Erling Hugo Jensen who was always helpful especially with computer issues. I am also grateful to all friends and colleagues at the university for sharing so many nice moments in the university and in Bergen. I would also like to take the opportunity to express my appreciation to all in the administration at the Earth Science Department, and Mona Wolf at the Center for Integrated Petroleum Research (CIPR) for her great helps at the beginning of my study. Last but not least, my gratitude goes to my parents and my wife. Without support from them, I would never have made it. Especially to my wife Lida who has been supportive and sympathetic during my study.

Journal of Petroleum Exploration and Production Technology, 2021

Hydrocarbon exploration has long been based on such costly and time-intensive methods as geophysi... more Hydrocarbon exploration has long been based on such costly and time-intensive methods as geophysical surveys, geological studies, and drilling. In recent years, however, researchers have started to consider such inexpensive alternatives as surface geochemistry for hydrocarbon exploration. Some 100 years ago, the leakage of hydrocarbons onto the surface in the form of micro- and macro-seepages motivated researchers toward drilling a well in the Khourian Desert in the south of Semnan Province, Iran. Upon drilling the well, researchers found evidences of non-released (free) hydrocarbons. These findings drove further study of the area using surface geochemistry while considering the nearby hydrocarbon accumulation in Qom Formation. Conventional and indirect surface geochemical methods provide an insight into the relationship between surface and subsurface hydrocarbons. In the present work, the results of the Rock–Eval pyrolysis showed total organic carbon (TOC) values in the range of 0....

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2021

Recent studies have investigated bilateral gaits based on the causality analysis of kinetic (or k... more Recent studies have investigated bilateral gaits based on the causality analysis of kinetic (or kinematic) signals recorded using both feet. However, these approaches have not considered the influence of their simultaneous causation, which might lead to inaccurate causality inference. Furthermore, the causal interaction of these signals has not been investigated within their frequency domain. Therefore, in this study we attempted to employ a causal-decomposition approach to analyze bilateral gait. The vertical ground reaction force (VGRF) signals of Parkinson's disease (PD) patients and healthy control (HC) individuals were taken as an example to illustrate this method. To achieve this, we used ensemble empirical mode decomposition to decompose the left and right VGRF signals into intrinsic mode functions (IMFs) from the high to low frequency bands. The causal interaction strength (CIS) between each pair of IMFs was then assessed through the use of their instantaneous phase dependency. The results show that the CISes between pairwise IMFs decomposed in the high frequency band of VGRF signals can not only markedly distinguish PD patients from HC individuals, but also found a significant correlation with disease progression, while other pairwise IMFs were not able to produce this. In sum, we found for the first time that the frequency specific causality of bilateral gait may reflect the health status and disease progression of individuals. This finding may help to understand the underlying mechanisms of walking and walking-related diseases, and offer broad applications in the fields of medicine and engineering.

Department of Plant breeding Sari University of Agricultural Sciences and Natural Resources, Sari... more Department of Plant breeding Sari University of Agricultural Sciences and Natural Resources, Sari, Iran. Seed and plant Improvement Research Department, South Khorasan Agricultural and Natural Resources Research and Eduction Center, AREEO,Birjand, Iran corresponding authors email: hmss_askare@yahoo.com. Abstract This study was performed to assess several indices for identifying barley genotypes with better germination at early growth stage under saline conditions. Nine barley promising lines and cultivars i.e. STW82153(A), MBS8712(B), ESBYTM8910(C), 4Shori (D), 5Shori (E), WB7910(F), Valfajr(G), MBS8715(H) and Jo torsh(I) were studied in five salinity levels (electrical conductivities, dsm-1) i,e, S1 =4.5 (control), S2=7.5, S3=10.5, S4=13.5 and S5=16.5. The experiment was laid out in completely randomized design with three replications. Salt stress significantly affected the performance of barley genotypes. Salt tolerance and salt damage index were more suitable indices for selectin...

