ICD-10-CM Diagnosis Code C48.0 - Malignant neoplasm of retroperitoneum (original) (raw)

ICD List 2025-2026 Edition

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6. 2026 ICD-10-CM Code C48.0

Malignant neoplasm of retroperitoneum

ICD-10-CM Code:

C48.0

ICD-10 Code for:

Malignant neoplasm of retroperitoneum

Is Billable?

Yes - Valid for Submission

Chronic Condition Indicator: [1]

Chronic

Code Navigator:

C48.0 is a billable diagnosis code used to specify a medical diagnosis of malignant neoplasm of retroperitoneum. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2025 through September 30, 2026.

The following anatomical sites found in the Table of Neoplasms reference this diagnosis code given the correct histological behavior: Neoplasm, neoplastic connective tissue NEC retroperitoneum ; Neoplasm, neoplastic paranephric ; Neoplasm, neoplastic periadrenal (tissue) ; Neoplasm, neoplastic perinephric ; Neoplasm, neoplastic peripancreatic ; Neoplasm, neoplastic perirenal (tissue) ; Neoplasm, neoplastic retrocecal ; etc

1. Code Information
2. Approximate Synonyms
3. Clinical Classification
4. Clinical Information
5. Tabular List of Diseases and Injuries
6. Diagnostic Related Groups Mapping
7. Convert to ICD-9 Code
8. Table of Neoplasms
9. Patient Education
10. Other Codes Used Similar Conditions
11. Code History

• Neoplasms
  C00–D49
  • Malignant neoplasms of mesothelial and soft tissue
    C45-C49
    * Malignant neoplasm of retroperitoneum and peritoneum
    C48

The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.

• Liposarcoma of retroperitoneum
• Malignant neoplasm of perinephric tissue
• Malignant neoplasm of retrocecal tissue
• Malignant retroperitoneal neoplasm
• Malignant teratoma
• Malignant teratoma of retroperitoneum
• Neoplasm of periadrenal tissue
• Neoplasm of perirenal tissue
• Neoplasm of perirenal tissue
• Neoplasm of retrocecal tissue
• Neoplasm of retrocecal tissue
• Primary giant cell sarcoma of retroperitoneum
• Primary leiomyosarcoma of abdomen
• Primary leiomyosarcoma of retroperitoneum
• Primary liposarcoma of retroperitoneum
• Primary malignant neoplasm of periadrenal tissue
• Primary malignant neoplasm of perirenal tissue
• Primary malignant neoplasm of retrocecal tissue
• Primary malignant neoplasm of retroperitoneum
• Primary sarcoma of retroperitoneum
• Retroperitoneal sarcoma

Clinical Classifications group individual ICD-10-CM diagnosis codes into broader, clinically meaningful categories. These categories help simplify complex data by organizing related conditions under common clinical themes.

They are especially useful for data analysis, reporting, and clinical decision-making. Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance. Each category is assigned a unique CCSR code that represents a specific clinical concept, often tied to a body system or medical specialty.

CCSR Code: NEO021

Inpatient Default: Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.

Outpatient Default: Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.

• Retroperitoneal Sarcoma

a sarcoma that occurs in the retroperitoneal region.

• Retroperitoneal Sarcoma by AJCC v8 Stage|Soft Tissue Sarcoma Retroperitoneum by AJCC v8 Stage

a term that refers to the staging of retroperitoneal soft tissue sarcoma, following the rules of the tnm ajcc v8 classification system. this staging system applies to common sarcomas in the retroperitoneum. (from ajcc 8th ed.)

• Stage I Retroperitoneal Sarcoma AJCC v8|Stage I Retroperitoneal Sarcoma

stage i includes: ia: (t1, n0, m0, g1, gx); ib: (t2, t3, t4, n0, m0, g1, gx). t1: tumor measuring 5 cm or less in greatest dimension. t2: tumor measuring more than 5 cm and less than or equal to 10 cm in greatest dimension. t3: tumor measuring more than 10 cm and less than or equal to 15 cm in greatest dimension. t4: tumor measuring more than 15 cm in greatest dimension. n0: no regional lymph node metastasis or unknown lymph node status. m0: no distant metastasis. gx: grade cannot be assessed. g1: total differentiation, mitotic count and necrosis score of 2 or 3. (ajcc 8th ed.)

