Basumitra Das - Academia.edu (original) (raw)
Papers by Basumitra Das
Journal of Evidence Based Medicine and Healthcare, Sep 3, 2016
BACKGROUND Thyroid carcinoma accounts for less than 1% of cancer cases. In the Indian subcontinen... more BACKGROUND Thyroid carcinoma accounts for less than 1% of cancer cases. In the Indian subcontinent, thyroid carcinoma exhibits a varied disease profile and geographic differences in the pattern of cancer, the knowledge of which impacts a more favourable clinical outcome. The present study aims to profile Thyroid carcinoma in areas of age, gender, geographic domicile, morphology & clinical features and referral paradigm of cases in King George Hospital, Visakhapatnam, the tertiary referral hospital for coastal Andhra Pradesh. METHODS & MATERIALS The Retrospective Study 1988-2004 includes 188 patients who attended Department of Nuclear Medicine for pre & postoperative nuclear scan, thyroid carcinoma treatment protocol, whose clinical features, relevant laboratory data, histopathological reports & prognosis were analysed. RESULTS Papillary thyroid carcinoma was present in 79% and Follicular thyroid carcinoma in 19%, Anaplastic & Medullary Thyroid Carcinoma in 2% of cases (n=188), male to female ratio 1:0.62. Coastal city of Visakhapatnam recorded highest 59% of cases who were in their 3 rd and 4 th decades. West Godavari District had lowest at 5%. Clinical presentation of cases of Thyroid carcinoma as a Nodule (61%) which was the most common form lead to maximum number of referrals (n=82) from the Department of Surgery, King George Hospital. CONCLUSION In coastal Andhra Pradesh, papillary thyroid carcinoma was the most dominant form. Women were more affected than men. Painless thyroid nodule was the most common clinical feature. Coastal city of Visakhapatnam recorded highest number of cases and maximum referrals were from Department of Surgery.
Indian Journal of Public Health Research and Development, 2012
Malignant melanoma is fatal skin cancer when detected and treated early prognosis will be good. R... more Malignant melanoma is fatal skin cancer when detected and treated early prognosis will be good. Recent reports indicate rising incidence globally. This case study indicates how the people neglect the problems so much. A female patient aged 65 years presented with a painful non healing ulcer with pigmented margins of eighteen months duration on plantar aspect of the right heel. Three lymph nodes were present in the right inguinal region aspirated and obtained tarry coloured fluid revealed malignant melanoma cells with melanin pigment. Biopsy report confirmed the diagnosis that nodular aggregates of infiltrating melanoma cells with melanin pigment in the background of necrosis. Malignant melanoma remains one of the most challenging malignant neoplasm, particularly in developing countries where majority of patients present with late stage disease. Size of the ulcer indicates negligence of the patient. Health education may lead to future decline in morbidity and mortality.
Research and reviews: journal of medical and health sciences, Dec 29, 2014
Sickle cell Disease a homozygous condition for the abnormal hemoglobin gene HbS, is associated wi... more Sickle cell Disease a homozygous condition for the abnormal hemoglobin gene HbS, is associated with decreased life expectancy and recurrent episodes of various types of crises like hemolytic crisis, sickle crisis, sequestration crisis, vaso-occlusive crisis and aplastic crisis. Disseminated intravascular coagulation (DIC) can sometimes occur in conditions of tissue trauma and septicemia and rarely without septicemia as well. If the pathogenesis of the disease is not correctly understood and the crises were not attended properly DIC may set in leading to shock,multi-organ failure and even death. We present a case of DIC in a young female patient of Sickle cell Disease who met with a motor accident and developed multi-organ failure resulting in death. It is important to have prior knowledge about the pathogenesis of the disease and attend the crises even before the complication sets in, so that the patient's life may be saved.
