Asressie Molla - Academia.edu (original) (raw)

Papers by Asressie Molla

BMJ paediatrics open, Jul 1, 2024

Health science reports, May 1, 2024

Zenodo (CERN European Organization for Nuclear Research), Mar 19, 2023

BMC pregnancy and childbirth, Feb 21, 2024

Global Pediatrics, Nov 30, 2023

PLOS Neglected Tropical Diseases, Sep 9, 2022

Background Cutaneous leishmaniasis (CL) is generally caused by Leishmania aethiopica in Ethiopia,... more Background Cutaneous leishmaniasis (CL) is generally caused by Leishmania aethiopica in Ethiopia, and is relatively hard to treat. Sodium stibogluconate (SSG) is the only routinely and widely available antileishmanial treatment, and can be used systemically for severe lesions and locally for smaller lesions. There is limited data on the effectiveness of intralesional (IL) SSG for localized CL in Ethiopia and therefore good data is necessary to improve our understanding of the effectiveness of the treatment. Methodology/Principal findings A pragmatic (before and after Quazi experimental) study was done to assess the effectiveness of intralesional SSG among localized CL patients at Boru Meda general hospital, Northeast Ethiopia. Patients who were assigned to intralesional SSG by the treating physician were eligible for this study. Study subjects were recruited between January and August 2021. Infiltration of intralesional SSG was given weekly to a maximum of six doses. However, when a patient's lesions were already cured before getting 6 doses, treatment was not conintued, and patient were only asked to come for lesion assessment. Skin slit smears (SSS) were taken each week until they became negative. Outcomes were assessed at day 90, with patients who had 100% reepithelization (for ulcerative lesions) and/or flattening (for indurated lesions) defined as cured. Multi-level logistic regression was done to assess factors associated with cure. A total of 83 patients were enrolled, and final outcomes were available for 72 (86.75%). From these 72, 43 (59.7%, 95% confidence interval 0.44-0.69) were cured at day 90. Adverse effects were common with 69/72 patients (95.8%) reporting injection site pain.

BMC Emergency Medicine, Jul 12, 2022

Introduction: For critically ill patients, mechanical ventilation is considered a pillar of respi... more Introduction: For critically ill patients, mechanical ventilation is considered a pillar of respiratory life support. The mortality of victims in intensive care units is high in resource-constrained Sub-Saharan African countries. The recovery and prognosis of mechanically ventilated victims are unknown, according to evidence. The goal of the study was to see how long critically ill patients on mechanical ventilation survived. Methods: A retrospective follow-up study was conducted. A total of 376 study medical charts were reviewed. Data was collected through reviewing medical charts. Data was entered into Epi-data manager version 4.6.0.4 and analyzed through Stata version 16. Descriptive analysis was performed. Kaplan-Meier survival estimates and log rank tests were performed. Cox proportional hazard model was undertaken. Results: Median recovery time was 15 days (IQR: 6-30) with a total recovery rate of 4.49 per 100 person-days. In cox proportional hazard regression,

F1000Research, Jun 28, 2022

Background: Implementation of recommended intrapartum care intervention varies across places due ... more Background: Implementation of recommended intrapartum care intervention varies across places due to contextual socio-cultural and behavioral determinants. Previous research has utilized several operationalizations to measure intrapartum intervention content and has failed to analyze provider and facility-related factors that influence intrapartum intervention content. So yet, no study has used intervention fidelity metrics to assess intrapartum care. Therefore, this study aimed at assessing institutional intrapartum care intervention fidelity & factors associated with it. Methods: On randomly selected keabeles (study sites), a crosssectional study design was used. All health posts and health extension workers within the specified area were included, as were 898 postnatal mothers within six months of delivery. Data was collected via an interview, self-administered questionnaires, and an observation checklist. To calculate the institutional delivery coverage and intrapartum care intervention fidelity, descriptive statistics were used. The weighted sum of all intrapartum care components and institutional delivery coverage were used to calculate intrapartum care intervention fidelity. The researchers utilized a multilevel linear regression analysis model to find characteristics linked to intrapartum care intervention fidelity. Results: In this study, institutional delivery coverage was 60.9% (95% CI: 57.7-64.1) with intrapartum care intervention fidelity of 35.6% (95% CI: 31.3-35.9). Moreover, only 21 (2.3%) of mothers received all of the contents of intrapartum care intervention. Health posts' distance from mothers' home, unskilled birth attendant, poor relationship Open Peer Review Approval Status AWAITING PEER REVIEW Any reports and responses or comments on the article can be found at the end of the article.

