Serpil Bozkurt - Academia.edu (original) (raw)
Papers by Serpil Bozkurt
LIPPINCOTT WILLIAMS & WILKINS, 2015
Zeynep Kamil tıp bülteni, Apr 1, 2005
Vulva karsinomu nadir olup çoðunlukla 60 yaþýn üstündeki kadýnlarda görülür. Nedeni halen çok açý... more Vulva karsinomu nadir olup çoðunlukla 60 yaþýn üstündeki kadýnlarda görülür. Nedeni halen çok açýk olmamakla birlikte etyopatogenezde baþlýca Human Papilloma Virüsü (HPV) ve liken sklerozus suçlanmaktadýr. Biz vulvasýnda, liken sklerozus zemininden geliþmiþ, iyi diferensiye, invaziv skuamöz hücreli kanseri olan 36 yaþýnda bir kadýn olgu sunmaktayýz.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1997
Amaç: Atrofik vajinit olgularında lokal östriol ve konjuge östrojen kremlerinin vagina epiteli ge... more Amaç: Atrofik vajinit olgularında lokal östriol ve konjuge östrojen kremlerinin vagina epiteli gelişimi üzerine etkilerini karşılaştırmalı olarak araştırmak.
artemisonline.net
Print ISSN: 1309-0399 Electronic ISSN: 1309-0380. J Turkish German Gynecol Assoc. Year: 2010 Volu... more Print ISSN: 1309-0399 Electronic ISSN: 1309-0380. J Turkish German Gynecol Assoc. Year: 2010 Volume: 11 Issue: 3 149-151. << Back. doi: 10.5152/jtgga.2010.23 Obez ve obez olmayan postmenopozal hastalarda serum androjen ...
Jinekoloji ve Obstetrik Derg., 2006
journalagent.com
We report a successful laparoscopic management of an interstitial pregnancy of a 24-year-old sing... more We report a successful laparoscopic management of an interstitial pregnancy of a 24-year-old single woman, treated by cornuostomy. The patient was first managed with methotrexate treatment. After the 2. methotrexate administration, the patient suffered from low ...
Jinekoloji ve Obstetrik Derg., 2006
Amac: Asemptomatik postmenopozal kadinlarda, transvajinal ultrasonografiografi (TV-USG) ile endom... more Amac: Asemptomatik postmenopozal kadinlarda, transvajinal ultrasonografiografi (TV-USG) ile endometrial kalinlik degerlendirmesinin, endometrium kanserinin erken tanisindaki etkinligini ve endometrial kalinlikla endometrium kanseri risk faktorleri arasindaki iliskiyi retro- spektif olarak arastirmayi amacladik, Materyal ve Metod: S,B, Istanbul Egitim ve Arastirma Hastanesi Menopoz Poliklinigine Haziran 2008- Agustos 2009 tarihleri arasinda rutin kontroller icin basvuran asemptomatik postmenopozal kadinlarin, bilgisayar ve dosya kayitlari incelenerek retrospektif olarak yapildi, Bulgular: Endometrial kalinligi >5 mm bulu- nan 54 (%13,5) hastaya endometrial ornekleme yapildi, Histopatolojik inceleme sonucunda, 1 vakada atipik kompleks hiperplazi (%0,3), 14 vakada endometrial polip (% 3,5), 7 vakada pro- liferasyon bulgulari (% 1,8) ve 32 vakada (% 8) normal histolojik bulgular saptandi, Endometrial kalinligi ≥ 5 mm olan postmenopozal hastalarda; diabetes mellitus, hipertansiyon ve...