Journal of Evidence Based Medicine and Healthcare, Jul 3, 2018
BACKGROUND The pathological spectrum of thyroid dysfunction varies from overactive to underactive... more BACKGROUND The pathological spectrum of thyroid dysfunction varies from overactive to underactive thyroidism. It is a common Endocrine disorder worldwide and leads to major consequences in the absence of appropriate treatment. MATERIALS AND METHODS This is a hospital based retrospective study based on medical records from the period of January 2013 to December 2015. Thyroid hormones were evaluated by RIA for T3 & T4 and IRMA for TSH, kits supplied by BRIT, Mumbai. RESULTS 2322 study subjects comprised of males 403 and 1919 females. Thyroid dysfunction categorized was as hypothyroidism, subclinical hypothyroidism, hyperthyroidism and Subclinical hyperthyroidism as per reference values for thyroid hormones. Prevalence of thyroid dysfunction was 43.7% in females and females were more affected than males. Hypothyroidism 15.80% and Subclinical hypothyroidism 21.40% were higher than hyperthyroidism 3.91% and subclinical hyperthyroidism 2.58% subjects aged 30-45 years had a higher prevalence. Euthyroid subjects constituted 56.28%. CONCLUSION Study revealed high prevalence of abnormal thyroid function. Females and elderly are more susceptible. Since untreated thyroid disease leads to significant morbidity, public awareness in the context of primary care setting will be valuable.
Indian journal of applied research, 2018
Background: The Clinical thyroid function comprises a major part of spectrum of thyroid disorders... more Background: The Clinical thyroid function comprises a major part of spectrum of thyroid disorders and entails progression to overt hypothyroidism if untreated with adverse sequelae such as increased risk of IHD, neurocognitive impairment and lowered quality of life. Aim : The present study aims to evaluate the prevalence of Subclinical Hypothyroidism in patient population of North Coastal Andhra Pradesh and analyze the effect of age and gender among the subjects. Materials & Methods : Retrospective cross-sectional hospital study. Data for evaluation obtained from patient records of thyroid lab at Department of Nuclear Medicine, King George Hospital, a tertiary referral hospital of North Coastal, Andhra Pradesh, from January to December 2013. Results : Total subjects were 738 comprising of 15.8% males and 84% females subjects with normal and hypothyroid were 56.6% and 43.36% respectively. Total of 194 cases (26.28%) had subclinical hypothyroidism including males 2.8% and females 23.4...
Indian Journal of Public Health Research and Development, 2012
Malignant melanoma is fatal skin cancer when detected and treated early prognosis will be good. R... more Malignant melanoma is fatal skin cancer when detected and treated early prognosis will be good. Recent reports indicate rising incidence globally. This case study indicates how the people neglect the problems so much. A female patient aged 65 years presented with a painful non healing ulcer with pigmented margins of eighteen months duration on plantar aspect of the right heel. Three lymph nodes were present in the right inguinal region aspirated and obtained tarry coloured fluid revealed malignant melanoma cells with melanin pigment. Biopsy report confirmed the diagnosis that nodular aggregates of infiltrating melanoma cells with melanin pigment in the background of necrosis. Malignant melanoma remains one of the most challenging malignant neoplasm, particularly in developing countries where majority of patients present with late stage disease. Size of the ulcer indicates negligence of the patient. Health education may lead to future decline in morbidity and mortality.
Background: The Sinonasal tract embraces nasal cavities and paranasal sinuses. This area is heart... more Background: The Sinonasal tract embraces nasal cavities and paranasal sinuses. This area is hearth for various non-neoplastic and neoplastic lesions. Because of its closed and complex architecture diagnosis by Fine Needle Aspiration Cytology (FNAC) was proved to be difficult. So, very few studies have been documented in literature. Aim: The aim of the study is to establish the importance of FNAC as a diagnostic contrivance for the sinonasal lesions with accommodating histopathology .This study also includes to assess the spectrum of lesions occurring in this region. Meterial & Methods: 77 cases with lesions in sinonasal tract were included in the present study. FNAC was performed and slides were stained by Haematoxylin and Eosin (H&E), Papanicolaou and Geimsa stains. The biopsy sections were processed and stained with H&E. Results: FNAC of 77 cases with sinonasal lesions were taken into study. The male to female ratio was 1.8: 1. Out of total cases, 43(58%) showed non neoplasticlesi...
