Aysin Akdogan - Academia.edu (original) (raw)

Papers by Aysin Akdogan

Research paper thumbnail of Do increased thyroid antibodies have any effect on first art cycles of euthyroid women?

Fertility and Sterility, 2007

TABLE. Characteristics of Donor Oocyte Cycles Clinical Pregnancy No Clinical Pregnancy Donor Age ... more TABLE. Characteristics of Donor Oocyte Cycles Clinical Pregnancy No Clinical Pregnancy Donor Age 28.0 AE 3.5 (160) 28.4 AE 3.2 (106) Age of Donor 21-25 (n ¼ 63) 42 (66.6%) 21 (33.3%) 26-30 (n ¼ 134) 79 (59.0%) 55 (41.0%) 31-35 (n ¼ 61) 33 (54.1%) 28 (45.9%) 36-42 (n ¼ 8) 6 (75.0%) 2 (25.0%) Recipient Age 43.3 AE 4.3 (160) 42.7 AE 4.7 (106) Stimulation Days 10.1 AE 1.3 (160) 10.1 AE 1.3 (106) Donor Stimulation Protocol FSH only (n ¼ 236) 136 (57.6%) 100 (42.4%) FSHþHMG/LH (n ¼ 29) 24 (82.8%) 5 (17.2%) Total IU 2042 AE 912 (145) 2097 AE 821 (97) Number of Follicles 20.5 AE 6.2 (160) 20.3 AE 7.0 (106) Oocytes Retrieved 20.9 AE 9.6 (160) 19.7 AE 8.8 (106) Fertilized Oocytes 12.0 AE 6.6 (160) 10.8 AE 7.3 (104) Transfer Stage* Cleavage (n ¼ 103) 48 (46.6%) 55 (53.4%) Blastocyst (n ¼ 161) 112 (69.6%) 49 (30.4%) Embryos Transferred 2.3 AE 0.5 (160) 2.5 AE 0.6 (93) Embryos Frozen 3.0 AE 3.6 (160) 3.0 AE 4.1 (104)

Research paper thumbnail of Does early follicular serum prolactin levels effect IVF cycle outcomes?

Fertility and Sterility, Sep 1, 2008

Early pregnancy villus gotten from mutiplefetal pregnancy reduction in ART revealed a methylation... more Early pregnancy villus gotten from mutiplefetal pregnancy reduction in ART revealed a methylation status at chromosome 15q11-13 identical to the methylation patterns in the normal control,we do not find assisted reproduction technology have effects on methylation status at chromosome 15q11-13. Supported by: National key basic research development plan of China.(2007CB948104).

Research paper thumbnail of Role of total antioxidant capacity and oxidative stress in fertilization and embryo selection in the IVF cycle

Cukurova Medical Journal

Purpose: This study aims to evaluate the oxidant and antioxidant parameters in follicular fluid a... more Purpose: This study aims to evaluate the oxidant and antioxidant parameters in follicular fluid and embryo culture medium in IVF cycles and investigate their effects on embryo quality, fertilization success, and pregnancy. Materials and Methods: Fifty-one patients who underwent IVF/ICSI were included in this prospective study. Two hundred sixty of a total of 454 follicular fluids and the cell culture media of transferred fifty-one embryos (one from each patient) were examined. Antioxidant activity (AOA), Trolox equivalent antioxidant capacity (TEAC), thiobarbiturate reactive substances (TBARS), ferric antioxidant power (FRAP), paraoxonase, nitrotyrosine were analyzed. Results: TBARS were significantly lower in the follicular fluid of fertilized oocytes than in non-fertilized oocytes (21 vs. 29.75 nmol/ml). There was no difference in terms of other parameters. TEAC levels were higher in oocytes in the agonist protocol group than in the antagonist protocol group. In terms of embryo qu...

Research paper thumbnail of In-Vitro Fertilization Outcome Predictors in Women With High Baseline Follicle-Stimulating Hormone Levels: Analysis of Over 1000 Cycles From A Tertiary Center

JBRA Assisted Reproduction

Objective: The present study aimed to evaluate reproductive outcomes and determine the predictors... more Objective: The present study aimed to evaluate reproductive outcomes and determine the predictors of clinical pregnancy and live birth in women with elevated baseline follicle-stimulating hormone (FSH) levels, who have undergone intracytoplasmic sperm injection (ICSI) treatment. Methods: This retrospective study included 1011 ICSI cycles of women with high baseline FSH levels (> 10 IU/L), from a tertiary university IVF center between 2010 and 2015. Logistic regression analysis was performed to evaluate the prognostic factors of clinical pregnancy and live birth. Results: Among the 1011 ICSI cycles, the clinical pregnancy and live birth rates per oocyte retrieval were 19.5% and 14.3%, respectively. The live birth rates were 21.1% and 1.7% in women aged ≤30 years and those aged ≥40 years, respectively. In addition, the live birth rate was 1.47-fold higher in women from whom >3 oocytes were retrieved, compared to those from whom ≤3 oocytes were retrieved (p=0.047). Logistic regression analysis indicated that the age categories ≤30y, 36-39y and ≥40y, level of baseline FSH (≥20 IU/L) and the ovarian response (≤3 or >3 oocytes retrieved) were significantly associated with live birth. Conclusions: Our study indicated that age, baseline FSH level, and ovarian response are independent predictive factors for clinical pregnancy and live birth among women with baseline FSH levels >10 IU/L.

