Alan Dattner - Academia.edu (original) (raw)
Papers by Alan Dattner
Archives of Dermatology, Feb 1, 1997
In a recent issue of theArchives, Burgdorf and Happle 1 gave an informative and partially accurat... more In a recent issue of theArchives, Burgdorf and Happle 1 gave an informative and partially accurate introduction to homeopathy by defining some of its concepts, but then went on to ridicule it on the basis of the concept of increased potency conferred by dilution and their misunderstanding of the specificity of the observations on which the similarity principle was based. In their mention of allopathy vs homeopathy, they do a service by opening up the viewpoint that the principles behind homeopathy and those behind the way we practice medicine are actually both belief systems. While we embrace the scientific method, the perspective that this controversy regarding homeopathic medicine presents can give us valuable insights. A major flaw of homeopathic medicine for Burgdorf and Happle is that it violates the pharmacological principle that substances have more of an effect at higher concentrations. I must first point out that immunologic
Journal of Immunology, May 1, 1979
Our group has previously reported that human sperm cells are capable of stimulating allogeneic ly... more Our group has previously reported that human sperm cells are capable of stimulating allogeneic lymphocytes. We now report that the HLA-D on sperm cells is resistant to ultraviolet (UV) light in contrast to HLA-D on leukocytes, which is very sensitive to UV light in the dosage range employed in these experiments. Responder leukocytes were cultured with varying concentrations of stimulating blood leukocytes and varying concentrations of sperm cells washed free of the highly suppressive seminal plasma factor(s). Stimulator blood and sperm cells were exposed simultaneously to UV light delivered from a G.E. cold quartz No. G 15-T8 (2537 Å germicidal) lamp at doses varying from 800 to 25,000 ergs/mm2 as measured by an IL 770 photometer with a narrow band NB254 filter. Even the lowest dosage of UV completely or nearly totally abrogated the stimulating capability of leukocytes whereas sperm cells showed excellent stimulating ability with as much as 25,000 ergs/mm2. We have also been able to clonally prime lymphocytes with sperms. After 10 to 14 days in first or primary culture, sperm-stimulated blast-derived lymphocytes were recultured. The allogeneic responding lymphocytes showed accelerated 3HTdR incorporation to leukocytes from the original sperm donor. We conclude that the UV-resistant HLA-D on sperms share some determinants with the UV-sensitive HLA-D on leukocytes.
Cellular Immunology, Aug 1, 1979
Scandinavian Journal of Immunology, Nov 1, 1978
Journal of Oral Pathology & Medicine, Nov 1, 1978
Dermatologic Clinics, Jul 1, 2004
This article is a description of how I have integrated Complementary Medicine into the practice o... more This article is a description of how I have integrated Complementary Medicine into the practice of dermatology over the past 2 decades. It emphasizes observing the principles of the system being used, such as the herbal concept of the synergy of the entire plant extract. Examples discussed include the use of flavonoids to protect the liver and capillaries. Herbs and techniques for reducing the inflammatory response, as well as for enhancing immunity, are given. The concept of homeopathy and a few remedies to use in office practice are discussed. Finally, a few methods to complement the treatment of melanoma are presented.
Journal of Immunology, Oct 1, 1978
HLA-A and -B antigens are resistant to ultraviolet (UV) light whereas HLA-D, as defined by the mi... more HLA-A and -B antigens are resistant to ultraviolet (UV) light whereas HLA-D, as defined by the mixed leukocyte culture reaction (MLR), is sensitive to UV light in initial or first culture. In primed LD typing, the HLA-D responsible for stimulation is relatively resistant to UV light in second culture. We have developed a method for evaluating a specific proliferative response to DNP in dinitrochlorobenzene (DNCB)-sensitized human subjects and found a requirement for a component of autologous leukocytes to activate DNP-responsive lymphocyte clones. Autologous DNBSO3-coupled leukocytes with and without UV were used to stimulate lymphocytes in DNCB-sensitized subjects. 3HTdR incorporation was measured after 4 or 5 dys in 1st or “primary” culture. After 9 to 14 days, blast-derived lymphocytes were set up in 2nd or “secondary” cultures and exposed to the same autologous DNBSO3-treated leukocytes with and without UV. Accelerated 3HTdR incorporation was measured in these secondary clonally primed cultures after 20 to 44 hr. The results showed that UV light abrogated the antigen-presenting or stimulator function in the 1st culture and diminished, but did not abrogate, the antigen-presenter function in the 2nd culture. These findings indicate that the DNP-antigen presenting function is behaving in a manner similar to that observed for mixed leukocyte culture determinants in 1st and 2nd cultures.
