Carina Crucho - Academia.edu (original) (raw)

Papers by Carina Crucho

Synlett, Dec 14, 2009

This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation... more This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research Ytterbium Triflate: A Green Catalyst Compiled by Carina I. C. Crucho Carina I. C. Crucho was born in Almada, Portugal in 1985. She received her Applied Chemistry Degree from the Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa in 2007. Presently she is working towards her M.Sc. degree in bioorganic chemistry under the supervision of Prof. Manuela Pereira at the same university. Her research is focused on ligand design and asymmetric organocatalysis.

ChemMedChem, Oct 16, 2014

ACS applied nano materials, Jul 1, 2022

Compounds, Mar 16, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Compounds

Organic–inorganic building blocks are an important class of hybrid materials due to the synergist... more Organic–inorganic building blocks are an important class of hybrid materials due to the synergistic versatility of organic compounds with the robust properties of inorganic materials. Currently, the growing interest in silica hybrid materials to modify the physical and chemical properties of the silica network has led to an increasing interest in organoalkoxysilanes. A general formula of R-[Si-(OR’)3]n, with OR’ as a hydrolysable alkoxy group and R acting as the organic functional group (n ≥ 1), has led to precursors for many molecules. By introducing adequate organic moieties (R), organoalkoxysilanes effectively engage in surface and matrix modification of silica-based materials with smart-responsive units, coupling agents, targeting moieties, bioactive moieties etc., opening promising applications, specifically biomedical ones. Several synthetic procedures have been established to introduce the alkoxysilane moieties, including hydrosilylation, coupling reactions, and addition reac...

I3S2022Warsaw, Aug 30, 2022

Boletim da Sociedade Portuguesa de Química, 2020

É doutorada em química pela FCT-Universidade Nova de Lisboa e atualmente é investigadora júnior n... more É doutorada em química pela FCT-Universidade Nova de Lisboa e atualmente é investigadora júnior no Instituto de Bioengenharia e Biociências do Instituto Superior Técnico. Os interesses de investigação têm incidido sobretudo no desenvolvimento de nanomateriais para aplicações biomédicas.

ACS Medicinal Chemistry Letters, 2017

A shocking state of affairs; the use of nanoparticles as simple carriers is dead and outdated. St... more A shocking state of affairs; the use of nanoparticles as simple carriers is dead and outdated. Stimuli-responsive nanoparticles have emerged as active participants in the therapeutic landscape, rather than inert molecule carriers. And this time they are here to join the ongoing war against an old enemy: bacteria.

ChemMedChem, 2015

Nature continues to be the ultimate in nanotechnology, where polymeric nanometer-scale architectu... more Nature continues to be the ultimate in nanotechnology, where polymeric nanometer-scale architectures play a central role in biological systems. Inspired by the way nature forms functional supramolecular assemblies, researchers are trying to make nanostructures and to incorporate these into macrostructures as nature does. Recent advances and progress in nanoscience have demonstrated the great potential that nanomaterials have for applications in healthcare. In the realm of drug delivery, nanomaterials have been used in vivo to protect the drug entity in the systemic circulation, ensuring reproducible absorption of bioactive molecules that do not naturally penetrate biological barriers, restricting drug access to specific target sites. Several building blocks have been used in the formulation of nanoparticles. Thus, stability, drug release, and targeting can be tailored by surface modification. Herein the state of the art of stimuli-responsive polymeric nanoparticles are reviewed. Suc...

Current Organic Chemistry, 2014

Synlett, 2009

Frontiers for young minds, May 27, 2024

When you feel cold, you might put on a wool sweater to stay warm. But on a rainy day, you might w... more When you feel cold, you might put on a wool sweater to stay warm. But on a rainy day, you might want to make your outer layer a waterproof shell, like a rain jacket. In both cases, you are protecting yourself from the surrounding environment (cold or rain), and the clothes you choose will depend on the weather outside. Now, what if we wanted to protect very tiny particles, called nanoparticles, in a similar way? Instead of clothing, we have to use a coating-a layer of another material that protects the particles from their environment. But it would be even better if this coating could be "smart" and change in response to the surrounding environment! In this article, we will tell you how a smart coating made out of silica (sand) can protect nanoparticles more e ciently, so that they can be used in many di erent applications, like delivering medicines to where they are needed in the body.

Nanomaterials Design for Sensing Applications, 2019

Abstract Carbohydrates are ubiquitous in nature and intervene in a wide range of biological activ... more Abstract Carbohydrates are ubiquitous in nature and intervene in a wide range of biological activities. They exhibit interesting properties such as low toxicity, biocompatibility, stability, low cost, hydrophilic nature, and availability of reactive sites for chemical modification. During the last decade, there have been many attempts to integrate carbohydrates in nanomaterials. In particular, smart glycopolymers have received remarkable attention due to their responsiveness to specific stimuli, making them promising candidates for more accurate and programmable drug delivery. Carbohydrate-based nanoparticles with pH, enzyme, magnetic, redox, and temperature-sensitive properties have been developed. In addition, sugar-based nanogels have also emerged as potential nanocarriers. Under this light, the state-of-the-art of stimuli-responsive glyconanoparticles will be covered. We highlight the design of tunable and versatile carbohydrate-based nanoparticles as targeted carriers with stimuli-triggered controlled and localized drug release. We hope this will stimulate the development of novel glyconanomedicines that are easier to handle, compatible with physiological media, and suitable for further clinical developments.

Materials Science and Engineering: C, 2017

Since the emergence of Nanotechnology in the past decades, the development and design of nanomate... more Since the emergence of Nanotechnology in the past decades, the development and design of nanomaterials has become an important field of research. An emerging component in this field is nanomedicine, wherein nanoscale materials are being developed for use as imaging agents or for drug delivery applications. Much work is currently focused in the preparation of well-defined nanomaterials in terms of size and shape. These factors play a significantly role in the nanomaterial behavior in vivo. In this context, this review focuses on the toolbox of available methods for the preparation of polymeric nanoparticles. We highlight some recent examples from the literature that demonstrate the influence of the preparation method on the physicochemical characteristics of the nanoparticles. Additionally, in the second part, the characterization methods for this type of nanoparticles are discussed.

Encyclopedia of Reagents for Organic Synthesis, 2016

[64030-44-0] C11H16N2 (MW 176.25) InChI = 1S/C11H16N2/c1-2-5-10(6-3-1)13-9-11-7-4-8-12-11/h1-3,5-... more [64030-44-0] C11H16N2 (MW 176.25) InChI = 1S/C11H16N2/c1-2-5-10(6-3-1)13-9-11-7-4-8-12-11/h1-3,5-6,11-13H,4,7-9H2/t11-/m0/s1 InChIKey = MCHWKJRTMPIHRA-NSHDSACASA-N (chiral ligand of LiAlH4 for enantioselective reduction of ketones;2 can form chiral aminals for diastereoselective alkylation,3, 4 1,2-,5 and 1,4-additions6) Physical Data: bp 111–112 °C/0.55 mmHg; [α]24D +19.7° (c 1.04, EtOH). Solubility: sol ether, THF. Form Supplied in: colorless oil. Preparative Methods: reaction of (S)-N-(benzyloxycarbonyl)proline with (1) ethyl chloroformate and N-methylmorpholine, (2) aniline, (3) hydrogenolysis with Pd/C, and (4) reduction with LiAlH4 affords the title compound in 59% overall yield.2b