Meenu Bhan - Profile on Academia.edu (original) (raw)

Papers by Meenu Bhan

Zenodo (CERN European Organization for Nuclear Research), Jul 21, 2023

Cancer is now recognized as one of the most common diseases in the world, due to its high mortali... more Cancer is now recognized as one of the most common diseases in the world, due to its high mortality rate. Inflammation is our body's immune system against potentially dangerous stimuli like allergens and/or tissue damage. However, a variety of disorders, including allergies, cardiovascular issues, metabolic syndrome, cancer, and autoimmune diseases are the underlying cause of uncontrollable inflammatory response. Inflammation is directly linked to cancer and plays an important role in the growth and development of tumour. Inflammation and cancer are linked through the extrinsic and intrinsic processes, respectively. Herbals play a very important role in treatment of cancer and inflammation. Several plant derived extracts inhibit and regulate signaling process and network associated with the growth as well as proliferation of cancer cells. It is necessary to invent new strategies to prevent and treat disease. Products obtained from plants are a valuable source for the development of novel medications, due to their diverse chemical composition. So researchers are focusing on various phytoconstituents and how well they may work against various diseases at the moment. The present review is therefore an effort to give the literature study for Mechanism, relation between inflammation and cancer and the list of medicinal plants that possessed anti-inflammatory and anticancer activity.

Journal of Molecular Liquids, Mar 1, 2017

Ionic liquid-based microwave-assisted extraction (MAE) of total isoflavonoids from Radix Pueraria... more Ionic liquid-based microwave-assisted extraction (MAE) of total isoflavonoids from Radix Puerariae was proposed. [bmim]Br was selected as the solvent. The microwave-assisted extraction parameters, including extraction time, extraction temperature, microwave power, and the concentration of [bmim]Br had been concerned. Response surface methodology was used to develop predictive models for simulation and optimization of the extraction process. The multivariate quadratic regression equation was obtained by Central Composite Design. The response surfaces were determined by using the yields of total isoflavonoids as response values. The optimum extraction conditions were: extraction temperature of 70 o C, extraction time of 8 min, microwave power of 400 W, and the concentration of [bmim]Br of 1.2 mol/L. The extraction yield of total isoflavonoids was 10.09%, which is well in close agreement with the value predicted by the model. Compared to conventional organic solvents, the ionic liquid based MAE could provide higher extraction yields and take much shorter extraction time.

Ionic liquids as green solvents in herbal extraction

International Journal of Advanced Research and Development, 2017

Conventional & recent techniques of extraction of active constituents from drugs

International Journal of Academic Research and Development, 2017

Response surface methodology: An important tool in optimization

International Journal of Advanced Research and Development, 2017

Tinospora cordifolia – Phytochemical and Pharmacological evaluation

International Journal of Advanced Scientific Research, 2016

Pharmacognosy and phytochemistry of Thuja occidentalis Linn

International Journal of Advanced Scientific Research, 2016

Asian Pacific Journal of Health Sciences

Medicinal herbs are active in curing various disorders by their distinct characteristics. In this... more Medicinal herbs are active in curing various disorders by their distinct characteristics. In this research, antioxidant and acetylcholinesterase (AChEI) inhibitory activity of Achyranthes aspera, Psidium guajava, Anthocephalus cadamba, Carissa carandas, Caesalpinia bonduc, Indian medicinal plants have been evaluated by collecting and extracting selected plants parts by using different solvents followed by assessment of AChEI inhibitory activity by autographic assay (TLC method) and microplate assay (Ellman method). Further assessment of antioxidant activity of selected plants by 2, 2-diphenyl-1-picrylhydryzyl method was done. In autographic assay, C. bonduc had more AChE inhibitory potential than other selected plants. In microplate assay method, C. bonduc has shown lowest IC50 value among all other extracts, suggesting its highest enzymatic inhibitory potential and C. carandas has been shown highest IC50 value, suggesting a lower enzymatic inhibitory potential. The Rf value of C. b...

Scholars Academic Journal of Pharmacy, 2022

Andrographis paniculata is an important medicinal plant belonging to family Acanthaceae and has b... more Andrographis paniculata is an important medicinal plant belonging to family Acanthaceae and has been used from ancient times. Andrographis paniculata is used as a traditional herbal medicine in Unani, Ayurvedic, Homeopathic, and Siddha system. It has potential to treat multiple health diseases like abortifacient, antithrombotic, expectorant, hepatoprotective and other uses also. The major marker chemical constituent found is andrographolide (2.39%) which had many therapeutic uses. Dominancy of the herbal drug depend’s on the quantity and quality of therapeutic chemical constituents present in it, which are investigated by using advanced and complex techniques. HPTLC is the advanced and sophisticated technique that can be used for the high-resolution chromatography and identify quality and quantity of therapeutic chemical constituents present in herbal drugs. HPTLC can determine the purity, quality, quantity and authenticity of the herbal crude drugs and marketed formulations very qu...

