Ayhan Dağdemir - Academia.edu (original) (raw)

Papers by Ayhan Dağdemir

Authorea (Authorea), Jan 31, 2024

Tumori Journal, Nov 1, 2007

Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon in children and adolescents but oc... more Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon in children and adolescents but occur more frequently in NF1 patients. Angiosarcomatous differentiation in MPNSTs is a rare entity with poor prognosis. We report on a 13-year-old boy with intrathoracic angiosarcoma arising in MPNST associated with NF1.

Journal of Experimental & Clinical Medicine, 2001

Analysis of The Cases With Henoch-Schonlein Vasculitis Henoch-Schonlein vasculitis is the most co... more Analysis of The Cases With Henoch-Schonlein Vasculitis Henoch-Schonlein vasculitis is the most common systemic vasculitis in children and it has a benign course and characterized purpura, arthritis and gastrointestinal and/or renal involvement. In this study we planned to analyze and compare of the clinical and laboratory characteristics of the patient with Henoch-Schonlein vasculitis with literature. We analyzed 135 cases with Henoch-Schonlein vasculitis, who.had been followed up at the departments of pediatrics of Ondokuz Mayis University and Gulhane Military Medical School between January 1993 and January 2000. retrospectively. Of the 135 patients, eighty (59.2%) were male and fifty-five (40.8%) were girl, and the median age was 9.5 years (10 months to 17 years). The distribution of the patients to Die season was as follows: 15% in spring. 18.5% in summer, 21.1% in autumn, and 45.4% in winter. The most complaints of admission were purpura (100%). abdominal pain (62%) and arthralgia (48.8%). There was a positive history of upper respiratory tract infection in the last month in 4.1.4% of the cases. On physical examination, purpura, arthritis, edema of the legs, fever and hypertension were, found in the 100%. 37.7%, 3-1.8%, 1 1%) and 5.9% of the cases, respectively. Gastrointestinal hemorrhage, renal involvement, and scrotal involvement were observed 29.6%, 55.5% and 7,4% of the cases, respectively. II was learned that one patient had been appendect.om.teed a month before. While the improvement lime has not been different between the cases with or without complication, microscopic hematuria continued 2 to 6 months in the patients who had renal involvement. Henoch-Schonlein purpura has a benign course and permanent complications resulted from organ involvement are very rare. Henoch-Schonlein vaskuliti, cocuklarda en sik gorulen sistemik vaskulit olup purpura. arlriL ve gastrointestinal ve/veya bobrek tutulumu ile karakterize selim seyirli bir hastaliktir. Bu calismada Henoch-Schonlein vaskuliti tanisi alan hastalarimizin klinik ve laboratuar bulgularini inceleyerek literatur bilgisi ile karsilastirilmasi planlandi. Bu cali-niada Ocak 1993 ile Ocak 2000 tarihleri arasinda Ondokuz Mayis Universitesi ve Gulhane Askeri Tip Akademisi Pediatri Anabilim Dallarinda Henoch-Schonlein vaskuliti tanisi almis 135 hasta retrospektif olarak gozden gecirildi. Hastalarin 80'i (%59.2) erkek. 55'i (%40.8) kiz olup, medyan yas 9.5 idi (10 ay - 17 yas arasi). Olgularin mevsimlere gore dagilimi: Ilkbahar %15, yaz %18.5. sonbahar %2 1.1 ve %45.4 kis. En sik basvuru sikayetleri dokuntu (%100), karin agrisi (%62) ve eklem agrisi (%48.8) idi. Fizik muayenede purpura, artrit, ayaklarda odem, ates ve hipertansiyon sirasiyla %100, %37.7, %31.8, %1 1 ve %5.9 oraninda bulundu. Hastalarin seyrinde gastrointestinal kanama, renal tutulum ve skrotal tutulum sirasiyla %29.6, %55.5 ve %7.4 oranlarinda saptandi. Bir hastanin bir ay once apendektomi gecirdigi ogrenildi. Organ tutulumu olan ve olmayan hastalarda iyilesme zamani farklilik gostermezken, renal tutulumu olan hastalarda mikroskobik hematini 2 ile 6 ay devam etli. Henoch-Schonlein vaskuliti selim seyiiii bir hastalik olup organ tutulumu sonucu kalici komplikasyonlar cok nadirdir.

Pediatric Neurology, Nov 1, 2006

Central nervous system involvement in Epstein-Barr virus infection usually presents as meningitis... more Central nervous system involvement in Epstein-Barr virus infection usually presents as meningitis, encephalitis, or encephalomyelitis, mostly in the acute form of the disease. In chronic active infection, the clinical situation may also resemble acute infection as well findings of chronic inflammation such as calcification. This report presents an 8-year-old female with chronic active Epstein-Barr virus infection and encephalitis complicated by increased intracranial pressure who was managed with repeated lumbar punctures and medical treatment including anti-edema and antiviral therapies.