• Stage IA Retroperitoneal Sarcoma AJCC v8|Stage IA Retroperitoneal Sarcoma|Stage IA Soft Tissue Retroperitoneal Sarcoma AJCC v8

stage ia includes: t1, n0, m0, g1, gx. t1: tumor measuring 5 cm or less in greatest dimension. n0: no regional lymph node metastasis or unknown lymph node status. m0: no distant metastasis. gx: grade cannot be assessed. g1: total differentiation, mitotic count and necrosis score of 2 or 3. (ajcc 8th ed.)

• Stage IB Retroperitoneal Sarcoma AJCC v8|Stage IB Retroperitoneal Sarcoma|Stage IB Soft Tissue Retroperitoneal Sarcoma AJCC v8

stage ib includes: t2, t3, t4, n0, m0, g1, gx. t2: tumor measuring more than 5 cm and less than or equal to 10 cm in greatest dimension. t3: tumor measuring more than 10 cm and less than or equal to 15 cm in greatest dimension. t4: tumor measuring more than 15 cm in greatest dimension. n0: no regional lymph node metastasis or unknown lymph node status. m0: no distant metastasis. gx: grade cannot be assessed. g1: total differentiation, mitotic count and necrosis score of 2 or 3. (ajcc 8th ed.)

• Stage II Retroperitoneal Sarcoma AJCC v8|Stage II Retroperitoneal Sarcoma|Stage II Soft Tissue Retroperitoneal Sarcoma AJCC v8

stage ii includes: t1, n0, m0, g2, g3. t1: tumor measuring 5 cm or less in greatest dimension. n0: no regional lymph node metastasis or unknown lymph node status. m0: no distant metastasis. g2: total differentiation, mitotic count and necrosis score of 4 or 5. g3: total differentiation, mitotic count and necrosis score of 6, 7, or 8. (ajcc 8th ed.)

• Stage III Retroperitoneal Sarcoma AJCC v8|Stage III Retroperitoneal Sarcoma

stage iii includes: iiia: (t2, n0, m0, g2, g3); iiib: (t3, t4, n0, m0, g2, g3); (any t, n1, m0, any g). t2: tumor measuring more than 5 cm and less than or equal to 10 cm in greatest dimension. t3: tumor measuring more than 10 cm and less than or equal to 15 cm in greatest dimension. t4: tumor measuring more than 15 cm in greatest dimension. n0: no regional lymph node metastasis or unknown lymph node status. n1: regional lymph node metastasis. m0: no distant metastasis. g2: total differentiation, mitotic count and necrosis score of 4 or 5. g3: total differentiation, mitotic count and necrosis score of 6, 7, or 8. (ajcc 8th ed.)

• Stage IIIA Retroperitoneal Sarcoma AJCC v8|Stage IIIA Retroperitoneal Sarcoma|Stage IIIA Soft Tissue Retroperitoneal Sarcoma AJCC v8

stage iiia includes: t2, n0, m0, g2, g3. t2: tumor measuring more than 5 cm and less than or equal to 10 cm in greatest dimension. n0: no regional lymph node metastasis or unknown lymph node status. m0: no distant metastasis. g2: total differentiation, mitotic count and necrosis score of 4 or 5. g3: total differentiation, mitotic count and necrosis score of 6, 7, or 8. (ajcc 8th ed.)

• Stage IIIB Retroperitoneal Sarcoma AJCC v8|Stage IIIB Retroperitoneal Sarcoma|Stage IIIB Soft Tissue Retroperitoneal Sarcoma AJCC v8

stage iiib includes: (t3, t4, n0, m0, g2, g3); (any t, n1, m0, any g). t3: tumor measuring more than 10 cm and less than or equal to 15 cm in greatest dimension. t4: tumor measuring more than 15 cm in greatest dimension. n0: no regional lymph node metastasis or unknown lymph node status. n1: regional lymph node metastasis. m0: no distant metastasis. g2: total differentiation, mitotic count and necrosis score of 4 or 5. g3: total differentiation, mitotic count and necrosis score of 6, 7, or 8. (ajcc 8th ed.)