Cancer, Jul 1, 1976
This report describes a de novo development of Kaposi's sarcoma in a Puerto-Rician man 9 ... more This report describes a de novo development of Kaposi's sarcoma in a Puerto-Rician man 9 months after a cadaveric renal transplant. Progression of the disease was observed despite local irradiation, while the patient remained immunosuppressed with prednisone and azathioprine. This was accompanied by depressed immunologic tests. Discontinuation of azathioprine and addition of chemotherapy (bleomycin and vincristine), while continuing prednisone to maintain functional survival of renal allograft, has led in this patient to regression of extensive cutaneous and suspected pulmonary Kaposi's sarcoma lesions. The possible importance of a depressed immunosurveillance mechanism and activation of latent oncogenic virus by the presence of an allograft in the de novo appearance of Kaposi's sarcoma in transplant recipients is briefly discussed.
Journal of Cosmetic Dermatology, Jun 1, 2006
Clinics in Dermatology, 2010
Conventional wisdom posits that breastfeeding during the first 4 months of life generally reduces... more Conventional wisdom posits that breastfeeding during the first 4 months of life generally reduces the incidence of atopic dermatitis in the child. Recent studies question this truism, especially in cases when the mother herself is allergic. Studies about maternal dietary allergens in breast milk and their influence on atopic dermatitis have been questioned as well. There is evidence that probiotic and essential fatty acid supplementation, along with an allergen-avoidance diet, may reduce the chance of maternal dietary allergens provoking atopic dermatitis in the infant. Evidence on both sides of the controversy is presented in an effort to produce meaningful guidelines for breastfeeding infants at risk for atopic dermatitis.
Journal of Drugs in Dermatology, Apr 1, 2021
(see Figure 1). 4 Our later studies demonstrated that a feeder layer of irradiated autologous leu... more (see Figure 1). 4 Our later studies demonstrated that a feeder layer of irradiated autologous leukocytes could restore the secondary culture response to optimal primary culture antigen levels. 5,6 One possible explanation is that we saturated the HLA-D antigen presenting and receptor sites so that lymphocytes could not be activated. It is also possible that we induced antiidiotype immunity. The concept is that with such a large dose of the specific stimulating antigen, a huge number of reactive lymphocytes are induced with the same or similar receptors recognizing that antigen early on. Subsequently, in that same culture, remaining lymphocytes develop receptors against the anti-tetanus toxoid receptor bearing cells in the culture. This possibility is further suggested by our later demonstration of specific suppression of response to microbial antigens by stimulated cells. 7 Work by others has also confirmed this possibility. 8,9 T-cells are involved in Covid-19 immunity directly as evidenced by studies of convalescent Covid-19 patients.
