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Papers by Baliram Vibhute

Asian Journal of Chemistry, 2022

A new quinoline Schiff base ligand was synthesized by the reaction of 2-hydroxy-7-methylquinolin-... more A new quinoline Schiff base ligand was synthesized by the reaction of 2-hydroxy-7-methylquinolin- 3-carbaldehyde and 4-methylbenzene sulfonohydrazide. Synthesized Schiff base further utilized for the formation of stable metal complexes with Cu(II), Ni(II), Co(II) and Cd(II) metal salts and characterized by different spectroscopic techniques i.e. 1H NMR, 13C NMR, FT-IR, UV-visible, ESR, MASS and TGA. The low molar conductance values indicate that synthesized metal(II) complexes were non-electrolytes. The magnetic moment value indicates that Cu(II), Ni(II) and Co(II) complexes were paramagnetic. Further, these compounds were screened for inhibition activity against four bacterial strains, three fungal strains and cytotoxicity against the A-549 and MCF-7 cell lines by using the MTT method. Among the synthesized complexes, metal complexes exhibited excellent anticancer activity against the human lung cancer cell line (A-549). Schiff base and its Cd(II) complex showed good antibacterial activity. Furthermore, molecular docking study shows the significant binding affinity of metal complexes with tubulin protein. Present study proposed that all the synthesized Schiff base metal(II) complexes have excellent biological activity and could be act as potential anticancer agents.

Arabian Journal of Chemistry, Aug 1, 2021

This work reports synthesis of novel Quinoline Schiff base by condensation of 2-hydro xyquinoline... more This work reports synthesis of novel Quinoline Schiff base by condensation of 2-hydro xyquinoline-3-carbaldehyde and 4-methylbenzenesulfonohydrazide. Prepared Schiff base was further used for the formation of metal complexes with Cu (II), Ni (II), Co (II) & Cd (II). The complete formation of Schiff base and its metal complexes were confirmed by spectroscopic techniques i.e. FT-IR, 1 H NMR, 13 C NMR, ESI-MS, UV-Visible, and EPR. Low conductivity data indicated that prepared compounds are non-electrolytic. FT-IR data suggested that ligand bears O, N, and O binding sites. Magnetic moment of the compounds indicated that Cu (II), Ni (II), and Co (II) metal complexes are paramagnetic. The synthesized compounds were further evaluated for their In vitro cytotoxicity against the A-549 and MCF-7 cell lines by using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium Bromide] assay. Among all prepared compounds, Cu-complex has shown prominent results with IC 50 values 37.03 and 39.43, for A-549 and MCF-7 cancer cells respectively. Further, most active Cu-complex was subjected for photo-cleavage study with pBR322 DNA.

European Journal of Medicinal Chemistry

European Journal of Nutrition & Food Safety

Flavoured tobacco is mainly consumed in India and neighbouring countries like Pakistan, Afghanist... more Flavoured tobacco is mainly consumed in India and neighbouring countries like Pakistan, Afghanistan, and Nepal and the hazards are known. Considering the need to identify such flavouring ingredients and a simple analytical method was required to quantify such favouring ingredients and hazardous / allergens, we selected top brands available in India for investigation. We simply extracted the ingredients by triturating with Diethyl Ether, evaporating solvent ether and reconstituting the extract in Acetone & Ethanol for GC-MS & GC-FID work respectively. The flavour ingredients were identified, and hazardous ingredients, viz. Diethyl Phthalate was identified. It was found around 2.5% to 3.0%. The GC-MS method was validated with GC-FID analysis with Linearity, LOD & LOQ study.

Arabian Journal of Geosciences, 2021

This current study is part of a comprehensive study being undertaken to evaluate the effect of va... more This current study is part of a comprehensive study being undertaken to evaluate the effect of various types of reinforcements and nanomaterials on the performance of geopolymer pastes. In this study fly ash–based geopolymer pastes were reinforced with micro-glass fibres and the influence of three dosages (i.e. 1%, 2% and 3%) of nano CaCO3 on the corresponding mechanical properties of the pastes were evaluated. The mechanical properties evaluated are compressive strength, flexural strength, fracture toughness and hardness. Microstructural observation of the pastes incorporating the nano CaCO3 was also carried out. The findings from this study showed that the use of nano CaCO3 at a dosage of 2% is optimum in improving the mechanical properties of micro glass-reinforced geopolymer pastes. The compressive strength, flexural strength and toughness of micro glass-reinforced geopolymer pastes incorporating 2% nano CaCO3 are 46.7%, 150.8% and 52.4%, respectively. The enhancement was attributed to the refinement of the microstructure and interfacial zones alongside the acceleration of the geopolymerization reaction.