Research Square (Research Square), Oct 29, 2020

Background: Rendering focused antenatal care activities are directed at sustaining the maternal h... more Background: Rendering focused antenatal care activities are directed at sustaining the maternal health and improving the fetal wellbeing to ensure the delivery of a live healthy neonate. Failure to implement focused antenatal care package can results in inability to reduce maternal and neonatal morbidity and mortality, perinatal death and stillbirth in developing countries. However, due to evidence-practice gaps, thousands of maternal, fetal and neonatal lives are still losing every day mostly from preventable causes. This study aimed to assess focused antenatal care package intervention delity and its determinant factors in South Wollo Zone, Northeast Ethiopia. Methods: A cross-sectional study design was employed and a total of 898 women who gave birth in the last six months prior to data collection were included. Also 16 health extension workers, working in the selected 10 health posts for facility audits, were included. Interviews and self-administered questionnaires were used to collect data from mothers and health extension workers. Facilities (Health posts) were audited to assess availability and functionality of drugs and supplies in the health posts to provide focused antenatal care. Mothers were asked whether or not the required level of care was provided. Health extension workers were provided self-administered questionnaires to assess sociodemographic characteristics, reception of training, facilitation strategies and ability to classify danger signs. Multilevel linear regression analysis was performed to identify individual and organizational levels factors in uencing focused antenatal care package intervention delity. Results: Overall weighted average focused antenatal care package intervention delity (implemented as intended/planned) was 49.8% (0.498) (95% CI: 47.7-51.8); which means the average amount of focused antenatal care package intervention a mother received is 49.8% (0.498). Of which 55.1% was implemented by health extension workers and 44.9% by skilled providers (nurses, midwives, health o cers or medical doctors). Overall antenatal care coverage, irrespective of frequency (at least one visit), was 752 women (83.7%; 95% CI: 81.3-86.1); 263 women (35.0%; 95% CI: of 31.6-38.4) of them received at least four antenatal visits and 46 women (6.1%, 95% CI: 4.4-7.8) received all recommended components of focused antenatal care. Previous pregnancy-related problems, paternal education, and implementation of supportive/facilitation strategies were found to be signi cant factors enhancing focused antenatal care package intervention delity. Conclusion: Focused antenatal care package intervention delity in the study area was low; this may imply that the current level of maternal, perinatal, neonatal mortality and stillbirth might be partly due to the low level of focused antenatal care delity. Improving implementation of facilitation strategies is highly required to contribute to the reduction of those mortalities.

Research Square (Research Square), Sep 3, 2020

Background: Home and community-based implementation of focused antenatal care intervention packag... more Background: Home and community-based implementation of focused antenatal care intervention packages have signi cantly reduced neonatal mortality particularly in resource constrained settings. However, due to evidence-practice gaps, thousands of neonates are still losing their lives every day mostly from preventable causes. This study aimed to assess focused antenatal care package intervention delity and its determinant factors in South Wollo Zone, Northeast Ethiopia. Methods: A cross-sectional study design was employed and a total of 898 women who gave birth in the last six months prior to data collection were included. Also 16 health extension workers working in health posts and 10 health posts for facility audits were included. Interviews and self-administered questionnaires were used to collect data from mothers and health extension workers. Facility audits were used to assess availability and functionality of drugs and supplies in the health posts to provide focused antenatal care. Mothers were asked whether or not the required level of care was provided. Health extension workers were provided self-administered questionnaires to assess socio-demographic characteristics, reception of training, facilitation strategies and ability to classify danger signs. Multilevel linear regression analysis was performed to identify individual and organizational levels factors in uencing focused antenatal care package intervention delity. Results: Overall weighted average focused antenatal care package intervention delity (implemented as intended/planned) was 49.8% (95% CI: 47.7-51.8); of which 55.1% was implemented by health extension workers and 44.9% by skilled providers (nurses, midwives, health o cers or medical doctors). Overall antenatal care coverage, irrespective of frequency, was 83.7% (95% CI: 81.3-86.1); 35.0% (95% CI: of 31.6-38.4) of them received at least four antenatal visits and 46 (6.1%, 95% CI: 4.4-7.8) received all recommended components of focused antenatal care. Previous pregnancy-related medical problems, paternal education, and implementation of supportive/facilitation strategies were found to be signi cant factors enhancing focused antenatal care package intervention delity. Conclusion: Focused antenatal care package intervention delity in the study area was low; this may imply that stagnation of neonatal mortality reduction might be partly due to the low level of focused antenatal care delity. Improving implementation of facilitation strategies is highly required to contribute in neonatal mortality reduction.