The antimicrobial zest of hydro-alcoholic and methanolic seed extracts of Datura fastuosa L. was ... more The antimicrobial zest of hydro-alcoholic and methanolic seed extracts of Datura fastuosa L. was evaluated against three clinical bacterial strains (Escherichia coli, Staphylococcus aureus and Bacillus subtilis) and two clinical fungal strains (Candida allbicans and Aspergillus niger) by tube dilution method. Both the plant extracts were found to be active against the tested micro-organisms. The methanolic extract of D. fastuosa was found to inhibit bacterial strain, E.coli effectively with minimum bactericidal concentration (MBC) of 25μg/ml. The hydroalcoholic extract of D. fastuosa seeds was found to be more potent in terms of its bactericidal concentration for B. subtilis with both minimum inhibitory concentration (MIC) and MBC values as 25 μg/ml. Also, methanolic extract was found to be more efficient in inhibiting S. aureus having MIC 12.5 μg/ml. Hydro alcoholic and methanolic seed extracts of D. fastuosa were also evaluated for antioxidant potential using 1,1-diphenyl-1-picryl...

Thuja occidentalis Linn. (Cupressaceae) has been widely used for many ailments in the traditional... more Thuja occidentalis Linn. (Cupressaceae) has been widely used for many ailments in the traditional system like hepatoprotection, anti-oxidant, anti-diabetic, anti-arthritic, anti-microbial, anti-cancer etc. because of its medicinal properties. In the nineteenth century, Thuja was commonly used as an externally applied tincture or ointment for the treatment of warts, ringworm and thrush, and a local injection of the tincture was used for treating venereal warts. The present paper summarizes a concise detail about pharmacognostic, phytohemistry and bioactivities of T. occidentalis Linn.

Applications of microwaves in pharmaceutical processes

International Journal of Academic Research and Development, 2017

Comparison of effectiveness of acupuncture thrust-debonding and three acupoints in patients shoulder with subacromial impingement syndrome: A randomized clinical trial

Alternative & Integrative Medicine, 2017

Pharmacognosy Journal, 2017

ILs' are now commonly termed as low-melting salts having melting-point typically less than 100°C ... more ILs' are now commonly termed as low-melting salts having melting-point typically less than 100°C obtained from the combination of large organic cations with variable anions. 3 Now, ILs are most frequently used as more than a Alternative ''green'' solvent. They diverge from molecular solvents by having a particular ionic character and its structural organisation which

Optimization of ionic liquid-based microwave-assisted dispersive liquid–liquid microextraction for the determination of plasticizers in water by response surface methodology

Analytical Methods, 2013

In this work, a simultaneous ionic liquid-based microwave-assisted dispersive liquid–liquid micro... more In this work, a simultaneous ionic liquid-based microwave-assisted dispersive liquid–liquid microextraction (IL-based MADLLME) method was developed for the determination of plasticizers in water using high-performance liquid chromatography (HPLC) with ultraviolet detection. Several parameters affecting the extraction efficiency, such as type and volume of ionic liquid and disperser solvent, microwave time and temperature, were investigated by single factor experiments. Then, the microwave irradiation time and temperature, and the volumes of extraction and disperser solvents were optimized using response surface methodology (RSM). The optimal values were determined to be within an extraction volume of 110 μL, a dispersive solvent volume of 0.26 mL, and a microwave irradiation temperature and time of 60 °C and 2 min, respectively. The calibration curves were linear in the range of 23–230 μg L−1 for dimethyl phthalate (DMP), 23.8–238 μg L−1 for diethyl phthalate (DEP), 16.5–165 μg L−1 for benzylbutyl phthalate (BBP), 19.5–195 μg L−1 for dibutyl phthalate (DBP), and 18.6–186 μg L−1 for diethylhexyl phthalate (DEHP). Under the optimum conditions, the limits of detection (LODs) of these plasticizers were in the range of 0.71–1.94 μg L−1. Validation of the methodology was carried out by the method of standard addition at two concentration levels for three water samples. The recoveries of the analytes were in the range of 85.2–103.3%, with the relative standard deviations (RSDs, n = 6) ≤ 5.9%. The results show that IL-based MADLLME is a suitable method for the determination of these five plasticizers in water.

