Daniel Gallego - Academia.edu (original) (raw)
Papers by Daniel Gallego
ABSTRACT En estudios previos realizados en nuestros laboratorios se demuestra un grado de Biocomp... more ABSTRACT En estudios previos realizados en nuestros laboratorios se demuestra un grado de Biocompatibilidad adecuado del Cemento Portland para ser utilizado en investigación Biomédica; por lo tanto, basados en las excelentes propiedades mecánico – estructurales de éste, proponemos una metodología (Particulate Leaching) para fabricar estructuras porosas tridimensionales y biomiméticas, que imiten la morfología del hueso esponjoso, y que eventualmente trabajarán como matrices implantables estables, capaces de soportar el crecimiento del tejido óseo (osteoconductivas) y que a su vez toleren las cargas biomecánicas asociadas con la remodelación del hueso, permitiendo así una recuperación mas pronta del paciente. Por lo anterior, se fabricaron estructuras porosas en Cemento Portland Blanco Tipo I siguiendo la metodología de “Particulate Leaching”, utilizando NaCl en diferentes concentraciones como Porógeno. Las muestras fueron hidratadas a 134°C y 35 Psi aproximadamente, en autoclave durante 24h. Los restos de NaCl se removieron por inmersión de las matrices en agua Tridestilada bajo condiciones de vacío (600 mm Hg.) durante 48h. La caracterización morfológica de las estructuras se hizo mediante Microscopía de Luz y un análisis digital de la imagen (LAB WORKS 4.5) para determinar la densidad y el tamaño de los poros, además se evaluó el comportamiento mecánico utilizando pruebas de compresión. Los resultados preliminares muestran estructuras con poros entre 100-200 μm de diámetro (180 μm en promedio aproximadamente), y porosidades entre el 30 y 60%; lo cual coincide con los valores sugeridos en la literatura como adecuados para matrices de cultivo de células óseas. Finalmente, en cuanto a sus propiedades mecánicas, los módulos de elasticidad se encuentran en un rango entre 78 y 370 MPa, y la fuerza máxima de compresión está entre 2 y 7 MPa, similar a lo observado en hueso esponjoso.
It has been clear that the surface properties of the materials used as substrates for cell cultur... more It has been clear that the surface properties of the materials used as substrates for cell culture can influence the cell behavior affecting different factors such as cell orientation, adhesion, growth, differentiation, and apoptosis. In the last few years, several micro and nanofabrication techniques have emerged as important tools used to modify the surface properties of those materials at the micro or nano scale, topologically or chemically. This paper reviews the most used microfabrication techniques to introduce modifications on the materials surfaces and its implications on cell behavior. This review ends up showing the possible medical applications derived as a source of future work in the field. Resumen: Ha quedado claro que las propiedades superficiales de los materiales utilizados como sustratos para cultivo celular pueden influir en el comportamiento de las celulas afectando diferentes factores tales como la orientacion celular, adhesion, crecimiento, diferenciacion y apo...
Transplant International, 2021
This article describes a pathway for collaboration between transplant healthcare professionals an... more This article describes a pathway for collaboration between transplant healthcare professionals and organ recipients. Under the umbrella of the European Society for Organ Transplantation (ESOT) a joint initiative started from three Sections and Committees of ESOT: EDTCO (European Donation and Transplant Coordination Organisation), ETHAP (European Transplant Allied Healthcare Professionals) and ELPAT (Ethical, Legal and Psycho‐social Aspects of Transplantation). The formal ‘kick‐off’ of the Advisory Board Meeting of the European Transplant Patient Organisation (ETPO) was during the ESOT congress in 2019. The aim was to produce a series of statements to serve as a path to dialogue between patients and transplant professionals and to define the next steps towards giving a voice to the patient network. To include the patients’ perspectives, two surveys have been performed. The results identified the unmet needs and lead to a proposal for future plans. Educational activities have since started leading to a patient learning workstream. All initiatives taken have one purpose: to include patients, give them a voice and build a foundation for collaboration between patients and transplant professionals. ESOT has created a platform for mutual understanding, learning and a collaborative partnership between ETPO and European donation and transplant professionals.
