Charles Stevens - Academia.edu (original) (raw)
Address: La Jolla, California, United States
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Sorbonne Université, Université Pierre et Marie Curie & CNRS
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Papers by Charles Stevens
Current Opinion in Neurobiology, 1994
Neuron, 1996
depletion of the pool was interpreted as a refilling of *Max-Planck-Institut fü r Biophysikalisch... more depletion of the pool was interpreted as a refilling of *Max-Planck-Institut fü r Biophysikalische Chemie empty docking sites with vesicles ready to undergo exo-AG Zellulä re Neurobiologie cytosis. D-37077 Gö ttingen
Science, 1998
The Tetrameric Structure of a Glutamate Receptor
Neuron, 2002
Cold Spring Harbor, New York 11724 but one of these quantities fixed, each quantity reaches an ex... more Cold Spring Harbor, New York 11724 but one of these quantities fixed, each quantity reaches an extremum when the wire fraction has a value of 3/5. 2
We have quantified hippocampal spine structure at the light and ultrastructural levels in cell cu... more We have quantified hippocampal spine structure at the light and ultrastructural levels in cell cultures ϳ1-3 weeks old and in the brains of rodents 5 and 21 d old. The number of spines bearing synapses increases with age in cultures and in brain, but the structures are similar in both. In culture, about half of the synapses are formed on spines and the remainder are formed on dendritic shafts. In the 5-d-old brain, about half of the synapses occur on dendritic shafts, by 3 weeks of age only ϳ20% of synapses are found on dendritic shafts, and in the adult shaft synapses are very rare.
Cell, 1993
This review focuses on two aspects of synaptic transmission that have recently attracted consider... more This review focuses on two aspects of synaptic transmission that have recently attracted considerable interest: the quantal release of neurotransmitter at synapses, and a phenomenon, hippocampal long-term potentiation (LTP), that is widely accepted as the substrate for certain forms of memory. The discussion is divided into two main parts. The first presents "standard views" of synaptic transmission and of LTP, and the second deals with challenges to and uncertainties about these views. The standard views presented are not my own--indeed, I would dispute a variety of their assumptions--but rather they represent classic or popular notions that serve as a framework for the critical discussion in the second part of the presentation. Such a short review of so vast a subject cannot, of course, be comprehensive, and I have selected for discussion several specific topics that currently are being most actively investigated and debated. Each of the sections can be read independently of the others.
Current Opinion in Neurobiology, 1994
Neuron, 1996
depletion of the pool was interpreted as a refilling of *Max-Planck-Institut fü r Biophysikalisch... more depletion of the pool was interpreted as a refilling of *Max-Planck-Institut fü r Biophysikalische Chemie empty docking sites with vesicles ready to undergo exo-AG Zellulä re Neurobiologie cytosis. D-37077 Gö ttingen
Science, 1998
The Tetrameric Structure of a Glutamate Receptor
Neuron, 2002
Cold Spring Harbor, New York 11724 but one of these quantities fixed, each quantity reaches an ex... more Cold Spring Harbor, New York 11724 but one of these quantities fixed, each quantity reaches an extremum when the wire fraction has a value of 3/5. 2
We have quantified hippocampal spine structure at the light and ultrastructural levels in cell cu... more We have quantified hippocampal spine structure at the light and ultrastructural levels in cell cultures ϳ1-3 weeks old and in the brains of rodents 5 and 21 d old. The number of spines bearing synapses increases with age in cultures and in brain, but the structures are similar in both. In culture, about half of the synapses are formed on spines and the remainder are formed on dendritic shafts. In the 5-d-old brain, about half of the synapses occur on dendritic shafts, by 3 weeks of age only ϳ20% of synapses are found on dendritic shafts, and in the adult shaft synapses are very rare.
Cell, 1993
This review focuses on two aspects of synaptic transmission that have recently attracted consider... more This review focuses on two aspects of synaptic transmission that have recently attracted considerable interest: the quantal release of neurotransmitter at synapses, and a phenomenon, hippocampal long-term potentiation (LTP), that is widely accepted as the substrate for certain forms of memory. The discussion is divided into two main parts. The first presents "standard views" of synaptic transmission and of LTP, and the second deals with challenges to and uncertainties about these views. The standard views presented are not my own--indeed, I would dispute a variety of their assumptions--but rather they represent classic or popular notions that serve as a framework for the critical discussion in the second part of the presentation. Such a short review of so vast a subject cannot, of course, be comprehensive, and I have selected for discussion several specific topics that currently are being most actively investigated and debated. Each of the sections can be read independently of the others.