Research Square (Research Square), Jan 8, 2021

Background: Focused antenatal care is directed at sustaining maternal health and improving fetal ... more Background: Focused antenatal care is directed at sustaining maternal health and improving fetal wellbeing to ensure birth of a healthy neonate. Failure to implement focused antenatal care can result in inability to reduce maternal and perinatal morbidity and mortality in low income countries. Due to evidence-practice gaps, however, thousands of maternal, fetal and neonatal lives are still lost every day, mostly from preventable causes. This study aimed to assess focused antenatal care package's intervention fidelity and its determinant factors in South Wollo Zone, Northeast Ethiopia. Methods: A cross-sectional study design was employed and a total of 898 women who gave birth in the last 6 months prior to data collection were included. Also 16 health extension workers, working in ten selected health posts, were included. Interviews and self-administered questionnaires were used to collect data from mothers and health extension workers. Ten [10] health posts were audited to assess availability and functionality of drugs and supplies to provide focused antenatal care. Mothers were asked whether or not the required level of care was provided. Health extension workers were provided with self-administered questionnaires to assess socio-demographic characteristics, reception of training, facilitation strategies for the implementation of focused antenatal care and ability to classify danger signs. Multilevel linear regression analysis was performed to identify individual and organizational level's factors influencing focused antenatal care package intervention fidelity. Results: Overall weighted average focused antenatal care package intervention fidelity (implemented as intended/ planned) was 49.8% (95% CI: 47.7-51.8), which means the average number of focused antenatal care package interventions women received is 49.8%. Health extension workers implemented 55.1% and skilled providers (nurses, midwives, health officers or medical doctors) 44.9% of focused antenatal care package interventions. Overall antenatal care coverage, irrespective of frequency (at least one visit), was 752/898 women (83.7%; 95% CI: 81.3-86.1); 263/752 women (35.0%; 95% CI: 31.6-38.4) received at least four antenatal visits and only 46/752 women (6.1%; 95% CI: 4.4-7.8) received all recommended components of focused antenatal care. Previous pregnancy-related problems, paternal education and implementation of facilitation strategies were found to be significant factors enhancing focused antenatal care package intervention fidelity.

International journal of scientific research, Jun 1, 2012

Background: KAP Study tells what people know about certain things, how they feel and how they beh... more Background: KAP Study tells what people know about certain things, how they feel and how they behave. Objective: To assess KAP & factors related to childhood eye diseases of Dale district. Method: Cross-sectional (quantitative & qualitative) methods. Hierarchal logistic regression (quantitative), multistage sampling (quantitative) design was employed. Result: Three-fourth of the respondents diagnose childhood eye disease by other individuals than health professionals, 52.92% of them either don't know or misunderstand the mode of transmission. Nearly half & 41.0% of mothers/caregivers misperceive that the risk is higher in poorer families & can be completely cured by praying. Two-third of children either received nothing or inappropriate medication. Conclusion: There were misunderstanding, misperception, malpractice and poor health seeking behavior of mothers/caregivers about childhood eye diseases. Marital & occupational status, source & time to fetch water, presence of animals in the near vicinity and waste disposal system are reasons. Awareness creation, tailored behavior change interventions are recommended.