International Journal of Medical Students, 2015
Ocular auscultation is a commonly neglected step of routine physical examination. An adequate ocu... more Ocular auscultation is a commonly neglected step of routine physical examination. An adequate ocular auscultation can be helpful in discovering an ocular bruit, which is an important diagnostic finding for a broad spectrum of pathologic conditions, some of which are potentially fatal. In this article, we present a literature review on the physical exam maneuver of ocular auscultation, as well as the pathophysiology and differential diagnosis of ocular bruits. We also included a description of the adequate auscultation technique and a discussion about the applicability of ocular auscultation in clinical practice
Open Chemistry, 2018
During the last ten years, base metals have become very attractive to the organometallic and cata... more During the last ten years, base metals have become very attractive to the organometallic and catalytic community on activation of C-H bonds for their catalytic functionalization. In contrast to the statement that base metals differ on their mode of action most of the manuscripts mistakenly rely on well-studied mechanisms for precious metals while proposing plausible mechanisms. Consequently, few literature examples are found where a thorough mechanistic investigation have been conducted with strong support either by theoretical calculations or experimentation. Therefore, we consider of highly scientific interest reviewing the last advances on mechanistic studies on Fe, Co and Mn on C-H functionalization in order to get a deep insight on how these systems could be handle to either enhance their catalytic activity or to study their own systems in a similar systematic fashion. Thus, in this review we try to cover the most insightful articles for mechanistic studies on C-H activation ca...
Clinica chimica acta; international journal of clinical chemistry, 2017
Case Reports in Pathology, 2016
Hepatoid adenocarcinoma of the urachus is a rare condition. We present the case of a 51-year-old ... more Hepatoid adenocarcinoma of the urachus is a rare condition. We present the case of a 51-year-old female who developed abdominal pain and hematuria. Pelvic magnetic resonance imaging (MRI) reported an urachal mass with invasion to the bladder that was resected by partial cystectomy. On light microscopy the tumor resembled liver architecture, with polygonal atypical cells in nest formation and trabecular structures. Immunochemistry was positive for alfa-fetoprotein (AFP) and serum AFP was elevated. Hepatoid adenocarcinomas have been reported in multiple organs, being most commonly found in the stomach and the ovaries. Bladder compromise has been rarely described in the literature, and it has been associated with poor prognosis, low remission rates, and early metastasis.
Anales de la Facultad de Medicina, 2016
La tripanosomiasis americana o enfermedad de Chagas es una infección parasitaria causada por el p... more La tripanosomiasis americana o enfermedad de Chagas es una infección parasitaria causada por el parásito flagelado Trypanosoma cruzi, cuyo principal vector es un insecto de la clase hemíptera conocido como triatomino. La quimioterapia, adicional a un control oportuno de vectores y rigurosidad en el control de las transfusiones, son los elementos más importantes para el manejo de esta parasitosis. En la actualidad, el mercado farmacéutico solo ofrece nifurtimox y benznidazol como opciones terapéuticas, y a pesar de que se han obtenido resultados satisfactorios con el uso de estos medicamentos en fases agudas de la enfermedad, tripanosomiasis congénita y accidentes de laboratorio, la efectividad en las fases crónicas es notoriamente menor. Además, ambos fármacos generan ciertos efectos adversos que deben ser tenidos en cuenta por el personal de la salud, antes de iniciar el debido manejo de esta enfermedad. El objetivo del presente artículo es revisar el estado actual del tratamiento ...
Opto-Acoustic Methods and Applications in Biophotonics II, 2015
Opto-acoustic imaging (OAI) shows particular promise for in-vivo biomedical diagnostics. Its appl... more Opto-acoustic imaging (OAI) shows particular promise for in-vivo biomedical diagnostics. Its applications include cardiovascular, gastrointestinal and urogenital systems imaging. Opto-acoustic endoscopy (OAE) allows the imaging of body parts through cavities permitting entry. The critical parameter is the physical size of the device, allowing compatibility with current technology, while governing flexibility of the distal end of the endoscope based on the needs of the sensor. Polymer optical fibre (POF) presents a novel approach for endoscopic applications and has been positively discussed and compared in existing publications. A great advantage can be obtained for endoscopy due to a small size and array potential to provide discrete imaging speed improvements. Optical fibre exhibits numerous advantages over conventional piezo-electric transducers, such as immunity from electromagnetic interference and a higher resolution at small sizes. Furthermore, micro structured polymer optical fibres offer over 12 times the sensitivity of silica fibre. We present a polymer fibre Bragg grating ultrasound detector with a core diameter of 125 microns. We discuss the ultrasonic signals received and draw conclusions on the opportunities and challenges of applying this technology in biomedical applications.