Research paper thumbnail of Do serum Anti-Mullerian hormon levels associate with assisted reproductive treatment cycle outcomes? A retrospective analysis of 1544 cycles from a single IVF center

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi

Introduction: To evaluate whether there is a predictive value of serum Anti-Mullerian Hormone (AM... more Introduction: To evaluate whether there is a predictive value of serum Anti-Mullerian Hormone (AMH) levels on ovarian response and pregnancy outcomes of infertile women undergoing intracytoplasmic sperm injection (ICSI) cycle. Methods: A total of 1544 consecutive ICSI cycles of women aged between 18-45 years, performed in a single tertiary In-Vitro Fertilization (IVF) Center between 2015-2018, were retrospectively analyzed. Along with patients' ages and AMH levels, cycle characteristics, clinical pregnancy and live birth outcomes were evaluated. Age and serum AMH levels were categorized. Regression analyses were used to determine the predictive value of AMH on the ovarian response and clinical pregnancy/live birth outcomes. Results: Among 1544 cycles, 1306 (84.6%) were ended with an embryo transfer cyle. AMH levels were found significantly positively correlated with the numbers of obtained oocytes and 2-pronuclear(2pn) zygotes. AMH value of >1 ng/ml was significantly and independently associated with obtaining more than 5 oocytes (OR: 6.7; 95% CI: 4.9-9.1). The clinical pregnancy and live birth rates per cycle were significantly lower in patients with low AMH for both age <35 and above 35 years groups. However, live birth rates per embryo transfers were not significantly different(25.6% vs 32.8%, p=0.065 for women <35 years age and 17.8% vs 21.8%, p=0.273 for women >=35 years age). Moreover, only age and number of metaphase-2 oocytes were found significant independent predictors for live birth outcome.

Research paper thumbnail of A comparison of intravenous general anesthesia and paracervical block for in vitro fertilization: effects on oocytes using the transvaginal technique

Turkish Journal of Medical Sciences

Aim: To compare the eff ects of 2 diff erent anesthetic techniques used for oocyte retrieval. Com... more Aim: To compare the eff ects of 2 diff erent anesthetic techniques used for oocyte retrieval. Comparison was made based on the number of retrieved and fertilized oocytes, metaphase 2 (M2, mature) oocytes, and transferred embryos, as well as fertilization, pregnancy, and live birth rates. Ultrasound-guided transvaginal oocyte retrieval for in vitro fertilization is one of the most common minor surgical procedures. Despite this, it is stressful and painful for the patient; most patients request sedation and/or pain relief. Propofol, which is frequently used for general anesthesia in such procedures, has been suspected to damage oocytes. Materials and methods: Results from 70 patients without premedication were compared in this randomized prospective study. Patients were divided into 2 groups based on treatment. Th ose in Group G received intravenous general anesthesia with atropine (10 μg kg-1), remifentanil (1 μg kg-1), and propofol (2.5 mg kg-1), while patients in Group P received a paracervical block with 100 mg of prilocaine (2%) and 0.75 mg kg-1 of intramuscular meperidine. Results: Our results revealed no statistically signifi cant diff erence between the 2 groups in terms of the fertilization rate. Th e numbers of retrieved and mature oocytes and transferred embryos and the pregnancy rate were greater in the general anesthesia group, although only the number of transferred embryos showed a statistically signifi cant diff erence (P = 0.045). Conclusion: According to our data, both anesthesia techniques can be used for oocyte retrieval since there were no diff erences in fertilization, pregnancy, or live birth rates between the 2 groups.

Research paper thumbnail of Anormal Uterın Kanamalar

modern tıp kitapevi, 2017

Research paper thumbnail of İn Vitro Fertilizasyon / Embriyo Transferi Sonrası 45,XO Embriyonun Servikal Ektopik Gebeliği

Research paper thumbnail of Total antioxidant capacity and oxidative stress in follicular fluid and embryo cell culture media, their role in fertilization and embryo selection in IVF cycles

Objective: The aim of this study is to evaluate antioxidant parameters as well as levels of lipid... more Objective: The aim of this study is to evaluate antioxidant parameters as well as levels of lipid peroxidation, paraoxonase enzyme, and nitrotyrosine in the follicular fluid and embryo culture media among patients under IVF treatment. Material and methods: Fifty-one patients who underwent IVF / ICSI were enrolled in this prospective study at the IVF Center of University Hospital. A long agonist protocol was used in 22 cases for controlled ovarian stimulation, and an antagonist protocol was used in 29 cases. Two-hundred sixty follicular fluid samples from a total of 454 follicular fluids obtained from the cases and cell culture media of 51 transferred embryos (one from each case) were examined. Follicle fluids and embryo cell culture media were divided into groups according to oocyte fertilization, the protocol applied, the day of transfer, the quality of the embryos obtained and whether pregnancy was achieved. medium obtained from 51 individually cultured embryos and investigating t...

