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Medicina
Preconception counseling is an essential tool for preventing adverse pregnancy outcomes associate... more Preconception counseling is an essential tool for preventing adverse pregnancy outcomes associated with thyroid dysfunction. The high prevalence of thyroid disease among women of reproductive age, and the increased risk of adverse pregnancy outcomes associated with thyroid dysfunction, emphasize the necessity for well-established screening and treatment criteria in the preconception period. We therefore conducted a literature review for relevant information on the screening, diagnosis and treatment of subclinical and overt hypothyroidism in women seeking pregnancy. While screening for thyroid disease is recommended only in the presence of risk factors, iodine supplementation should be recommended in most regions, with higher doses in areas with severe deficiency. Known hypothyroid women should be counseled about increasing their levothyroxine dose by 20–30% in the case of suspected or confirmed pregnancy (missed menstrual cycle or positive pregnancy test). Treating subclinical hypot...
Endocrine Abstracts, 2018
Life, 2022
Background: Bone impairment of multifactorial etiology is a common feature in inflammatory bowel ... more Background: Bone impairment of multifactorial etiology is a common feature in inflammatory bowel disease (IBD). Body composition parameters, which might be selectively modified in these patients, are important determinants of bone strength. Our aim was to investigate the relationship between components of body composition and bone parameters in IBD patients. Methods: This is a cross-sectional, retrospective study including 80 IBD patients (43 women, 37 men). Lumbar spine (LS), femoral neck (FN) and whole body DXA scans were performed to analyze regional bone mineral density (BMD), as well as body composition, including appendicular skeletal muscle mass index (ASMI), total and visceral fat mass (VAT). Trabecular bone score (TBS) was assessed using iNsight Software. Results: Twenty (25%) IBD patients had inadequate LS-BMD z scores (<=−2DS). Lean mass (LM) was a significant determinant of LS-BMD, after adjusting for age, gender, BMI and fat mass (p < 0.01), while fat mass% remain...
Central European Annals of Clinical Research, 2020
Endocrine Connections, 2021
Background and aim Low bone mineral density (BMD) is a common complication in patients with infla... more Background and aim Low bone mineral density (BMD) is a common complication in patients with inflammatory bowel disease (IBD). However, debates are ongoing with regard to the other involved factors, especially in younger patients. This study aimed to evaluate the parameters that contribute to decreased BMD, focusing on premenopausal women and men aged <50 years. Methods This study included 81 patients with IBD and 81 age-, sex- and BMI-matched controls. Blood tests were conducted on IBD patients, and a dual-energy X-ray absorptiometry (DXA) scan was performed on both groups. Results Low BMD and fragility fracture were found to be more prevalent in IBD patients than in healthy subjects (49.3% vs 23.4%, P = 0.001 and 9.8% vs 1.2%, P = 0.01, respectively). Patients with low BMD were older, with a longer disease duration, higher faecal calprotectin (FC) levels and lower magnesium and lean mass (appreciated as appendicular skeletal muscle index (ASMI)). Multiple regression analysis rev...
The metabolic syndrome is a complex combination of interrelated risk factors of metabolic origin ... more The metabolic syndrome is a complex combination of interrelated risk factors of metabolic origin that, when occurring together, increase the risk of developing cardiovascular disease and diabetes. Adipocytokines are bioactive mediators released from the adipose tissue including adipocytes and other cells present at the level of fat tissues. These include several novel and highly active molecules released abundantly by adipocytes like leptin, resistin, adiponectin, as well as some more classical cytokines released possibly by inflammatory cells infiltrating fat, like tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). The most abundantly expressed cytokines within the adipose tissue are leptin and adiponectin [1, 3]. Adiponectin, is highly expressed in adipose cells, and circulates in high concentrations in the blood. Decreased serum levels of adiponectin are associated with insulin resistance. The role of adiponectin in systemic inflammation and critical illness is not...
1. Ferranti et al. Prevalence of the metabolic syndrome in American adolescents: findings from th... more 1. Ferranti et al. Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation. 2004 2. Freedman DS et al. Classification of body fatness by body mass index-for-age categories among children. Arch Pediatr Adolesc Med. 2009 Metabolic syndrome (MS) is a long-term complication of pediatric haematopoietic stem cell transplantation (HSCT) and it was described more often in patients who were exposed to total body irradiation (TBI). Since previous studies reported discrepancy in the presence of metabolic complications in HSCT survivors who underwent chemotherapy-only conditioning, we investigated the frequency of MS in our HSCT-treated children for various disorders without being exposed to TBI in the conditioning regimen.