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1997
Materyel ve Metod: Atrofik vajinit bulguları taşıyan veya pelvik relaksasyon nedeniyle operasyon ... more Materyel ve Metod: Atrofik vajinit bulguları taşıyan veya pelvik relaksasyon nedeniyle operasyon için yatırılmış olan toplam 35 postmenopozal olgu çalışma kapsamına alındı. 15 olgu kontrol grubunu oluştururken, 10 olguya östriol krem (0.5-1 mg/gün), 10 olguya da konjuge östrojen krem (1.25 mg/gün) intravaginal olarak 7-10 gün süreyle verildi. Vagina epitel gelişimi üzerine olan etkileri histopatolojik ve histokimyasal olarak araştırıldı. Epitel kalınlığı, sıra sayısı, diferansiyasyon derecesi, epitel içi glikojen varlığı ve ker atin miktarı kriter alınarak epitel proliferasyon ve maturasyonu incelendi.
Journal of the Turkish German Gynecological Association, 2010
In this study, we investigated whether serum androgen levels and endometrial thickness differed i... more In this study, we investigated whether serum androgen levels and endometrial thickness differed in obese and non-obese women. Material and Methods: Thirtytwo non-obese (BMI <30) and 48 obese (BMI 30) women were enrolled. Blood samples were analyzed for testosterone, free testosterone, androstenedione, DHEAS, and SHBG, and transvaginal ultrasonography was performed. Results: Obese women had significantly higher free testosterone and endometrial thickness and significantly lower SHBG. Eight of 17 women with endometrial thickness >5 mm had significant pathology. Conclusion: These results suggest that obesity may be a risk factor for endometrial carcinoma and other pathologies in post-menopausal women through an action on androgen concentrations.
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2009
... Extrarenal Wilms' tumor of the uterus with ovarian dermoid cyst. Cem Leblebici: Affiliat... more ... Extrarenal Wilms' tumor of the uterus with ovarian dermoid cyst. Cem Leblebici: Affiliations. ... Istanbul Egitim Hastanesi, Patoloji Lab., Koca M Pasa, Fatih, Istanbul, Turkey. Tel.: +90 5055784122; fax: +90 212 589 32 35. email address ,; Pelin Yıldız: Affiliations. ...
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2011
To determine the effect of a sudden decrease in estrogen levels via bilateral oophorectomy on ser... more To determine the effect of a sudden decrease in estrogen levels via bilateral oophorectomy on serum turnover markers and to examine their correlation with bone mineral density (BMD). Study design: This study included 51 women who had regular menses preoperatively and underwent bilateral oophorectomy for benign reasons. These women did not have any systemic disease or drug use that would influence bone metabolism. For each woman, spine and femur BMD were measured preoperatively and sixth months after surgery. Serum C-terminal telopeptide (CTX) and bone alkaline phosphatase (BAP) were measured preoperatively and at the first and sixth months after surgery. Correlations between bone turnover markers and BMD were pre-and post-operatively analyzed. Results: The mean serum CTX and BAP concentrations at the first and sixth postoperative months were significantly higher compared to the preoperative measurements (p = 0.001). Spine BMD values at the sixth postoperative month was significantly lower compared to preoperative period (p = 0.0001). There was a significant negative correlation between spine BMD values and BAP levels both in the preoperative period and at the sixth postoperative month (r = À0.407, p = 0.001), whereas a significant positive correlation between serum CTX and BAP was noted at this time periods (r = 0.615, p < 0.001). Conclusions: The results of this study showed that serum BAP and CTX levels rapidly increase in women after bilateral oophorectomy. Therefore, these markers (especially BAP) could be useful in the evaluation of osteoporosis risk in the early period of surgical menopause.
… Klinikleri Journal of …, 1997
... (14:36) Kolesterol tedavisinde yeni umut. ... Jinekoloji-Obstetrik Dergisi Year: 1997 / Volum... more ... (14:36) Kolesterol tedavisinde yeni umut. ... Jinekoloji-Obstetrik Dergisi Year: 1997 / Volume: 7 / No: 1. Lokal Östriol Ve Konjuge Östrojenin Vagina Epitel Gelişimi Üzerine Etkilerinin Karşılaştırılması Nesrin AKÇA * , Gülseren ERHAN * , Serpil BOZKURT ** , Erol Rüştü BOZKURT ...