Research paper thumbnail of Ligneous Cervicovaginitis Associated with Plasminogen Deficiency: A Rare Cause of Infertility

International Journal of Hematology and Oncology, 2015

Research paper thumbnail of Servi̇kal Yetmezli̇k Tedavi̇si̇nde Serklajin Yeri̇

Bu calismada, servikal yetmezlik tanisi almis infertil olgularda serklaj operasyonunun gebelik so... more Bu calismada, servikal yetmezlik tanisi almis infertil olgularda serklaj operasyonunun gebelik sonuclari uzerine etkilerinin tanimlanmasi amaclanmistir. Calismaya Ege Universitesi Rektorlugu Aile Planlamasi Kisirlik Arastirma Uygulama Merkezine infertilitesi nedeniyle basvurmus ve servikal yetmezlik tanisi alarak gebeligi sirasinda serklaj operasyonu uygulanmis olan olgular dahil edilmis ve soz konusu hastalarin gebelik sonuclari incelenmistir. Arastirmanin sonunda infertil olgularda servikal yetmezlik tedavisinde serklajin erken dogum yonunden alinabilecek etkin bir tedbir oldugu sonucuna varilmistir.

Research paper thumbnail of Kısım III ıvf , Bölüm 36 . IVF ve Genetik

Research paper thumbnail of Evaluation of Preimplantation Genetic Aneuploidy Screening Cases at a Reference Genetics Center: 10 Years' Experience

Genetic counseling, 2016

The aim of this study is to review and evaluate our preimplantation genetic screening (PGS) recor... more The aim of this study is to review and evaluate our preimplantation genetic screening (PGS) records in terms of their demographic data, indications, cytogenetic results, pregnancy outcomes and discuss these findings in different aspects. PGS was performed in a total of 84 couples (87 cycles) between the period 2005 to 2015. Biopsied blastomeres from embryos on day 3 were fixed and fluorescence in situ hybridization was carried out for chromosomes 13, 16, 18, 21, 22, X and Y depending on the indication. The diagnostic and clinical data were retrospectively evaluated. A total of 450 blastomeres were biopsied. Ninety-eight of them were found to be suitable for transfer. They were transferred to 72 patients in 75 cycles resulting in 23 pregnancies and 20 healthy births. The most common indication was unexplained infertility. The implantation rate was calculated as 23.4% whereas the take-home baby rate was 26.6% per transfer. The highest rate of healthy living births is achieved in patie...

Research paper thumbnail of Evaluating the role of endometrial colour Doppler dynamic tissue perfusion measurements in in vitro fertilisation success

Journal of Obstetrics and Gynaecology, 2021

The role of uterine receptivity and endometrial perfusion in in vitro fertilisation (IVF) remains... more The role of uterine receptivity and endometrial perfusion in in vitro fertilisation (IVF) remains unclear. In our prospective pilot study, we used a new dynamic tissue perfusion measurement method to evaluate this relationship in humans. A standard ovulation induction and embryo transfer method were applied to all the volunteers. On the day of embryo transfer, dynamic images of the uterus were recorded using colour Doppler ultrasound, and these images were uploaded onto PixelFlux Chameleon Software (GmbH, Münster, Germany). After determining the region of interest (ROI), the average velocity, intensity, and area values for all coloured pixels in the ROI, the tissue resistance index (RI) and the tissue pulsatility index were calculated. Endometrial thickness, morphology and dynamic endometrial perfusion parameters were compared between the clinically pregnant and non-pregnant groups. Endometrial thickness, morphology values and endometrial dynamic tissue perfusion measurements were similar between the groups. This study compared perfusion parameters between clinically pregnant and non-pregnant patients by accurately calculating endometrial tissue perfusion using standard software to establish its relationship with implantation success in IVF treatment.IMPACT STATEMENTWhat is already known about this subject? The relationship between IVF success, endometrial receptivity and perfusion is known. Clear valuations of endometrial receptivity require an endometrial biopsy which may cause endometrial damage to the actual IVF cycle. This problem has led researchers to conduct non-interventional studies. Studies have revealed the value of endometrial thickness, pattern and Doppler examination of endometrial uterine arteries in predicting the success of IVF treatment.What do the results of this study add? This prospective pilot study is the first one to use this programme in humans to evaluate uterine receptivity in IVF. Successful results can be obtained by using computer programmes in tissues where perfusion parameters cannot be measured using traditional colour Doppler ultrasonography. Revealing the relationship between tissue perfusion and IVF success will be more effective and accurate with the development of software technologies.What are the implications of these findings for clinical practice and/or further research? To increase the success of IVF treatment, current and new technological developments, as well as imaging methods should continue to be tested.

