Basaran Dulger - Academia.edu (original) (raw)

Papers by Basaran Dulger

Social Science Research Network, 2021

Background: Geopropolis is a type of propolis containing resin, wax, and soil, collected by threa... more Background: Geopropolis is a type of propolis containing resin, wax, and soil, collected by threatened stingless bee species native to tropical countries and used in folk medicine. However, studies concerning the biological activity and chemical composition of geopropolis are scarce. In this study, we evaluated the antimicrobial and antiproliferative activity of the ethanolic extract of geopropolis (EEGP) collected by Melipona scutellaris and its bioactive fraction against important clinical microorganisms as well as their in vitro cytotoxicity and chemical profile. Methods: The antimicrobial activity of EEGP and fractions was examined by determining their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against six bacteria strains as well as their ability to inhibit Streptococcus mutans biofilm adherence. Total growth inhibition (TGI) was chosen to assay the antiproliferative activity of EEGP and its bioactive fraction against normal and cancer cell lines. The chemical composition of M. scutellaris geopropolis was identified by reversed-phase high-performance liquid chromatography and gas chromatography-mass spectrometry. Results: EEGP significantly inhibited the growth of Staphylococcus aureus strains and S. mutans at low concentrations, and its hexane fraction (HF) presented the highest antibacterial activity. Also, both EEGP and HF inhibited S. mutans biofilm adherence (p < 0.05) and showed selectivity against human cancer cell lines, although only HF demonstrated selectivity at low concentrations. The chemical analyses performed suggest the absence of flavonoids and the presence of benzophenones as geopropolis major compounds. Conclusions: The empirical use of this unique type of geopropolis by folk medicine practitioners was confirmed in the present study, since it showed antimicrobial and antiproliferative potential against the cancer cell lines studied. It is possible that the major compounds found in this type of geopropolis are responsible for its properties.

Journal of Medicinal Plants Studies, Sep 1, 2015

The methanol extracts obtained from the seeds of Hyoscyamus niger L. (Solanaceae) were investigat... more The methanol extracts obtained from the seeds of Hyoscyamus niger L. (Solanaceae) were investigated for their antimicrobial activities against the pathogens causing complicated urine tract infections. Methods: The seeds of plant were extracted with aqueous 60% methanol. The extract was screened against urinary tract pathogens (Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis and Candida albicans) by disc diffusion method and microdilution method. Some antibacterial and antifungal antibiotics were used as a positive reference standard to determine the sensitivity of the strains. Results: The extracts showed strong antimicrobial activity against Enterococcus faecalis, Klebsiella pneumoniae and Candida albicans with inhibition zones of 26.0, 19.0 and 16.0 mm, with MIC's and MBC's or MFC's of 4.0(8.0), 32(64) and 64(128) µg/mL, respectively. Also, the extracts exhibited moderate activity against the other test microorganisms. Conclusion: Our findings support the use of Hyoscyamus niger L. in traditional medicine for the treatment against the urine tract pathogens.

DergiPark (Istanbul University), Aug 1, 2016

Bitkinin en yüksek antibakteriyel aktivitesi etil asetat ekstraktında Staphylococcus aureus ATCC ... more Bitkinin en yüksek antibakteriyel aktivitesi etil asetat ekstraktında Staphylococcus aureus ATCC 6538P (19.42 mm) bakterisine karşı ölçülmüştür. En yüksek antifungal aktivitesi etanol ekstraktında Candida glabrata ATCC 90030 (17.36 mm) maya kültürüne karşı ölçülmüştür. Etanolün, bitki bileşiklerinin ekstraksiyonunda diğer çözücülerden daha etkili olduğu saptanmıştır. Bulgular bu bitkinin mikrobiyal enfeksiyonlara karşı halk ilacı olarak kullanımını destekler niteliktedir.