Journal of Investigative Dermatology, Sep 1, 1979
Human lymphocytes from dinitrochlorobenzene (DNCB)-sensitized human subjects primed in first cult... more Human lymphocytes from dinitrochlorobenzene (DNCB)-sensitized human subjects primed in first culture with dinitrophenylated-antigens yield a population of cells which respond in an accelerated manner to the same or similar antigen in second culture. Using this "clonal priming" approach, we have demonstrated that such a primed population showed maximal proliferative response to dinitrophenylated autologous cells. These DNP primed clones also showed responses to some dinitrophenylated allogeneic leukocytes. The magnitude of the accelerated blastogenic response with allogeneic leukocytes varied in most instances in relation to the degree of sharing of HLA-A, B, and DRw antigens with the original autologous stimulator. These findings show that the self-specific factors recognized in conjunction with the dinitrophenyl antigen are closely but not invariably associated with established major histocompatibility (MHC)-associated serologic typing results. While DNP primed clones fail to respond to unmodified autologous leukocytes, they often show significant responses to unmodified allogeneic leukocytes. If such accelerated responses to unmodified allogeneic leukocytes are not the result of nonspecific activation of allogeneic responding lymphocyte clones, these findings further indicate that DNP modified self can resemble some alloantigens.
Integrative Medicine Reports, Dec 1, 2022
Vaccines
Vaccine safety is measured by the disease protection it confers compared to the harm it may cause... more Vaccine safety is measured by the disease protection it confers compared to the harm it may cause; both factors and their relative numbers have been the subject of disagreement. Cross-reactive attack of analogous self-antigens modified by dietary and microbiome factors is one of the poorly explored likely causes of harm. Screening for that and other risk factors might point out those most likely to develop severe vaccine reactions. Cooperation from those with opinions for and against vaccination in data gathering and vetting will lead to greater safety. Screening should include an integrative medical perspective regarding diet, microbiome, leaky gut, and other antigen sources. It might include emerging electronic technology or integrative energetic techniques vetted ultimately by cross-reactive lymphocyte testing or genetic evaluation. The knowledge gained from evaluating those with reactions could enhance the screening process and, since similar antigenic stimuli and reactions are ...
American Journal of Clinical Hypnosis, 1998
Abstract Relaxation mental imagery (RMI), standard topical treatment (TopTx), and equal time-cont... more Abstract Relaxation mental imagery (RMI), standard topical treatment (TopTx), and equal time-control interventions were compared on measures of wart regression in sixty one, 612-year-old children. Subjects chose one common (index) wart and attended 4 visits over 8 ...
Archives of Dermatology, Feb 1, 1997
In a recent issue of theArchives, Burgdorf and Happle 1 gave an informative and partially accurat... more In a recent issue of theArchives, Burgdorf and Happle 1 gave an informative and partially accurate introduction to homeopathy by defining some of its concepts, but then went on to ridicule it on the basis of the concept of increased potency conferred by dilution and their misunderstanding of the specificity of the observations on which the similarity principle was based. In their mention of allopathy vs homeopathy, they do a service by opening up the viewpoint that the principles behind homeopathy and those behind the way we practice medicine are actually both belief systems. While we embrace the scientific method, the perspective that this controversy regarding homeopathic medicine presents can give us valuable insights. A major flaw of homeopathic medicine for Burgdorf and Happle is that it violates the pharmacological principle that substances have more of an effect at higher concentrations. I must first point out that immunologic
Journal of Immunology, May 1, 1979
Our group has previously reported that human sperm cells are capable of stimulating allogeneic ly... more Our group has previously reported that human sperm cells are capable of stimulating allogeneic lymphocytes. We now report that the HLA-D on sperm cells is resistant to ultraviolet (UV) light in contrast to HLA-D on leukocytes, which is very sensitive to UV light in the dosage range employed in these experiments. Responder leukocytes were cultured with varying concentrations of stimulating blood leukocytes and varying concentrations of sperm cells washed free of the highly suppressive seminal plasma factor(s). Stimulator blood and sperm cells were exposed simultaneously to UV light delivered from a G.E. cold quartz No. G 15-T8 (2537 Å germicidal) lamp at doses varying from 800 to 25,000 ergs/mm2 as measured by an IL 770 photometer with a narrow band NB254 filter. Even the lowest dosage of UV completely or nearly totally abrogated the stimulating capability of leukocytes whereas sperm cells showed excellent stimulating ability with as much as 25,000 ergs/mm2. We have also been able to clonally prime lymphocytes with sperms. After 10 to 14 days in first or primary culture, sperm-stimulated blast-derived lymphocytes were recultured. The allogeneic responding lymphocytes showed accelerated 3HTdR incorporation to leukocytes from the original sperm donor. We conclude that the UV-resistant HLA-D on sperms share some determinants with the UV-sensitive HLA-D on leukocytes.