Research paper thumbnail of Cervical Ectopic Pregnancy of 45,XO Embryo After In Vitro Fertilization/Embryo Transfer

Türk Üreme Tıbbı ve Cerrahisi Dergisi, 2017

ervical pregnancy is usually considered as a life threatening event. It is a rare form of ectopic... more ervical pregnancy is usually considered as a life threatening event. It is a rare form of ectopic gestation and accounts for less than 1% of all pregnancies. 1 Cervical pregnancy was defined as implantation of the gestation in the endocervical canal. The incidence is approximately 1 in 2500-12000 pregnancies. 2 It is a well known complication of ART procedures. Early diagnosis is important and allows conservative treatment option to preserve fertility. Hysterectomy was the only treatment for cervical pregnancy in the past. 2 Current treatment modalities include aspiration curettage with hypogastric/uterine artery embolization, curettage and local prostoglandin injection, insertion of foley catheter in the cervical canal after curettage , local administration of methotrexate (MTX) with/without local potassium chloride, systemic administration of MTX and hysterescopic resection of the gestation in conjuction with uterine artery embolization. 3-5 Early diagnosis is important to prevent serious complications such as

Research paper thumbnail of Ovulation Induction in Intrauterine Insemination Cycles

Türk Üreme Tıbbı ve Cerrahisi Dergisi, 2017

Etkinliği konusundaki tartışmalara rağmen IUI, seçilmiş çiftlerde infertilite tedavisinde sıklıkl... more Etkinliği konusundaki tartışmalara rağmen IUI, seçilmiş çiftlerde infertilite tedavisinde sıklıkla uygulanan bir yöntemdir. IUI başarısı birçok faktöre bağlıdır. Gebelik oranlarında artış sağlamak için sıklıkla ovaryan stimülasyonla kombine edilmektedir. Değişik ovulasyon indüksiyon ajanları bu amaçla kullanılabilinir. Bu yaklaşımın mantığı, bazı hafif ovulatuar problemlerin düzeltilmesi, fertilizasyon şansının artırılması ve IUI zamanlamasının doğru yapılmasıdır. Ovulasyon indüksiyonuna gereksinim olduğunda, çoğul gebelik ve ovaryan hiperstimülasyon sendromundan kaçınmak için minimal stimülasyon rejimleri kullanılmalıdır.

Research paper thumbnail of The Influence of the Number of Retrived Oocytes on Pregnancy Rates in IVF Cycles

Türk Üreme Tıbbı ve Cerrahisi Dergisi, 2017

Bu yazıda tüpbebek uygulamalarında gebelik elde etmek için elde edilmesi gereken optimum oosit sa... more Bu yazıda tüpbebek uygulamalarında gebelik elde etmek için elde edilmesi gereken optimum oosit sayısı ve elde edilen oosit sayısının farklı yaş gruplarında başarıya etkisi araştırıldı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Ege Üniversitesi Aile Planlaması ve Kısırlık Araştırma ve Uygulama Merkezinde 2008-2013 yılları arasındaki 6405 IVF siklusu retrospektif olarak tarandı. Tüm sikluslar yaş gruplarına göre 30 yaş altı (n:1870), 30-34 (n:2074), 35-39 (n:1920) ve 40 (n:541) yaş üstü olarak 4 gruba ayrıldı. Temel özellikleri, tedaviye cevap ve sonuçlar kaydedildi. B Bu ul lg gu ul la ar r: : Yaşla birlikte kullanılan ilaç dozu artmakta, indüksiyon süresi uzamakta ve oosit sayısı azalmaktadır.yaş grupları elde edilen oositler açısından karşılaştırıldığında <5 oosit elde edilenlerde yaştan bağımsız gebelik başarısı düşüktür. ≥20 oositte ovarian hiperstimülasyon riski nedeniyle transfer iptalleri artmaktadır. S So on nu uç ç: : Elde edilen 10-15 oosit aralığı başarı ve yan etki açısından en avantajlı görünen sayı olarak değerlendirilmiştir.

Research paper thumbnail of Ovulasyon İndüksiyonunda Gonadotropinler

Turkiye Klinikleri Journal of Gynecology and Obstetrics Special Topics, 2012

Research paper thumbnail of Yardımcı Üreme Teknikleri Öncesi Cerrahi

Turkiye Klinikleri Journal of Gynecology and Obstetrics Special Topics, 2013

Research paper thumbnail of Screening for Hepatitis and Viral Infections in a Significant Risk Group

Mediterranean Journal of Infection Microbes and Antimicrobials, 2014

Özellikle yüksek riskli popülasyonlarda, sağlık kuruluşlarına yapılan her başvuru, viral enfeksiy... more Özellikle yüksek riskli popülasyonlarda, sağlık kuruluşlarına yapılan her başvuru, viral enfeksiyonların tespiti için iyi değerlendirilmesi ve fırsat bilinmesi gereken bir durumdur. Gebelik planlayan kişilerde de, viral hepatit ve TORCH enfeksiyonları için serolojik testlerin değerlendirilmesi gerekir. Bu nedenle hastanemizde in vitro fertilizasyon programına alınan hastalarda bazı enfeksiyon etkenlerinin taranmasını amaçladık.