Indian Journal of Pediatrics, Jun 19, 2023

Objectives To retrospectively compare the overall and event-free survival rates of patients with ... more Objectives To retrospectively compare the overall and event-free survival rates of patients with standard and high risk medulloblastoma who received postoperative radiotherapy (RT) followed by maintenance chemotherapy. Methods The study included 48 patients with medulloblastoma who were treated and followed-up between 2005 and 2021. Patients were classified according to the Chang classification because no molecular analysis was done. Immediately after surgery all patients received postoperative RT followed by eight cycles of chemotherapy (SIOP/UKCCSG PNET-3 protocol); if thrombocytopenia developed, carboplatin was replaced by cisplatin to avoid treatment delay. The clinical characteristics, risk categories and treatment outcomes of all patients were analyzed. Results The mean age of the 48 patients (26 males, 22 females) at diagnosis was 7.27±4.21 y. The median start time of RT after surgery was 37 (range 19-80) d. The median follow-up was 56 (3-216) mo. The 5-year event-free survival was 61.2±10% in the high-risk group and 82.5±11.5% in the standard-risk group. The 5-year overall survival was 73.2±7.1%; it was 61.2±10% and 92.9±6.9% for high-and standard-risk patients, respectively (p = 0.026). Conclusions The outcomes of patients who were started on the modified SIOP/UKCCSG PNET-3 chemotherapy protocol, in which RT was begun as soon as possible after surgery, were comparable to those of current treatment protocols. Although a definitive conclusion is difficult, given the limited number of patients in the present study, authors suggest that their treatment protocol is a viable option for centers with limited facilities (such as an inability to perform molecular analysis).

Selçuk Üniversitesi Tıp Fakültesi dergisi, Sep 1, 2022

Amaç: Bu çalışmada yüksek riskli pediatrik solid tümör hastalarında uyguladığımız otolog hematopo... more Amaç: Bu çalışmada yüksek riskli pediatrik solid tümör hastalarında uyguladığımız otolog hematopoietik kök hücre tedavisinin (OHKHT) etkinlik ve güvenilirliğini 12 yıllık tecrübemizle paylaşmayı amaçladık.

Türkiye parazitoloji dergisi, 2001

TURKISH JOURNAL OF MEDICAL SCIENCES, 2020

The main purpose of this study is to determine the current status of long-term follow-up (LTFU) f... more The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey. Material and methods: A questionnaire was e-mailed to the directors of 33 pediatric oncology centers (POCs) registered in the Turkish Pediatric Oncology Group (TPOG). Of these 33 active TPOG institutions, 21 participated in the study and returned their completed questionnaires. Results: Only 1 of the 21 participating centers had a separate LTFU clinic. The remaining centers provided LTFU care for childhood cancer survivors at the pediatric oncology outpatient clinic. Of these centers, 17 (80.9%) reported difficulty in transition from the pediatric clinic to the adult clinic, 14 (66.6%) reported insufficient care providers, and 12 (57.1%) reported insufficient time and transportation problems. As neglected late effects, 16 (76.1%) centers reported psychosocial and getty job problems and 11 (52.3%) reported sexual and cognitive problems. None of the centers had their own LTFU guidelines for their daily LTFU practice. Conclusion: This study was the first to gain an overview of the needs of POCs and the gaps in survivorship services in Turkey. The results from this study will help to develop a national health care system and national guidelines for pediatric cancer survivors.

Journal of Experimental & Clinical Medicine, 2007

Acute Infantile Hemorrhagic Edema: Case Report Acute infantile hemorrhagic edema is a rare benign... more Acute Infantile Hemorrhagic Edema: Case Report Acute infantile hemorrhagic edema is a rare benign leukcytoclastic vasculitis of childhood, usually seen under 2 two-year old, characterized by fever and purpuric rashes on face, ears and extremities. Most of the cases resolve spontaneously without any sequel. Cases of life-threatening and requiring emergent and intensive care, especially purpura fulminans and meningococcemia, should be thought in the differential diagnosis. We described here a 16-month old boy with acute infantile hemorrhagic edema. Akut infantil hemorajik odem genellikle iki yasindan kucuk cocuklarda gorulen ve klinik olarak ates, deride purpurik dokuntu, yuz, kulaklar ve ekstremitelerde odem ile karekterize, derinin nadir gorulen bir beniyn lokositoklastik vaskulitidir. Olgularin cogu sekel birakmaksizin spontan iyilesir. Ayirici tanida ozellikle purpura fulminans ve meningokosemi gibi hayati tehdit eden ve acil ve yogun tedavi yaklasimi gerektiren hastaliklar dusunu...

