Дарья Кузнецова - Academia.edu (original) (raw)
Дарья Кузнецова
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State University of Medicine and Pharmacy Nicolae Testemitanu in Chisinau
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Papers by Дарья Кузнецова
Problems of Particularly Dangerous Infections
This review systematizes and analyzes the data published over the past decade, devoted to the stu... more This review systematizes and analyzes the data published over the past decade, devoted to the study of low-molecular-weight high affinity iron chelators – siderophores. Siderophores, which are found in bacteria, fungi and mammals, are able to extract iron from insoluble inorganic compounds, and in the host organism – from complexes with proteins that perform the function of nonspecific protection of mammals from infections. The extracted iron is delivered to cells through surface protein receptors specific for each siderophore, as well as various protein transport systems that make up membranes. Siderophores play an important role in virulence in pathogenic bacteria, performing many functions in the host organism, in addition to providing microbes with iron and other biological metals. They participate in the storage of excess iron, toxic to cells, protect bacteria from reactive oxygen compounds, compete for iron with phagocytes, and have a harmful effect on host cells, acting as se...
Текст работы не публикуется.Автором проведен анализ деятельности выбранного объекта исследования ... more Текст работы не публикуется.Автором проведен анализ деятельности выбранного объекта исследования по методике, адаптированной непосредственно к предприятию строительной отрасли, и на основе аналитического исследования разработаны мероприятия по улучшению финансово-хозяйственной деятельности объекта исследовани
Problems of Particularly Dangerous Infections
This review systematizes and analyzes the data published over the past decade, devoted to the stu... more This review systematizes and analyzes the data published over the past decade, devoted to the study of low-molecular-weight high affinity iron chelators – siderophores. Siderophores, which are found in bacteria, fungi and mammals, are able to extract iron from insoluble inorganic compounds, and in the host organism – from complexes with proteins that perform the function of nonspecific protection of mammals from infections. The extracted iron is delivered to cells through surface protein receptors specific for each siderophore, as well as various protein transport systems that make up membranes. Siderophores play an important role in virulence in pathogenic bacteria, performing many functions in the host organism, in addition to providing microbes with iron and other biological metals. They participate in the storage of excess iron, toxic to cells, protect bacteria from reactive oxygen compounds, compete for iron with phagocytes, and have a harmful effect on host cells, acting as se...
Текст работы не публикуется.Автором проведен анализ деятельности выбранного объекта исследования ... more Текст работы не публикуется.Автором проведен анализ деятельности выбранного объекта исследования по методике, адаптированной непосредственно к предприятию строительной отрасли, и на основе аналитического исследования разработаны мероприятия по улучшению финансово-хозяйственной деятельности объекта исследовани