Research paper thumbnail of Do increased thyroid antibodies have any effect on first art cycles of euthyroid women?

Fertility and Sterility, 2007

TABLE. Characteristics of Donor Oocyte Cycles Clinical Pregnancy No Clinical Pregnancy Donor Age ... more TABLE. Characteristics of Donor Oocyte Cycles Clinical Pregnancy No Clinical Pregnancy Donor Age 28.0 AE 3.5 (160) 28.4 AE 3.2 (106) Age of Donor 21-25 (n ¼ 63) 42 (66.6%) 21 (33.3%) 26-30 (n ¼ 134) 79 (59.0%) 55 (41.0%) 31-35 (n ¼ 61) 33 (54.1%) 28 (45.9%) 36-42 (n ¼ 8) 6 (75.0%) 2 (25.0%) Recipient Age 43.3 AE 4.3 (160) 42.7 AE 4.7 (106) Stimulation Days 10.1 AE 1.3 (160) 10.1 AE 1.3 (106) Donor Stimulation Protocol FSH only (n ¼ 236) 136 (57.6%) 100 (42.4%) FSHþHMG/LH (n ¼ 29) 24 (82.8%) 5 (17.2%) Total IU 2042 AE 912 (145) 2097 AE 821 (97) Number of Follicles 20.5 AE 6.2 (160) 20.3 AE 7.0 (106) Oocytes Retrieved 20.9 AE 9.6 (160) 19.7 AE 8.8 (106) Fertilized Oocytes 12.0 AE 6.6 (160) 10.8 AE 7.3 (104) Transfer Stage* Cleavage (n ¼ 103) 48 (46.6%) 55 (53.4%) Blastocyst (n ¼ 161) 112 (69.6%) 49 (30.4%) Embryos Transferred 2.3 AE 0.5 (160) 2.5 AE 0.6 (93) Embryos Frozen 3.0 AE 3.6 (160) 3.0 AE 4.1 (104)

Research paper thumbnail of Does early follicular serum prolactin levels effect IVF cycle outcomes?

Fertility and Sterility, Sep 1, 2008

Early pregnancy villus gotten from mutiplefetal pregnancy reduction in ART revealed a methylation... more Early pregnancy villus gotten from mutiplefetal pregnancy reduction in ART revealed a methylation status at chromosome 15q11-13 identical to the methylation patterns in the normal control,we do not find assisted reproduction technology have effects on methylation status at chromosome 15q11-13. Supported by: National key basic research development plan of China.(2007CB948104).

Research paper thumbnail of Role of total antioxidant capacity and oxidative stress in fertilization and embryo selection in the IVF cycle

Cukurova Medical Journal

Purpose: This study aims to evaluate the oxidant and antioxidant parameters in follicular fluid a... more Purpose: This study aims to evaluate the oxidant and antioxidant parameters in follicular fluid and embryo culture medium in IVF cycles and investigate their effects on embryo quality, fertilization success, and pregnancy. Materials and Methods: Fifty-one patients who underwent IVF/ICSI were included in this prospective study. Two hundred sixty of a total of 454 follicular fluids and the cell culture media of transferred fifty-one embryos (one from each patient) were examined. Antioxidant activity (AOA), Trolox equivalent antioxidant capacity (TEAC), thiobarbiturate reactive substances (TBARS), ferric antioxidant power (FRAP), paraoxonase, nitrotyrosine were analyzed. Results: TBARS were significantly lower in the follicular fluid of fertilized oocytes than in non-fertilized oocytes (21 vs. 29.75 nmol/ml). There was no difference in terms of other parameters. TEAC levels were higher in oocytes in the agonist protocol group than in the antagonist protocol group. In terms of embryo qu...

Research paper thumbnail of In-Vitro Fertilization Outcome Predictors in Women With High Baseline Follicle-Stimulating Hormone Levels: Analysis of Over 1000 Cycles From A Tertiary Center

JBRA Assisted Reproduction

Objective: The present study aimed to evaluate reproductive outcomes and determine the predictors... more Objective: The present study aimed to evaluate reproductive outcomes and determine the predictors of clinical pregnancy and live birth in women with elevated baseline follicle-stimulating hormone (FSH) levels, who have undergone intracytoplasmic sperm injection (ICSI) treatment. Methods: This retrospective study included 1011 ICSI cycles of women with high baseline FSH levels (> 10 IU/L), from a tertiary university IVF center between 2010 and 2015. Logistic regression analysis was performed to evaluate the prognostic factors of clinical pregnancy and live birth. Results: Among the 1011 ICSI cycles, the clinical pregnancy and live birth rates per oocyte retrieval were 19.5% and 14.3%, respectively. The live birth rates were 21.1% and 1.7% in women aged ≤30 years and those aged ≥40 years, respectively. In addition, the live birth rate was 1.47-fold higher in women from whom >3 oocytes were retrieved, compared to those from whom ≤3 oocytes were retrieved (p=0.047). Logistic regression analysis indicated that the age categories ≤30y, 36-39y and ≥40y, level of baseline FSH (≥20 IU/L) and the ovarian response (≤3 or >3 oocytes retrieved) were significantly associated with live birth. Conclusions: Our study indicated that age, baseline FSH level, and ovarian response are independent predictive factors for clinical pregnancy and live birth among women with baseline FSH levels >10 IU/L.