Cellular Immunology, Aug 1, 1979
Scandinavian Journal of Immunology, Nov 1, 1978
Journal of Oral Pathology & Medicine, Nov 1, 1978
Dermatologic Clinics, Jul 1, 2004
This article is a description of how I have integrated Complementary Medicine into the practice o... more This article is a description of how I have integrated Complementary Medicine into the practice of dermatology over the past 2 decades. It emphasizes observing the principles of the system being used, such as the herbal concept of the synergy of the entire plant extract. Examples discussed include the use of flavonoids to protect the liver and capillaries. Herbs and techniques for reducing the inflammatory response, as well as for enhancing immunity, are given. The concept of homeopathy and a few remedies to use in office practice are discussed. Finally, a few methods to complement the treatment of melanoma are presented.
Journal of Immunology, Oct 1, 1978
HLA-A and -B antigens are resistant to ultraviolet (UV) light whereas HLA-D, as defined by the mi... more HLA-A and -B antigens are resistant to ultraviolet (UV) light whereas HLA-D, as defined by the mixed leukocyte culture reaction (MLR), is sensitive to UV light in initial or first culture. In primed LD typing, the HLA-D responsible for stimulation is relatively resistant to UV light in second culture. We have developed a method for evaluating a specific proliferative response to DNP in dinitrochlorobenzene (DNCB)-sensitized human subjects and found a requirement for a component of autologous leukocytes to activate DNP-responsive lymphocyte clones. Autologous DNBSO3-coupled leukocytes with and without UV were used to stimulate lymphocytes in DNCB-sensitized subjects. 3HTdR incorporation was measured after 4 or 5 dys in 1st or “primary” culture. After 9 to 14 days, blast-derived lymphocytes were set up in 2nd or “secondary” cultures and exposed to the same autologous DNBSO3-treated leukocytes with and without UV. Accelerated 3HTdR incorporation was measured in these secondary clonally primed cultures after 20 to 44 hr. The results showed that UV light abrogated the antigen-presenting or stimulator function in the 1st culture and diminished, but did not abrogate, the antigen-presenter function in the 2nd culture. These findings indicate that the DNP-antigen presenting function is behaving in a manner similar to that observed for mixed leukocyte culture determinants in 1st and 2nd cultures.
Cancer, Jul 1, 1976
This report describes a de novo development of Kaposi's sarcoma in a Puerto-Rician man 9 ... more This report describes a de novo development of Kaposi's sarcoma in a Puerto-Rician man 9 months after a cadaveric renal transplant. Progression of the disease was observed despite local irradiation, while the patient remained immunosuppressed with prednisone and azathioprine. This was accompanied by depressed immunologic tests. Discontinuation of azathioprine and addition of chemotherapy (bleomycin and vincristine), while continuing prednisone to maintain functional survival of renal allograft, has led in this patient to regression of extensive cutaneous and suspected pulmonary Kaposi's sarcoma lesions. The possible importance of a depressed immunosurveillance mechanism and activation of latent oncogenic virus by the presence of an allograft in the de novo appearance of Kaposi's sarcoma in transplant recipients is briefly discussed.
Journal of Cosmetic Dermatology, Jun 1, 2006
Clinics in Dermatology, 2010
Conventional wisdom posits that breastfeeding during the first 4 months of life generally reduces... more Conventional wisdom posits that breastfeeding during the first 4 months of life generally reduces the incidence of atopic dermatitis in the child. Recent studies question this truism, especially in cases when the mother herself is allergic. Studies about maternal dietary allergens in breast milk and their influence on atopic dermatitis have been questioned as well. There is evidence that probiotic and essential fatty acid supplementation, along with an allergen-avoidance diet, may reduce the chance of maternal dietary allergens provoking atopic dermatitis in the infant. Evidence on both sides of the controversy is presented in an effort to produce meaningful guidelines for breastfeeding infants at risk for atopic dermatitis.
