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Emre Asiltürk

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Papers by Emre Asiltürk

Research paper thumbnail of Evaluation of Exercise Time and Cardiac Autonomic Responses with an Exercise Stress Test in Primary Adrenal Insufficiency

Research paper thumbnail of Di̇yabetes Melli̇tus Hastalarinda Anji̇ogeni̇k Büyüme Faktörleri̇ İle Ateroskleroti̇k Peri̇feri̇k Damar Hastaliklarinin İli̇şki̇si̇

Research paper thumbnail of The association of urotensin and #953; and #953; with arterial stiffness and atherosclerosis in patients with autosomal dominant polycystic kidney disease

Annals of medical research, 2019

Aim: Cardiovascular events are associated with increased mortality in patients with autosomal dom... more Aim: Cardiovascular events are associated with increased mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Urotensin II (UT II) is the most potent vasoconstrictor peptide. The aim of the study was to investigate the relationship between UT II and arterial stiffness (AS) and atherosclerosis in ADPKD patients. Material and Methods: 55 ADPKD patients with a mean age of 50±14.4 years. The presence of AS was determined with brachial-ankle pulse wave velocity (baPWV) and the presence of atherosclerosis was determined with carotid artery intima-media thickness (CA-IMT). Plasma UT II levels were determined by enzyme-linked immunosorbent assay. Results: Mean log10 UT II was 0.92±0.16 ng/mL. 12 (10.9%) patients had LVH. Mean baPWV and CA-IMT were 7.65±1.5 m/sec and 0.63±0.13 mm, respectively. Log10 UT II (p=0.009), baPWV (p < 0.001) and CA-IMT (p=0.001) were high in patients compared to healthy individuals. There was an independent relationship between log10 UT II and creatinine (p=0.044) and spot urine protein-creatinine ratio (UPCR) (p=0.026) in multiple regression analysis. There was no relationship between log10 UT II and baPWV and CA-IMT. Conclusion: High plasma UT II levels were observed in ADPKD patients compared to healthy individuals. There was a relationship between UT II and kidney dysfunction and proteinuria. There was no relationship between UT II and AS and atherosclerosis.

Research paper thumbnail of Non-vitamin K antagonist oral anticoagulant discontinuation in non-valvular atrial fibrillation patients (ASPECT-NOAC)

European Heart Journal, 2021

Background and aim Data on NOAC discontinuation patterns in Turkey are lacking. We conducted a su... more Background and aim Data on NOAC discontinuation patterns in Turkey are lacking. We conducted a subgroup analysis in ASPECT-NOAC study to determine anticoagulant discontinuation pattern in AF patients with recently initiated NOAC therapy. Methods ASPECT-NOAC was a national, multicenter, 12-month observational study conducted in 34 outpatient cardiology clinics of state, university, private, and research hospitals covering all geographic regions of Turkey. Adult AF patients who were under NOAC therapy for less than four months were enrolled. Patients who discontinued using their NOACs were recorded at the end of 12 months. A comparative analysis of patients with discontinuation of medication was conducted. Results This study included 991 non-valvular AF patients. NOAC continuation data were available for 854 patients. During study follow-up, 74 patients (8.7%) discontinued their NOAC medication. Mean age of these patients was 67.1±11.3 years old and 38 patients (51.4%) were female. Mo...

Research paper thumbnail of Association of fibroblast growth factor-23 with arterial stiffness in the Multi-Ethnic Study of Atherosclerosis

Nephrology Dialysis Transplantation, 2014

Higher strength lanthanum carbonate provides serum phosphorus control with a low tablet burden an... more Higher strength lanthanum carbonate provides serum phosphorus control with a low tablet burden and is preferred by patients and physicians: a multicenter study.

Research paper thumbnail of Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis

Dicle Tıp Dergisi, 2020

Objective: Peripheral vascular complications frequently seen in hemodialysis patients are associa... more Objective: Peripheral vascular complications frequently seen in hemodialysis patients are associated with mortality. Fibroblast growth factor 23 (FGF23) is thought to be a phosphaturic hormone that causes mortality in hemodialysis patients. The purpose of our study was to determine the association of intact FGF23 (I-FGF23) with atherosclerotic peripheral vascular complications in patients on hemodialysis. Methods: This cross-sectional study was performed with 50 [28 (56%) male, 22 (44%) female] hemodialysis patients. Patient characteristics were compared with an age +-and sex-matched control group of 40 healthy volunteers. Atherosclerosis development was measured by carotid intima media thickness (CIMT) and arterial stiffness development was measured by brachial ankle pulse wave velocity (PWV) device. Results: Increased atherosclerosis and arterial stiffness were observed in patients with high I-FGF23 and low alpha klotho (α-KL) levels compared to healthy subjects. I-FGF23 showed an inverse and independent relationship between lipid profile. There was no relationship between I-FGF23 and atherosclerosis and arterial stiffness.

