Amparo Solé - Academia.edu (original) (raw)
Papers by Amparo Solé
Archivos De Bronconeumologia, Jun 1, 2023
Transplantation Proceedings, Jul 1, 2009
Introduction and Objectives. Primary graft dysfunction (PGD) is a form of acute lung injury secon... more Introduction and Objectives. Primary graft dysfunction (PGD) is a form of acute lung injury secondary to lung transplantation (LT). The objective of our study was to analyse N terminal pro-brain natriuretic peptide (NT-pro-BNP) as a prognostic marker of morbidity and mortality and its possible relationship with the development of PGD. Materials and Methods. This prospective study of 50 consecutive lung transplantation patients used blood samples obtained at baseline, 24, 48, and 72 hours after admission. We analyzed the amino terminal fraction of the BNP prohormone (NT-pro-BNP). The development of PGD was defined following the criteria of the International Society for Heart and Lung Transplantation (ISHLT). Results. In this study 72% of patients developed PGD at T24, 42% of whom had severe grade III. There was no relationship between the development of PGD at any grade and NT-pro-BNP levels. Elevated levels of NT-pro-BNP were accompanied by greater postoperative mortality (P Ͻ .05).
General Hospital Psychiatry, May 1, 2016
Background: Cystic fibrosis (CF) is a chronic disease with an impact on the quality of life. Self... more Background: Cystic fibrosis (CF) is a chronic disease with an impact on the quality of life. Self-reported symptoms of depression and anxiety were assessed in the Spanish cohort of the International Epidemiological Study on Depression and Anxiety in patients with CF (International Depression-Anxiety Epidemiological Study) and their relationship with health status and health-related quality of life (HRQoL) was evaluated. Methods: This cross-sectional study recruited adult patients with CF at 10 Spanish centers. Patients completed the Hospital Anxiety and Depression Scale (HADS) and the Revised Cystic Fibrosis Questionnaire. Demographic and health data were recorded from medical charts. Logistic regression was used to determine the predictors of elevated symptoms of depression and anxiety (HADS≥8). Results: Of the 336 participants recruited (mean age, 28.1 years; 48.2% women), 41 (12.2%) had elevated depression-related scores, and 100 (29.7%) had elevated anxiety-related scores (HADS≥8). After adjusting for confounders, only less education, intravenous antibiotics, psychiatric medications and psychotherapy were significantly associated with elevated psychological symptoms. Specifically, regardless of lung function, patients who were depressed or anxious reported worse HRQoL. General Hospital Psychiatry xxx (2016) xxx-xxx ☆ Conflicts of Interest: None of the authors has any conflict of interest to disclose. ☆☆ Ethical Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. ☆☆☆ Study protocols were approved by local ethics committees at all CF centers. ★ Informed Consent: Informed consent was obtained from all individual participants included in the study. ★★ Patients' Data Protection: The authors declare that they have followed the protocols of their work center on the publication of patient data. ★★★ Statement of Authorship: Quittner A, Olveira C, and Olveira G: contributed to the conception and design of the study; Olveira C, and Olveira G contributed to the acquisition, analysis and interpretation of the data; and statistical analysis and drafting of the manuscript. Both authors (Olveira C and Olveira G) are the guarantor of the paper, taking responsibility for the integrity of the work as a whole from inception to published article. Sole A, Girón RM, Quintana-Gallego E, Mondejar P, Baranda F, Alvarez A, Prados C, Rodríguez-González J, Herrero-Labarga I contributed to data acquisition and critical revision of the manuscript.