Natural and engineering sciences, Aug 8, 2022

The ethanol extracts obtained from the leaves of Stachys sylvatica L. (Lamiaceae) were evaluated ... more The ethanol extracts obtained from the leaves of Stachys sylvatica L. (Lamiaceae) were evaluated for their antibacterial activity against some human eye pathogens by disc diffusion method against hospital isolates of Bacillus cereus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus capitis, Staphylococcus aureus, Staphylococcus epidermidis, Moraxella nonliquefaciens and Cutibacterium acnes. Besides, Penicillin, Ampicillin and Tobramycin as antibacterial antibiotics were used as a positive reference standard to determine the sensitivity of the isolates. The extracts showed a potential antibacterial effect against Staphylococcus capitis, Moraxella nonliquefaciens and Cutibacterium acnes, with inhibition zones of 22.4 mm, 21.6 mm and 20.2 mm, respectively. The extracts also exhibited a moderate effect against the other bacterial isolates. The plant may be useful in the treatment of eye infections.

Pharmaceutical Biology, 2005

The methanol extracts obtained from endemic Scrophulariaceae members Verbascum protractum Fenel e... more The methanol extracts obtained from endemic Scrophulariaceae members Verbascum protractum Fenel ex Tchihat., Verbascum bellum Hub.-Mor., Verbascum dalamanicum Hub.-Mor., Scrophularia mersinensis Lall, Scrophularia cryptophila Boiss. & Heldr., Pedicularis olympica Boiss., and Veronica lycica E. Lehm. have been investigated for their antimicrobial activity. Antimicrobial activity was determined with Escherichia coli ATCC 11230, Staphylococcus aureus ATCC 6538P, Klebsiella pneumoniae UC57, Pseudomonas aeruginosa ATCC 27853, Proteus vulgaris ATCC 8427, Bacillus cereus ATCC 7064, Mycobacterium smegmatis CCM 2067, Listeria monocytogenes ATCC 15313, Micrococcus luteus CCM 169, Candida albicans ATCC 10231, Rhodotorula rubra DSM 70403, and Kluyveromyces fragilisATCC 8608 by the disk diffusion method. The extracts of all Scrophulariaceae members used in this study had strong antimicrobial activity against the Gram-positive bacteria and yeast cultures.

Asian Journal of Chemistry, 2009

Turk J Bot, 2002

Thirty myxomycetes species are new records for Turkey. Among these species, Craterium minutum (Le... more Thirty myxomycetes species are new records for Turkey. Among these species, Craterium minutum (Leers) Fries, Dianema repens G.Lister & Cran., Lindbladia tubulina Fries and Tubifera ferrruginosa (Batsch) J.F.Gmel. are also new genus record taxa for the myxomycetes flora of Turkey.

BMC Complementary and Alternative Medicine, 2013

Background Geopropolis is a type of propolis containing resin, wax, and soil, collected by threat... more Background Geopropolis is a type of propolis containing resin, wax, and soil, collected by threatened stingless bee species native to tropical countries and used in folk medicine. However, studies concerning the biological activity and chemical composition of geopropolis are scarce. In this study, we evaluated the antimicrobial and antiproliferative activity of the ethanolic extract of geopropolis (EEGP) collected by Melipona scutellaris and its bioactive fraction against important clinical microorganisms as well as their in vitro cytotoxicity and chemical profile. Methods The antimicrobial activity of EEGP and fractions was examined by determining their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against six bacteria strains as well as their ability to inhibit Streptococcus mutans biofilm adherence. Total growth inhibition (TGI) was chosen to assay the antiproliferative activity of EEGP and its bioactive fraction against normal and cancer cel...

MYCOTAXON-ITHACA NY-, 2006

Page 1. 1 Myxomycetes of Belgrad Forest (Istanbul) R. BATUR ORAN 1 C. CEM ERGÜL 1 , & BASARAN... more Page 1. 1 Myxomycetes of Belgrad Forest (Istanbul) R. BATUR ORAN 1 C. CEM ERGÜL 1 , & BASARAN DÜLGER 2 ergulc@uludag.edu.tr ... Macbrideola cornea. Badhamia nitens Berk. 1. Falih Rıfkı Atay Picnic place, alt. 80m, on ...

Mycotaxon, 2005

Page 1. Myxomycetes of the Western Black Sea Region of Turkey C. CEM ERGÜL 1 ,BAŞARAN DÜLGER 2 , ... more Page 1. Myxomycetes of the Western Black Sea Region of Turkey C. CEM ERGÜL 1 ,BAŞARAN DÜLGER 2 , R. BATUR ORAN 1 & HASAN AKGÜL 1 ... 30 m, 19.07.2000, CE218. 7. Cribraria elegans Berk. & MA Curtis in Berkeley Bartın-Arıt road,ca. ...