Journal of Evidence Based Medicine and Healthcare, 2018
BACKGROUND The pathological spectrum of thyroid dysfunction varies from overactive to underactive... more BACKGROUND The pathological spectrum of thyroid dysfunction varies from overactive to underactive thyroidism. It is a common Endocrine disorder worldwide and leads to major consequences in the absence of appropriate treatment. MATERIALS AND METHODS This is a hospital based retrospective study based on medical records from the period of January 2013 to December 2015. Thyroid hormones were evaluated by RIA for T3 & T4 and IRMA for TSH, kits supplied by BRIT, Mumbai. RESULTS 2322 study subjects comprised of males 403 and 1919 females. Thyroid dysfunction categorized was as hypothyroidism, subclinical hypothyroidism, hyperthyroidism and Subclinical hyperthyroidism as per reference values for thyroid hormones. Prevalence of thyroid dysfunction was 43.7% in females and females were more affected than males. Hypothyroidism 15.80% and Subclinical hypothyroidism 21.40% were higher than hyperthyroidism 3.91% and subclinical hyperthyroidism 2.58% subjects aged 30-45 years had a higher prevalence. Euthyroid subjects constituted 56.28%. CONCLUSION Study revealed high prevalence of abnormal thyroid function. Females and elderly are more susceptible. Since untreated thyroid disease leads to significant morbidity, public awareness in the context of primary care setting will be valuable.
International Journal of Research in Medical Sciences, Jan 24, 2018
Astrocytic tumors are the most common primary tumors of the central nervous system. 1 Several gra... more Astrocytic tumors are the most common primary tumors of the central nervous system. 1 Several grading systems are used to grade astrocytomas. The most widely used system is the World Health Organization (WHO) classification (1979, 1993, 2000, and 2007) that grades astrocytomas (I-IV) based on cytological atypia, mitotic activity, vascular proliferation, and necrosis: pilocytic astrocytoma (grade I), diffuse astrocytoma (grade II), anaplastic astrocytoma (grade III), and glioblastoma (grade IV). 2 Though histopathological features largely help in the determination of prognosis, histological differentiation may not be clear in some cases, especially when only small fragments of tissue biopsies are available. Studies have employed a wide range of parameters from tumor suppressor genes to proliferation indices for predicting clinical outcome and survival. 3 A variety of methods have been employed to estimate the proliferative index of central nervous system tumors. Of these, one of the most potent methods is the Ki-67 labeling index (Ki-67 LI). The value of Ki-67 LI in the
Journal of Evidence Based Medicine and Healthcare, 2016
BACKGROUND Thyroid carcinoma accounts for less than 1% of cancer cases. In the Indian subcontinen... more BACKGROUND Thyroid carcinoma accounts for less than 1% of cancer cases. In the Indian subcontinent, thyroid carcinoma exhibits a varied disease profile and geographic differences in the pattern of cancer, the knowledge of which impacts a more favourable clinical outcome. The present study aims to profile Thyroid carcinoma in areas of age, gender, geographic domicile, morphology & clinical features and referral paradigm of cases in King George Hospital, Visakhapatnam, the tertiary referral hospital for coastal Andhra Pradesh. METHODS & MATERIALS The Retrospective Study 1988-2004 includes 188 patients who attended Department of Nuclear Medicine for pre & postoperative nuclear scan, thyroid carcinoma treatment protocol, whose clinical features, relevant laboratory data, histopathological reports & prognosis were analysed. RESULTS Papillary thyroid carcinoma was present in 79% and Follicular thyroid carcinoma in 19%, Anaplastic & Medullary Thyroid Carcinoma in 2% of cases (n=188), male to female ratio 1:0.62. Coastal city of Visakhapatnam recorded highest 59% of cases who were in their 3 rd and 4 th decades. West Godavari District had lowest at 5%. Clinical presentation of cases of Thyroid carcinoma as a Nodule (61%) which was the most common form lead to maximum number of referrals (n=82) from the Department of Surgery, King George Hospital. CONCLUSION In coastal Andhra Pradesh, papillary thyroid carcinoma was the most dominant form. Women were more affected than men. Painless thyroid nodule was the most common clinical feature. Coastal city of Visakhapatnam recorded highest number of cases and maximum referrals were from Department of Surgery.
