Bilal Sheikh - Academia.edu (original) (raw)

Papers by Bilal Sheikh

The purpose of the study was to study the Effect of Music and Aerobic Exercise programme on selec... more The purpose of the study was to study the Effect of Music and Aerobic Exercise programme on selected physiological parameters of Football Players of J & K State. The subjects of the study were selected from the Football Players of J & K State. The subject of study were selected randomly. 40 subjects 20 for control group and 20 for experimental group. The age of the subjects were ranged between 18 to 25 years. The criterion measures of selected physiological parameter were chosen for the purpose of the study were resting pulse rate which was measured by feeling the palpation of redial artery, chest expansion which was measured with the help of metallic tape and cardiovascular endurance which was measured by 600 yard run/walk test. The necessary data on the selected physical parameters were collected at different time of day by administrating the specific test at the play field of Govt. College of Physical Education, Ganderbal J & K. For testing the statistical significance on selecte...

Contemporary Clinical Trials Communications, 2020

Background Herein, we propose a novel RCT study to collect preliminary data on the impact of a 24... more Background Herein, we propose a novel RCT study to collect preliminary data on the impact of a 24-week home-based exercise program that can improve prognosis, physical function, and quality of life (QoL) in men with prostate cancer (PCa). This study will provide data on the feasibility of conducting a home-based exercise study and pilot data on the impact of exercise on circulating concentrations of biomarkers reported in the literature to be beneficial for the prognostication of PCa. Methods/design Thirty male patients, clinically-diagnosed with prostate cancer under active surveillance, will be recruited to participate in a 2-arm, 24-week home-based program. Random allocation to each arm - intervention, and control – will be performed in a 1:1 ratio. Participants assigned to the intervention group will perform 30 min of light-to-moderate intensity walking five days a week (40–60% heart rate reserve) and three sets of 15 repetitions of light callisthenic exercises (bodyweight squat...

This booklet is designed for all those people who are working in aviation, hospitality and touris... more This booklet is designed for all those people who are working in aviation, hospitality and tourism industry. Most companies and organizations in the aviation and tourism industry could make use of this booklet as a training guide for new employees who are involved in issuing passports and visas. I have touched all aspects of passports and visas in this handout. Everything dealing with passports and visas have been given and explained in a simple and understandable language. Even those people, who are not in to this business, will find this booklet helpful as I am sure people travel as a part of tourism from one country to another.

International Journal of Molecular Sciences

The vascular system is critical infrastructure that transports oxygen and nutrients around the bo... more The vascular system is critical infrastructure that transports oxygen and nutrients around the body, and dynamically adapts its function to an array of environmental changes. To fulfil the demands of diverse organs, each with unique functions and requirements, the vascular system displays vast regional heterogeneity as well as specialized cell types. Our understanding of the heterogeneity of vascular cells and the molecular mechanisms that regulate their function is beginning to benefit greatly from the rapid development of single cell technologies. Recent studies have started to analyze and map vascular beds in a range of organs in healthy and diseased states at single cell resolution. The current review focuses on recent biological insights on the vascular system garnered from single cell analyses. We cover the themes of vascular heterogeneity, phenotypic plasticity of vascular cells in pathologies such as atherosclerosis and cardiovascular disease, as well as the contribution of ...

Medicine & Science in Sports & Exercise

SPE International Conference and Exhibition on Formation Damage Control

Asphaltenes flow in equilibrium with the liquid phase as other components of the produced hydroca... more Asphaltenes flow in equilibrium with the liquid phase as other components of the produced hydrocarbon. If asphaltenes are in solution during production, there are not negative impact to well productivity. However, asphaltenes could precipitate as pressure, temperature and composition change. If precipitated, due to pressure decrease, asphaltene could deposit as a solid phase in the formation rock near wellbore becoming an obstruction to flow and inducing formation damage. Skin due to asphaltene deposition near wellbore was confirmed in several wells of a carbonate reservoir. Asphaltene deposition was also observed in the production tubing. The objective of this work is to investigate the main variables affecting asphaltene deposition in the Magwa-Marrat field is South East Kuwait and develop a technique to manage and/or decrease formation damage due to this solid deposition phenomena. In order to estimate the skin value and predict the location of any impairment to production, a pre...

