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Research paper thumbnail of Chemistry Learning Innovation with Religious Character Integrated Reaction Rate Module for Class XI Students of Senior High School

Fenomena

Kegiatan pembelajaran kimia untuk siswa SMA agar lebih menarik dapat dilakukan dengan inovasi med... more Kegiatan pembelajaran kimia untuk siswa SMA agar lebih menarik dapat dilakukan dengan inovasi media pembelajaran. Media pembelajaran yang sesuai untuk bisa diterapkan pada saat ini adalah media berbasis blended learning. Pembentukan karakter yang perlu dikem-bangkan dalam model pembelajaran blended learning salah satunya adalah karakter religius. Karakter religius pada pelajaran kimia dapat dikaitkan dengan ayat yang ada pada Al-Qur'an salah satunya adalah materi laju reaksi. Tujuan penelitian ini adalah untuk mengetahui keefektifan modul, respon siswa, dan kelayakan modul bagi siswa kelas XI pada materi laju reaksi. Metode penelitian ini menggunakan R&D (Research and Development) Borg & Gall. Hasil penelitian menunjukkan bahwa uji validasi modul laju reaksi terintegrasi karakter religius menunjukkan nilai yang sangat tinggi dengan rata-rata skor materi 87,6% dan media 89%. Pada uji coba skala kecil hasil respon tanggapan siswa terhadap modul terintegrasi dengan karakter religiu...

Research paper thumbnail of Formulation of roselle extract water-in-oil nanoemulsion for controlled pulmonary delivery

Journal of Dispersion Science and Technology

Research paper thumbnail of Ananas comosus Peels Extract as a New Natural Cosmetic Ingredient: Oil-in-Water (O/W) Topical Nano Cream Stability and Safety Evaluation

Evidence-Based Complementary and Alternative Medicine

Ananas comosus peels (AcP) are among the agro-industrial biomasses contributing to a significant ... more Ananas comosus peels (AcP) are among the agro-industrial biomasses contributing to a significant volume of waste in Malaysia. Thus, the AcP extract (AcPE) may prove useful for other applications, such as an ingredient in a nanocream for controlled delivery for dermal application. Therefore, this study aimed to develop an oil-in-water (O/W) nanocream using ingredients derived from the AcPE and test its stability alongside safety evaluation. The extract is a rich source of polyphenolic compounds viz., catechin, quercetin, and gallic acid. The study discovered that the optimized AcPE nano cream was stable against coalescence during the accelerated test but was influenced by Ostwald ripening over 6 weeks of storage at 4°C. Safety assessments affirmed the AcPE nano cream to be free of microbial contamination and heavy metals. The findings conveyed that the A. comosus nano cream is a good cosmetic ingredient and may contribute to the cosmeceutical industry’s new and safe topical products.

Research paper thumbnail of Formulation of a stable water-in-oil nanoemulsion rich in anti-diabetic components of the roselle extract for controlled release

Research paper thumbnail of Statistical Optimization and Characterization of Acoustically Extracted Ananas Comosus Peel Powder with Enhanced Antioxidant Capacity

Ananas comosus (L.) Merr is one of many commercially popular fruits in the cannery food industry ... more Ananas comosus (L.) Merr is one of many commercially popular fruits in the cannery food industry that contributes to the increasingly mounting agro-industrial waste. In this study, a four−factor−three−level Box−Behnken design (BBD) that comprised of sonication time (A), solvent ratio (B), amplitude (C) and liquid−solid ratio (D) for the ultrasound−assisted extraction (UAE) of pineapple peels (PP) was utilized to optimize the yield of total phenolic content (TPC). Under an optimized UAE condition [5 min; 50 % of ethanol: water; 65 % of amplitude; 35:1 mL/g of liquid−solid ratio], the highest TPC from PP of 708.10 mg gallic acid equivalent (GAE)/g DW was achieved. Antioxidant capacity analysis of PP revealed a high total flavonoid content (TFC) with the IC 50 for 2,2−diphenyl−1−picrylhydrazyl (DPPH), and ferric reducing antioxidant power (FRAP) of 1146.86 ± 11.83 mg QE/g, 11.83 mg/mL and 1578.07 ± 25.96 µM Fe (II)/100g, respectively. High-performance liquid chromatography (HPLC) analy...

Research paper thumbnail of An overview of cosmeceutically relevant plant extracts and strategies for extraction of plant-based bioactive compounds

Food and Bioproducts Processing

Research paper thumbnail of Formulation and Characterization of a Kinetically Stable Topical Nanoemulsion Containing the Whitening Agent Kojic Acid

Indonesian Journal of Chemistry

The research was carried out to synthesize a stable kojic acid (KA) encapsulated nanoemulsion as ... more The research was carried out to synthesize a stable kojic acid (KA) encapsulated nanoemulsion as a whitening agent for topical skin usage. In this study, the oil-in-water (O/W) KA nanoemulsion was formulated using integrated low and high energy methods that combined ultrasonic and hot temperature inversion methods. Several different combinations of parameters were screened, viz. xanthan gum amount (1.0 to 2.0 g), kojic acid (KA) amount (0.5 to 1.5 g), and surfactant-to-water ratio (1:10.75 to 1:4.875), to prepare a stable KA nanoemulsion. The identified best parameters to design the O/W KA nanoemulsion were then subjected to different stability tests: storage and pH stability (freeze-thaw and centrifugal tests). Results revealed that the Trial 6 formulation, with the highest ratio of Tween 80 to water (1:4.875 v/v), yielded the best polydispersity index at 0.255 ± 0.006 with an average particle size of 90.57 ± 1.401 nm. The formulation retained the recommended pH range (pH 4.95–5.18...