Journal of Evidence Based Medicine and Healthcare, 2016
BACKGROUND Chronic kidney disease (CKD) is a major public health problem causing significant morb... more BACKGROUND Chronic kidney disease (CKD) is a major public health problem causing significant morbidity and mortality worldwide. Diabetes mellitus (DM) and hypertension are common causes and anaemia is a common complication. It is important to identify the cause and complication, to treat it and prevent its progression to end-stage renal disease (ESRD). AIM To identify the haematological pattern in chronic kidney disease patients and to study the clinical presentation. MATERIALS AND METHODS 72 cases of CKD were studied for a period of 6 months and thorough assessment of clinical features and haematological examinations were done. RESULTS CKD is observed in all age groups and predominantly in older age group greater than 50 yrs., with male preponderance. DM and hypertension are common causes. 89% of the patients presented with anaemia and 4 cases of sickle cell anaemia were observed. Neutrophilic leucocytosis was seen in 29.2% and thrombocytopenia in 8.3% of cases. CONCLUSION CKD is seen in all age groups with a male predominance, common in older age group, anaemia being the most common and important haematological complication. Few cases of sickle cell anaemia (SCA) were seen presenting with CKD. Knowledge and treatment of these conditions has proved to improve the quality of life.
Journal of the American Podiatric Medical Association, 1975
... 59 Malignant melanoma: A Case report Hetal Shah* Zankhana Vyas** *MDS, Reader, Department of ... more ... 59 Malignant melanoma: A Case report Hetal Shah* Zankhana Vyas** *MDS, Reader, Department of Oral Pathology, Ahmedabad Dental College, Ahmedabad, Gujarat. India. ... Acta Clin Croat 2006;45:153. 7. Patel SG, Prasad ML, Escrig M, Singh B, Shah Haar, Kraus DH, et al. ...
Journal of Evidence Based Medicine and Healthcare, 2017
BACKGROUND Paediatric Solid Neoplasms (PSN) are a global problem. There is significant variation ... more BACKGROUND Paediatric Solid Neoplasms (PSN) are a global problem. There is significant variation of incidence of paediatric solid neoplasms in various regions of the world. Benign tumours are more common than cancer. In an effort to better understand the prevalence of paediatric solid tumours in our region, a retrospective review of the tumours diagnosed histopathologically was carried out. MATERIALS AND METHODS This is a retrospective study undertaken in a tertiary care hospital for a period of five years. All the benign and malignant paediatric solid tumours of children below 14 years from January 2012 to December 2016 were retrieved and analysed according to age, sex and histopathological diagnosis. Leukaemias were excluded from our study. All tumours were diagnosed on conventional haematoxylin and eosin-stained sections. RESULTS A total of 109 cases of solid paediatric tumours were received during this period. Of these, maximum of 30 tumours were of soft tissue tumours followed by Central Nervous System (CNS) and bone tumours with 24 and 23 cases, respectively. 7 cases of blastomas were also observed. CONCLUSION This study showed benign and malignant tumours to be of near-equal prevalence. Soft tissue tumours were the most common. Ratio of benign tumours to malignant were almost equal below 4 years. Malignant tumours were higher in 5-9 years group.
Proliferating trichilemmal tumour is a solid-cystic neoplasm that shows trichilemmal differentiat... more Proliferating trichilemmal tumour is a solid-cystic neoplasm that shows trichilemmal differentiation similar to that of the isthmus of the hair follicle histologically characteristed by the presence of trichilemmal keratinization. Proliferating Trichilemmal Tumour (PTT) appears mainly in elderly women and is in general a solitary lesion on the scalp. Proliferating trichilemmal tumours generally have a benign clinical course, and a clinical differentiation from squamous cell carcinoma is often difficult. We report a case of PTT in a 30 year old man presenting as a solitary 10x8 cm ulcerated nodule on the scalp since 3 months clinically resembled a malignant tumour. The therapeutic approach is surgical removal with a wide clear margin.