International Journal of Research in Medical Sciences

Background: Primary leiomyosarcoma of the kidney is an exceptionally rare tumor with an aggressiv... more Background: Primary leiomyosarcoma of the kidney is an exceptionally rare tumor with an aggressive behavior. However, reported literature is very limited. Since the prognosis for a renal sarcoma is extremely poor, differentiation from sarcomatoid renal cell carcinoma (RCC) is necessary. Histopathology and immunohistochemistry are the only modes of diagnosing these sarcomas as they have no specific diagnostic features clinically and radiologically. Objectives was to evaluate the clinicopathological pattern of leiomyosarcomas arising from kidney.Methods: This study was conducted in the Department of Pathology, Government Medical College, Srinagar. It was a retrospective study done over a period of 3 years, July 2014 to June 2017. A total of 4 patients, who underwent surgery and were diagnosed with primary LMS of the kidney, were included in the present study.Results: The study was done to evaluate the clinicopathological pattern of 4 cases of primary renal LMS diagnosed at a tertiary ...

European Journal of Translational Myology

The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarc... more The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04). Myostatin was significantly lower in the exercise group compared to controls (p=0.01). Exercise mice maintained forelimb grip force while control mice had a significaint decrease (p=0.01). No significant difference was observed in pre-post all limb grip strength. Further, forelimb and all limb grip strength was negatively associated with tumor mass (p<0.01).

iScience

Isolation of embryonic neural, mural, endothelial, and microglial cells to >94% purity Transcript... more Isolation of embryonic neural, mural, endothelial, and microglial cells to >94% purity Transcriptome analyses of neural, vascular, and microglial cells from E14.5 brain Generation of intercellular communication network with 1,710 unique interactions Established ''Brain interactome explorer,'' a searchable cell communication database

International Journal of Audiology

Abstract Objective: Evaluation of the Sennheiser HDA 280-CL circumaural headphone for the determi... more Abstract Objective: Evaluation of the Sennheiser HDA 280-CL circumaural headphone for the determination of (1) equivalent threshold sound pressure levels (ETSPL) for 125–18,000 Hz.; (2) real ear attenuation (250–8000 Hz); (3) insertion loss (63–18,000 Hz); (4) frequency response (125–18,000 Hz); (5) total harmonic distortion (THD) (125–10,000 Hz); and, (6) linearity (11,200–18,000 Hz).Study Sample: Twenty-five normal hearing adults aged 18–25 participated in (1) and (2).Design: (1) Hearing thresholds were measured using the Sennheiser HDA 280-CL. Frequency specific ETSPL values were calculated in an artificial ear. (2) Sound field thresholds were measured with the ears open and covered with the headphone to obtain the real ear attenuation thresholds (REAT). These values were used to determine the maximum permissible ambient noise levels (MPANL). (3) A B&K HATS mannequin recorded the output levels of a broadband pink noise with the ears open and covered with the headphones. (4, 5) The frequency response, THD and linearity were measured in an artificial ear.Results: Values for ETSPL, REAT, MPANL, insertion loss, as well as measures of frequency response, THD and linearity are presented.Conclusions: The Sennheiser HDA 280-CL meets the requirements for audiometric testing and the values presented can be used for calibration.

Blood

Key Points PHF6 is a tumor suppressor, and loss of PHF6 synergizes with ectopic TLX3 expression t... more Key Points PHF6 is a tumor suppressor, and loss of PHF6 synergizes with ectopic TLX3 expression to cause rapid-onset fully penetrant leukemia. Loss of PHF6 leads to sustained and robust HSC reconstitution beyond quaternary transplants and promotes progenitor production.

International Journal of Educational Science and Research

The usage of Banking Functions through Internet mechanism is comfortable and time saving process;... more The usage of Banking Functions through Internet mechanism is comfortable and time saving process; since the adoption rates of different Banking Functions through Internet Banking mechanism is very low. An attempt has been made in the current study to check the variations on Internet Banking between different Banking Functions.

Indian Journal of Science and Technology

Cell reports, Jan 18, 2018

Apoptotic cell death removes unwanted cells and is regulated by interactions between pro-survival... more Apoptotic cell death removes unwanted cells and is regulated by interactions between pro-survival and pro-apoptotic members of the BCL-2 protein family. The regulation of apoptosis is thought to be crucial for normal embryonic development. Accordingly, complete loss of pro-survival MCL-1 or BCL-XL (BCL2L1) causes embryonic lethality. However, it is not known whether minor reductions in pro-survival proteins could cause developmental abnormalities. We explored the rate-limiting roles of MCL-1 and BCL-XL in development and show that combined loss of single alleles of Mcl-1 and Bcl-x causes neonatal lethality. Mcl-1;Bcl-x mice display craniofacial anomalies, but additional loss of a single allele of pro-apoptotic Bim (Bcl2l11) restores normal development. These findings demonstrate that the control of cell survival during embryogenesis is finely balanced and suggest that some human craniofacial defects, for which causes are currently unknown, may be due to subtle imbalances between pro...

Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors, Jan 17, 2018

The aging population in Canada is steadily increasing and is placing greater demand on paramedic ... more The aging population in Canada is steadily increasing and is placing greater demand on paramedic services, especially through the growing number of non-emergent lift assist (LA) calls. A LA occurs when a person calls paramedic services and requests assistance to get up or mobilize, usually after experiencing a fall. The patient refuses transport to the emergency department for further medical attention. LA calls are time consuming and are non-reimbursable. The increase in number of this call type, specifically amongst older adults, is placing strain on paramedic services. The purpose of this study was to describe the characteristics of LA calls in patients aged 65 and older and determine their impact on paramedic services. A dataset of 1,121 LA calls of patients aged 65 and older was extracted from Middlesex-London Emergency Medical Services (MLEMS) database of electronic patient care reports collected over 1 year in 2015. Statistical and qualitative analyses were performed to descr...

Nature, Aug 1, 2018

Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organizati... more Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function. Among the genes coding for the MYST family of KATs (KAT5-KAT8) are the oncogenes KAT6A (also known as MOZ) and KAT6B (also known as MORF and QKF). KAT6A has essential roles in normal haematopoietic stem cells and is the target of recurrent chromosomal translocations, causing acute myeloid leukaemia. Similarly, chromosomal translocations in KAT6B have been identified in diverse cancers. KAT6A suppresses cellular senescence through the regulation of suppressors of the CDKN2A locus, a function that requires its KAT activity. Loss of one allele of KAT6A extends the median survival of mice with MYC-induced lymphoma from 105 to 413 days. These findings suggest that inhibition of KAT6A and KAT6B may provide a therapeutic benefit in cancer. Here we present highly potent, selective inhibitors of KAT6A and KAT6B, denoted WM-8014 and WM-1119. Biochemical and structural studies demo...

Asian Journal of Research in Social Sciences and Humanities

International Journal Of Medical Science And Clinical Invention

BACKGROUND: A variety of lesions affect large bowel which include both neoplastic and non-neoplas... more BACKGROUND: A variety of lesions affect large bowel which include both neoplastic and non-neoplastic pathologies,with some of the inflammatory diseases being premalignant. Due to vague symptoms, the clinical diagnosis is usually delayed. A battery of laboratory tests including biopsy is essential to arrive at a specific diagnosis for appropriate management. AIMS: To study the histopathological spectrum of lesions of colon and rectum on colonoscopic biopsies. MATERIALS AND METHODS: The present study was undertaken in the Department of Pathology, Government Medical College, Srinagar over a one year period from October 2015 to October 2016. A total of two hundred and eighty four (284) colorectal biopsies were included in the present study. All tissues were fixed in formalin, stained with H&E and special stains like Periodic Acid Schiff (PAS), Reticulin, Zeihl Neelsen (ZN) along with Immunohistochemistry (IHC) were done as and when required. RESULTS: Out of total 284 cases, 113 were non-neoplastic and 171 were neoplastic. In our study we observed that neoplastic lesions predominated over non-neoplastic lesion. Of 171 neoplastic lesions, 60 were benign and 111 were malignant. Malignant lesions were more in number than the benign lesions in our study. Out of a total of 284 colorectal lesions 180 (63.38%) were present in males and 104 (36.62%) were present in females with male to female ratio being 1.73:1. Non specific colitis was the commonest type seen among non-neoplastic lesions. Tubular adenoma was the most common benign neoplastic lesion and moderately differentiated adenocarcinoma was the commonest malignancy seen. Rectum was the most common site for malignant lesions. CONCLUSION: We observed that neoplastic lesions were more common than non-neoplastic lesions in large intestine. Present study emphasizes the need for early histopathological diagnosis for appropriate treatment

Blood, Nov 23, 2016

Hematopoietic stem cells (HSCs) are conventionally thought to be at the apex of a hierarchy that ... more Hematopoietic stem cells (HSCs) are conventionally thought to be at the apex of a hierarchy that produces all mature cells of the blood. The quintessential property of these cells is their ability to reconstitute the entire hematopoietic system of hemoablated recipients. This characteristic has enabled HSCs to be used to replenish the hematopoietic system of patients after chemotherapy or radiotherapy. Here, we use deletion of the monocytic leukemia zinc finger gene (Moz/Kat6a/Myst3) to examine the effects of removing HSCs. Loss of MOZ, in adult mice leads to the rapid loss of HSCs as defined by transplantation. This is accompanied by a reduction of the LSK-CD48(-)CD150(+) and LSK-CD34(-)Flt3(-) populations in the bone marrow and a reduction in quiescent cells in G0 Surprisingly, the loss of classically defined HSCs did not affect mouse viability and there was no recovery of the LSK-CD48(-)CD150(+) and LSK-CD34(-)Flt3(-) populations 15-18 months after Moz deletion. Clonal analysis o...

Abu Dhabi International Petroleum Exhibition & Conference, 2016