Ahmed Rasheed - Academia.edu (original) (raw)
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Chemoprevention is an important strategy to control the process of carcinogenesis. The potential ... more Chemoprevention is an important strategy to control the process of carcinogenesis. The potential of using medicinal herbs as cancer chemo-preventive nutraceuticals and functional food is promising. Thus, there is a need for exploring drugs/agents which act as best chemo-preventive agents. Ricinus communis is a well known medicinal plant which has been used in Ayurvedic medicine as hepatoprotective, antiviral, antibacterial, analgesic, antispasmodic and anti-diabetic. The present study was undertaken to evaluate the anti-tumor activity of Ricinus communis leaves in an in-vivo model. Results: For the in-vivo screening in present study, the LD 50 value of crude extract, when given p.o. (per oral) was found to be 30mg/kg. 1/10 th and 1/5 th of this dose was taken as effective dose. The test groups (3mg/kgbw and 6mg/kgbw) showed effective tumor reduction (75.66±3.98 and 75. 17±2.99 respectively) on day 14 th . However, there was meager difference between the two test groups, but both showed the considerable action in comparison to control group. Therefore, a significant reduction in size of tumor was observed in a dose dependent manner. Conclusion: After in-vivo screening of crude extract it was concluded that the aqueous extract contains some anti-tumor agents when it was applied against mice bearing melanoma and depicted significant reduction in tumor size.
Chemoprevention is an important strategy to control the process of carcinogenesis. The potential ... more Chemoprevention is an important strategy to control the process of carcinogenesis. The potential of using medicinal herbs as cancer chemo-preventive nutraceuticals and functional food is promising. Thus, there is a need for exploring drugs/agents which act as best chemo-preventive agents. Ricinus communis is a well known medicinal plant which has been used in Ayurvedic medicine as hepatoprotective, antiviral, antibacterial, analgesic, antispasmodic and anti-diabetic. The present study was undertaken to evaluate the anti-tumor activity of Ricinus communis leaves in an in-vivo model. Results: For the in-vivo screening in present study, the LD 50 value of crude extract, when given p.o. (per oral) was found to be 30mg/kg. 1/10 th and 1/5 th of this dose was taken as effective dose. The test groups (3mg/kgbw and 6mg/kgbw) showed effective tumor reduction (75.66±3.98 and 75. 17±2.99 respectively) on day 14 th . However, there was meager difference between the two test groups, but both showed the considerable action in comparison to control group. Therefore, a significant reduction in size of tumor was observed in a dose dependent manner. Conclusion: After in-vivo screening of crude extract it was concluded that the aqueous extract contains some anti-tumor agents when it was applied against mice bearing melanoma and depicted significant reduction in tumor size.