Archives of Medical Science, 2013
Congenital agenesis of the uterine cervix and vagina in the presence of a functional endometrium ... more Congenital agenesis of the uterine cervix and vagina in the presence of a functional endometrium is an extremely rare mullerian anomaly [1]. Congenital vaginal agenesis occurs with a prevalence of 1/4000-1/5000 live-born females, while the accurate incidence of cervicovaginal agenesis is controversial [1-3]. Cervicovaginal agenesis is usually not diagnosed until menarche. It is manifested by the collection of menstrual blood in the functional endometrium, Fallopian tubes and peritoneal cavity, leading to primary amenorrhea and cyclic abdominal pain [1, 4]. The primary goal of cervicovaginal reconstruction in cervicovaginal agenesis cases is to preserve reproductive performance [5-8]. In routine clinical practice, hysterectomy was advised in cases with complete cervical aplasia, to control pain and dysmenorrhea and also prevent complications such as peritonitis [4, 9, 10]. But recent studies are more encouraging [3]. However, as different techniques were performed for each individual type of cervical agenesis case, there is great controversy as to the best technique because each has associated advantages and disadvantages. In this case report, a functional reconstruction with pudendal thigh flaps complicated with endometrioma and hematosalpinx in a cervicovaginal agenesis case will be discussed in the light of the literature. An 18-year-old virgin woman with a history of primary amenorrhea and cyclic abdominal pain was referred to our gynecology clinic with normal secondary sex characteristics. Adrenarche and thelarche had occurred by age 13 years. Physical examination revealed no abnormalities. The vagina ended with a 1 cm blind pouch. A pelvic sonographic examination showed an abnormally enlarged uterus due to hematometra and also a left ovarian endometrioma. No cervical tissue was observed in inspection or sonographic imaging, indicating complete cervical agenesis. The intravenous pyelogram showed a normal urinary tract system. Magnetic resonance imaging (MRI) revealed an arcuate uterus and a normal endometrial cavity with complete cervical agenesis (Figure 1). The laboratory work-up showed normal serum levels of follicle-stimulating hormone, thyroid-stimu-C Co or rr re es sp po on nd di in ng g a au ut th ho or r: :
Journal of Turkish Society of Obstetric and Gynecology, 2011
Objective: To investigate the etiology of menstrual disorders among patients undergoing hemodialy... more Objective: To investigate the etiology of menstrual disorders among patients undergoing hemodialysis due to chronic renal failure by assessing menstrual history, serum hormone levels and other biochemical factors. Material and methods: Thirty patients undergoing hemodialysis and 30 healthy women at reproductive age were enrolled in our study. Demographic characteristics, hormonal and biochemical data, sonographically measured endometrial thickness values of the subjects were compared. In addition, the present and the pre-hemodialysis menstrual pattern of the patients undergoing hemodialysis were recorded. The hormonal, hematological and biochemical data of the patients were compared according to their menstrual patterns. Results: No statistical significance was seen between age, BMI, gravida, parity, abortion and curettage among groups (p>0.05). Hemoglobin and hematocrit levels were significantly lower in the hemodialysis group than in the control (p<0.05). Although serum FSH levels were higher and estradiol levels were lower in the hemodialysis group, these differences were not statistically significant (p>0.05). Mean serum LH and prolactin levels were significantly higher in the hemodialysis group compared to the control (p<0.05). No statistically significant difference was noted for endometrial thickness between the groups (p>0.05). Serum LH and prolactin levels were higher and serum FSH, estradiol and TSH levels were lower in patients who developed amenorrhea after hemodialysis treatment when compared to non-amenorrheic subjects. However, these differences were not statistically significant (p>0.05). Discussion: The most important factor in the etiology of menstrual disorders seen in chronic renal failure patients was high serum LH and prolactin levels. Hemodialysis is a successful treatment that extends life expectancy and ameliorates the hypothalamo-pituitary-ovarian axis in chronic renal failure patients.