Journal of Experimental & Clinical Medicine, 2004

Rosai-Dorfman Hastaligi (RDH) etiyolojisi bilinmeyen, genellikle kendini sinirlayan kliniko-patol... more Rosai-Dorfman Hastaligi (RDH) etiyolojisi bilinmeyen, genellikle kendini sinirlayan kliniko-patolojik tablo olusturan nadir bir benign hastaliktir. Olgularin cogunlugunu lenfadenopati ve ekstranodal bolge tutulumu ile basvuran cocuklar ve genc eriskinler olusturur. Bu yazida servikal lenfadenopati ile birlikte orbita tutulumu olan 4 yasinda bir kiz hasta sunularak hastalik tartisilmistir. RDH'nin lenfadenopatiye yol acan diger benign ve malign hastaliklarin ayirici tanisinda dusunulmesi gerektigi vurgulanmis ve tedavi endikasyonlari belirtilmistir. Rosai-Dorfman Disease with Extranodal Involvement: A Case Report and Discussion Rosai-Dorfman Disease (RDD) is a rare, benign, generally self-limiting clinicopathological entity with unknown etiology. Most of the cases are children and young adults with lym-phadenopathy and extranodal involvement. Here we present a 4-year-old girl with cervical lymphadenopathy and orbital disease. RDD should be considered in the differential diagnosis...

European Urology Supplements, 2018

Diagnostic Pathology, 2020

Background Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive neoplasm seen in chi... more Background Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive neoplasm seen in children and young adults, usually manifested by involvement of abdominal serosa. Here, we present an unusual case of primary DSRCT of kidney. Case presentation The patient was an 8-year-old girl with a large renal mass which was confused with primitive neuroectodermal tumor (PNET) in the needle biopsy. The tumor had a variegated histology revealing frequent pseudo-rosette formations, pseudopapillary architecture, rhabdoid, clear or pleomorphic cells in addition to typical small round cell morphology and desmoplasia. It showed immunohistochemical features of DSRCT, and EWSR1 re-arrangement. Conclusions Proffering this diagnosis is particularly difficult for tumors of viscera because of the incognizance of the entity in these locations. Moreover, DSRCT is a great mimicker and may get easily confused with more common kidney malignancies of childhood such as Wilms tumor, PNET/EWS, rhabdoid tum...

Indian Pediatrics, 2018

Background: Infantile choriocarcinoma is usually fatal without appropriate treatment. Case charac... more Background: Infantile choriocarcinoma is usually fatal without appropriate treatment. Case characteristics: A 3-month-old boy who presented with respiratory distress, hepatomegaly, amemia and bilateral nodular lesions on chest X-ray. Observation: Fine-needle liver aspiration revealed necrotic tumour cells. The serum β-hCG level was very high (2057 mIU/ L), supporting a diagnosis of infantile choriocarcinoma of the liver. Surgical resection after cisplatin-based multiagent chemotherapy afforded successful remission. Message: Early treatment of infantile choriocarcinoma can yield a successful outcome.

Tumori Journal, 2009

Background Cytarabine (ARA-C) has been used for many years in the treatment of patients with leuk... more Background Cytarabine (ARA-C) has been used for many years in the treatment of patients with leukemia and lymphoma. Gastrointestinal ulceration and mucositis are two of the well-known side effects of ARA-C. We set out to investigate whether vitamin A (VA) can help prevent ARA-C-induced mucosal lesions in mice. Materials and methods Mice were divided into 5 groups. Group I (control group) received only saline; group II received ARA-C plus saline; group III received ARA-C plus VA; group IV received ARA-C plus a lipid solution, and group V received VA alone. VA (5000 IU/kg) was administered orally to the mice once daily for 7 days. ARA-C (3.6 mg) was administered intraperitoneally for 5 days to groups II, III and IV, starting on the third day of VA treatment. Intestinal segments from the proximal end of the jejunum of treated mice were isolated. Results There was improved mucosal integrity, less necrosis and increased villus length with advanced mucosal proliferation in crypts in the V...

International Archives of Clinical Pharmacology, 2016

Chloral hydrate is very frequently used in medical procedures with the purpose of sedation. After... more Chloral hydrate is very frequently used in medical procedures with the purpose of sedation. After oral or rectal administration, central nervous system (CNS) and respiratory depression, cardiac arrhythmia and gastric irritation are known as classical adverse effects. Although the adverse effects developing after enteral usage are well known, there are limited data in literature about the misuse of chloral hydrate oral solution intravenously and the adverse effects that may be seen after this usage. In this article, it is intended that chloral hydrate oral solution has been mistakenly administered intravenously and it is a fact that there isn't any seen complication except localized skin erythema.