Archivos De Bronconeumologia, Mar 1, 2015
Artículo especial Consenso español para la prevención y el tratamiento de la infección bronquial ... more Artículo especial Consenso español para la prevención y el tratamiento de la infección bronquial por Pseudomonas aeruginosa en el paciente con fibrosis quística Spanish consensus on the prevention and treatment of
Revista Clinica Espanola, Aug 1, 2014
To know the prevalence of the patients diagnosed of cystic fibrosis (CF) older than 18 years old ... more To know the prevalence of the patients diagnosed of cystic fibrosis (CF) older than 18 years old of five specific Spanish Units and to analyze their clinical, genetic and microbiological characteristics. Observational, cross-sectional, descriptive study of patients diagnosed with CF at age or older than 18 years. The variables analyzed were: current age, age at diagnosis, sex, nationality, lung function parameters, pathologies presented at diagnosis, microbiological features and genetic findings. Eigthy nine patients (14.8% of the total of 600 CF patients followed at the participating units), of which 45 patients were female (50.6%) and 44 were males (49.4%), were included with a mean age at diagnosis of 36.4 years. Eigthy one patients (91%) were Spaniards. The sweat test was diagnostic in 77 (86.5%) of the patients studied. The sweat test was diagnostic in 77 of the 89 patients studied (86.5%). The most frequently detected mutations were F508del/other and G542X/other, and the most frequent clinical findings at diagnosis were the presence of bronchiectasis in 33 patients (37.1%) followed by sterility in 12 patients (13.5%). The most common colonizing organisms were meticillin-sensitive Staphylococcus aureus (S.aureus) (23.6%) and Pseudomonas aeruginosa (P. aeruginosa) (13.5%). Most patients presented a mild obstructive ventilatory defect and had no pancreatic involvement. The sweat test used to be indeterminate. CF is also a disease which diagnosis can be in adulthood. CF patients diagnosed in adulthood have a mild lung function and lower incidence of pancreatic involvement, so their prognosis tends to be favorable.
Archivos De Bronconeumologia, Jul 1, 1999
Biomedicines
The search for biomarkers that can help to establish an early diagnosis and prognosis of intersti... more The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP p...
C38. RARE AND COMMON ILDS: EPIDEMIOLOGY, DIAGNOSIS, AND MANAGEMENT
European Respiratory Journal, 2012
Treatment of chronic colonization with methicillin-resistant Staphylococcus aureus (MRSA) and non... more Treatment of chronic colonization with methicillin-resistant Staphylococcus aureus (MRSA) and non-MR in cystic fibrosis (CF) patients shows a wide variability among CF units. While some caregivers prescribe continuous treatment with inhaled/ oral antibiotics, others only treat infectious exacerbations. Methods: 52 CF patients were included. Mean age was 25, 1 years. All patients were chronically colonized by SA (5% MR) and showed a poor clinical progress and respiratory function after receiving several conventional antibiotic cycles to treat infectious exacerbation. Every patient was prescribed continuous treatment with oral Linezolid: 600mg/12h for 15-21 days every 45 days, for a minimum of 1 year. Serial spirometry, sputum analysis and blood analysis were determined to rule out toxicity derived from a chronic treatment with Linezolid. Health related quality of life was measured every three months with the Cystic Fibrosis Questionnaire-Revised (CFQ-R) to detect any change. Results:...
The Journal of Heart and Lung Transplantation, 2021
The Journal of Heart and Lung Transplantation, 2019
Lack of association of Aspergillus colonization with the development of bronchiolitis obliterans ... more Lack of association of Aspergillus colonization with the development of bronchiolitis obliterans syndrome in lung transplant recipients Law
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Jan 6, 2018
Infection is still a leading cause of death during the first year after lung transplantation. We ... more Infection is still a leading cause of death during the first year after lung transplantation. We performed a multicenter study among teaching hospitals to assess monitoring of early humoral immunity as a means of identifying lung recipients at risk of serious infections. We prospectively analyzed 82 adult lung recipients at 5 centers in Spain. Data were collected before transplantation and at 7 and 30 days after transplantation. Biomarkers included IgG, IgM, IgA, complement factors C3 and C4, titers of antibodies to pneumococcal polysaccharide antigens (IgG, IgA, IgM) and antibodies to cytomegalovirus (IgG), and serum B-cell activating factor (BAFF) levels. The clinical follow-up period lasted 6 months. Clinical outcomes were bacterial infections requiring intravenous anti-microbial agents, cytomegalovirus (CMV) disease, and fungal infections requiring therapy. We found that 33 patients (40.2%) developed at least 1 serious bacterial infection, 8 patients (9.8%) had CMV disease, and ...
Journal of Cystic Fibrosis, 2017
Results: A total of 36 subjects, 17 male and 19 female, with mean [range] age 24.7 years [18-45] ... more Results: A total of 36 subjects, 17 male and 19 female, with mean [range] age 24.7 years [18-45] entered the study. Baseline characteristics: predicted FEV 1 91.4% [67.6-128.7]; BMI 22.4 kg/m 2 [18-28]; sweat chloride 104 mmol/L [76-120]. After a single 50 mg dose of QR-010 (n = 6), median serum C max was 2.0950 ng/mL [1.1100-4.6500] at 0.5 hours with median AUC (0-t last) 12.4825 ng/mL [0.2775-24.7175]. No subjects withdrew from the study. No serious adverse events were reported; all treatmentemergent adverse events were mild or moderate. Conclusions: Single doses up to 50 mg of QR-010 were safe and welltolerated. A maximum tolerated dose was not established. Systemic concentrations of QR-010 were measured following a single dose administration, indicating that QR-010 has the potential to treat both pulmonary and extra-pulmonary manifestations of CF.