Mantar dergisi, Apr 29, 2016

In the current study, Las osphaer a ov na (Pers.) Ces. & De Not (Las osphaer aceae) was recorded ... more In the current study, Las osphaer a ov na (Pers.) Ces. & De Not (Las osphaer aceae) was recorded for the f rst t me from Turkey at fam ly level. A short description, the photographs of macro and the micro morphologies of the species are prov ded.

Transition Metal Chemistry, Mar 1, 2006

Background: Biosurfactants constitute a structurally diverse group of surface-active compounds de... more Background: Biosurfactants constitute a structurally diverse group of surface-active compounds derived from microorganisms. They are widely used industrially in various industrial applications such as pharmaceutical and environmental sectors. Major limiting factor in biosurfactant production is their production cost. Objectives: The aim of this study was to investigate biosurfactant production under laboratory conditions with potato peels as the sole source of carbon source. Materials and Methods: A biosurfactant-producing bacterial strain (Bacillus pumilus DSVP18, NCBI GenBank accession no. GQ865643) was isolated from motor oil contaminated soil samples. Biochemical characteristics of the purified biosurfactant were determined and its chemical structure was analyzed. Stability studies were performed and biological activity of the biosurfactant was also evaluated. Results: The strain, when grown on modified minimal salt media supplemented with 2% potato peels as the sole carbon source, showed the ability to reduce Surface Tension (ST) value of the medium from 72 to 28.7 mN/m. The isolated biosurfactant (3.2 ± 0.32 g/L) was stable over a wide range of temperatures (20-120 ºC), pH (2-12) and salt concentrations (2-12%). When characterized using high-performance liquid chromatography (HPLC) and Fourier transform infrared spectroscopy, it was found to be a lipopeptide in nature, which was further confirmed by Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (mass peak 1044.60) and nuclear magnetic resonance (NMR) studies. Data showed that the isolated biosurfactant at the concentration range of 30-35 µg/ml had strong antimicrobial activity when tested against standard strains of Bacillus cereus, Escherichia coli, Salmonella enteritidis, Staphylococcus aureus and Paenibacillus larvae. Conclusions: Potato peels were proved to be potentially useful substrates for biosurfactant production by B. pumilus DSVP18. The strain possessed a unique property to reduce surface tension of the media from 72 to 28.7 mN/m. In addition, it showed a stable surface activity over a wide range of temperatures, pH, and saline conditions and had strong antimicrobial activity. This potential of the identified biosurfactant can be exploited by pharmaceutical industries for its commercial usage.

European journal of medicinal chemistry, Feb 1, 2007

2,6-Bis(benzimidazol-2-yl)pyridine (L) ligand and complexes [M(L)Cl2] and [Fe(L)2](ClO4)2 (M=Zn, ... more 2,6-Bis(benzimidazol-2-yl)pyridine (L) ligand and complexes [M(L)Cl2] and [Fe(L)2](ClO4)2 (M=Zn, Cd, Hg) have been synthesized. The geometries of the [M(L)Cl2] complexes were derived from theoretical calculation in DGauss/DFT level (DZVP basis set) on CACHE. The central M(II) ion is penta-coordinated and surrounded by N3Cl2 environment, adopting a distorted trigonal bipyramidal geometry. The ligand is tridentate, via three nitrogen atoms to metal

European Journal of Experimental Biology, 2011

In this study microbial quality and prevalence of antimicrobial resistance among the enteric bact... more In this study microbial quality and prevalence of antimicrobial resistance among the enteric bacteria found in Saricay stream. For microbial quality total and faecal coliform and faecal enterococci parameters were determined. From isolated enteric bacteria Escherichia coli was the prevalent bacteria (63.33%) followed by Citrobacter freundii (10%), Enterobacter spp. (10%), Proteus vulgaris (8.33%), Klebsiella pneumoniae (5%) and Salmonella typhimurium (3.33%). Antimicrobial activity test was performed for 14 antibiotics. The highest rates of resistance were showed against erythromycin (91.66%), and Multiple Antibiotic Resistance Index of five stations vary between 0.21-0.33 values.