SPIE Proceedings, 2008
Use of gold nanoparticles (GNPs) as a contrast agent for medical imaging is shown to improve the ... more Use of gold nanoparticles (GNPs) as a contrast agent for medical imaging is shown to improve the efficiency of optoacoustic signal generation; signal enhancement allows differentiation between different tissue types. This aspect of medical imaging is important when concerned with early cancer detection. The present paper presents a comparative analysis of two different optical techniques, optical transmission and optoacoustics, to
Advanced Laser Technologies 2007, 2007
Use of gold nanoparticles (NPs) as a contrast agent for medical imaging is shown to improve the e... more Use of gold nanoparticles (NPs) as a contrast agent for medical imaging is shown to improve the efficiency of optoacoustic signal generation; this signal enhancement allows differentiation between different tissue types. This aspect of medical imaging is important when concerned early cancer detection. The present paper presents the results on the interaction process between the laser light and gold NPs,
Fiber Optic Sensors and Applications VIII, 2011
ABSTRACT A non-metallic interferometric optical fiber ultrasonic wideband sensor is presented for... more ABSTRACT A non-metallic interferometric optical fiber ultrasonic wideband sensor is presented for optoacoustic imaging applications. The ultrasonic sensitivity of intrinsic fiber optic interferometric sensors depends strongly of the material which is composed of. We compare experimentally the acoustic sensitivity of two fiber optic sensors based on singlemode silica optical fiber and multimode graded-index perfluorinated polymer optical fiber, respectively. Both sensors are designed for detection of optoacoustic wave sources with frequencies in the range from 100 kHz to 5 MHz. These results are also compared with a PVDF ultra wideband sensor. We evaluated detection of real world optoacoustic signals, generated from an optically absorbing object embedded in a tissue mimicking phantom, between our silica optical fiber sensor and an array of piezoelectric transducers. Reconstructed two dimensional acoustic images of the phantom are presented and compared with images obtained with the Laser Optoacoustic Imaging System, LOIS-64B, demonstrating the feasibility of our fiber optic sensor as a wideband ultrasonic sensor.
Organometallics, 2014
The first neutral bis(metallylene)pyridine pincer-type [ENE] ligands (E = Si II , Ge II) were syn... more The first neutral bis(metallylene)pyridine pincer-type [ENE] ligands (E = Si II , Ge II) were synthesized, and their coordination chemistry and reactivity toward iron was studied. First, the unprecedented fourcoordinate complexes κ 2 E,E′-[ENE]FeCl 2 were isolated. Unexpectedly and in contrast to other related pyridine-based pincer-type Fe(II) complexes, the N atom of pyridine is reluctant to coordinate to the Fe(II) site due to the enhanced σ-donor strength of the E atoms, which disfavors this coordination mode. Subsequent reduction of κ 2 Si,Si′-[SiNSi]FeCl 2 with KC 8 in the presence of PMe 3 or direct reaction of the [ENE] ligands using Fe(PMe 3) 4 produced the highly electron-rich iron(0) complexes [ENE]-Fe(PMe 3) 2. The reduction of the iron center substantially changes its coordination features, as shown by the results of a single-crystal X-ray diffraction analysis of [SiNSi]Fe(PMe 3) 2. The iron center, in the latter, exhibits a pseudosquare pyramidal (PSQP) coordination environment, with a coordinative (pyridine)N→Fe bond, and a trimethylphosphine ligand occupying the apical position. This geometry is very unusual for Fe(0) low-spin complexes, and variable-temperature 1 H and 31 P NMR spectra of the [ENE]Fe(PMe 3) 2 complexes revealed that they represent the first examples of configurationally stable PSQP-coordinated Fe(0) complexes: even after heating at 70°C for >7 days, no changes are observed. The substitution reaction of [ENE]Fe(PMe 3) 2 with CO resulted in the isolation of [ENE]Fe(CO) 2 and the hitherto unknown κ 2 E,E′-[ENE]Fe(CO) 2 L (L = CO, PMe 3) complexes. All complexes were fully characterized (NMR, MS, XRD, IR, and 57 Fe Mossbauer spectroscopy), showing the highest electron density on the iron center for pincer-type complexes reported to date. DFT calculations and 57 Fe Mossbauer spectroscopy confirmed the innocent behavior of these ligands. Moreover, preliminary results showed that these complexes can serve as active precatalysts for the hydrosilylation of ketones.