Research paper thumbnail of Do serum Anti-Mullerian hormon levels associate with assisted reproductive treatment cycle outcomes? A retrospective analysis of 1544 cycles from a single IVF center

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi

Introduction: To evaluate whether there is a predictive value of serum Anti-Mullerian Hormone (AM... more Introduction: To evaluate whether there is a predictive value of serum Anti-Mullerian Hormone (AMH) levels on ovarian response and pregnancy outcomes of infertile women undergoing intracytoplasmic sperm injection (ICSI) cycle. Methods: A total of 1544 consecutive ICSI cycles of women aged between 18-45 years, performed in a single tertiary In-Vitro Fertilization (IVF) Center between 2015-2018, were retrospectively analyzed. Along with patients' ages and AMH levels, cycle characteristics, clinical pregnancy and live birth outcomes were evaluated. Age and serum AMH levels were categorized. Regression analyses were used to determine the predictive value of AMH on the ovarian response and clinical pregnancy/live birth outcomes. Results: Among 1544 cycles, 1306 (84.6%) were ended with an embryo transfer cyle. AMH levels were found significantly positively correlated with the numbers of obtained oocytes and 2-pronuclear(2pn) zygotes. AMH value of >1 ng/ml was significantly and independently associated with obtaining more than 5 oocytes (OR: 6.7; 95% CI: 4.9-9.1). The clinical pregnancy and live birth rates per cycle were significantly lower in patients with low AMH for both age <35 and above 35 years groups. However, live birth rates per embryo transfers were not significantly different(25.6% vs 32.8%, p=0.065 for women <35 years age and 17.8% vs 21.8%, p=0.273 for women >=35 years age). Moreover, only age and number of metaphase-2 oocytes were found significant independent predictors for live birth outcome.

Research paper thumbnail of A comparison of intravenous general anesthesia and paracervical block for in vitro fertilization: effects on oocytes using the transvaginal technique

Turkish Journal of Medical Sciences

Aim: To compare the eff ects of 2 diff erent anesthetic techniques used for oocyte retrieval. Com... more Aim: To compare the eff ects of 2 diff erent anesthetic techniques used for oocyte retrieval. Comparison was made based on the number of retrieved and fertilized oocytes, metaphase 2 (M2, mature) oocytes, and transferred embryos, as well as fertilization, pregnancy, and live birth rates. Ultrasound-guided transvaginal oocyte retrieval for in vitro fertilization is one of the most common minor surgical procedures. Despite this, it is stressful and painful for the patient; most patients request sedation and/or pain relief. Propofol, which is frequently used for general anesthesia in such procedures, has been suspected to damage oocytes. Materials and methods: Results from 70 patients without premedication were compared in this randomized prospective study. Patients were divided into 2 groups based on treatment. Th ose in Group G received intravenous general anesthesia with atropine (10 μg kg-1), remifentanil (1 μg kg-1), and propofol (2.5 mg kg-1), while patients in Group P received a paracervical block with 100 mg of prilocaine (2%) and 0.75 mg kg-1 of intramuscular meperidine. Results: Our results revealed no statistically signifi cant diff erence between the 2 groups in terms of the fertilization rate. Th e numbers of retrieved and mature oocytes and transferred embryos and the pregnancy rate were greater in the general anesthesia group, although only the number of transferred embryos showed a statistically signifi cant diff erence (P = 0.045). Conclusion: According to our data, both anesthesia techniques can be used for oocyte retrieval since there were no diff erences in fertilization, pregnancy, or live birth rates between the 2 groups.

Research paper thumbnail of Anormal Uterın Kanamalar

modern tıp kitapevi, 2017

Research paper thumbnail of İn Vitro Fertilizasyon / Embriyo Transferi Sonrası 45,XO Embriyonun Servikal Ektopik Gebeliği

Research paper thumbnail of Total antioxidant capacity and oxidative stress in follicular fluid and embryo cell culture media, their role in fertilization and embryo selection in IVF cycles

Objective: The aim of this study is to evaluate antioxidant parameters as well as levels of lipid... more Objective: The aim of this study is to evaluate antioxidant parameters as well as levels of lipid peroxidation, paraoxonase enzyme, and nitrotyrosine in the follicular fluid and embryo culture media among patients under IVF treatment. Material and methods: Fifty-one patients who underwent IVF / ICSI were enrolled in this prospective study at the IVF Center of University Hospital. A long agonist protocol was used in 22 cases for controlled ovarian stimulation, and an antagonist protocol was used in 29 cases. Two-hundred sixty follicular fluid samples from a total of 454 follicular fluids obtained from the cases and cell culture media of 51 transferred embryos (one from each case) were examined. Follicle fluids and embryo cell culture media were divided into groups according to oocyte fertilization, the protocol applied, the day of transfer, the quality of the embryos obtained and whether pregnancy was achieved. medium obtained from 51 individually cultured embryos and investigating t...