Journal of Evidence Based Medicine and Healthcare, Sep 3, 2016
BACKGROUND Thyroid carcinoma accounts for less than 1% of cancer cases. In the Indian subcontinen... more BACKGROUND Thyroid carcinoma accounts for less than 1% of cancer cases. In the Indian subcontinent, thyroid carcinoma exhibits a varied disease profile and geographic differences in the pattern of cancer, the knowledge of which impacts a more favourable clinical outcome. The present study aims to profile Thyroid carcinoma in areas of age, gender, geographic domicile, morphology & clinical features and referral paradigm of cases in King George Hospital, Visakhapatnam, the tertiary referral hospital for coastal Andhra Pradesh. METHODS & MATERIALS The Retrospective Study 1988-2004 includes 188 patients who attended Department of Nuclear Medicine for pre & postoperative nuclear scan, thyroid carcinoma treatment protocol, whose clinical features, relevant laboratory data, histopathological reports & prognosis were analysed. RESULTS Papillary thyroid carcinoma was present in 79% and Follicular thyroid carcinoma in 19%, Anaplastic & Medullary Thyroid Carcinoma in 2% of cases (n=188), male to female ratio 1:0.62. Coastal city of Visakhapatnam recorded highest 59% of cases who were in their 3 rd and 4 th decades. West Godavari District had lowest at 5%. Clinical presentation of cases of Thyroid carcinoma as a Nodule (61%) which was the most common form lead to maximum number of referrals (n=82) from the Department of Surgery, King George Hospital. CONCLUSION In coastal Andhra Pradesh, papillary thyroid carcinoma was the most dominant form. Women were more affected than men. Painless thyroid nodule was the most common clinical feature. Coastal city of Visakhapatnam recorded highest number of cases and maximum referrals were from Department of Surgery.
Indian Journal of Public Health Research and Development, 2012
Malignant melanoma is fatal skin cancer when detected and treated early prognosis will be good. R... more Malignant melanoma is fatal skin cancer when detected and treated early prognosis will be good. Recent reports indicate rising incidence globally. This case study indicates how the people neglect the problems so much. A female patient aged 65 years presented with a painful non healing ulcer with pigmented margins of eighteen months duration on plantar aspect of the right heel. Three lymph nodes were present in the right inguinal region aspirated and obtained tarry coloured fluid revealed malignant melanoma cells with melanin pigment. Biopsy report confirmed the diagnosis that nodular aggregates of infiltrating melanoma cells with melanin pigment in the background of necrosis. Malignant melanoma remains one of the most challenging malignant neoplasm, particularly in developing countries where majority of patients present with late stage disease. Size of the ulcer indicates negligence of the patient. Health education may lead to future decline in morbidity and mortality.
Research and reviews: journal of medical and health sciences, Dec 29, 2014
Sickle cell Disease a homozygous condition for the abnormal hemoglobin gene HbS, is associated wi... more Sickle cell Disease a homozygous condition for the abnormal hemoglobin gene HbS, is associated with decreased life expectancy and recurrent episodes of various types of crises like hemolytic crisis, sickle crisis, sequestration crisis, vaso-occlusive crisis and aplastic crisis. Disseminated intravascular coagulation (DIC) can sometimes occur in conditions of tissue trauma and septicemia and rarely without septicemia as well. If the pathogenesis of the disease is not correctly understood and the crises were not attended properly DIC may set in leading to shock,multi-organ failure and even death. We present a case of DIC in a young female patient of Sickle cell Disease who met with a motor accident and developed multi-organ failure resulting in death. It is important to have prior knowledge about the pathogenesis of the disease and attend the crises even before the complication sets in, so that the patient's life may be saved.