Leukemia & Lymphoma, 1997

A nine-year old girl with T cell acute lymphoblastic leukemia (ALL) had acute severe neurologic c... more A nine-year old girl with T cell acute lymphoblastic leukemia (ALL) had acute severe neurologic complications at the end of the remission-induction chemotherapy course. Thirty-six hours following triple intrathecal (IT) therapy and intravenous (IV) administration of L-asparaginase (L-asp), tetraplegia developed and she became unconscious. She had bouts of hypertension and persistent tachycardia unresponsive to digitalis therapy. Magnetic resonance imaging (MRI) showed multiple brain white matter hyperintensities and filling defects in the saggital sinus, suggesting thrombosis. Over the 40 days, in addition to her neurologic compromise she also had transient diabetes mellitus, severe hyperlipidemia, hypoproteinemia and edema, liver and heart failure and staphylococcus aureus sepsis with prolonged bone marrow depression. Despite, coexistence of all these chemotherapy related complications, her neurologic functions and multiple organ failure improved gradually. After a 70 days' period of interruption, chemotherapy was resumed and continued without any further complications. Although, the etiology of her extensive sensitivity to some drugs remains unclear, we believe that it is important to document these unusual events in this child.

Leukemia & Lymphoma, 1998

Soluble L-selectin was determined in the CSF samples of 20 children with CNS leukemia at the time... more Soluble L-selectin was determined in the CSF samples of 20 children with CNS leukemia at the time they had blasts in CSF and/or clinical findings of CNS involvement; 17 CSF fluid samples were obtained from 17 of these 20 children, 29-91 days before the appearance of CSF cytological and/or clinical findings of CNS involvement; while 15 CSF samples were withdrawn from among the same group of children, after treatment of meningeal leukemia. In addition, CSF sL-selectin was also assayed in 17 children with ALL, who remained in complete remission at least for a year and, as controls, in 12 children without malignant or meningeal disorders. There was no significant difference in CSF sL-selectin levels between the children with ALL without evidence of meningeal involvement and the controls (1.34 +/- 0.21 ng/ml, 1.46 +/- 0.18 ng/ml respectively, p > 0.05). However, in children with CNS leukemia, not only at the time CNS involvement was diagnosed, but also 29-91 days before the diagnosis of CNS leukemia, the concentrations of the CSF sL-selectin (12.41 +/- 2.14 ng/ml, 7.70 +/- 1.60 ng/ml respectively) were significantly higher than those in controls (p < 0.001 and p < 0.01 respectively). After treatment and disappearance of the blasts in CSF, sL-selectin was found to be decreased and even normalized in the majority of children who had meningeal involvement (2.87 +/- 2.14 ng/ml). In 5 children, the CSF sL-selectin remained high, after the blasts in CSF had disappeared and CNS leukemia recurred within 3 months in 4 of these 5 children. In conclusion, assay of sL-selectin in CSF seems to be a good diagnostic tool in the detection of CNS involvement in children with ALL. This method may also be used as an indicator, in prediction of the CNS leukemia, which is going to develop.

Pediatric Blood & Cancer, 2006

The antiemetic efficacy of serotonin-type 3 (5-HT3) receptor antagonists has been found to be sup... more The antiemetic efficacy of serotonin-type 3 (5-HT3) receptor antagonists has been found to be superior to older antiemetic drugs in cancer patients. Following the administration of these agents, changes in ECG parameters and increased or decreased heart rates have been demonstrated, but there is no sufficient data in children with cancer who are treated with cytotoxic agents. The objective of this study is to evaluate the ECG changes after administration of 5-HT3 receptor antagonists and chemotherapeutic agents in children with cancer. Thirty-eight patients with an age range between 2 and 19 years receiving chemotherapy for solid tumors were included in the study. The patients received 5-HT3 receptor antagonists 30 min before antineoplastic agents in 83 chemotherapy days. Antiemetic therapy consisted of ondansetron in 43 and granisetron in 40 chemotherapy days. Twelve-leads ECGs were obtained four times at the first day of each chemotherapy: just before 30, 90 min, and 24 hr after 5-HT3 receptor antagonists were given. Rate, rhythm, PR interval, QRS duration, ST segment, the shortest (QTca) and the longest (QTcb) QTc intervals with QTc dispersion (QTcd) were all evaluated. We found a significant shortening of the PR interval and QRS complex durations in the granisetron group at 90th min and at 24th hr, respectively. Also, granisetron infusion caused a significant prolongation of the QTca interval at 90 min. Although we observed minor ECG changes after 5-HT3 receptor antagonists and chemotherapy, neither dangerous rhythm disturbances nor serious ECG changes were seen.