Dalton Transactions, 2014
The complexation of anions of selected α-amino acids (alanine, valine, proline, tyrosine) and sma... more The complexation of anions of selected α-amino acids (alanine, valine, proline, tyrosine) and small peptides (L-alanyl-L-alanine, L-alanyl-L-alanyl-L-alanine, and L-alanyl-L-alanyl-L-alanyl-L-alanine) by the dinuclear nickel(II) complex [LNi 2 (μ-Cl)] + (1), where (L) 2− represents a 24-membered binucleating hexaminedithiophenolato ligand, has been investigated. The following complexes were prepared, isolated as perchlorate or tetraphenylborate salts, and characterized by UV/Vis, IR, and CD spectroscopy: [LNi 2 (μ-Lalaninato)] + (2), [LNi 2 (μ-L-valinato)] + (3), [LNi 2 (μ-L-prolinato)] + (4), [LNi 2 (μ-L-tyrosinato)] + (5a), [LNi 2 (μ-Dtyrosinato)] + (5b), [LNi 2 (μ-L,D-tyrosinato)] + (5c), [LNi 2 (μ-L-alanyl-L-alaninato)] + (6), [LNi 2 (μ-(L-alanyl) 2-Lalaninato)] + (7), [LNi 2 (μ-(L-alanyl) 3-L-alaninato)] + (8). Compounds 4, 5a and 6 were additionally identified by X-ray crystallography. In contrast to unsupported amino carboxylate complexes which typically contain five membered NO chelate rings, the [LNi 2 ] 2+ fragment selectively binds the α-amino acids and peptides via μ 1,3-bridging carboxylato groups. Coordination of the carboxylato coligands in this way confers dissymmetry on the complexes. The CD spectra of the syn,syn-bridged structures are significantly different from those of the NO chelates, and can distinguish between the two coordination modes. The encapsulation of the peptides increases their solubility in the solvent system MeOH-MeCN by up to two orders of magnitude. This is discussed in terms of the absence of intermolecular hydrogen bonding interactions as indicated in the X-ray structure of 6.
Molbank, 2010
A new flexible fluorescent compound L derived from 1,5-bis(2-aminophenoxy)-3-oxapentane (A) has b... more A new flexible fluorescent compound L derived from 1,5-bis(2-aminophenoxy)-3-oxapentane (A) has been synthesized by classical Schiff-base reaction between (A) and 2,2-bithiophene carbaldehyde (B). The same synthesis was reproduced by a green methodology using an ultrasonication reaction in a classical sonication bath. The structure of the new compound was confirmed by elemental analysis, IR, 1 H-NMR, MALDI-TOF-MS and EI-MS-spectra, UV-vis and fluorescence emission spectroscopy.
Estudios de Traducción, 2012
RESUMEN El intérprete de conferencias debe llevar a cabo un trabajo documental antes, durante y d... more RESUMEN El intérprete de conferencias debe llevar a cabo un trabajo documental antes, durante y después de los eventos en los que presta sus servicios, independientemente de su subcompetencia extralingüística. Desafortunadamente, pocas son las propuestas metodológicas que se hayan planteado para que este profesional pueda realizar esta tarea de manera sistemática. En el presente artículo, repasamos algunos de los trabajos que se han referido a las posibilidades que tiene el intérprete de satisfacer sus necesidades informativas. Una vez reseñada la mencionada escasez de propuestas, presentamos, en un estudio de caso, una aproximación metodológica a este trabajo de documentación, fundamentada en la compilación de corpus paralelos ad hoc y la extracción terminológica en forma de glosarios.
Avances en Periodoncia e Implantología Oral, 2002
Inserción de implantes dentales en la apófisis pterigoides: Una alternativa en el tratamiento reh... more Inserción de implantes dentales en la apófisis pterigoides: Una alternativa en el tratamiento rehabilitador del maxilar posterior atrófico * Odontólogo. ** Médico Estomatólogo. Doctor en Odontología. tratamiento de pacientes totalmente desdentados como en los parcialmente desdentados. Sin embargo, en todos los estudios encontramos un porcentaje variable de fracasos, debido a diferentes problemas (1-4) .
2013 IEEE Frontiers in Education Conference (FIE), 2013
Reusing Learning Objects saves time and reduces development costs. Hence, achieving their interop... more Reusing Learning Objects saves time and reduces development costs. Hence, achieving their interoperability in multiple contexts is essential when creating a Learning Object Repository. On the other hand, novel web videoconference services are available due to technological advancements. Several benefits can be gained by integrating Learning Objects into these services. For instance, they can allow sharing, co-viewing and synchronized co-browsing of these resources at the same time that provide real time communication. However, several efforts need to be undertaken to achieve the interoperability with these systems. In this paper, we propose a model to integrate the resources of the Learning Object Repositories into web videoconference services. The experience of applying this model in a real e-Learning scenario achieving interoperability with a web videoconference service is also described.