Arch Bronconeumol, 2011
La presente normativa ha sido elaborada con el consenso de, al menos, un representante de cada un... more La presente normativa ha sido elaborada con el consenso de, al menos, un representante de cada uno de los hospitales con programa de trasplante pulmonar en España. Además, previamente a su publicación, ha sido revisada por un grupo de revisores destacados por su reconocida trayectoria en el campo del trasplante pulmonar. En las siguientes páginas, el lector encontrará los criterios de selección de pacientes candidatos a trasplante pulmonar, cuándo y cómo remitir un paciente a un centro trasplantador y, finalmente, cuándo incluir al paciente en lista de espera. Se ha atribuido un nivel de evidencia a las cuestiones más relevantes. Este documento pretende ser una guía práctica para los neumólogos que no participan directamente en el trasplante pulmonar pero que deben considerar este tratamiento para sus pacientes. Finalmente, se ha propuesto de una forma consensuada un documento que recoge de forma estructurada los datos del paciente potencial candidato a trasplante pulmonar que son relevantes para poder tomar la mejor decisión.The present guidelines have been prepared with the consensus of at least one representative of each of the hospitals with lung transplantation programs in Spain. In addition, prior to their publication, these guidelines have been reviewed by a group of prominent reviewers who are recognized for their professional experience in the field of lung transplantation. Within the following pages, the reader will find the selection criteria for lung transplantation candidates, when and how to remit a patient to a transplantation center and, lastly, when to add the patient to the waiting list. A level of evidence has been identified for the most relevant questions. Our intention is for this document to be a practical guide for pulmonologists who do not directly participate in lung transplantations but who should consider this treatment for their patients. Finally, these guidelines also propose an information form in order to compile in an organized manner the patient data of the potential candidate for lung transplantation, which are relevant in order to be able to make the best decisions possible.
The Journal of Heart and Lung Transplantation, 2016
Data derived from a single randomized clinical trial or large non-randomized studies Level of evi... more Data derived from a single randomized clinical trial or large non-randomized studies Level of evidence C Consensus of opinion of the experts and/or small studies, retrospective studies, registries
Revista española de anestesiología y reanimación
Lung transplantation has become a valid therapeutic option for patients with pulmonary fibrosis i... more Lung transplantation has become a valid therapeutic option for patients with pulmonary fibrosis in terminal stage, and the number of such interventions has increased exponentially in recent years. We undertook a retrospective study of 46 pulmonary fibrosis patients who received lung transplants from 1992 through 2002 with the aim of describing the most common intra- and early postoperative complications in the recovery unit. We also aimed to analyze the impact of each complication on mortality during the study period. The most frequent complications during surgery were reperfusion syndrome (47.5%), hemodynamic instability (41%), arrhythmias (23.9%), and pulmonary hypertension (15%), with exitus secondary to reperfusion syndrome. The most common postoperative complications were infection (56.5%), reimplantation response (45.7%), and kidney failure (19.6%). Overall mortality during the study period was 23.9%. The following complications were statistically significant in the univariate...
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia, 2013
To elaborate practical recommendations based on scientific evidence, when available, or on expert... more To elaborate practical recommendations based on scientific evidence, when available, or on expert opinions for the diagnosis, treatment and prevention of fungal respiratory infections in the critically ill patient, including solid organ transplant recipients. Twelve experts from two scientific societies (The Spanish Society for Chemotherapy and The Spanish Society of Intensive Care and Coronary Units) reviewed in a meeting held in March 2012 epidemiological issues and risk factors as basis for a document about prevention, diagnosis and treatment of respiratory fungal infections caused by Candida spp., Aspergillus spp or Zygomycetes. Despite the frequent isolation of Candida spp. from respiratory tract samples, antifungal treatment is not recommended since pneumonia by this fungal species is exceptional in non-neutropenic patients. In the case of Aspergillus spp., approximately 50% isolates from the ICU represent colonization, and the remaining 50% cases are linked to invasive pulmon...