Research paper thumbnail of Ligneous Cervicovaginitis Associated with Plasminogen Deficiency: A Rare Cause of Infertility

International Journal of Hematology and Oncology, 2015

Research paper thumbnail of Servi̇kal Yetmezli̇k Tedavi̇si̇nde Serklajin Yeri̇

Bu calismada, servikal yetmezlik tanisi almis infertil olgularda serklaj operasyonunun gebelik so... more Bu calismada, servikal yetmezlik tanisi almis infertil olgularda serklaj operasyonunun gebelik sonuclari uzerine etkilerinin tanimlanmasi amaclanmistir. Calismaya Ege Universitesi Rektorlugu Aile Planlamasi Kisirlik Arastirma Uygulama Merkezine infertilitesi nedeniyle basvurmus ve servikal yetmezlik tanisi alarak gebeligi sirasinda serklaj operasyonu uygulanmis olan olgular dahil edilmis ve soz konusu hastalarin gebelik sonuclari incelenmistir. Arastirmanin sonunda infertil olgularda servikal yetmezlik tedavisinde serklajin erken dogum yonunden alinabilecek etkin bir tedbir oldugu sonucuna varilmistir.

Research paper thumbnail of Kısım III ıvf , Bölüm 36 . IVF ve Genetik

Research paper thumbnail of Evaluation of Preimplantation Genetic Aneuploidy Screening Cases at a Reference Genetics Center: 10 Years' Experience

Genetic counseling, 2016

The aim of this study is to review and evaluate our preimplantation genetic screening (PGS) recor... more The aim of this study is to review and evaluate our preimplantation genetic screening (PGS) records in terms of their demographic data, indications, cytogenetic results, pregnancy outcomes and discuss these findings in different aspects. PGS was performed in a total of 84 couples (87 cycles) between the period 2005 to 2015. Biopsied blastomeres from embryos on day 3 were fixed and fluorescence in situ hybridization was carried out for chromosomes 13, 16, 18, 21, 22, X and Y depending on the indication. The diagnostic and clinical data were retrospectively evaluated. A total of 450 blastomeres were biopsied. Ninety-eight of them were found to be suitable for transfer. They were transferred to 72 patients in 75 cycles resulting in 23 pregnancies and 20 healthy births. The most common indication was unexplained infertility. The implantation rate was calculated as 23.4% whereas the take-home baby rate was 26.6% per transfer. The highest rate of healthy living births is achieved in patie...

Research paper thumbnail of Evaluating the role of endometrial colour Doppler dynamic tissue perfusion measurements in in vitro fertilisation success

Journal of Obstetrics and Gynaecology, 2021

The role of uterine receptivity and endometrial perfusion in in vitro fertilisation (IVF) remains... more The role of uterine receptivity and endometrial perfusion in in vitro fertilisation (IVF) remains unclear. In our prospective pilot study, we used a new dynamic tissue perfusion measurement method to evaluate this relationship in humans. A standard ovulation induction and embryo transfer method were applied to all the volunteers. On the day of embryo transfer, dynamic images of the uterus were recorded using colour Doppler ultrasound, and these images were uploaded onto PixelFlux Chameleon Software (GmbH, Münster, Germany). After determining the region of interest (ROI), the average velocity, intensity, and area values for all coloured pixels in the ROI, the tissue resistance index (RI) and the tissue pulsatility index were calculated. Endometrial thickness, morphology and dynamic endometrial perfusion parameters were compared between the clinically pregnant and non-pregnant groups. Endometrial thickness, morphology values and endometrial dynamic tissue perfusion measurements were similar between the groups. This study compared perfusion parameters between clinically pregnant and non-pregnant patients by accurately calculating endometrial tissue perfusion using standard software to establish its relationship with implantation success in IVF treatment.IMPACT STATEMENTWhat is already known about this subject? The relationship between IVF success, endometrial receptivity and perfusion is known. Clear valuations of endometrial receptivity require an endometrial biopsy which may cause endometrial damage to the actual IVF cycle. This problem has led researchers to conduct non-interventional studies. Studies have revealed the value of endometrial thickness, pattern and Doppler examination of endometrial uterine arteries in predicting the success of IVF treatment.What do the results of this study add? This prospective pilot study is the first one to use this programme in humans to evaluate uterine receptivity in IVF. Successful results can be obtained by using computer programmes in tissues where perfusion parameters cannot be measured using traditional colour Doppler ultrasonography. Revealing the relationship between tissue perfusion and IVF success will be more effective and accurate with the development of software technologies.What are the implications of these findings for clinical practice and/or further research? To increase the success of IVF treatment, current and new technological developments, as well as imaging methods should continue to be tested.