Journal of Evidence Based Medicine and Healthcare, Jul 3, 2018
BACKGROUND The pathological spectrum of thyroid dysfunction varies from overactive to underactive... more BACKGROUND The pathological spectrum of thyroid dysfunction varies from overactive to underactive thyroidism. It is a common Endocrine disorder worldwide and leads to major consequences in the absence of appropriate treatment. MATERIALS AND METHODS This is a hospital based retrospective study based on medical records from the period of January 2013 to December 2015. Thyroid hormones were evaluated by RIA for T3 & T4 and IRMA for TSH, kits supplied by BRIT, Mumbai. RESULTS 2322 study subjects comprised of males 403 and 1919 females. Thyroid dysfunction categorized was as hypothyroidism, subclinical hypothyroidism, hyperthyroidism and Subclinical hyperthyroidism as per reference values for thyroid hormones. Prevalence of thyroid dysfunction was 43.7% in females and females were more affected than males. Hypothyroidism 15.80% and Subclinical hypothyroidism 21.40% were higher than hyperthyroidism 3.91% and subclinical hyperthyroidism 2.58% subjects aged 30-45 years had a higher prevalence. Euthyroid subjects constituted 56.28%. CONCLUSION Study revealed high prevalence of abnormal thyroid function. Females and elderly are more susceptible. Since untreated thyroid disease leads to significant morbidity, public awareness in the context of primary care setting will be valuable.
Indian journal of applied research, 2018
Background: The Clinical thyroid function comprises a major part of spectrum of thyroid disorders... more Background: The Clinical thyroid function comprises a major part of spectrum of thyroid disorders and entails progression to overt hypothyroidism if untreated with adverse sequelae such as increased risk of IHD, neurocognitive impairment and lowered quality of life. Aim : The present study aims to evaluate the prevalence of Subclinical Hypothyroidism in patient population of North Coastal Andhra Pradesh and analyze the effect of age and gender among the subjects. Materials & Methods : Retrospective cross-sectional hospital study. Data for evaluation obtained from patient records of thyroid lab at Department of Nuclear Medicine, King George Hospital, a tertiary referral hospital of North Coastal, Andhra Pradesh, from January to December 2013. Results : Total subjects were 738 comprising of 15.8% males and 84% females subjects with normal and hypothyroid were 56.6% and 43.36% respectively. Total of 194 cases (26.28%) had subclinical hypothyroidism including males 2.8% and females 23.4...
Indian Journal of Public Health Research and Development, 2012
Malignant melanoma is fatal skin cancer when detected and treated early prognosis will be good. R... more Malignant melanoma is fatal skin cancer when detected and treated early prognosis will be good. Recent reports indicate rising incidence globally. This case study indicates how the people neglect the problems so much. A female patient aged 65 years presented with a painful non healing ulcer with pigmented margins of eighteen months duration on plantar aspect of the right heel. Three lymph nodes were present in the right inguinal region aspirated and obtained tarry coloured fluid revealed malignant melanoma cells with melanin pigment. Biopsy report confirmed the diagnosis that nodular aggregates of infiltrating melanoma cells with melanin pigment in the background of necrosis. Malignant melanoma remains one of the most challenging malignant neoplasm, particularly in developing countries where majority of patients present with late stage disease. Size of the ulcer indicates negligence of the patient. Health education may lead to future decline in morbidity and mortality.
Background: The Sinonasal tract embraces nasal cavities and paranasal sinuses. This area is heart... more Background: The Sinonasal tract embraces nasal cavities and paranasal sinuses. This area is hearth for various non-neoplastic and neoplastic lesions. Because of its closed and complex architecture diagnosis by Fine Needle Aspiration Cytology (FNAC) was proved to be difficult. So, very few studies have been documented in literature. Aim: The aim of the study is to establish the importance of FNAC as a diagnostic contrivance for the sinonasal lesions with accommodating histopathology .This study also includes to assess the spectrum of lesions occurring in this region. Meterial & Methods: 77 cases with lesions in sinonasal tract were included in the present study. FNAC was performed and slides were stained by Haematoxylin and Eosin (H&E), Papanicolaou and Geimsa stains. The biopsy sections were processed and stained with H&E. Results: FNAC of 77 cases with sinonasal lesions were taken into study. The male to female ratio was 1.8: 1. Out of total cases, 43(58%) showed non neoplasticlesi...