Archivos De Bronconeumologia, Jun 1, 2023
Transplantation Proceedings, Jul 1, 2009
Introduction and Objectives. Primary graft dysfunction (PGD) is a form of acute lung injury secon... more Introduction and Objectives. Primary graft dysfunction (PGD) is a form of acute lung injury secondary to lung transplantation (LT). The objective of our study was to analyse N terminal pro-brain natriuretic peptide (NT-pro-BNP) as a prognostic marker of morbidity and mortality and its possible relationship with the development of PGD. Materials and Methods. This prospective study of 50 consecutive lung transplantation patients used blood samples obtained at baseline, 24, 48, and 72 hours after admission. We analyzed the amino terminal fraction of the BNP prohormone (NT-pro-BNP). The development of PGD was defined following the criteria of the International Society for Heart and Lung Transplantation (ISHLT). Results. In this study 72% of patients developed PGD at T24, 42% of whom had severe grade III. There was no relationship between the development of PGD at any grade and NT-pro-BNP levels. Elevated levels of NT-pro-BNP were accompanied by greater postoperative mortality (P Ͻ .05).
General Hospital Psychiatry, May 1, 2016
Background: Cystic fibrosis (CF) is a chronic disease with an impact on the quality of life. Self... more Background: Cystic fibrosis (CF) is a chronic disease with an impact on the quality of life. Self-reported symptoms of depression and anxiety were assessed in the Spanish cohort of the International Epidemiological Study on Depression and Anxiety in patients with CF (International Depression-Anxiety Epidemiological Study) and their relationship with health status and health-related quality of life (HRQoL) was evaluated. Methods: This cross-sectional study recruited adult patients with CF at 10 Spanish centers. Patients completed the Hospital Anxiety and Depression Scale (HADS) and the Revised Cystic Fibrosis Questionnaire. Demographic and health data were recorded from medical charts. Logistic regression was used to determine the predictors of elevated symptoms of depression and anxiety (HADS≥8). Results: Of the 336 participants recruited (mean age, 28.1 years; 48.2% women), 41 (12.2%) had elevated depression-related scores, and 100 (29.7%) had elevated anxiety-related scores (HADS≥8). After adjusting for confounders, only less education, intravenous antibiotics, psychiatric medications and psychotherapy were significantly associated with elevated psychological symptoms. Specifically, regardless of lung function, patients who were depressed or anxious reported worse HRQoL. General Hospital Psychiatry xxx (2016) xxx-xxx ☆ Conflicts of Interest: None of the authors has any conflict of interest to disclose. ☆☆ Ethical Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. ☆☆☆ Study protocols were approved by local ethics committees at all CF centers. ★ Informed Consent: Informed consent was obtained from all individual participants included in the study. ★★ Patients' Data Protection: The authors declare that they have followed the protocols of their work center on the publication of patient data. ★★★ Statement of Authorship: Quittner A, Olveira C, and Olveira G: contributed to the conception and design of the study; Olveira C, and Olveira G contributed to the acquisition, analysis and interpretation of the data; and statistical analysis and drafting of the manuscript. Both authors (Olveira C and Olveira G) are the guarantor of the paper, taking responsibility for the integrity of the work as a whole from inception to published article. Sole A, Girón RM, Quintana-Gallego E, Mondejar P, Baranda F, Alvarez A, Prados C, Rodríguez-González J, Herrero-Labarga I contributed to data acquisition and critical revision of the manuscript.