Insights Into Incontinence and the Pelvic Floor
Insights Into Incontinence and the Pelvic Floor
LIPPINCOTT WILLIAMS & WILKINS, 2015
Zeynep Kamil tıp bülteni, Apr 1, 2005
Vulva karsinomu nadir olup çoðunlukla 60 yaþýn üstündeki kadýnlarda görülür. Nedeni halen çok açý... more Vulva karsinomu nadir olup çoðunlukla 60 yaþýn üstündeki kadýnlarda görülür. Nedeni halen çok açýk olmamakla birlikte etyopatogenezde baþlýca Human Papilloma Virüsü (HPV) ve liken sklerozus suçlanmaktadýr. Biz vulvasýnda, liken sklerozus zemininden geliþmiþ, iyi diferensiye, invaziv skuamöz hücreli kanseri olan 36 yaþýnda bir kadýn olgu sunmaktayýz.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1997
Amaç: Atrofik vajinit olgularında lokal östriol ve konjuge östrojen kremlerinin vagina epiteli ge... more Amaç: Atrofik vajinit olgularında lokal östriol ve konjuge östrojen kremlerinin vagina epiteli gelişimi üzerine etkilerini karşılaştırmalı olarak araştırmak.
artemisonline.net
Print ISSN: 1309-0399 Electronic ISSN: 1309-0380. J Turkish German Gynecol Assoc. Year: 2010 Volu... more Print ISSN: 1309-0399 Electronic ISSN: 1309-0380. J Turkish German Gynecol Assoc. Year: 2010 Volume: 11 Issue: 3 149-151. << Back. doi: 10.5152/jtgga.2010.23 Obez ve obez olmayan postmenopozal hastalarda serum androjen ...
Jinekoloji ve Obstetrik Derg., 2006
journalagent.com
We report a successful laparoscopic management of an interstitial pregnancy of a 24-year-old sing... more We report a successful laparoscopic management of an interstitial pregnancy of a 24-year-old single woman, treated by cornuostomy. The patient was first managed with methotrexate treatment. After the 2. methotrexate administration, the patient suffered from low ...
Jinekoloji ve Obstetrik Derg., 2006
Amac: Asemptomatik postmenopozal kadinlarda, transvajinal ultrasonografiografi (TV-USG) ile endom... more Amac: Asemptomatik postmenopozal kadinlarda, transvajinal ultrasonografiografi (TV-USG) ile endometrial kalinlik degerlendirmesinin, endometrium kanserinin erken tanisindaki etkinligini ve endometrial kalinlikla endometrium kanseri risk faktorleri arasindaki iliskiyi retro- spektif olarak arastirmayi amacladik, Materyal ve Metod: S,B, Istanbul Egitim ve Arastirma Hastanesi Menopoz Poliklinigine Haziran 2008- Agustos 2009 tarihleri arasinda rutin kontroller icin basvuran asemptomatik postmenopozal kadinlarin, bilgisayar ve dosya kayitlari incelenerek retrospektif olarak yapildi, Bulgular: Endometrial kalinligi >5 mm bulu- nan 54 (%13,5) hastaya endometrial ornekleme yapildi, Histopatolojik inceleme sonucunda, 1 vakada atipik kompleks hiperplazi (%0,3), 14 vakada endometrial polip (% 3,5), 7 vakada pro- liferasyon bulgulari (% 1,8) ve 32 vakada (% 8) normal histolojik bulgular saptandi, Endometrial kalinligi ≥ 5 mm olan postmenopozal hastalarda; diabetes mellitus, hipertansiyon ve...