Journal of Drugs in Dermatology, Apr 1, 2021
(see Figure 1). 4 Our later studies demonstrated that a feeder layer of irradiated autologous leu... more (see Figure 1). 4 Our later studies demonstrated that a feeder layer of irradiated autologous leukocytes could restore the secondary culture response to optimal primary culture antigen levels. 5,6 One possible explanation is that we saturated the HLA-D antigen presenting and receptor sites so that lymphocytes could not be activated. It is also possible that we induced antiidiotype immunity. The concept is that with such a large dose of the specific stimulating antigen, a huge number of reactive lymphocytes are induced with the same or similar receptors recognizing that antigen early on. Subsequently, in that same culture, remaining lymphocytes develop receptors against the anti-tetanus toxoid receptor bearing cells in the culture. This possibility is further suggested by our later demonstration of specific suppression of response to microbial antigens by stimulated cells. 7 Work by others has also confirmed this possibility. 8,9 T-cells are involved in Covid-19 immunity directly as evidenced by studies of convalescent Covid-19 patients.
Journal of Investigative Dermatology, Sep 1, 1979
Human lymphocytes from dinitrochlorobenzene (DNCB)-sensitized human subjects primed in first cult... more Human lymphocytes from dinitrochlorobenzene (DNCB)-sensitized human subjects primed in first culture with dinitrophenylated-antigens yield a population of cells which respond in an accelerated manner to the same or similar antigen in second culture. Using this "clonal priming" approach, we have demonstrated that such a primed population showed maximal proliferative response to dinitrophenylated autologous cells. These DNP primed clones also showed responses to some dinitrophenylated allogeneic leukocytes. The magnitude of the accelerated blastogenic response with allogeneic leukocytes varied in most instances in relation to the degree of sharing of HLA-A, B, and DRw antigens with the original autologous stimulator. These findings show that the self-specific factors recognized in conjunction with the dinitrophenyl antigen are closely but not invariably associated with established major histocompatibility (MHC)-associated serologic typing results. While DNP primed clones fail to respond to unmodified autologous leukocytes, they often show significant responses to unmodified allogeneic leukocytes. If such accelerated responses to unmodified allogeneic leukocytes are not the result of nonspecific activation of allogeneic responding lymphocyte clones, these findings further indicate that DNP modified self can resemble some alloantigens.
Integrative Medicine Reports, Dec 1, 2022
Vaccines
Vaccine safety is measured by the disease protection it confers compared to the harm it may cause... more Vaccine safety is measured by the disease protection it confers compared to the harm it may cause; both factors and their relative numbers have been the subject of disagreement. Cross-reactive attack of analogous self-antigens modified by dietary and microbiome factors is one of the poorly explored likely causes of harm. Screening for that and other risk factors might point out those most likely to develop severe vaccine reactions. Cooperation from those with opinions for and against vaccination in data gathering and vetting will lead to greater safety. Screening should include an integrative medical perspective regarding diet, microbiome, leaky gut, and other antigen sources. It might include emerging electronic technology or integrative energetic techniques vetted ultimately by cross-reactive lymphocyte testing or genetic evaluation. The knowledge gained from evaluating those with reactions could enhance the screening process and, since similar antigenic stimuli and reactions are ...
American Journal of Clinical Hypnosis, 1998
Abstract Relaxation mental imagery (RMI), standard topical treatment (TopTx), and equal time-cont... more Abstract Relaxation mental imagery (RMI), standard topical treatment (TopTx), and equal time-control interventions were compared on measures of wart regression in sixty one, 612-year-old children. Subjects chose one common (index) wart and attended 4 visits over 8 ...