Research paper thumbnail of Evaluation of Exercise Time and Cardiac Autonomic Responses with an Exercise Stress Test in Primary Adrenal Insufficiency

Research paper thumbnail of Di̇yabetes Melli̇tus Hastalarinda Anji̇ogeni̇k Büyüme Faktörleri̇ İle Ateroskleroti̇k Peri̇feri̇k Damar Hastaliklarinin İli̇şki̇si̇

Research paper thumbnail of The association of urotensin and #953; and #953; with arterial stiffness and atherosclerosis in patients with autosomal dominant polycystic kidney disease

Annals of medical research, 2019

Aim: Cardiovascular events are associated with increased mortality in patients with autosomal dom... more Aim: Cardiovascular events are associated with increased mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Urotensin II (UT II) is the most potent vasoconstrictor peptide. The aim of the study was to investigate the relationship between UT II and arterial stiffness (AS) and atherosclerosis in ADPKD patients. Material and Methods: 55 ADPKD patients with a mean age of 50±14.4 years. The presence of AS was determined with brachial-ankle pulse wave velocity (baPWV) and the presence of atherosclerosis was determined with carotid artery intima-media thickness (CA-IMT). Plasma UT II levels were determined by enzyme-linked immunosorbent assay. Results: Mean log10 UT II was 0.92±0.16 ng/mL. 12 (10.9%) patients had LVH. Mean baPWV and CA-IMT were 7.65±1.5 m/sec and 0.63±0.13 mm, respectively. Log10 UT II (p=0.009), baPWV (p < 0.001) and CA-IMT (p=0.001) were high in patients compared to healthy individuals. There was an independent relationship between log10 UT II and creatinine (p=0.044) and spot urine protein-creatinine ratio (UPCR) (p=0.026) in multiple regression analysis. There was no relationship between log10 UT II and baPWV and CA-IMT. Conclusion: High plasma UT II levels were observed in ADPKD patients compared to healthy individuals. There was a relationship between UT II and kidney dysfunction and proteinuria. There was no relationship between UT II and AS and atherosclerosis.

Research paper thumbnail of Non-vitamin K antagonist oral anticoagulant discontinuation in non-valvular atrial fibrillation patients (ASPECT-NOAC)

European Heart Journal, 2021

Background and aim Data on NOAC discontinuation patterns in Turkey are lacking. We conducted a su... more Background and aim Data on NOAC discontinuation patterns in Turkey are lacking. We conducted a subgroup analysis in ASPECT-NOAC study to determine anticoagulant discontinuation pattern in AF patients with recently initiated NOAC therapy. Methods ASPECT-NOAC was a national, multicenter, 12-month observational study conducted in 34 outpatient cardiology clinics of state, university, private, and research hospitals covering all geographic regions of Turkey. Adult AF patients who were under NOAC therapy for less than four months were enrolled. Patients who discontinued using their NOACs were recorded at the end of 12 months. A comparative analysis of patients with discontinuation of medication was conducted. Results This study included 991 non-valvular AF patients. NOAC continuation data were available for 854 patients. During study follow-up, 74 patients (8.7%) discontinued their NOAC medication. Mean age of these patients was 67.1±11.3 years old and 38 patients (51.4%) were female. Mo...

Research paper thumbnail of Association of fibroblast growth factor-23 with arterial stiffness in the Multi-Ethnic Study of Atherosclerosis

Nephrology Dialysis Transplantation, 2014

Higher strength lanthanum carbonate provides serum phosphorus control with a low tablet burden an... more Higher strength lanthanum carbonate provides serum phosphorus control with a low tablet burden and is preferred by patients and physicians: a multicenter study.

Research paper thumbnail of Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis

Dicle Tıp Dergisi, 2020

Objective: Peripheral vascular complications frequently seen in hemodialysis patients are associa... more Objective: Peripheral vascular complications frequently seen in hemodialysis patients are associated with mortality. Fibroblast growth factor 23 (FGF23) is thought to be a phosphaturic hormone that causes mortality in hemodialysis patients. The purpose of our study was to determine the association of intact FGF23 (I-FGF23) with atherosclerotic peripheral vascular complications in patients on hemodialysis. Methods: This cross-sectional study was performed with 50 [28 (56%) male, 22 (44%) female] hemodialysis patients. Patient characteristics were compared with an age +-and sex-matched control group of 40 healthy volunteers. Atherosclerosis development was measured by carotid intima media thickness (CIMT) and arterial stiffness development was measured by brachial ankle pulse wave velocity (PWV) device. Results: Increased atherosclerosis and arterial stiffness were observed in patients with high I-FGF23 and low alpha klotho (α-KL) levels compared to healthy subjects. I-FGF23 showed an inverse and independent relationship between lipid profile. There was no relationship between I-FGF23 and atherosclerosis and arterial stiffness.

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