Zenodo (CERN European Organization for Nuclear Research), Jul 21, 2023

Cancer is now recognized as one of the most common diseases in the world, due to its high mortali... more Cancer is now recognized as one of the most common diseases in the world, due to its high mortality rate. Inflammation is our body's immune system against potentially dangerous stimuli like allergens and/or tissue damage. However, a variety of disorders, including allergies, cardiovascular issues, metabolic syndrome, cancer, and autoimmune diseases are the underlying cause of uncontrollable inflammatory response. Inflammation is directly linked to cancer and plays an important role in the growth and development of tumour. Inflammation and cancer are linked through the extrinsic and intrinsic processes, respectively. Herbals play a very important role in treatment of cancer and inflammation. Several plant derived extracts inhibit and regulate signaling process and network associated with the growth as well as proliferation of cancer cells. It is necessary to invent new strategies to prevent and treat disease. Products obtained from plants are a valuable source for the development of novel medications, due to their diverse chemical composition. So researchers are focusing on various phytoconstituents and how well they may work against various diseases at the moment. The present review is therefore an effort to give the literature study for Mechanism, relation between inflammation and cancer and the list of medicinal plants that possessed anti-inflammatory and anticancer activity.

Journal of Molecular Liquids, Mar 1, 2017

Ionic liquid-based microwave-assisted extraction (MAE) of total isoflavonoids from Radix Pueraria... more Ionic liquid-based microwave-assisted extraction (MAE) of total isoflavonoids from Radix Puerariae was proposed. [bmim]Br was selected as the solvent. The microwave-assisted extraction parameters, including extraction time, extraction temperature, microwave power, and the concentration of [bmim]Br had been concerned. Response surface methodology was used to develop predictive models for simulation and optimization of the extraction process. The multivariate quadratic regression equation was obtained by Central Composite Design. The response surfaces were determined by using the yields of total isoflavonoids as response values. The optimum extraction conditions were: extraction temperature of 70 o C, extraction time of 8 min, microwave power of 400 W, and the concentration of [bmim]Br of 1.2 mol/L. The extraction yield of total isoflavonoids was 10.09%, which is well in close agreement with the value predicted by the model. Compared to conventional organic solvents, the ionic liquid based MAE could provide higher extraction yields and take much shorter extraction time.

Ionic liquids as green solvents in herbal extraction

International Journal of Advanced Research and Development, 2017

Conventional & recent techniques of extraction of active constituents from drugs

International Journal of Academic Research and Development, 2017

Response surface methodology: An important tool in optimization

International Journal of Advanced Research and Development, 2017

Tinospora cordifolia – Phytochemical and Pharmacological evaluation

International Journal of Advanced Scientific Research, 2016

Pharmacognosy and phytochemistry of Thuja occidentalis Linn

International Journal of Advanced Scientific Research, 2016

Asian Pacific Journal of Health Sciences

Medicinal herbs are active in curing various disorders by their distinct characteristics. In this... more Medicinal herbs are active in curing various disorders by their distinct characteristics. In this research, antioxidant and acetylcholinesterase (AChEI) inhibitory activity of Achyranthes aspera, Psidium guajava, Anthocephalus cadamba, Carissa carandas, Caesalpinia bonduc, Indian medicinal plants have been evaluated by collecting and extracting selected plants parts by using different solvents followed by assessment of AChEI inhibitory activity by autographic assay (TLC method) and microplate assay (Ellman method). Further assessment of antioxidant activity of selected plants by 2, 2-diphenyl-1-picrylhydryzyl method was done. In autographic assay, C. bonduc had more AChE inhibitory potential than other selected plants. In microplate assay method, C. bonduc has shown lowest IC50 value among all other extracts, suggesting its highest enzymatic inhibitory potential and C. carandas has been shown highest IC50 value, suggesting a lower enzymatic inhibitory potential. The Rf value of C. b...

Scholars Academic Journal of Pharmacy, 2022

Andrographis paniculata is an important medicinal plant belonging to family Acanthaceae and has b... more Andrographis paniculata is an important medicinal plant belonging to family Acanthaceae and has been used from ancient times. Andrographis paniculata is used as a traditional herbal medicine in Unani, Ayurvedic, Homeopathic, and Siddha system. It has potential to treat multiple health diseases like abortifacient, antithrombotic, expectorant, hepatoprotective and other uses also. The major marker chemical constituent found is andrographolide (2.39%) which had many therapeutic uses. Dominancy of the herbal drug depend’s on the quantity and quality of therapeutic chemical constituents present in it, which are investigated by using advanced and complex techniques. HPTLC is the advanced and sophisticated technique that can be used for the high-resolution chromatography and identify quality and quantity of therapeutic chemical constituents present in herbal drugs. HPTLC can determine the purity, quality, quantity and authenticity of the herbal crude drugs and marketed formulations very qu...