Asian Journal of Chemistry, 2022

A new quinoline Schiff base ligand was synthesized by the reaction of 2-hydroxy-7-methylquinolin-... more A new quinoline Schiff base ligand was synthesized by the reaction of 2-hydroxy-7-methylquinolin- 3-carbaldehyde and 4-methylbenzene sulfonohydrazide. Synthesized Schiff base further utilized for the formation of stable metal complexes with Cu(II), Ni(II), Co(II) and Cd(II) metal salts and characterized by different spectroscopic techniques i.e. 1H NMR, 13C NMR, FT-IR, UV-visible, ESR, MASS and TGA. The low molar conductance values indicate that synthesized metal(II) complexes were non-electrolytes. The magnetic moment value indicates that Cu(II), Ni(II) and Co(II) complexes were paramagnetic. Further, these compounds were screened for inhibition activity against four bacterial strains, three fungal strains and cytotoxicity against the A-549 and MCF-7 cell lines by using the MTT method. Among the synthesized complexes, metal complexes exhibited excellent anticancer activity against the human lung cancer cell line (A-549). Schiff base and its Cd(II) complex showed good antibacterial ...

Medicinal plants were the best source of therapeutic molecules to cure various diseases in the in... more Medicinal plants were the best source of therapeutic molecules to cure various diseases in the in the different living organism. The amount of heavy metals in the plants was analyzed to show the adverse affects to the animals and human beings who consume them as such or their derived products. The work is more beneficial as the actual nutrient content of the medicinal plants in terms of the essential trace elements could also be identified. The concentration levels (mg/l) of the selected trace metals (Ni, Cu, Cr, Zn, Mn, Pb) were estimated in some of the important herbal plants of the Raigad district. The atomic absorption spectrophotometer was employed for the estimation of heavy metals of five different plant species that were collected from different locations within Riagad district. The plants selected for the analysis were Emblica officinalis, Phyllanthus emblica, Ocimum tenuiflorum. Azadirachta indica and Balanites aegyptiaca. The metal contents in the samples were determined ...

Asian Journal of Chemistry, 2022

A new quinoline Schiff base ligand was synthesized by the reaction of 2-hydroxy-7-methylquinolin-... more A new quinoline Schiff base ligand was synthesized by the reaction of 2-hydroxy-7-methylquinolin- 3-carbaldehyde and 4-methylbenzene sulfonohydrazide. Synthesized Schiff base further utilized for the formation of stable metal complexes with Cu(II), Ni(II), Co(II) and Cd(II) metal salts and characterized by different spectroscopic techniques i.e. 1H NMR, 13C NMR, FT-IR, UV-visible, ESR, MASS and TGA. The low molar conductance values indicate that synthesized metal(II) complexes were non-electrolytes. The magnetic moment value indicates that Cu(II), Ni(II) and Co(II) complexes were paramagnetic. Further, these compounds were screened for inhibition activity against four bacterial strains, three fungal strains and cytotoxicity against the A-549 and MCF-7 cell lines by using the MTT method. Among the synthesized complexes, metal complexes exhibited excellent anticancer activity against the human lung cancer cell line (A-549). Schiff base and its Cd(II) complex showed good antibacterial activity. Furthermore, molecular docking study shows the significant binding affinity of metal complexes with tubulin protein. Present study proposed that all the synthesized Schiff base metal(II) complexes have excellent biological activity and could be act as potential anticancer agents.

Arabian Journal of Chemistry, Aug 1, 2021

This work reports synthesis of novel Quinoline Schiff base by condensation of 2-hydro xyquinoline... more This work reports synthesis of novel Quinoline Schiff base by condensation of 2-hydro xyquinoline-3-carbaldehyde and 4-methylbenzenesulfonohydrazide. Prepared Schiff base was further used for the formation of metal complexes with Cu (II), Ni (II), Co (II) & Cd (II). The complete formation of Schiff base and its metal complexes were confirmed by spectroscopic techniques i.e. FT-IR, 1 H NMR, 13 C NMR, ESI-MS, UV-Visible, and EPR. Low conductivity data indicated that prepared compounds are non-electrolytic. FT-IR data suggested that ligand bears O, N, and O binding sites. Magnetic moment of the compounds indicated that Cu (II), Ni (II), and Co (II) metal complexes are paramagnetic. The synthesized compounds were further evaluated for their In vitro cytotoxicity against the A-549 and MCF-7 cell lines by using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium Bromide] assay. Among all prepared compounds, Cu-complex has shown prominent results with IC 50 values 37.03 and 39.43, for A-549 and MCF-7 cancer cells respectively. Further, most active Cu-complex was subjected for photo-cleavage study with pBR322 DNA.