Archivos De Bronconeumologia, Mar 1, 2015
Artículo especial Consenso español para la prevención y el tratamiento de la infección bronquial ... more Artículo especial Consenso español para la prevención y el tratamiento de la infección bronquial por Pseudomonas aeruginosa en el paciente con fibrosis quística Spanish consensus on the prevention and treatment of
Revista Clinica Espanola, Aug 1, 2014
To know the prevalence of the patients diagnosed of cystic fibrosis (CF) older than 18 years old ... more To know the prevalence of the patients diagnosed of cystic fibrosis (CF) older than 18 years old of five specific Spanish Units and to analyze their clinical, genetic and microbiological characteristics. Observational, cross-sectional, descriptive study of patients diagnosed with CF at age or older than 18 years. The variables analyzed were: current age, age at diagnosis, sex, nationality, lung function parameters, pathologies presented at diagnosis, microbiological features and genetic findings. Eigthy nine patients (14.8% of the total of 600 CF patients followed at the participating units), of which 45 patients were female (50.6%) and 44 were males (49.4%), were included with a mean age at diagnosis of 36.4 years. Eigthy one patients (91%) were Spaniards. The sweat test was diagnostic in 77 (86.5%) of the patients studied. The sweat test was diagnostic in 77 of the 89 patients studied (86.5%). The most frequently detected mutations were F508del/other and G542X/other, and the most frequent clinical findings at diagnosis were the presence of bronchiectasis in 33 patients (37.1%) followed by sterility in 12 patients (13.5%). The most common colonizing organisms were meticillin-sensitive Staphylococcus aureus (S.aureus) (23.6%) and Pseudomonas aeruginosa (P. aeruginosa) (13.5%). Most patients presented a mild obstructive ventilatory defect and had no pancreatic involvement. The sweat test used to be indeterminate. CF is also a disease which diagnosis can be in adulthood. CF patients diagnosed in adulthood have a mild lung function and lower incidence of pancreatic involvement, so their prognosis tends to be favorable.
Archivos De Bronconeumologia, Jul 1, 1999
Biomedicines
The search for biomarkers that can help to establish an early diagnosis and prognosis of intersti... more The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP p...
C38. RARE AND COMMON ILDS: EPIDEMIOLOGY, DIAGNOSIS, AND MANAGEMENT
European Respiratory Journal, 2012
Treatment of chronic colonization with methicillin-resistant Staphylococcus aureus (MRSA) and non... more Treatment of chronic colonization with methicillin-resistant Staphylococcus aureus (MRSA) and non-MR in cystic fibrosis (CF) patients shows a wide variability among CF units. While some caregivers prescribe continuous treatment with inhaled/ oral antibiotics, others only treat infectious exacerbations. Methods: 52 CF patients were included. Mean age was 25, 1 years. All patients were chronically colonized by SA (5% MR) and showed a poor clinical progress and respiratory function after receiving several conventional antibiotic cycles to treat infectious exacerbation. Every patient was prescribed continuous treatment with oral Linezolid: 600mg/12h for 15-21 days every 45 days, for a minimum of 1 year. Serial spirometry, sputum analysis and blood analysis were determined to rule out toxicity derived from a chronic treatment with Linezolid. Health related quality of life was measured every three months with the Cystic Fibrosis Questionnaire-Revised (CFQ-R) to detect any change. Results:...
The Journal of Heart and Lung Transplantation, 2021
The Journal of Heart and Lung Transplantation, 2019
Lack of association of Aspergillus colonization with the development of bronchiolitis obliterans ... more Lack of association of Aspergillus colonization with the development of bronchiolitis obliterans syndrome in lung transplant recipients Law
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Jan 6, 2018
Infection is still a leading cause of death during the first year after lung transplantation. We ... more Infection is still a leading cause of death during the first year after lung transplantation. We performed a multicenter study among teaching hospitals to assess monitoring of early humoral immunity as a means of identifying lung recipients at risk of serious infections. We prospectively analyzed 82 adult lung recipients at 5 centers in Spain. Data were collected before transplantation and at 7 and 30 days after transplantation. Biomarkers included IgG, IgM, IgA, complement factors C3 and C4, titers of antibodies to pneumococcal polysaccharide antigens (IgG, IgA, IgM) and antibodies to cytomegalovirus (IgG), and serum B-cell activating factor (BAFF) levels. The clinical follow-up period lasted 6 months. Clinical outcomes were bacterial infections requiring intravenous anti-microbial agents, cytomegalovirus (CMV) disease, and fungal infections requiring therapy. We found that 33 patients (40.2%) developed at least 1 serious bacterial infection, 8 patients (9.8%) had CMV disease, and ...
Journal of Cystic Fibrosis, 2017
Results: A total of 36 subjects, 17 male and 19 female, with mean [range] age 24.7 years [18-45] ... more Results: A total of 36 subjects, 17 male and 19 female, with mean [range] age 24.7 years [18-45] entered the study. Baseline characteristics: predicted FEV 1 91.4% [67.6-128.7]; BMI 22.4 kg/m 2 [18-28]; sweat chloride 104 mmol/L [76-120]. After a single 50 mg dose of QR-010 (n = 6), median serum C max was 2.0950 ng/mL [1.1100-4.6500] at 0.5 hours with median AUC (0-t last) 12.4825 ng/mL [0.2775-24.7175]. No subjects withdrew from the study. No serious adverse events were reported; all treatmentemergent adverse events were mild or moderate. Conclusions: Single doses up to 50 mg of QR-010 were safe and welltolerated. A maximum tolerated dose was not established. Systemic concentrations of QR-010 were measured following a single dose administration, indicating that QR-010 has the potential to treat both pulmonary and extra-pulmonary manifestations of CF.