The antimicrobial zest of hydro-alcoholic and methanolic seed extracts of Datura fastuosa L. was ... more The antimicrobial zest of hydro-alcoholic and methanolic seed extracts of Datura fastuosa L. was evaluated against three clinical bacterial strains (Escherichia coli, Staphylococcus aureus and Bacillus subtilis) and two clinical fungal strains (Candida allbicans and Aspergillus niger) by tube dilution method. Both the plant extracts were found to be active against the tested micro-organisms. The methanolic extract of D. fastuosa was found to inhibit bacterial strain, E.coli effectively with minimum bactericidal concentration (MBC) of 25μg/ml. The hydroalcoholic extract of D. fastuosa seeds was found to be more potent in terms of its bactericidal concentration for B. subtilis with both minimum inhibitory concentration (MIC) and MBC values as 25 μg/ml. Also, methanolic extract was found to be more efficient in inhibiting S. aureus having MIC 12.5 μg/ml. Hydro alcoholic and methanolic seed extracts of D. fastuosa were also evaluated for antioxidant potential using 1,1-diphenyl-1-picryl...

Thuja occidentalis Linn. (Cupressaceae) has been widely used for many ailments in the traditional... more Thuja occidentalis Linn. (Cupressaceae) has been widely used for many ailments in the traditional system like hepatoprotection, anti-oxidant, anti-diabetic, anti-arthritic, anti-microbial, anti-cancer etc. because of its medicinal properties. In the nineteenth century, Thuja was commonly used as an externally applied tincture or ointment for the treatment of warts, ringworm and thrush, and a local injection of the tincture was used for treating venereal warts. The present paper summarizes a concise detail about pharmacognostic, phytohemistry and bioactivities of T. occidentalis Linn.

Applications of microwaves in pharmaceutical processes

International Journal of Academic Research and Development, 2017

Comparison of effectiveness of acupuncture thrust-debonding and three acupoints in patients shoulder with subacromial impingement syndrome: A randomized clinical trial

Alternative & Integrative Medicine, 2017

Pharmacognosy Journal, 2017

ILs' are now commonly termed as low-melting salts having melting-point typically less than 100°C ... more ILs' are now commonly termed as low-melting salts having melting-point typically less than 100°C obtained from the combination of large organic cations with variable anions. 3 Now, ILs are most frequently used as more than a Alternative ''green'' solvent. They diverge from molecular solvents by having a particular ionic character and its structural organisation which

Optimization of ionic liquid-based microwave-assisted dispersive liquid–liquid microextraction for the determination of plasticizers in water by response surface methodology

Analytical Methods, 2013

In this work, a simultaneous ionic liquid-based microwave-assisted dispersive liquid–liquid micro... more In this work, a simultaneous ionic liquid-based microwave-assisted dispersive liquid–liquid microextraction (IL-based MADLLME) method was developed for the determination of plasticizers in water using high-performance liquid chromatography (HPLC) with ultraviolet detection. Several parameters affecting the extraction efficiency, such as type and volume of ionic liquid and disperser solvent, microwave time and temperature, were investigated by single factor experiments. Then, the microwave irradiation time and temperature, and the volumes of extraction and disperser solvents were optimized using response surface methodology (RSM). The optimal values were determined to be within an extraction volume of 110 μL, a dispersive solvent volume of 0.26 mL, and a microwave irradiation temperature and time of 60 °C and 2 min, respectively. The calibration curves were linear in the range of 23–230 μg L−1 for dimethyl phthalate (DMP), 23.8–238 μg L−1 for diethyl phthalate (DEP), 16.5–165 μg L−1 for benzylbutyl phthalate (BBP), 19.5–195 μg L−1 for dibutyl phthalate (DBP), and 18.6–186 μg L−1 for diethylhexyl phthalate (DEHP). Under the optimum conditions, the limits of detection (LODs) of these plasticizers were in the range of 0.71–1.94 μg L−1. Validation of the methodology was carried out by the method of standard addition at two concentration levels for three water samples. The recoveries of the analytes were in the range of 85.2–103.3%, with the relative standard deviations (RSDs, n = 6) ≤ 5.9%. The results show that IL-based MADLLME is a suitable method for the determination of these five plasticizers in water.