European Journal of Medicinal Chemistry

European Journal of Nutrition & Food Safety

Flavoured tobacco is mainly consumed in India and neighbouring countries like Pakistan, Afghanist... more Flavoured tobacco is mainly consumed in India and neighbouring countries like Pakistan, Afghanistan, and Nepal and the hazards are known. Considering the need to identify such flavouring ingredients and a simple analytical method was required to quantify such favouring ingredients and hazardous / allergens, we selected top brands available in India for investigation. We simply extracted the ingredients by triturating with Diethyl Ether, evaporating solvent ether and reconstituting the extract in Acetone & Ethanol for GC-MS & GC-FID work respectively. The flavour ingredients were identified, and hazardous ingredients, viz. Diethyl Phthalate was identified. It was found around 2.5% to 3.0%. The GC-MS method was validated with GC-FID analysis with Linearity, LOD & LOQ study.

Arabian Journal of Geosciences, 2021

This current study is part of a comprehensive study being undertaken to evaluate the effect of va... more This current study is part of a comprehensive study being undertaken to evaluate the effect of various types of reinforcements and nanomaterials on the performance of geopolymer pastes. In this study fly ash–based geopolymer pastes were reinforced with micro-glass fibres and the influence of three dosages (i.e. 1%, 2% and 3%) of nano CaCO3 on the corresponding mechanical properties of the pastes were evaluated. The mechanical properties evaluated are compressive strength, flexural strength, fracture toughness and hardness. Microstructural observation of the pastes incorporating the nano CaCO3 was also carried out. The findings from this study showed that the use of nano CaCO3 at a dosage of 2% is optimum in improving the mechanical properties of micro glass-reinforced geopolymer pastes. The compressive strength, flexural strength and toughness of micro glass-reinforced geopolymer pastes incorporating 2% nano CaCO3 are 46.7%, 150.8% and 52.4%, respectively. The enhancement was attributed to the refinement of the microstructure and interfacial zones alongside the acceleration of the geopolymerization reaction.

Asian Journal of Chemistry, 2022

A new quinoline Schiff base ligand was synthesized by the reaction of 2-hydroxy-7-methylquinolin-... more A new quinoline Schiff base ligand was synthesized by the reaction of 2-hydroxy-7-methylquinolin- 3-carbaldehyde and 4-methylbenzene sulfonohydrazide. Synthesized Schiff base further utilized for the formation of stable metal complexes with Cu(II), Ni(II), Co(II) and Cd(II) metal salts and characterized by different spectroscopic techniques i.e. 1H NMR, 13C NMR, FT-IR, UV-visible, ESR, MASS and TGA. The low molar conductance values indicate that synthesized metal(II) complexes were non-electrolytes. The magnetic moment value indicates that Cu(II), Ni(II) and Co(II) complexes were paramagnetic. Further, these compounds were screened for inhibition activity against four bacterial strains, three fungal strains and cytotoxicity against the A-549 and MCF-7 cell lines by using the MTT method. Among the synthesized complexes, metal complexes exhibited excellent anticancer activity against the human lung cancer cell line (A-549). Schiff base and its Cd(II) complex showed good antibacterial ...

Medicinal plants were the best source of therapeutic molecules to cure various diseases in the in... more Medicinal plants were the best source of therapeutic molecules to cure various diseases in the in the different living organism. The amount of heavy metals in the plants was analyzed to show the adverse affects to the animals and human beings who consume them as such or their derived products. The work is more beneficial as the actual nutrient content of the medicinal plants in terms of the essential trace elements could also be identified. The concentration levels (mg/l) of the selected trace metals (Ni, Cu, Cr, Zn, Mn, Pb) were estimated in some of the important herbal plants of the Raigad district. The atomic absorption spectrophotometer was employed for the estimation of heavy metals of five different plant species that were collected from different locations within Riagad district. The plants selected for the analysis were Emblica officinalis, Phyllanthus emblica, Ocimum tenuiflorum. Azadirachta indica and Balanites aegyptiaca. The metal contents in the samples were determined ...