Iranian Journal of Basic Medical Sciences, 2010

Objective(s) In recent years highly selective COX-2inhibitors were withdrawn from the market beca... more Objective(s) In recent years highly selective COX-2inhibitors were withdrawn from the market because of an increased risk of cardiovascular complications. In this study we were looking for potent compounds with moderate selectivity for cox-2. So, four analogues of 4, 5-diaryl-2-(2-alkylthio-5-imidazolyl) imidazole derivatives were synthesized and their anti-inflammatory and anti-nociceptive activities were evaluated on male BALB/c mice (25-30 g). Molecular modeling and in vitro COX-1 and COX-2 isozyme inhibition studies were also performed. Materials and Methods 2-(2-Alkylthio-5-imidazolyl)-4,5-diphenylimidazole compounds were obtained by the reaction of benzyl with 2-alkylthio-1-benzylimidazole-5-carbaldehyde, in the presence of ammonium acetate. Spectroscopic data and elemental analysis of compounds were obtained and their structures elucidated. Anti-nociception effects were examined using writhing test in mice. The effect of the analogues (7.5, 30, 52.5 and 75 mg/kg) against acut...

Reports of Biochemistry and Molecular Biology, 2021

Background: Dilated cardiomyopathy (DCM) is a progressive heart condition characterized by left v... more Background: Dilated cardiomyopathy (DCM) is a progressive heart condition characterized by left ventricular chamber enlargement associated with systolic heart failure and prolonged action potential duration. Genetic variations in genes that encode cytoskeleton, sarcomere, and nuclear envelope proteins are responsible for 45% of cases. In our study, we focused on a pedigree with familial DCM to decipher the potential genetic cause(s) in affected members developing arrhythmia, end-stage heart failure, and sudden death. Methods: Whole-exome sequencing (WES) was exploited for a 27-year-old heart-transplanted female as the proband, and the derived data were filtered using the standard pipelines. Results: A 57-nucleotide deletion (c.405_422+39del) in the desmoplakin gene (DSP) (NM_004415.4) was identified as a novel pathogenic variant. Familial segregation analysis indicated that this variant is present in clinically affected members and absent in unaffected members. Conclusions: It seems that the detected variant induces intron retention, resulting in a premature stop codon in intron 3 of DSP leading to production of a truncated, nonfunctional protein. Additionally, it can trigger a nonsense-mediated mRNA decay pathway associated with inhibition of protein production. The present study results illustrated that a novel deletion in DSP can cause DCM in an Iranian family.

Frontiers in Neuroscience, 2019

Editorial on the Research Topic Through a Glass, Darkly: The Influence of the EEG Reference on In... more Editorial on the Research Topic Through a Glass, Darkly: The Influence of the EEG Reference on Inference About Brain Function and Disorders This Research Topic summarizes recent advances in a conflictive and controversy laden topic in neurophysiology: the selection of the electroencephalographic reference that is best for inference about brain function. Since its discovery, the human EEG has proven itself an indispensable tool for brain research. Despite this success story, there is a fundamental technical issue that has yet to be solve: selection of the correct EEG reference. Ideally one would like to measure neural activity restricted to certain brain regions. Since EEG amplifiers measure potential difference between the activities recorded by two electrodes, in addition to the active electrode, one must employ a reference electrode which should ideally be at zero. In theory, this might be achieved by placing the reference at a point infinitely far away. Yet the "infinite reference, " in practice, is an antenna for ambient noise which would preempt brain measurements-for example cephalic references that minimize unwanted signal pickup. Examples of such references are the unilateral-mastoid, ear, linked mastoids or ears, vertex, the tip of the nose, neck ring, etc. Unfortunately, all such references are doomed to fail since there is no point on the scalp or body surface where the potential is actually zero or a constant. This has serious consequences since the non-neutral reference may itself reflect physiological dynamic processes that will be inevitably embedded into all EEG recordings. Without solving the reference issue, we are looking at brain activity, as it were, "through a glass, darkly." This Research Topic focused the comparison of the effect that various EEG references may have on inference about brain function and disorders-with respect to both physical and computational issues. The crucial point is to determine the reference that best identifies neural activity and therefore be the basis of improved estimates of various linear and non-linear EEG features. These include spectra, amplitude, latency, coherence/correlation, network, symmetry/asymmetry, fractal dimension, complexity, covariance, and related statistical tests. If a single reference can be finally recognized universally as the optimal one for general use, we will have indeed rendered the "glass less opaque" and thus "know in part" more about brain function. Recent attempts to make this "glass" more transparent have been based on mathematically constructing a reference based on physical principles and subtracting it from all EEG recordings.