Research paper thumbnail of Optimization of oil-in-water nanoemulsion system of ananas comosus peels extract by D-optimal mixture design and its physicochemical properties

Journal of Dispersion Science and Technology

Research paper thumbnail of Ultrasound-assisted extraction of polyphenols from pineapple skin

PROCEEDINGS OF THE 2ND INTERNATIONAL CONFERENCE ON BIOSCIENCES AND MEDICAL ENGINEERING (ICBME2019): Towards innovative research and cross-disciplinary collaborations

Pineapple skin (PS) is among the major food wastes from canning industries which contributes to e... more Pineapple skin (PS) is among the major food wastes from canning industries which contributes to environmental pollution. Nonetheless, PS contains an appreciable quantity of valuable phenolic compounds that may have potential applications in pharmaceutical and cosmetics industries. Since much of the PS waste are discarded, recovery of this agroindustrial biomass for possible transformations into value-added products merit scientific attention. In this study, phenolic compounds were recovered from PS using a greener method of ultrasonic-assisted extraction (UAE). The study aimed to assess the effect of sonication time to extract the highest concentration of polyphenolics from the PP waste. It was demonstrated that the highest extraction yield (29.04 %) was obtained at 6.49 min sonication time, whereas maximum total phenolic content (TPC) and total flavonoid content (TFC) of 1078.68 ± 1.32 mg GAE/g DW and 1276.64 ± 5.92 mg QE/g DW, respectively, were attained following sonication at 5.92 min. These values seen here were considerably higher than that obtained using Soxhlet reflux extraction (24.95% and 7.98 mg GAE/g DW) and drying process (4.16 ± 0.24 mg GAE/100g DW and 76.93 ± 11.85 μg rutin equivalent/100g DW). The findings, therefore, envisioned the efficacious UAE method for a greener and higher recovery of polyphenolic compounds from PS waste.

Research paper thumbnail of Chemistry Learning Innovation with Religious Character Integrated Reaction Rate Module for Class XI Students of Senior High School

Fenomena

Kegiatan pembelajaran kimia untuk siswa SMA agar lebih menarik dapat dilakukan dengan inovasi med... more Kegiatan pembelajaran kimia untuk siswa SMA agar lebih menarik dapat dilakukan dengan inovasi media pembelajaran. Media pembelajaran yang sesuai untuk bisa diterapkan pada saat ini adalah media berbasis blended learning. Pembentukan karakter yang perlu dikem-bangkan dalam model pembelajaran blended learning salah satunya adalah karakter religius. Karakter religius pada pelajaran kimia dapat dikaitkan dengan ayat yang ada pada Al-Qur'an salah satunya adalah materi laju reaksi. Tujuan penelitian ini adalah untuk mengetahui keefektifan modul, respon siswa, dan kelayakan modul bagi siswa kelas XI pada materi laju reaksi. Metode penelitian ini menggunakan R&D (Research and Development) Borg & Gall. Hasil penelitian menunjukkan bahwa uji validasi modul laju reaksi terintegrasi karakter religius menunjukkan nilai yang sangat tinggi dengan rata-rata skor materi 87,6% dan media 89%. Pada uji coba skala kecil hasil respon tanggapan siswa terhadap modul terintegrasi dengan karakter religiu...

Research paper thumbnail of Formulation of roselle extract water-in-oil nanoemulsion for controlled pulmonary delivery

Journal of Dispersion Science and Technology

Research paper thumbnail of Ananas comosus Peels Extract as a New Natural Cosmetic Ingredient: Oil-in-Water (O/W) Topical Nano Cream Stability and Safety Evaluation

Evidence-Based Complementary and Alternative Medicine

Ananas comosus peels (AcP) are among the agro-industrial biomasses contributing to a significant ... more Ananas comosus peels (AcP) are among the agro-industrial biomasses contributing to a significant volume of waste in Malaysia. Thus, the AcP extract (AcPE) may prove useful for other applications, such as an ingredient in a nanocream for controlled delivery for dermal application. Therefore, this study aimed to develop an oil-in-water (O/W) nanocream using ingredients derived from the AcPE and test its stability alongside safety evaluation. The extract is a rich source of polyphenolic compounds viz., catechin, quercetin, and gallic acid. The study discovered that the optimized AcPE nano cream was stable against coalescence during the accelerated test but was influenced by Ostwald ripening over 6 weeks of storage at 4°C. Safety assessments affirmed the AcPE nano cream to be free of microbial contamination and heavy metals. The findings conveyed that the A. comosus nano cream is a good cosmetic ingredient and may contribute to the cosmeceutical industry’s new and safe topical products.