• Stage IV Retroperitoneal Sarcoma AJCC v8|Stage IV Retroperitoneal Sarcoma|Stage IV Soft Tissue Retroperitoneal Sarcoma AJCC v8

stage iv includes: any t, any n, m1, any g. m1: distant metastasis. (ajcc 8th ed.)

Below are the ICD-9 codes that most closely match this ICD-10 code, based on the General Equivalence Mappings (GEMs). This ICD-10 to ICD-9 crosswalk tool is helpful for coders who need to reference legacy diagnosis codes for audits, historical claims, or approximate code comparisons.

ICD-9-CM: 158.0

This is a direct match with no additional mapping qualifiers. The absence of a flag generally means the mapping is considered exact or precise. In other words, the ICD-10 code maps cleanly to the ICD-9 code without qualification, approximation, or needing multiple codes.

This code is referenced in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

Filter table of neoplasms:

Cancer

What is cancer?

Cancer is not just one disease but many diseases. Cancer begins in your cells, which are the building blocks of your body. Usually, your body forms new cells as needed, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor.

Tumors can be benign or malignant. Benign tumors aren't cancer, while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of your body. The spread of cancer from one part of the body to another is called metastasis. Symptoms and treatment depend on the type of cancer and how advanced it is.

What are the types of cancer?

There are more than 100 different types of cancer. Cancer can start almost anywhere in your body. Most cancers are named for where they start. For example, lung cancer starts in the lung, and breast cancer starts in the breast.

Cancer may also be described by the type of cell that formed it, such as sarcoma if cancer begins in your bone and soft tissue. Carcinoma is the most common type of cancer. It is formed by epithelial cells, the cells that cover the inside and outside surfaces of your body.

How does cancer develop?

Cancer is a genetic disease. That means changes in your genes cause it. Changes in your genes are also called gene variants or mutations. Genes are parts of DNA in your cells that you inherit from your parents. However, only some cancers are caused by genes passed down from your parents.

Genetic changes can occur to your genes over your lifetime that affect how your cells function. Usually, your body gets rid of damaged cells before they turn cancerous, but this ability goes down as you age. Other factors that may affect your risk of developing cancer can include:

• Exposure to ultraviolet (UV) rays from the sun
• Smoking
• Your diet
• Physical inactivity

What are the symptoms of cancer?

Cancer symptoms depend on the type of cancer. For example, some of the symptoms that cancer may cause can include:

• A lump in your breast
• Blood in your urine (pee) or stool (poop)
• Bleeding or bruising for no known reason
• A sore that doesn't heal
• Trouble swallowing
• A new mole or a change to a mole you already have

Cancer may cause various symptoms but often doesn't cause pain. Don't wait until you're having pain before seeing your health care provider. See your provider if you have symptoms that don't get better in a few weeks.

How is cancer diagnosed?

There is no single test that can diagnose cancer. The tests ordered are usually based on your symptoms. Your provider may:

• Ask about your medical history
• Ask about your family health history, including relatives who have had cancer
• Do a physical exam
• Do a screening test such as a mammogram, colonoscopy, or a Pap test
• Order blood tests or imaging tests

To find out if you have cancer, your provider may order a biopsy. A biopsy is the procedure of removing and examining tissue, cells, or fluids from your body.

What are the treatments for cancer?

Treatment depends on the type of cancer and how advanced it is. Most treatment plans may include surgery, radiation, and/or chemotherapy. Some may involve hormone therapy, immunotherapy or other types of biological therapy, or stem cell transplantation.

Can cancer be prevented?

It's usually not possible to know exactly why cancer develops in some people but not others. There are some things that you can't control which may increase or decrease your risk of getting cancer, such as inheriting certain genes or your age. But some lifestyle habits may increase your risk of certain types of cancer. Avoid or reduce lifestyle habits such as:

• Smoking and tobacco use
• Having too much sun exposure
• Drinking too much alcohol
• Not getting enough physical activity
• Having obesity

NIH: National Cancer Institute

[Learn More in MedlinePlus]

Soft Tissue Sarcoma-Patient Version

Learn about soft tissue sarcoma risk factors, symptoms, tests to diagnose, factors affecting prognosis, staging, and treatment.
[Learn More in MedlinePlus]

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