ABSTRACT En estudios previos realizados en nuestros laboratorios se demuestra un grado de Biocomp... more ABSTRACT En estudios previos realizados en nuestros laboratorios se demuestra un grado de Biocompatibilidad adecuado del Cemento Portland para ser utilizado en investigación Biomédica; por lo tanto, basados en las excelentes propiedades mecánico – estructurales de éste, proponemos una metodología (Particulate Leaching) para fabricar estructuras porosas tridimensionales y biomiméticas, que imiten la morfología del hueso esponjoso, y que eventualmente trabajarán como matrices implantables estables, capaces de soportar el crecimiento del tejido óseo (osteoconductivas) y que a su vez toleren las cargas biomecánicas asociadas con la remodelación del hueso, permitiendo así una recuperación mas pronta del paciente. Por lo anterior, se fabricaron estructuras porosas en Cemento Portland Blanco Tipo I siguiendo la metodología de “Particulate Leaching”, utilizando NaCl en diferentes concentraciones como Porógeno. Las muestras fueron hidratadas a 134°C y 35 Psi aproximadamente, en autoclave durante 24h. Los restos de NaCl se removieron por inmersión de las matrices en agua Tridestilada bajo condiciones de vacío (600 mm Hg.) durante 48h. La caracterización morfológica de las estructuras se hizo mediante Microscopía de Luz y un análisis digital de la imagen (LAB WORKS 4.5) para determinar la densidad y el tamaño de los poros, además se evaluó el comportamiento mecánico utilizando pruebas de compresión. Los resultados preliminares muestran estructuras con poros entre 100-200 μm de diámetro (180 μm en promedio aproximadamente), y porosidades entre el 30 y 60%; lo cual coincide con los valores sugeridos en la literatura como adecuados para matrices de cultivo de células óseas. Finalmente, en cuanto a sus propiedades mecánicas, los módulos de elasticidad se encuentran en un rango entre 78 y 370 MPa, y la fuerza máxima de compresión está entre 2 y 7 MPa, similar a lo observado en hueso esponjoso.
It has been clear that the surface properties of the materials used as substrates for cell cultur... more It has been clear that the surface properties of the materials used as substrates for cell culture can influence the cell behavior affecting different factors such as cell orientation, adhesion, growth, differentiation, and apoptosis. In the last few years, several micro and nanofabrication techniques have emerged as important tools used to modify the surface properties of those materials at the micro or nano scale, topologically or chemically. This paper reviews the most used microfabrication techniques to introduce modifications on the materials surfaces and its implications on cell behavior. This review ends up showing the possible medical applications derived as a source of future work in the field. Resumen: Ha quedado claro que las propiedades superficiales de los materiales utilizados como sustratos para cultivo celular pueden influir en el comportamiento de las celulas afectando diferentes factores tales como la orientacion celular, adhesion, crecimiento, diferenciacion y apo...
Transplant International, 2021
This article describes a pathway for collaboration between transplant healthcare professionals an... more This article describes a pathway for collaboration between transplant healthcare professionals and organ recipients. Under the umbrella of the European Society for Organ Transplantation (ESOT) a joint initiative started from three Sections and Committees of ESOT: EDTCO (European Donation and Transplant Coordination Organisation), ETHAP (European Transplant Allied Healthcare Professionals) and ELPAT (Ethical, Legal and Psycho‐social Aspects of Transplantation). The formal ‘kick‐off’ of the Advisory Board Meeting of the European Transplant Patient Organisation (ETPO) was during the ESOT congress in 2019. The aim was to produce a series of statements to serve as a path to dialogue between patients and transplant professionals and to define the next steps towards giving a voice to the patient network. To include the patients’ perspectives, two surveys have been performed. The results identified the unmet needs and lead to a proposal for future plans. Educational activities have since started leading to a patient learning workstream. All initiatives taken have one purpose: to include patients, give them a voice and build a foundation for collaboration between patients and transplant professionals. ESOT has created a platform for mutual understanding, learning and a collaborative partnership between ETPO and European donation and transplant professionals.
International Journal of Medical Students, 2015
Ocular auscultation is a commonly neglected step of routine physical examination. An adequate ocu... more Ocular auscultation is a commonly neglected step of routine physical examination. An adequate ocular auscultation can be helpful in discovering an ocular bruit, which is an important diagnostic finding for a broad spectrum of pathologic conditions, some of which are potentially fatal. In this article, we present a literature review on the physical exam maneuver of ocular auscultation, as well as the pathophysiology and differential diagnosis of ocular bruits. We also included a description of the adequate auscultation technique and a discussion about the applicability of ocular auscultation in clinical practice
Open Chemistry, 2018
During the last ten years, base metals have become very attractive to the organometallic and cata... more During the last ten years, base metals have become very attractive to the organometallic and catalytic community on activation of C-H bonds for their catalytic functionalization. In contrast to the statement that base metals differ on their mode of action most of the manuscripts mistakenly rely on well-studied mechanisms for precious metals while proposing plausible mechanisms. Consequently, few literature examples are found where a thorough mechanistic investigation have been conducted with strong support either by theoretical calculations or experimentation. Therefore, we consider of highly scientific interest reviewing the last advances on mechanistic studies on Fe, Co and Mn on C-H functionalization in order to get a deep insight on how these systems could be handle to either enhance their catalytic activity or to study their own systems in a similar systematic fashion. Thus, in this review we try to cover the most insightful articles for mechanistic studies on C-H activation ca...