Endocrine Abstracts, 2016
Medicina
Preconception counseling is an essential tool for preventing adverse pregnancy outcomes associate... more Preconception counseling is an essential tool for preventing adverse pregnancy outcomes associated with thyroid dysfunction. The high prevalence of thyroid disease among women of reproductive age, and the increased risk of adverse pregnancy outcomes associated with thyroid dysfunction, emphasize the necessity for well-established screening and treatment criteria in the preconception period. We therefore conducted a literature review for relevant information on the screening, diagnosis and treatment of subclinical and overt hypothyroidism in women seeking pregnancy. While screening for thyroid disease is recommended only in the presence of risk factors, iodine supplementation should be recommended in most regions, with higher doses in areas with severe deficiency. Known hypothyroid women should be counseled about increasing their levothyroxine dose by 20–30% in the case of suspected or confirmed pregnancy (missed menstrual cycle or positive pregnancy test). Treating subclinical hypot...
Endocrine Abstracts, 2018
Life, 2022
Background: Bone impairment of multifactorial etiology is a common feature in inflammatory bowel ... more Background: Bone impairment of multifactorial etiology is a common feature in inflammatory bowel disease (IBD). Body composition parameters, which might be selectively modified in these patients, are important determinants of bone strength. Our aim was to investigate the relationship between components of body composition and bone parameters in IBD patients. Methods: This is a cross-sectional, retrospective study including 80 IBD patients (43 women, 37 men). Lumbar spine (LS), femoral neck (FN) and whole body DXA scans were performed to analyze regional bone mineral density (BMD), as well as body composition, including appendicular skeletal muscle mass index (ASMI), total and visceral fat mass (VAT). Trabecular bone score (TBS) was assessed using iNsight Software. Results: Twenty (25%) IBD patients had inadequate LS-BMD z scores (<=−2DS). Lean mass (LM) was a significant determinant of LS-BMD, after adjusting for age, gender, BMI and fat mass (p < 0.01), while fat mass% remain...
Central European Annals of Clinical Research, 2020
Endocrine Connections, 2021
Background and aim Low bone mineral density (BMD) is a common complication in patients with infla... more Background and aim Low bone mineral density (BMD) is a common complication in patients with inflammatory bowel disease (IBD). However, debates are ongoing with regard to the other involved factors, especially in younger patients. This study aimed to evaluate the parameters that contribute to decreased BMD, focusing on premenopausal women and men aged <50 years. Methods This study included 81 patients with IBD and 81 age-, sex- and BMI-matched controls. Blood tests were conducted on IBD patients, and a dual-energy X-ray absorptiometry (DXA) scan was performed on both groups. Results Low BMD and fragility fracture were found to be more prevalent in IBD patients than in healthy subjects (49.3% vs 23.4%, P = 0.001 and 9.8% vs 1.2%, P = 0.01, respectively). Patients with low BMD were older, with a longer disease duration, higher faecal calprotectin (FC) levels and lower magnesium and lean mass (appreciated as appendicular skeletal muscle index (ASMI)). Multiple regression analysis rev...
The metabolic syndrome is a complex combination of interrelated risk factors of metabolic origin ... more The metabolic syndrome is a complex combination of interrelated risk factors of metabolic origin that, when occurring together, increase the risk of developing cardiovascular disease and diabetes. Adipocytokines are bioactive mediators released from the adipose tissue including adipocytes and other cells present at the level of fat tissues. These include several novel and highly active molecules released abundantly by adipocytes like leptin, resistin, adiponectin, as well as some more classical cytokines released possibly by inflammatory cells infiltrating fat, like tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). The most abundantly expressed cytokines within the adipose tissue are leptin and adiponectin [1, 3]. Adiponectin, is highly expressed in adipose cells, and circulates in high concentrations in the blood. Decreased serum levels of adiponectin are associated with insulin resistance. The role of adiponectin in systemic inflammation and critical illness is not...
1. Ferranti et al. Prevalence of the metabolic syndrome in American adolescents: findings from th... more 1. Ferranti et al. Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation. 2004 2. Freedman DS et al. Classification of body fatness by body mass index-for-age categories among children. Arch Pediatr Adolesc Med. 2009 Metabolic syndrome (MS) is a long-term complication of pediatric haematopoietic stem cell transplantation (HSCT) and it was described more often in patients who were exposed to total body irradiation (TBI). Since previous studies reported discrepancy in the presence of metabolic complications in HSCT survivors who underwent chemotherapy-only conditioning, we investigated the frequency of MS in our HSCT-treated children for various disorders without being exposed to TBI in the conditioning regimen.
Endocrine Abstracts, 2016