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1997
Materyel ve Metod: Atrofik vajinit bulguları taşıyan veya pelvik relaksasyon nedeniyle operasyon ... more Materyel ve Metod: Atrofik vajinit bulguları taşıyan veya pelvik relaksasyon nedeniyle operasyon için yatırılmış olan toplam 35 postmenopozal olgu çalışma kapsamına alındı. 15 olgu kontrol grubunu oluştururken, 10 olguya östriol krem (0.5-1 mg/gün), 10 olguya da konjuge östrojen krem (1.25 mg/gün) intravaginal olarak 7-10 gün süreyle verildi. Vagina epitel gelişimi üzerine olan etkileri histopatolojik ve histokimyasal olarak araştırıldı. Epitel kalınlığı, sıra sayısı, diferansiyasyon derecesi, epitel içi glikojen varlığı ve ker atin miktarı kriter alınarak epitel proliferasyon ve maturasyonu incelendi.
Journal of the Turkish German Gynecological Association, 2010
In this study, we investigated whether serum androgen levels and endometrial thickness differed i... more In this study, we investigated whether serum androgen levels and endometrial thickness differed in obese and non-obese women. Material and Methods: Thirtytwo non-obese (BMI <30) and 48 obese (BMI 30) women were enrolled. Blood samples were analyzed for testosterone, free testosterone, androstenedione, DHEAS, and SHBG, and transvaginal ultrasonography was performed. Results: Obese women had significantly higher free testosterone and endometrial thickness and significantly lower SHBG. Eight of 17 women with endometrial thickness >5 mm had significant pathology. Conclusion: These results suggest that obesity may be a risk factor for endometrial carcinoma and other pathologies in post-menopausal women through an action on androgen concentrations.
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2009
... Extrarenal Wilms' tumor of the uterus with ovarian dermoid cyst. Cem Leblebici: Affiliat... more ... Extrarenal Wilms' tumor of the uterus with ovarian dermoid cyst. Cem Leblebici: Affiliations. ... Istanbul Egitim Hastanesi, Patoloji Lab., Koca M Pasa, Fatih, Istanbul, Turkey. Tel.: +90 5055784122; fax: +90 212 589 32 35. email address ,; Pelin Yıldız: Affiliations. ...
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2011
To determine the effect of a sudden decrease in estrogen levels via bilateral oophorectomy on ser... more To determine the effect of a sudden decrease in estrogen levels via bilateral oophorectomy on serum turnover markers and to examine their correlation with bone mineral density (BMD). Study design: This study included 51 women who had regular menses preoperatively and underwent bilateral oophorectomy for benign reasons. These women did not have any systemic disease or drug use that would influence bone metabolism. For each woman, spine and femur BMD were measured preoperatively and sixth months after surgery. Serum C-terminal telopeptide (CTX) and bone alkaline phosphatase (BAP) were measured preoperatively and at the first and sixth months after surgery. Correlations between bone turnover markers and BMD were pre-and post-operatively analyzed. Results: The mean serum CTX and BAP concentrations at the first and sixth postoperative months were significantly higher compared to the preoperative measurements (p = 0.001). Spine BMD values at the sixth postoperative month was significantly lower compared to preoperative period (p = 0.0001). There was a significant negative correlation between spine BMD values and BAP levels both in the preoperative period and at the sixth postoperative month (r = À0.407, p = 0.001), whereas a significant positive correlation between serum CTX and BAP was noted at this time periods (r = 0.615, p < 0.001). Conclusions: The results of this study showed that serum BAP and CTX levels rapidly increase in women after bilateral oophorectomy. Therefore, these markers (especially BAP) could be useful in the evaluation of osteoporosis risk in the early period of surgical menopause.
… Klinikleri Journal of …, 1997
... (14:36) Kolesterol tedavisinde yeni umut. ... Jinekoloji-Obstetrik Dergisi Year: 1997 / Volum... more ... (14:36) Kolesterol tedavisinde yeni umut. ... Jinekoloji-Obstetrik Dergisi Year: 1997 / Volume: 7 / No: 1. Lokal Östriol Ve Konjuge Östrojenin Vagina Epitel Gelişimi Üzerine Etkilerinin Karşılaştırılması Nesrin AKÇA * , Gülseren ERHAN * , Serpil BOZKURT ** , Erol Rüştü BOZKURT ...