Arch Bronconeumol, 2011
La presente normativa ha sido elaborada con el consenso de, al menos, un representante de cada un... more La presente normativa ha sido elaborada con el consenso de, al menos, un representante de cada uno de los hospitales con programa de trasplante pulmonar en España. Además, previamente a su publicación, ha sido revisada por un grupo de revisores destacados por su reconocida trayectoria en el campo del trasplante pulmonar. En las siguientes páginas, el lector encontrará los criterios de selección de pacientes candidatos a trasplante pulmonar, cuándo y cómo remitir un paciente a un centro trasplantador y, finalmente, cuándo incluir al paciente en lista de espera. Se ha atribuido un nivel de evidencia a las cuestiones más relevantes. Este documento pretende ser una guía práctica para los neumólogos que no participan directamente en el trasplante pulmonar pero que deben considerar este tratamiento para sus pacientes. Finalmente, se ha propuesto de una forma consensuada un documento que recoge de forma estructurada los datos del paciente potencial candidato a trasplante pulmonar que son relevantes para poder tomar la mejor decisión.The present guidelines have been prepared with the consensus of at least one representative of each of the hospitals with lung transplantation programs in Spain. In addition, prior to their publication, these guidelines have been reviewed by a group of prominent reviewers who are recognized for their professional experience in the field of lung transplantation. Within the following pages, the reader will find the selection criteria for lung transplantation candidates, when and how to remit a patient to a transplantation center and, lastly, when to add the patient to the waiting list. A level of evidence has been identified for the most relevant questions. Our intention is for this document to be a practical guide for pulmonologists who do not directly participate in lung transplantations but who should consider this treatment for their patients. Finally, these guidelines also propose an information form in order to compile in an organized manner the patient data of the potential candidate for lung transplantation, which are relevant in order to be able to make the best decisions possible.
The Journal of Heart and Lung Transplantation, 2016
Data derived from a single randomized clinical trial or large non-randomized studies Level of evi... more Data derived from a single randomized clinical trial or large non-randomized studies Level of evidence C Consensus of opinion of the experts and/or small studies, retrospective studies, registries
Revista española de anestesiología y reanimación
Lung transplantation has become a valid therapeutic option for patients with pulmonary fibrosis i... more Lung transplantation has become a valid therapeutic option for patients with pulmonary fibrosis in terminal stage, and the number of such interventions has increased exponentially in recent years. We undertook a retrospective study of 46 pulmonary fibrosis patients who received lung transplants from 1992 through 2002 with the aim of describing the most common intra- and early postoperative complications in the recovery unit. We also aimed to analyze the impact of each complication on mortality during the study period. The most frequent complications during surgery were reperfusion syndrome (47.5%), hemodynamic instability (41%), arrhythmias (23.9%), and pulmonary hypertension (15%), with exitus secondary to reperfusion syndrome. The most common postoperative complications were infection (56.5%), reimplantation response (45.7%), and kidney failure (19.6%). Overall mortality during the study period was 23.9%. The following complications were statistically significant in the univariate...
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia, 2013
To elaborate practical recommendations based on scientific evidence, when available, or on expert... more To elaborate practical recommendations based on scientific evidence, when available, or on expert opinions for the diagnosis, treatment and prevention of fungal respiratory infections in the critically ill patient, including solid organ transplant recipients. Twelve experts from two scientific societies (The Spanish Society for Chemotherapy and The Spanish Society of Intensive Care and Coronary Units) reviewed in a meeting held in March 2012 epidemiological issues and risk factors as basis for a document about prevention, diagnosis and treatment of respiratory fungal infections caused by Candida spp., Aspergillus spp or Zygomycetes. Despite the frequent isolation of Candida spp. from respiratory tract samples, antifungal treatment is not recommended since pneumonia by this fungal species is exceptional in non-neutropenic patients. In the case of Aspergillus spp., approximately 50% isolates from the ICU represent colonization, and the remaining 50% cases are linked to invasive pulmon...