Clinica chimica acta; international journal of clinical chemistry, 2017
Case Reports in Pathology, 2016
Hepatoid adenocarcinoma of the urachus is a rare condition. We present the case of a 51-year-old ... more Hepatoid adenocarcinoma of the urachus is a rare condition. We present the case of a 51-year-old female who developed abdominal pain and hematuria. Pelvic magnetic resonance imaging (MRI) reported an urachal mass with invasion to the bladder that was resected by partial cystectomy. On light microscopy the tumor resembled liver architecture, with polygonal atypical cells in nest formation and trabecular structures. Immunochemistry was positive for alfa-fetoprotein (AFP) and serum AFP was elevated. Hepatoid adenocarcinomas have been reported in multiple organs, being most commonly found in the stomach and the ovaries. Bladder compromise has been rarely described in the literature, and it has been associated with poor prognosis, low remission rates, and early metastasis.
Anales de la Facultad de Medicina, 2016
La tripanosomiasis americana o enfermedad de Chagas es una infección parasitaria causada por el p... more La tripanosomiasis americana o enfermedad de Chagas es una infección parasitaria causada por el parásito flagelado Trypanosoma cruzi, cuyo principal vector es un insecto de la clase hemíptera conocido como triatomino. La quimioterapia, adicional a un control oportuno de vectores y rigurosidad en el control de las transfusiones, son los elementos más importantes para el manejo de esta parasitosis. En la actualidad, el mercado farmacéutico solo ofrece nifurtimox y benznidazol como opciones terapéuticas, y a pesar de que se han obtenido resultados satisfactorios con el uso de estos medicamentos en fases agudas de la enfermedad, tripanosomiasis congénita y accidentes de laboratorio, la efectividad en las fases crónicas es notoriamente menor. Además, ambos fármacos generan ciertos efectos adversos que deben ser tenidos en cuenta por el personal de la salud, antes de iniciar el debido manejo de esta enfermedad. El objetivo del presente artículo es revisar el estado actual del tratamiento ...
Opto-Acoustic Methods and Applications in Biophotonics II, 2015
Opto-acoustic imaging (OAI) shows particular promise for in-vivo biomedical diagnostics. Its appl... more Opto-acoustic imaging (OAI) shows particular promise for in-vivo biomedical diagnostics. Its applications include cardiovascular, gastrointestinal and urogenital systems imaging. Opto-acoustic endoscopy (OAE) allows the imaging of body parts through cavities permitting entry. The critical parameter is the physical size of the device, allowing compatibility with current technology, while governing flexibility of the distal end of the endoscope based on the needs of the sensor. Polymer optical fibre (POF) presents a novel approach for endoscopic applications and has been positively discussed and compared in existing publications. A great advantage can be obtained for endoscopy due to a small size and array potential to provide discrete imaging speed improvements. Optical fibre exhibits numerous advantages over conventional piezo-electric transducers, such as immunity from electromagnetic interference and a higher resolution at small sizes. Furthermore, micro structured polymer optical fibres offer over 12 times the sensitivity of silica fibre. We present a polymer fibre Bragg grating ultrasound detector with a core diameter of 125 microns. We discuss the ultrasonic signals received and draw conclusions on the opportunities and challenges of applying this technology in biomedical applications.
SPIE Proceedings, 2008
Use of gold nanoparticles (GNPs) as a contrast agent for medical imaging is shown to improve the ... more Use of gold nanoparticles (GNPs) as a contrast agent for medical imaging is shown to improve the efficiency of optoacoustic signal generation; signal enhancement allows differentiation between different tissue types. This aspect of medical imaging is important when concerned with early cancer detection. The present paper presents a comparative analysis of two different optical techniques, optical transmission and optoacoustics, to
Advanced Laser Technologies 2007, 2007
Use of gold nanoparticles (NPs) as a contrast agent for medical imaging is shown to improve the e... more Use of gold nanoparticles (NPs) as a contrast agent for medical imaging is shown to improve the efficiency of optoacoustic signal generation; this signal enhancement allows differentiation between different tissue types. This aspect of medical imaging is important when concerned early cancer detection. The present paper presents the results on the interaction process between the laser light and gold NPs,
Fiber Optic Sensors and Applications VIII, 2011
ABSTRACT A non-metallic interferometric optical fiber ultrasonic wideband sensor is presented for... more ABSTRACT A non-metallic interferometric optical fiber ultrasonic wideband sensor is presented for optoacoustic imaging applications. The ultrasonic sensitivity of intrinsic fiber optic interferometric sensors depends strongly of the material which is composed of. We compare experimentally the acoustic sensitivity of two fiber optic sensors based on singlemode silica optical fiber and multimode graded-index perfluorinated polymer optical fiber, respectively. Both sensors are designed for detection of optoacoustic wave sources with frequencies in the range from 100 kHz to 5 MHz. These results are also compared with a PVDF ultra wideband sensor. We evaluated detection of real world optoacoustic signals, generated from an optically absorbing object embedded in a tissue mimicking phantom, between our silica optical fiber sensor and an array of piezoelectric transducers. Reconstructed two dimensional acoustic images of the phantom are presented and compared with images obtained with the Laser Optoacoustic Imaging System, LOIS-64B, demonstrating the feasibility of our fiber optic sensor as a wideband ultrasonic sensor.