Research paper thumbnail of Cervical Ectopic Pregnancy of 45,XO Embryo After In Vitro Fertilization/Embryo Transfer

Türk Üreme Tıbbı ve Cerrahisi Dergisi, 2017

ervical pregnancy is usually considered as a life threatening event. It is a rare form of ectopic... more ervical pregnancy is usually considered as a life threatening event. It is a rare form of ectopic gestation and accounts for less than 1% of all pregnancies. 1 Cervical pregnancy was defined as implantation of the gestation in the endocervical canal. The incidence is approximately 1 in 2500-12000 pregnancies. 2 It is a well known complication of ART procedures. Early diagnosis is important and allows conservative treatment option to preserve fertility. Hysterectomy was the only treatment for cervical pregnancy in the past. 2 Current treatment modalities include aspiration curettage with hypogastric/uterine artery embolization, curettage and local prostoglandin injection, insertion of foley catheter in the cervical canal after curettage , local administration of methotrexate (MTX) with/without local potassium chloride, systemic administration of MTX and hysterescopic resection of the gestation in conjuction with uterine artery embolization. 3-5 Early diagnosis is important to prevent serious complications such as

Research paper thumbnail of Ovulation Induction in Intrauterine Insemination Cycles

Türk Üreme Tıbbı ve Cerrahisi Dergisi, 2017

Etkinliği konusundaki tartışmalara rağmen IUI, seçilmiş çiftlerde infertilite tedavisinde sıklıkl... more Etkinliği konusundaki tartışmalara rağmen IUI, seçilmiş çiftlerde infertilite tedavisinde sıklıkla uygulanan bir yöntemdir. IUI başarısı birçok faktöre bağlıdır. Gebelik oranlarında artış sağlamak için sıklıkla ovaryan stimülasyonla kombine edilmektedir. Değişik ovulasyon indüksiyon ajanları bu amaçla kullanılabilinir. Bu yaklaşımın mantığı, bazı hafif ovulatuar problemlerin düzeltilmesi, fertilizasyon şansının artırılması ve IUI zamanlamasının doğru yapılmasıdır. Ovulasyon indüksiyonuna gereksinim olduğunda, çoğul gebelik ve ovaryan hiperstimülasyon sendromundan kaçınmak için minimal stimülasyon rejimleri kullanılmalıdır.

Research paper thumbnail of The Influence of the Number of Retrived Oocytes on Pregnancy Rates in IVF Cycles

Türk Üreme Tıbbı ve Cerrahisi Dergisi, 2017

Bu yazıda tüpbebek uygulamalarında gebelik elde etmek için elde edilmesi gereken optimum oosit sa... more Bu yazıda tüpbebek uygulamalarında gebelik elde etmek için elde edilmesi gereken optimum oosit sayısı ve elde edilen oosit sayısının farklı yaş gruplarında başarıya etkisi araştırıldı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Ege Üniversitesi Aile Planlaması ve Kısırlık Araştırma ve Uygulama Merkezinde 2008-2013 yılları arasındaki 6405 IVF siklusu retrospektif olarak tarandı. Tüm sikluslar yaş gruplarına göre 30 yaş altı (n:1870), 30-34 (n:2074), 35-39 (n:1920) ve 40 (n:541) yaş üstü olarak 4 gruba ayrıldı. Temel özellikleri, tedaviye cevap ve sonuçlar kaydedildi. B Bu ul lg gu ul la ar r: : Yaşla birlikte kullanılan ilaç dozu artmakta, indüksiyon süresi uzamakta ve oosit sayısı azalmaktadır.yaş grupları elde edilen oositler açısından karşılaştırıldığında <5 oosit elde edilenlerde yaştan bağımsız gebelik başarısı düşüktür. ≥20 oositte ovarian hiperstimülasyon riski nedeniyle transfer iptalleri artmaktadır. S So on nu uç ç: : Elde edilen 10-15 oosit aralığı başarı ve yan etki açısından en avantajlı görünen sayı olarak değerlendirilmiştir.

Research paper thumbnail of Ovulasyon İndüksiyonunda Gonadotropinler

Turkiye Klinikleri Journal of Gynecology and Obstetrics Special Topics, 2012

Research paper thumbnail of Yardımcı Üreme Teknikleri Öncesi Cerrahi

Turkiye Klinikleri Journal of Gynecology and Obstetrics Special Topics, 2013

Research paper thumbnail of Screening for Hepatitis and Viral Infections in a Significant Risk Group

Mediterranean Journal of Infection Microbes and Antimicrobials, 2014

Özellikle yüksek riskli popülasyonlarda, sağlık kuruluşlarına yapılan her başvuru, viral enfeksiy... more Özellikle yüksek riskli popülasyonlarda, sağlık kuruluşlarına yapılan her başvuru, viral enfeksiyonların tespiti için iyi değerlendirilmesi ve fırsat bilinmesi gereken bir durumdur. Gebelik planlayan kişilerde de, viral hepatit ve TORCH enfeksiyonları için serolojik testlerin değerlendirilmesi gerekir. Bu nedenle hastanemizde in vitro fertilizasyon programına alınan hastalarda bazı enfeksiyon etkenlerinin taranmasını amaçladık.