Journal of Evidence Based Medicine and Healthcare, 2018
BACKGROUND The pathological spectrum of thyroid dysfunction varies from overactive to underactive... more BACKGROUND The pathological spectrum of thyroid dysfunction varies from overactive to underactive thyroidism. It is a common Endocrine disorder worldwide and leads to major consequences in the absence of appropriate treatment. MATERIALS AND METHODS This is a hospital based retrospective study based on medical records from the period of January 2013 to December 2015. Thyroid hormones were evaluated by RIA for T3 & T4 and IRMA for TSH, kits supplied by BRIT, Mumbai. RESULTS 2322 study subjects comprised of males 403 and 1919 females. Thyroid dysfunction categorized was as hypothyroidism, subclinical hypothyroidism, hyperthyroidism and Subclinical hyperthyroidism as per reference values for thyroid hormones. Prevalence of thyroid dysfunction was 43.7% in females and females were more affected than males. Hypothyroidism 15.80% and Subclinical hypothyroidism 21.40% were higher than hyperthyroidism 3.91% and subclinical hyperthyroidism 2.58% subjects aged 30-45 years had a higher prevalence. Euthyroid subjects constituted 56.28%. CONCLUSION Study revealed high prevalence of abnormal thyroid function. Females and elderly are more susceptible. Since untreated thyroid disease leads to significant morbidity, public awareness in the context of primary care setting will be valuable.
International Journal of Research in Medical Sciences, Jan 24, 2018
Astrocytic tumors are the most common primary tumors of the central nervous system. 1 Several gra... more Astrocytic tumors are the most common primary tumors of the central nervous system. 1 Several grading systems are used to grade astrocytomas. The most widely used system is the World Health Organization (WHO) classification (1979, 1993, 2000, and 2007) that grades astrocytomas (I-IV) based on cytological atypia, mitotic activity, vascular proliferation, and necrosis: pilocytic astrocytoma (grade I), diffuse astrocytoma (grade II), anaplastic astrocytoma (grade III), and glioblastoma (grade IV). 2 Though histopathological features largely help in the determination of prognosis, histological differentiation may not be clear in some cases, especially when only small fragments of tissue biopsies are available. Studies have employed a wide range of parameters from tumor suppressor genes to proliferation indices for predicting clinical outcome and survival. 3 A variety of methods have been employed to estimate the proliferative index of central nervous system tumors. Of these, one of the most potent methods is the Ki-67 labeling index (Ki-67 LI). The value of Ki-67 LI in the
Journal of Evidence Based Medicine and Healthcare, 2016
BACKGROUND Thyroid carcinoma accounts for less than 1% of cancer cases. In the Indian subcontinen... more BACKGROUND Thyroid carcinoma accounts for less than 1% of cancer cases. In the Indian subcontinent, thyroid carcinoma exhibits a varied disease profile and geographic differences in the pattern of cancer, the knowledge of which impacts a more favourable clinical outcome. The present study aims to profile Thyroid carcinoma in areas of age, gender, geographic domicile, morphology & clinical features and referral paradigm of cases in King George Hospital, Visakhapatnam, the tertiary referral hospital for coastal Andhra Pradesh. METHODS & MATERIALS The Retrospective Study 1988-2004 includes 188 patients who attended Department of Nuclear Medicine for pre & postoperative nuclear scan, thyroid carcinoma treatment protocol, whose clinical features, relevant laboratory data, histopathological reports & prognosis were analysed. RESULTS Papillary thyroid carcinoma was present in 79% and Follicular thyroid carcinoma in 19%, Anaplastic & Medullary Thyroid Carcinoma in 2% of cases (n=188), male to female ratio 1:0.62. Coastal city of Visakhapatnam recorded highest 59% of cases who were in their 3 rd and 4 th decades. West Godavari District had lowest at 5%. Clinical presentation of cases of Thyroid carcinoma as a Nodule (61%) which was the most common form lead to maximum number of referrals (n=82) from the Department of Surgery, King George Hospital. CONCLUSION In coastal Andhra Pradesh, papillary thyroid carcinoma was the most dominant form. Women were more affected than men. Painless thyroid nodule was the most common clinical feature. Coastal city of Visakhapatnam recorded highest number of cases and maximum referrals were from Department of Surgery.