BMC Pregnancy and Childbirth, Feb 19, 2021

13th World Congress on Public Health (April 23-27, 2012), Apr 24, 2012

ABSTRACT Introduction: The discovery of combined antiretroviral therapy was the turning point tha... more ABSTRACT Introduction: The discovery of combined antiretroviral therapy was the turning point that changed the outlook of AIDS from virtually a death sentence to a chronic manageable disease. Although field of HIV medicine rapidly changing, there is a lack of recent knowledge about the predictors of survival HIV infected patients taking HAART. Objective: Assessing the predictors of survival for patients taking highly active antiretroviral therapy. Methods: Retrospective three years follow up study was employed for randomly selected 436 HIV infected adult patients on HAART at Hawassa University referral hospital. Data was collected from the patients’ record by trained BSc. nurses using pretested and structured checklist. Kaplan-Meier and Cox proportional hazards model was used to estimate survival and to identify predictors respectively. Result: 257 (58.9%) study subjects were females and the median age of patients was 31years (IQR=27-39). one hundred ninety nine (45.6%) were ambulatory and bedridden in functional status, 413 (94.7%) were in stage III & IV at the initiation of ART and 285 (65.4%) were having CD4 cell count less than 200cells/µl. There were 52 deaths during follow up period, of which 32 (61.5%) & 42 (80.8%) were within the first three and six months of treatment initiation respectively. The cumulative probabilities of survival were 90%, 88%, 87.5% and 87% at 6, 12, 24 and 36 months respectively. Being male (HR=1.961), bedridden (HR=6.023), CD4 count below 50cells/µl (HR=3.388), not using chemoprophylaxis (HR=2.883) and hemoglobin level below 10mg/dl (HR=6.393) were statistically significant predictors of survival. Indicating that being male, bedridden, CD4 count less than 50cells/µl, not using chemoprophylaxis and hemoglobin level <10mg/dl will increase the risk of death of HIV infected patients taking ART with. Conclusion: Delayed initiation, being anemic, male sex and not taking chemoprophylaxis plays an important role in the survival of patients on HAART.

BMC Infectious Diseases, Oct 14, 2020

Background: HIV is a major public health issue, especially in developing countries. It is importa... more Background: HIV is a major public health issue, especially in developing countries. It is important to track and design successful intervention programs to explore the spatial pattern, distribution, and associated factors of HIV Seropositivity. This study therefore showed the spatial variation of HIV Seropositivity and related factors in Ethiopia. Methods: A total sample of 25,774 individual data collected from the 2016 EDHS data were primarily HIV biomarkers, IR, MR, and GPS. Spatial heterogeneity analysis was used with methods such as Morans I, Interpolation, and Kulldorff 's scan statistic. Spatial analysis was conducted using open source tools (QGIS, GeoDa, SaTScan). Multilevel logistic regression analysis was performed using Stata14 to identify HIV-associated factors. Finally, the AOR with a 95% confidence interval was used to report the mixed-effect logistic regression result in the full model.

Global journal for research analysis, Jun 15, 2012

Introduction: HIV/AIDS remains one of the most serious challenges to global public health for mor... more Introduction: HIV/AIDS remains one of the most serious challenges to global public health for more than 25 years. 15-24 aged people represent 45% new HIV infections worldwide. Objective: To assess risky sexual behaviors and related factors among students at secondary and tertiary level Hawassa, Ethiopia. Methods: cross-sectional study with stratified random sampling from1550 respondents. Results: 37.5 % had ever sex with the commonest time of preparatory level (33.2%) grades nine and ten (31.5%) with 6.5% of them initiated their first sex with commercial sex workers. 9.7% had paid sex, 13.4% with non regular partner and 34.8% of them had multiple sexual partners. 20% committed paid sexes without condom, 27.5% non regular partners who committed paid sex (47.3%) use it inconsistently. Summary: Condom non use is common with all types of partners. HIV Risk perception is very low. Behavioral change intervention on misperceptions, safe sexual practices should be more strengthened.

PLOS Global Public Health

Community-based newborn care (CBNC) has been implemented in Ethiopia across the maternal, neonata... more Community-based newborn care (CBNC) has been implemented in Ethiopia across the maternal, neonatal, and child health continuum of care with the goal of lowering newborn mortality. However, neonatal mortality rate in Ethiopian is among the highest in the world. Why neonatal mortality remains high in the face of such effective interventions is the issue. As a result, the authors claim that it is unknown whether the planned intervention is carried out effectively or not. The purpose of this study was to investigate the fidelity of community-based newborn care intervention and its implementation drivers. Multicenter community-based mixed method study was employed on 898 postpartum women, 16 health extension workers (HEWs) and 10 health posts to evaluate CBNC intervention fidelity. Structured questionnaire and facility audit checklist was used to collect quantitative data. In-depth interview technique was used to explore lived experiences of HEWs on CBNC implementation. CBNC intervention...

ecancermedicalscience, 2021

Background: Assessment of supportive care needs for cancer patients and identifying factors affec... more Background: Assessment of supportive care needs for cancer patients and identifying factors affecting these needs is important for the implementation of supportive care programmes, as the burden of cancer is increasing in Ethiopia.