Ankur Borah - Academia.edu (original) (raw)
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UERJ - Universidade do Estado do Rio de Janeiro / Rio de Janeiro State University
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Papers by Ankur Borah
Journal of Evolution of Medical and Dental Sciences
BACKGROUND In India, haemoglobinopathies and thalassemias contribute in a significant number of p... more BACKGROUND In India, haemoglobinopathies and thalassemias contribute in a significant number of paediatric cases with anaemia. As corrective treatment like bone marrow transplantation is costly, prevention through population screening, and genetic counselling is the best possible strategy. AIMS Data pertaining to the pattern of these disorders is scarce in this region and hence it was considered worthwhile to study these disorders using a large series of patients referred to clinical diagnostic laboratory. METHOD A retrospective study was done on 800 patients who were referred for Hb variant analysis to two clinical diagnostic laboratories in Jorhat District in upper Assam region of North East India between the age group of 7 months to 18 years. This study was performed by high performance liquid chromatography (HPLC) using BIORAD (D-10) variant Hb typing system. RESULT Out of 800 patients, abnormal Hb fractions were seen in 417 (51.9%) patients. HbE gene was detected in 373 patients of which HbE trait was seen in 243 (58.7%) followed by HbE disease in 100 (23.9%). There were 30 (7.19%) HbE beta thalassemia cases. Out of 46 tea garden community cases, 41 showed HbS gene of which 12 (2.87%) each in HbS trait and HbS thalassemia groups and 17 patients in sickle cell anaemia group (4.07%). HbE thalassemia was mainly found in Chutia (1.92%), Ahom (1.43%) and Mishing (1.67%) communities. CONCLUSION A high incidence of haemoglobinopathies and thalassemias and their combinations is unique for this part of the country particularly the high prevalence of HbE thalassemia. HbS gene is mainly found in tea garden community.
Journal of Evolution of Medical and Dental Sciences
BACKGROUND In India, haemoglobinopathies and thalassemias contribute in a significant number of p... more BACKGROUND In India, haemoglobinopathies and thalassemias contribute in a significant number of paediatric cases with anaemia. As corrective treatment like bone marrow transplantation is costly, prevention through population screening, and genetic counselling is the best possible strategy. AIMS Data pertaining to the pattern of these disorders is scarce in this region and hence it was considered worthwhile to study these disorders using a large series of patients referred to clinical diagnostic laboratory. METHOD A retrospective study was done on 800 patients who were referred for Hb variant analysis to two clinical diagnostic laboratories in Jorhat District in upper Assam region of North East India between the age group of 7 months to 18 years. This study was performed by high performance liquid chromatography (HPLC) using BIORAD (D-10) variant Hb typing system. RESULT Out of 800 patients, abnormal Hb fractions were seen in 417 (51.9%) patients. HbE gene was detected in 373 patients of which HbE trait was seen in 243 (58.7%) followed by HbE disease in 100 (23.9%). There were 30 (7.19%) HbE beta thalassemia cases. Out of 46 tea garden community cases, 41 showed HbS gene of which 12 (2.87%) each in HbS trait and HbS thalassemia groups and 17 patients in sickle cell anaemia group (4.07%). HbE thalassemia was mainly found in Chutia (1.92%), Ahom (1.43%) and Mishing (1.67%) communities. CONCLUSION A high incidence of haemoglobinopathies and thalassemias and their combinations is unique for this part of the country particularly the high prevalence of HbE thalassemia. HbS gene is mainly found in tea garden community.
Journal of Evolution of Medical and Dental Sciences
BACKGROUND In India, haemoglobinopathies and thalassemias contribute in a significant number of p... more BACKGROUND In India, haemoglobinopathies and thalassemias contribute in a significant number of paediatric cases with anaemia. As corrective treatment like bone marrow transplantation is costly, prevention through population screening, and genetic counselling is the best possible strategy. AIMS Data pertaining to the pattern of these disorders is scarce in this region and hence it was considered worthwhile to study these disorders using a large series of patients referred to clinical diagnostic laboratory. METHOD A retrospective study was done on 800 patients who were referred for Hb variant analysis to two clinical diagnostic laboratories in Jorhat District in upper Assam region of North East India between the age group of 7 months to 18 years. This study was performed by high performance liquid chromatography (HPLC) using BIORAD (D-10) variant Hb typing system. RESULT Out of 800 patients, abnormal Hb fractions were seen in 417 (51.9%) patients. HbE gene was detected in 373 patients of which HbE trait was seen in 243 (58.7%) followed by HbE disease in 100 (23.9%). There were 30 (7.19%) HbE beta thalassemia cases. Out of 46 tea garden community cases, 41 showed HbS gene of which 12 (2.87%) each in HbS trait and HbS thalassemia groups and 17 patients in sickle cell anaemia group (4.07%). HbE thalassemia was mainly found in Chutia (1.92%), Ahom (1.43%) and Mishing (1.67%) communities. CONCLUSION A high incidence of haemoglobinopathies and thalassemias and their combinations is unique for this part of the country particularly the high prevalence of HbE thalassemia. HbS gene is mainly found in tea garden community.
Journal of Evolution of Medical and Dental Sciences
BACKGROUND In India, haemoglobinopathies and thalassemias contribute in a significant number of p... more BACKGROUND In India, haemoglobinopathies and thalassemias contribute in a significant number of paediatric cases with anaemia. As corrective treatment like bone marrow transplantation is costly, prevention through population screening, and genetic counselling is the best possible strategy. AIMS Data pertaining to the pattern of these disorders is scarce in this region and hence it was considered worthwhile to study these disorders using a large series of patients referred to clinical diagnostic laboratory. METHOD A retrospective study was done on 800 patients who were referred for Hb variant analysis to two clinical diagnostic laboratories in Jorhat District in upper Assam region of North East India between the age group of 7 months to 18 years. This study was performed by high performance liquid chromatography (HPLC) using BIORAD (D-10) variant Hb typing system. RESULT Out of 800 patients, abnormal Hb fractions were seen in 417 (51.9%) patients. HbE gene was detected in 373 patients of which HbE trait was seen in 243 (58.7%) followed by HbE disease in 100 (23.9%). There were 30 (7.19%) HbE beta thalassemia cases. Out of 46 tea garden community cases, 41 showed HbS gene of which 12 (2.87%) each in HbS trait and HbS thalassemia groups and 17 patients in sickle cell anaemia group (4.07%). HbE thalassemia was mainly found in Chutia (1.92%), Ahom (1.43%) and Mishing (1.67%) communities. CONCLUSION A high incidence of haemoglobinopathies and thalassemias and their combinations is unique for this part of the country particularly the high prevalence of HbE thalassemia. HbS gene is mainly found in tea garden community.