Research paper thumbnail of Formulation of a stable water-in-oil nanoemulsion rich in anti-diabetic components of the roselle extract for controlled release

Research paper thumbnail of Statistical Optimization and Characterization of Acoustically Extracted Ananas Comosus Peel Powder with Enhanced Antioxidant Capacity

Ananas comosus (L.) Merr is one of many commercially popular fruits in the cannery food industry ... more Ananas comosus (L.) Merr is one of many commercially popular fruits in the cannery food industry that contributes to the increasingly mounting agro-industrial waste. In this study, a four−factor−three−level Box−Behnken design (BBD) that comprised of sonication time (A), solvent ratio (B), amplitude (C) and liquid−solid ratio (D) for the ultrasound−assisted extraction (UAE) of pineapple peels (PP) was utilized to optimize the yield of total phenolic content (TPC). Under an optimized UAE condition [5 min; 50 % of ethanol: water; 65 % of amplitude; 35:1 mL/g of liquid−solid ratio], the highest TPC from PP of 708.10 mg gallic acid equivalent (GAE)/g DW was achieved. Antioxidant capacity analysis of PP revealed a high total flavonoid content (TFC) with the IC 50 for 2,2−diphenyl−1−picrylhydrazyl (DPPH), and ferric reducing antioxidant power (FRAP) of 1146.86 ± 11.83 mg QE/g, 11.83 mg/mL and 1578.07 ± 25.96 µM Fe (II)/100g, respectively. High-performance liquid chromatography (HPLC) analy...

Research paper thumbnail of An overview of cosmeceutically relevant plant extracts and strategies for extraction of plant-based bioactive compounds

Food and Bioproducts Processing

Research paper thumbnail of Formulation and Characterization of a Kinetically Stable Topical Nanoemulsion Containing the Whitening Agent Kojic Acid

Indonesian Journal of Chemistry

The research was carried out to synthesize a stable kojic acid (KA) encapsulated nanoemulsion as ... more The research was carried out to synthesize a stable kojic acid (KA) encapsulated nanoemulsion as a whitening agent for topical skin usage. In this study, the oil-in-water (O/W) KA nanoemulsion was formulated using integrated low and high energy methods that combined ultrasonic and hot temperature inversion methods. Several different combinations of parameters were screened, viz. xanthan gum amount (1.0 to 2.0 g), kojic acid (KA) amount (0.5 to 1.5 g), and surfactant-to-water ratio (1:10.75 to 1:4.875), to prepare a stable KA nanoemulsion. The identified best parameters to design the O/W KA nanoemulsion were then subjected to different stability tests: storage and pH stability (freeze-thaw and centrifugal tests). Results revealed that the Trial 6 formulation, with the highest ratio of Tween 80 to water (1:4.875 v/v), yielded the best polydispersity index at 0.255 ± 0.006 with an average particle size of 90.57 ± 1.401 nm. The formulation retained the recommended pH range (pH 4.95–5.18...

Research paper thumbnail of Optimization of oil-in-water nanoemulsion system of ananas comosus peels extract by D-optimal mixture design and its physicochemical properties

Journal of Dispersion Science and Technology

Research paper thumbnail of Ultrasound-assisted extraction of polyphenols from pineapple skin

PROCEEDINGS OF THE 2ND INTERNATIONAL CONFERENCE ON BIOSCIENCES AND MEDICAL ENGINEERING (ICBME2019): Towards innovative research and cross-disciplinary collaborations

Pineapple skin (PS) is among the major food wastes from canning industries which contributes to e... more Pineapple skin (PS) is among the major food wastes from canning industries which contributes to environmental pollution. Nonetheless, PS contains an appreciable quantity of valuable phenolic compounds that may have potential applications in pharmaceutical and cosmetics industries. Since much of the PS waste are discarded, recovery of this agroindustrial biomass for possible transformations into value-added products merit scientific attention. In this study, phenolic compounds were recovered from PS using a greener method of ultrasonic-assisted extraction (UAE). The study aimed to assess the effect of sonication time to extract the highest concentration of polyphenolics from the PP waste. It was demonstrated that the highest extraction yield (29.04 %) was obtained at 6.49 min sonication time, whereas maximum total phenolic content (TPC) and total flavonoid content (TFC) of 1078.68 ± 1.32 mg GAE/g DW and 1276.64 ± 5.92 mg QE/g DW, respectively, were attained following sonication at 5.92 min. These values seen here were considerably higher than that obtained using Soxhlet reflux extraction (24.95% and 7.98 mg GAE/g DW) and drying process (4.16 ± 0.24 mg GAE/100g DW and 76.93 ± 11.85 μg rutin equivalent/100g DW). The findings, therefore, envisioned the efficacious UAE method for a greener and higher recovery of polyphenolic compounds from PS waste.