Journal of Applied Biomedicine, 2016

Background: PEGylation is an increasingly important strategy for improving stability, pharmacokin... more Background: PEGylation is an increasingly important strategy for improving stability, pharmacokinetic and pharmacodynamic properties of proteins. Objective: In this study, site-specific PEGylated human growth hormone (hGH) was prepared by microbial transglutaminase and physicochemical and stability properties of bioconjugates were tested. Method: hGH was PEGylated [ 5 _ T D $ D I F F ] by 20 kDa mPEG-NH 2. PEG-hGH was purified by size exclusion chromatography method and analyzed by SDS-PAGE, IEF gel and CD spectroscopy methods. Physicochemical properties, size and zeta potentials, of native and PEGylated hGH were evaluated by Dynamic Light Scattering (DLS) method. Physical and chemical stabilities were assayed at different temperatures (37, 25 and 4 C) within three weeks by SEC-and RP-HPLC methods, respectively. Results: By this preparation method, mono-PEG-hGH was obtained and the secondary structure was unchanged. [ 6 _ T D $ D I F F ] The DLS results indicated that by PEGylation the size and zeta potentials of [ 7 _ T D $ D I F F ] the protein were increased and decreased, respectively.[ 8 _ T D $ D I F F ] These data indicated that PEG chain covered the protein surface. The isoelectric point (pI) of protein was not altered following PEGylation. The results of stability indicated that, the mono-PEG-hGH was considerably more stable especially in elevated temperatures as compared with the non-PEGylated one. Conclusion: PEGylation changed the physicochemical properties of hGH and [ 9 _ T D $ D I F F ] also enhanced the stability of the protein.

Research in pharmaceutical sciences

The objective of this study was to determine incidence rate, type, and pattern of clinically rele... more The objective of this study was to determine incidence rate, type, and pattern of clinically relevant potential drug-drug interactions (pDDIs) in a large outpatient population of a developing country. A retrospective, descriptive cross-sectional study was conducted on outpatients' prescriptions in Khorasan Razavi province, Iran, over 12 months. A list of 25 clinically relevant DDIs, which are likely to occur in the outpatient setting, was used as the reference. Most frequent clinically relevant pDDIs, most common drugs contributing to the pDDIs, and the pattern of pDDIs for each medical specialty were determined. Descriptive statistics were used to report the results. In total, out of 8,169,142 prescriptions, 6,096 clinically relevant pDDIs were identified. The most common identified pDDIs were theophyllines-quinolones, warfarin-nonsteroidal anti-inflammatory drugs, benzodiazepines-azole antifungal agents, and anticoagulants-thyroid hormones. The most common drugs contributing t...