Organometallics, 2014
The first neutral bis(metallylene)pyridine pincer-type [ENE] ligands (E = Si II , Ge II) were syn... more The first neutral bis(metallylene)pyridine pincer-type [ENE] ligands (E = Si II , Ge II) were synthesized, and their coordination chemistry and reactivity toward iron was studied. First, the unprecedented fourcoordinate complexes κ 2 E,E′-[ENE]FeCl 2 were isolated. Unexpectedly and in contrast to other related pyridine-based pincer-type Fe(II) complexes, the N atom of pyridine is reluctant to coordinate to the Fe(II) site due to the enhanced σ-donor strength of the E atoms, which disfavors this coordination mode. Subsequent reduction of κ 2 Si,Si′-[SiNSi]FeCl 2 with KC 8 in the presence of PMe 3 or direct reaction of the [ENE] ligands using Fe(PMe 3) 4 produced the highly electron-rich iron(0) complexes [ENE]-Fe(PMe 3) 2. The reduction of the iron center substantially changes its coordination features, as shown by the results of a single-crystal X-ray diffraction analysis of [SiNSi]Fe(PMe 3) 2. The iron center, in the latter, exhibits a pseudosquare pyramidal (PSQP) coordination environment, with a coordinative (pyridine)N→Fe bond, and a trimethylphosphine ligand occupying the apical position. This geometry is very unusual for Fe(0) low-spin complexes, and variable-temperature 1 H and 31 P NMR spectra of the [ENE]Fe(PMe 3) 2 complexes revealed that they represent the first examples of configurationally stable PSQP-coordinated Fe(0) complexes: even after heating at 70°C for >7 days, no changes are observed. The substitution reaction of [ENE]Fe(PMe 3) 2 with CO resulted in the isolation of [ENE]Fe(CO) 2 and the hitherto unknown κ 2 E,E′-[ENE]Fe(CO) 2 L (L = CO, PMe 3) complexes. All complexes were fully characterized (NMR, MS, XRD, IR, and 57 Fe Mossbauer spectroscopy), showing the highest electron density on the iron center for pincer-type complexes reported to date. DFT calculations and 57 Fe Mossbauer spectroscopy confirmed the innocent behavior of these ligands. Moreover, preliminary results showed that these complexes can serve as active precatalysts for the hydrosilylation of ketones.
Dalton Transactions, 2014
The complexation of anions of selected α-amino acids (alanine, valine, proline, tyrosine) and sma... more The complexation of anions of selected α-amino acids (alanine, valine, proline, tyrosine) and small peptides (L-alanyl-L-alanine, L-alanyl-L-alanyl-L-alanine, and L-alanyl-L-alanyl-L-alanyl-L-alanine) by the dinuclear nickel(II) complex [LNi 2 (μ-Cl)] + (1), where (L) 2− represents a 24-membered binucleating hexaminedithiophenolato ligand, has been investigated. The following complexes were prepared, isolated as perchlorate or tetraphenylborate salts, and characterized by UV/Vis, IR, and CD spectroscopy: [LNi 2 (μ-Lalaninato)] + (2), [LNi 2 (μ-L-valinato)] + (3), [LNi 2 (μ-L-prolinato)] + (4), [LNi 2 (μ-L-tyrosinato)] + (5a), [LNi 2 (μ-Dtyrosinato)] + (5b), [LNi 2 (μ-L,D-tyrosinato)] + (5c), [LNi 2 (μ-L-alanyl-L-alaninato)] + (6), [LNi 2 (μ-(L-alanyl) 2-Lalaninato)] + (7), [LNi 2 (μ-(L-alanyl) 3-L-alaninato)] + (8). Compounds 4, 5a and 6 were additionally identified by X-ray crystallography. In contrast to unsupported amino carboxylate complexes which typically contain five membered NO chelate rings, the [LNi 2 ] 2+ fragment selectively binds the α-amino acids and peptides via μ 1,3-bridging carboxylato groups. Coordination of the carboxylato coligands in this way confers dissymmetry on the complexes. The CD spectra of the syn,syn-bridged structures are significantly different from those of the NO chelates, and can distinguish between the two coordination modes. The encapsulation of the peptides increases their solubility in the solvent system MeOH-MeCN by up to two orders of magnitude. This is discussed in terms of the absence of intermolecular hydrogen bonding interactions as indicated in the X-ray structure of 6.