Archives of Medical Science, 2013
Congenital agenesis of the uterine cervix and vagina in the presence of a functional endometrium ... more Congenital agenesis of the uterine cervix and vagina in the presence of a functional endometrium is an extremely rare mullerian anomaly [1]. Congenital vaginal agenesis occurs with a prevalence of 1/4000-1/5000 live-born females, while the accurate incidence of cervicovaginal agenesis is controversial [1-3]. Cervicovaginal agenesis is usually not diagnosed until menarche. It is manifested by the collection of menstrual blood in the functional endometrium, Fallopian tubes and peritoneal cavity, leading to primary amenorrhea and cyclic abdominal pain [1, 4]. The primary goal of cervicovaginal reconstruction in cervicovaginal agenesis cases is to preserve reproductive performance [5-8]. In routine clinical practice, hysterectomy was advised in cases with complete cervical aplasia, to control pain and dysmenorrhea and also prevent complications such as peritonitis [4, 9, 10]. But recent studies are more encouraging [3]. However, as different techniques were performed for each individual type of cervical agenesis case, there is great controversy as to the best technique because each has associated advantages and disadvantages. In this case report, a functional reconstruction with pudendal thigh flaps complicated with endometrioma and hematosalpinx in a cervicovaginal agenesis case will be discussed in the light of the literature. An 18-year-old virgin woman with a history of primary amenorrhea and cyclic abdominal pain was referred to our gynecology clinic with normal secondary sex characteristics. Adrenarche and thelarche had occurred by age 13 years. Physical examination revealed no abnormalities. The vagina ended with a 1 cm blind pouch. A pelvic sonographic examination showed an abnormally enlarged uterus due to hematometra and also a left ovarian endometrioma. No cervical tissue was observed in inspection or sonographic imaging, indicating complete cervical agenesis. The intravenous pyelogram showed a normal urinary tract system. Magnetic resonance imaging (MRI) revealed an arcuate uterus and a normal endometrial cavity with complete cervical agenesis (Figure 1). The laboratory work-up showed normal serum levels of follicle-stimulating hormone, thyroid-stimu-C Co or rr re es sp po on nd di in ng g a au ut th ho or r: :
Journal of Turkish Society of Obstetric and Gynecology, 2011
Objective: To investigate the etiology of menstrual disorders among patients undergoing hemodialy... more Objective: To investigate the etiology of menstrual disorders among patients undergoing hemodialysis due to chronic renal failure by assessing menstrual history, serum hormone levels and other biochemical factors. Material and methods: Thirty patients undergoing hemodialysis and 30 healthy women at reproductive age were enrolled in our study. Demographic characteristics, hormonal and biochemical data, sonographically measured endometrial thickness values of the subjects were compared. In addition, the present and the pre-hemodialysis menstrual pattern of the patients undergoing hemodialysis were recorded. The hormonal, hematological and biochemical data of the patients were compared according to their menstrual patterns. Results: No statistical significance was seen between age, BMI, gravida, parity, abortion and curettage among groups (p>0.05). Hemoglobin and hematocrit levels were significantly lower in the hemodialysis group than in the control (p<0.05). Although serum FSH levels were higher and estradiol levels were lower in the hemodialysis group, these differences were not statistically significant (p>0.05). Mean serum LH and prolactin levels were significantly higher in the hemodialysis group compared to the control (p<0.05). No statistically significant difference was noted for endometrial thickness between the groups (p>0.05). Serum LH and prolactin levels were higher and serum FSH, estradiol and TSH levels were lower in patients who developed amenorrhea after hemodialysis treatment when compared to non-amenorrheic subjects. However, these differences were not statistically significant (p>0.05). Discussion: The most important factor in the etiology of menstrual disorders seen in chronic renal failure patients was high serum LH and prolactin levels. Hemodialysis is a successful treatment that extends life expectancy and ameliorates the hypothalamo-pituitary-ovarian axis in chronic renal failure patients.
Insights Into Incontinence and the Pelvic Floor
Insights Into Incontinence and the Pelvic Floor