Ssu_Journals, Jun 15, 2014

Introduction: Chlorpyrifos (CPF) is a broad-spectrum organophosphorus insecticide that has been u... more Introduction: Chlorpyrifos (CPF) is a broad-spectrum organophosphorus insecticide that has been used abundantly over the globe during the past 40 years. Chemical pesticides may induce oxidative stress via generating free radicals and altering antioxidant levels of the free radical scavenging enzyme activity. Therefore, this study aimed to evaluate the toxicity of Chlorpyrifos-induced oxidative stress in the plasma samples of Wistar rat. Methods: Twenty-four male Wistar rats were selected randomly which were assigned to 2 equal groups, e.g. control and test. The control group received corn oil as the solvent, and the experimental group received 16.5mg/kg/day of CPF (4mg/ml) orally via a stomach tube for four weeks. Plasma samples were taken on 1 st , 7 th , 14 th , 21 st , and 28 th days, at a specific time. Catalase (CAT) , superoxide dismutase (SOD) activities and also levels of malondialdehyde (MDA) and glutathione (GSH) were determined. Results: The oral administration of CPF could induce symptoms such as tremors, hair erection, weakness, diarrhea and asthma on Day 7 and onward. The data analysis of plasma samples showed significant (P<0.001) decrease in the levels of glutathione and CAT enzymatic activity and a significant increase in SOD enzymatic activity and the MDA level. Conclusion: CPF could induce oxidative stress probably via production of free radicals as was evident by reduction of GSH level and CAT activity accompanied by increase in the activity of SOD and enhancement in the level of MDA in plasma samples. This necessitates the application of antioxidants when having exposure with OP pesticides.

Archives of Hygiene Sciences, Mar 18, 2014

Iranian biomedical journal, Apr 1, 2008

Selective phosphodiesterase (PDE3) inhibitors improve cardiac contractility and may use in conges... more Selective phosphodiesterase (PDE3) inhibitors improve cardiac contractility and may use in congestive heart failure. However, their proarrhythmic potential is the most important side effect. In this research, we evaluated the potential cardiotonic activity of six new synthesized selective PDE3 inhibitors (6-hydroxy-4-methylquinolin-2(1H)-one derivatives) using the spontaneously beating atria model. In each experiment, atrium of reserpine-treated rat was isolated and the contractile and chronotropic effects of a synthesized compound were assessed. The 3-isobutyl-1-methylxanthine, a non-selective PDE inhibitor, was used for comparison. The results showed that, among new compounds, the best pharmacological profile was obtained with the compound 6-[4-(4-methylpiperazine-1-yl)-4-oxobutoxy]-4-methylquinolin-2(1H)-one, C6, which displayed selectivity for increasing the force of contraction (168 +/- 5% change over the control) rather than the frequency rate (138 +/- 5% change over the contr...

Molecules, 2013

The interactions between cyclophosphamide (CYC) and lysozyme (LYZ) in the presence of different c... more The interactions between cyclophosphamide (CYC) and lysozyme (LYZ) in the presence of different cyclodextrins (CDs) were investigated by UV absorption, fluorescence spectroscopy, circular dichroism (CD), and molecular modeling techniques under imitated physiological conditions. The UV absorption results showed the formation of complexes between CYC and LYZ in the presence of different CDs. Fluorescence data show that CYC has a stronger quenching effect on LYZ, and the red shifts suggested that the microenvironment of Trp residues was changed and became more hydrophilic. The interaction of CYC with LYZ and quenching properties of the complexes caused strong static fluorescence quenching in binary and ternary systems. The binding affinities as well as the number of binding sites were obtained from interaction between CYC and LYZ in the presence of different CDs as binary and ternary systems by modified Stern-Volmer plots. The Resonance Light Scattering (RLS) technique was utilized to investigate the effect of drug and CDs on conformational changes of LYZ as separate and simultaneous. The results suggested that the enhancement of RLS intensity was attributed to the formation of a complex between drug and protein in absence and presence of CDs. The