DOAJ (DOAJ: Directory of Open Access Journals), Feb 1, 2014

Bu calismada, Haziran-Agustos 2008 tarihleri arasinda aylik periyotlar halinde insan populasyonun... more Bu calismada, Haziran-Agustos 2008 tarihleri arasinda aylik periyotlar halinde insan populasyonun yogun oldugu 5 istasyondan, sedimantasyon teknigi kullanarak acilan kanli agar plaklari kullanilarak ev disi havasindaki bazi bakteri yogunluklari arastirilmistir. Alinan 90 ornekten toplam 1050 bakteriyal koloni incelenmis ve 154 aktinomiset kolonisi izole edilmistir. Istasyonlarda en sik ureyen bakteri gruplari Gram (+) koklar, Gram (-) basiller, Aktinomisetler, Gram (+) basiller, Gram (-) kokkobasiller ve son olarak da hemolitik bakteriler olarak belirlenmistir. Izole edilen aktinomisetlerin bakteri ve mayalara karsi antimikrobiyal aktiviteleri incelendiginde 18 izolatin guclu antimikrobiyal etki olusturdugu belirlenmistir. Anahtar kelimeler: Canakkale Evdisi Havasi, Bakteriyal Flora, Aktinomiset, Antimikrobiyal Aktivite

DOAJ (DOAJ: Directory of Open Access Journals), Apr 1, 2015

9796 maya kültürlerine karşı antimikrobiyal aktiviteleri araştırıldı. Sonuçlar standart antifunga... more 9796 maya kültürlerine karşı antimikrobiyal aktiviteleri araştırıldı. Sonuçlar standart antifungal ve antibakteriyel antibiyotiklerle karşılaştırıldı ve kontrol olarak sadece çözücünün emdirildiği diskler kullanıldı. Bulgulara göre; Ramalina farinacea likeninin en yüksek antimikrobiyal aktivitesi Salmonella enteritidis ATCC 13076 ve Candida albicans ATCC 90028 türlerine karşı bulundu. Usnea intermedia likeninin en yüksek antimikrobiyal aktivitesi Streptococcus pyogenes ATCC 19615 ve Candida albicans ATCC 90028 türlerinde ölçüldü. Liken türlerinin diğer tüm mikroorganizmalara karşı farklı seviyelerde antimikrobiyal aktivite gösterdikleri saptandı.

Chemistry of Heterocyclic Compounds, Sep 1, 2012

ABSTRACT Macrocyclic 16,76-dimethyl-1,7(2,4)-ditriazina-2,6,8,12-tetraaza-3,5,9,11-tetraoxocyclod... more ABSTRACT Macrocyclic 16,76-dimethyl-1,7(2,4)-ditriazina-2,6,8,12-tetraaza-3,5,9,11-tetraoxocyclododecaphane, 16,86-dimethyl-1,8(2,4)-ditriazina-2,7,9,14-tetraaza-3,6,10,13-tetraoxocyclotetradecaphane, 16,96-dimethyl-1,9(2,4)-ditriazina-2,8,10,16-tetraaza-3,7,11,15-tetraoxocyclohexadecaphane, and 16,106-dimethyl-1,10(2,4)-ditriazina-2,9,11,18-tetraaza-3,8,12,17-tetraoxocyclooctadecaphane are synthesized. The compounds are characterized by elemental analyses, Raman, IR, 1H, 13C NMR and mass spectral data. The antimicrobial activities of the compounds are evaluated against several bacteria and yeast cultures and the results were compared with those of commercial antibiotic and antifungal agents. Structure–activity relationships are also discussed.

Journal of The Serbian Chemical Society, 2007

New crown ether ligands of the Schiff base type (4a-d) were synthesized by the reaction of 2-hydr... more New crown ether ligands of the Schiff base type (4a-d) were synthesized by the reaction of 2-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde and 2-hydroxy-1-naphthaldehyde with 6,7-dihydro-13H-dibenzo[e,h] [1,4]dioxonin-2,11-diamine (3). The structures of ligands were investigated by elemental analysis as well as IR, UV-visible, 1 H-NMR, 13 C-NMR and MS spectroscopic data. The antimicrobial and anti-yeast activities of the ligands were screened in vitro against the organisms