Molbank, 2010
A new flexible fluorescent compound L derived from 1,5-bis(2-aminophenoxy)-3-oxapentane (A) has b... more A new flexible fluorescent compound L derived from 1,5-bis(2-aminophenoxy)-3-oxapentane (A) has been synthesized by classical Schiff-base reaction between (A) and 2,2-bithiophene carbaldehyde (B). The same synthesis was reproduced by a green methodology using an ultrasonication reaction in a classical sonication bath. The structure of the new compound was confirmed by elemental analysis, IR, 1 H-NMR, MALDI-TOF-MS and EI-MS-spectra, UV-vis and fluorescence emission spectroscopy.
Estudios de Traducción, 2012
RESUMEN El intérprete de conferencias debe llevar a cabo un trabajo documental antes, durante y d... more RESUMEN El intérprete de conferencias debe llevar a cabo un trabajo documental antes, durante y después de los eventos en los que presta sus servicios, independientemente de su subcompetencia extralingüística. Desafortunadamente, pocas son las propuestas metodológicas que se hayan planteado para que este profesional pueda realizar esta tarea de manera sistemática. En el presente artículo, repasamos algunos de los trabajos que se han referido a las posibilidades que tiene el intérprete de satisfacer sus necesidades informativas. Una vez reseñada la mencionada escasez de propuestas, presentamos, en un estudio de caso, una aproximación metodológica a este trabajo de documentación, fundamentada en la compilación de corpus paralelos ad hoc y la extracción terminológica en forma de glosarios.
Avances en Periodoncia e Implantología Oral, 2002
Inserción de implantes dentales en la apófisis pterigoides: Una alternativa en el tratamiento reh... more Inserción de implantes dentales en la apófisis pterigoides: Una alternativa en el tratamiento rehabilitador del maxilar posterior atrófico * Odontólogo. ** Médico Estomatólogo. Doctor en Odontología. tratamiento de pacientes totalmente desdentados como en los parcialmente desdentados. Sin embargo, en todos los estudios encontramos un porcentaje variable de fracasos, debido a diferentes problemas (1-4) .
2013 IEEE Frontiers in Education Conference (FIE), 2013
Reusing Learning Objects saves time and reduces development costs. Hence, achieving their interop... more Reusing Learning Objects saves time and reduces development costs. Hence, achieving their interoperability in multiple contexts is essential when creating a Learning Object Repository. On the other hand, novel web videoconference services are available due to technological advancements. Several benefits can be gained by integrating Learning Objects into these services. For instance, they can allow sharing, co-viewing and synchronized co-browsing of these resources at the same time that provide real time communication. However, several efforts need to be undertaken to achieve the interoperability with these systems. In this paper, we propose a model to integrate the resources of the Learning Object Repositories into web videoconference services. The experience of applying this model in a real e-Learning scenario achieving interoperability with a web videoconference service is also described.
Biblia Satánica
Todos los derechos reservados. No está permitida la reproducción total ni parcial de este libro, ... more Todos los derechos reservados. No está permitida la reproducción total ni parcial de este libro, ni la recopilción en un sistema informático, ni la transmisión por medios electrónicos, mecánicos, por fotocopias, por registro o por otros métodos, salvo en breves extractos a efectos de reseña, , sin la autorización previa y por escrito del ditor o el propietario del copyright. 3 4 DEDICATORIAS Bernardino Logara, que conocía el valor del dinero Karl Haushofer, un profesor sin aula Rasputin, que conoció la magia de un niño Sir Basil Zaharoff, un caballero Cagliostro, un pícaro Barnabas Saul, el primer adivino Ragnar Redbeard, cuyo poder tenía la razón William Mortensen, que miró... y vió Hans Brick, que conoce la ley Max Reinhardt, un constructor de sueños Orrin Klapp, el caminante Fritz Lang, quien hizo cianotipos animados Friedrich Nietzsche, un realista W.C. Fields, que me ahorró un viaje al Tibet P.T. Barnum, otro gran gurú Hans Poelzig, que conocía todos los ángulos Reginald Marsh, un gran artista Wilhem Reich, más que un constructor de gabinetes Mark Twain, un hombre muy valiente.