Journal of Evidence Based Medicine and Healthcare, 2016
BACKGROUND Chronic kidney disease (CKD) is a major public health problem causing significant morb... more BACKGROUND Chronic kidney disease (CKD) is a major public health problem causing significant morbidity and mortality worldwide. Diabetes mellitus (DM) and hypertension are common causes and anaemia is a common complication. It is important to identify the cause and complication, to treat it and prevent its progression to end-stage renal disease (ESRD). AIM To identify the haematological pattern in chronic kidney disease patients and to study the clinical presentation. MATERIALS AND METHODS 72 cases of CKD were studied for a period of 6 months and thorough assessment of clinical features and haematological examinations were done. RESULTS CKD is observed in all age groups and predominantly in older age group greater than 50 yrs., with male preponderance. DM and hypertension are common causes. 89% of the patients presented with anaemia and 4 cases of sickle cell anaemia were observed. Neutrophilic leucocytosis was seen in 29.2% and thrombocytopenia in 8.3% of cases. CONCLUSION CKD is seen in all age groups with a male predominance, common in older age group, anaemia being the most common and important haematological complication. Few cases of sickle cell anaemia (SCA) were seen presenting with CKD. Knowledge and treatment of these conditions has proved to improve the quality of life.
Journal of the American Podiatric Medical Association, 1975
... 59 Malignant melanoma: A Case report Hetal Shah* Zankhana Vyas** *MDS, Reader, Department of ... more ... 59 Malignant melanoma: A Case report Hetal Shah* Zankhana Vyas** *MDS, Reader, Department of Oral Pathology, Ahmedabad Dental College, Ahmedabad, Gujarat. India. ... Acta Clin Croat 2006;45:153. 7. Patel SG, Prasad ML, Escrig M, Singh B, Shah Haar, Kraus DH, et al. ...
Journal of Evidence Based Medicine and Healthcare, 2017
BACKGROUND Paediatric Solid Neoplasms (PSN) are a global problem. There is significant variation ... more BACKGROUND Paediatric Solid Neoplasms (PSN) are a global problem. There is significant variation of incidence of paediatric solid neoplasms in various regions of the world. Benign tumours are more common than cancer. In an effort to better understand the prevalence of paediatric solid tumours in our region, a retrospective review of the tumours diagnosed histopathologically was carried out. MATERIALS AND METHODS This is a retrospective study undertaken in a tertiary care hospital for a period of five years. All the benign and malignant paediatric solid tumours of children below 14 years from January 2012 to December 2016 were retrieved and analysed according to age, sex and histopathological diagnosis. Leukaemias were excluded from our study. All tumours were diagnosed on conventional haematoxylin and eosin-stained sections. RESULTS A total of 109 cases of solid paediatric tumours were received during this period. Of these, maximum of 30 tumours were of soft tissue tumours followed by Central Nervous System (CNS) and bone tumours with 24 and 23 cases, respectively. 7 cases of blastomas were also observed. CONCLUSION This study showed benign and malignant tumours to be of near-equal prevalence. Soft tissue tumours were the most common. Ratio of benign tumours to malignant were almost equal below 4 years. Malignant tumours were higher in 5-9 years group.
Proliferating trichilemmal tumour is a solid-cystic neoplasm that shows trichilemmal differentiat... more Proliferating trichilemmal tumour is a solid-cystic neoplasm that shows trichilemmal differentiation similar to that of the isthmus of the hair follicle histologically characteristed by the presence of trichilemmal keratinization. Proliferating Trichilemmal Tumour (PTT) appears mainly in elderly women and is in general a solitary lesion on the scalp. Proliferating trichilemmal tumours generally have a benign clinical course, and a clinical differentiation from squamous cell carcinoma is often difficult. We report a case of PTT in a 30 year old man presenting as a solitary 10x8 cm ulcerated nodule on the scalp since 3 months clinically resembled a malignant tumour. The therapeutic approach is surgical removal with a wide clear margin.