The Open Geology Journal, 2010

Velocity behaviour in chalks is determined by a combination of their depositional conditions and ... more Velocity behaviour in chalks is determined by a combination of their depositional conditions and subsequent diagenesis. Based on rock physics data from three drill sites on the Ontong Java Plateau, a strategy for velocity modelling is proposed where geological information is imposed via pore structure models. The Reuss and time-average relations define upper and lower bounds of the velocity data and the self-consistent approximation was applied to find direct links between velocity and changes in microstructure. The latter approach provides an estimate of the dynamic changes of the pore structure as a result of diagenesis in chalks. Depositional pore-models of chalks were determined from environmental conditions and can be defined from textural information. Mechanical compaction and cementation decrease porosity as a function of depth, but may increase the velocity by different rates as the pore structure changes differently. Discrimination between sediment stiffness and pore structure stiffness enables us to justify low velocity for indurated sediments and high velocity for soft sediments. Our results indicate the relevance of the pore structure to velocity interpretation because some variations in velocity data may result from pore structure differences rather than changes in fluid or porosity.

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2012

This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: http://www.elsevier.com/copyright

PLoS ONE, 2014

Holo transferrin (TF) and the natural complex of human serum albumin and protoporphyrin IX (HSA-P... more Holo transferrin (TF) and the natural complex of human serum albumin and protoporphyrin IX (HSA-PPIX) are two serum carrier proteins that can interact with each other. Such an interaction may alter their binding sites. In this study, fluorescence spectroscopy, as well as zeta potential and molecular modeling techniques, have been used to compare the complexes (HSA-PPIX)-LMF and [(HSA-PPIX)-TF]-LMF. The K a1 , K a2 , values of (HSA-PPIX)-LMF and [(HSA-PPIX)-TF]-LMF were 1.1610 5 M 21 , 9.7610 6 M 21 , and 2.0610 4 M 21 , 1.8610 5 M 21 , respectively, and the n 1 , n 2 values were respectively 1.19, 1.53 and 1.17, 1.65. The second derivative of the Trp emission scan of (HSA-PPIX)-LMF exhibited one negative band at 310 nm, whereas for the [(HSA-PPIX)-TF]-LMF system, we observed one negative band at 316 nm indicating an increase in polarity around Trp. The effect of TF on the conformation of (HSA-PPIX)-TF was analyzed using three-dimensional fluorescence spectroscopy. The phase diagram indicated that the presence of a second binding site on HSA and TF was due to the existence of intermediate structures. Zeta potential analysis showed that the presence of TF increased the positive charges of the HSA-PPIX system. Site marker experiments revealed that the binding site of LMF to HSA-PPIX changed from Sudlow's site IIA to Sudlow's site IIIB in the presence of TF. Moreover, molecular modeling studies suggested the sub-domain IIIB in HSA as the candidate place for the formation of the binding site of LMF on the (HSA-PPIX)-TF complex.

Petroleum Geoscience, 2009

Molecules, 2012

For the first time, the binding of ropinirole hydrochloride (ROP) and aspirin (ASA) to human holo... more For the first time, the binding of ropinirole hydrochloride (ROP) and aspirin (ASA) to human holo-transferrin (hTf) has been investigated by spectroscopic approaches (fluorescence quenching, synchronous fluorescence, time-resolved fluorescence, three-dimensional fluorescence, UV-vis absorption, circular dichroism, resonance light scattering), as well as zeta potential and molecular modeling techniques, under simulated physiological conditions. Fluorescence analysis was used to estimate the effect of the ROP and ASA drugs on the fluorescence of hTf as well as to define the binding and quenching properties of binary and ternary complexes. The synchronized fluorescence and three-dimensional fluorescence spectra demonstrated some micro-environmental and conformational changes around the Trp and Tyr residues with a faint red shift. Thermodynamic analysis displayed the van der Waals forces and hydrogen bonds interactions are the major acting forces in stabilizing the complexes. Steady-state and time-resolved fluorescence data revealed that the fluorescence quenching of complexes are static mechanism. The effect of the drugs aggregating on the hTf resulted in an enhancement of the resonance light scattering (RLS) intensity. The average binding

Journal of Luminescence, 2011