Vida Castro - Academia.edu (original) (raw)
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Papers by Vida Castro
ACS combinatorial science, Jan 11, 2015
Click Chemistry is an approach that uses efficient and reliable reactions, such as Cu(I)-catalyze... more Click Chemistry is an approach that uses efficient and reliable reactions, such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), mainly to bind two molecular building blocks. In addition, CuAAC has showed broad applications in medicinal chemistry and other fields of chemistry. The present review describes the general features and applications of CuAAC in solid-phase (CuAAC-SP), highlighting the suitability of this kind of reaction for peptides, nucleotides, small molecules, supramolecular structures, and polymers, among others. This versatile reaction is expected to become pivotal for meeting future challenges in solid-phase chemistry.
ACS Combinatorial Science, 2013
An efficient, standard, mild, and copper-free imidazole-1-sulfonyl azide hydrochloride-based diaz... more An efficient, standard, mild, and copper-free imidazole-1-sulfonyl azide hydrochloride-based diazo-transfer method was implemented in a set of four resins that cover a broad range of hydrophobicity. The imidazole-1-sulfonyl azide hydrochloride is easily prepared/commercially available, stable upon storage at 4°C
Peptides as drugs show unique characteristics (high biological activity, high specificity and low... more Peptides as drugs show unique characteristics (high biological activity, high specificity and low toxicity), thereby making them particularly attractive therapeutic agents. During the last years, the pharmaceutical industry, which was traditionally focused on small molecules, has been attracted by the benefits that peptides confer. This is due in part, for the great number of developments carried out in their synthetic strategies, mostly in the Solid-Phase mode.
Organic Letters, 2013
A new resin for the solid-phase synthesis of peptide acids was developed. It was based on a linke... more A new resin for the solid-phase synthesis of peptide acids was developed. It was based on a linker with two unique features: methoxy groups as the only activating groups of the phenyl ring and a copper(I)-catalyzed Click chemistry reaction to anchor it to the solid support. The efficiency of this new resin in solid phase peptide synthesis was compared with that of Wang resin.
ACS combinatorial science, Jan 11, 2015
Click Chemistry is an approach that uses efficient and reliable reactions, such as Cu(I)-catalyze... more Click Chemistry is an approach that uses efficient and reliable reactions, such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), mainly to bind two molecular building blocks. In addition, CuAAC has showed broad applications in medicinal chemistry and other fields of chemistry. The present review describes the general features and applications of CuAAC in solid-phase (CuAAC-SP), highlighting the suitability of this kind of reaction for peptides, nucleotides, small molecules, supramolecular structures, and polymers, among others. This versatile reaction is expected to become pivotal for meeting future challenges in solid-phase chemistry.
ACS Combinatorial Science, 2013
An efficient, standard, mild, and copper-free imidazole-1-sulfonyl azide hydrochloride-based diaz... more An efficient, standard, mild, and copper-free imidazole-1-sulfonyl azide hydrochloride-based diazo-transfer method was implemented in a set of four resins that cover a broad range of hydrophobicity. The imidazole-1-sulfonyl azide hydrochloride is easily prepared/commercially available, stable upon storage at 4°C
Peptides as drugs show unique characteristics (high biological activity, high specificity and low... more Peptides as drugs show unique characteristics (high biological activity, high specificity and low toxicity), thereby making them particularly attractive therapeutic agents. During the last years, the pharmaceutical industry, which was traditionally focused on small molecules, has been attracted by the benefits that peptides confer. This is due in part, for the great number of developments carried out in their synthetic strategies, mostly in the Solid-Phase mode.
Organic Letters, 2013
A new resin for the solid-phase synthesis of peptide acids was developed. It was based on a linke... more A new resin for the solid-phase synthesis of peptide acids was developed. It was based on a linker with two unique features: methoxy groups as the only activating groups of the phenyl ring and a copper(I)-catalyzed Click chemistry reaction to anchor it to the solid support. The efficiency of this new resin in solid phase peptide synthesis was compared with that of Wang resin.