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Papers by David Krason

Research paper thumbnail of Lyme Disease

Retinal Cases & Brief Reports, 2012

Research paper thumbnail of The Clustering of Infected SIV Cells in Lymphatic Tissue

Journal of the American Statistical Association, 2002

Here we investigate the clustering of simian immunodeficiency virus (SIV)-infected cells in a lym... more Here we investigate the clustering of simian immunodeficiency virus (SIV)-infected cells in a lymphatic tissue sample taken from a rhesus macaque to test a spatial proximity model of the spread of infection. We see that standard methods for analysis of the clustering of point processes are not entirely satisfactory for this application, so we define a novel statistic to understand the clustering in the data. This statistic examines how events spread out from certain points deemed cluster centers. Using this statistic, we can demonstrate the statistical significance of the clustering and examine over what distances this clustering is witnessed. We use Bayesian methods to fully assess the uncertainty in the estimation of this statistic by positing a model for the process. (We assume the process is a nonhomogeneous Poisson process with an intensity that is a linear combination of Gaussian densities.) We see that the distances at which clustering is present are consistent with a simple model of SIV spread within the lymph node.

Research paper thumbnail of Poor Initial CD4+ Recovery With Antiretroviral Therapy Prolongs Immune Depletion and Increases Risk for AIDS and Non-AIDS Diseases

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2008

Background-Low CD4+ increases risk for both AIDS-and non-AIDS-related morbidity and mortality. Th... more Background-Low CD4+ increases risk for both AIDS-and non-AIDS-related morbidity and mortality. The magnitude of CD4+ recovery early after initial antiretroviral therapy (ART) is important in the ultimate duration of immune depletion.

Research paper thumbnail of Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count

AIDS, 2005

The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostas... more The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts the niche and limits the size of the resident CD4 cell population. In this report we show that a single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the peripheral CD4 cell pool with HAART (P < 0.001). This suggests that collagen-targeted therapies might be of benefit.

Research paper thumbnail of Lyme Disease

Retinal Cases & Brief Reports, 2012

Research paper thumbnail of The Clustering of Infected SIV Cells in Lymphatic Tissue

Journal of the American Statistical Association, 2002

Here we investigate the clustering of simian immunodeficiency virus (SIV)-infected cells in a lym... more Here we investigate the clustering of simian immunodeficiency virus (SIV)-infected cells in a lymphatic tissue sample taken from a rhesus macaque to test a spatial proximity model of the spread of infection. We see that standard methods for analysis of the clustering of point processes are not entirely satisfactory for this application, so we define a novel statistic to understand the clustering in the data. This statistic examines how events spread out from certain points deemed cluster centers. Using this statistic, we can demonstrate the statistical significance of the clustering and examine over what distances this clustering is witnessed. We use Bayesian methods to fully assess the uncertainty in the estimation of this statistic by positing a model for the process. (We assume the process is a nonhomogeneous Poisson process with an intensity that is a linear combination of Gaussian densities.) We see that the distances at which clustering is present are consistent with a simple model of SIV spread within the lymph node.

Research paper thumbnail of Poor Initial CD4+ Recovery With Antiretroviral Therapy Prolongs Immune Depletion and Increases Risk for AIDS and Non-AIDS Diseases

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2008

Background-Low CD4+ increases risk for both AIDS-and non-AIDS-related morbidity and mortality. Th... more Background-Low CD4+ increases risk for both AIDS-and non-AIDS-related morbidity and mortality. The magnitude of CD4+ recovery early after initial antiretroviral therapy (ART) is important in the ultimate duration of immune depletion.

Research paper thumbnail of Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count

AIDS, 2005

The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostas... more The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts the niche and limits the size of the resident CD4 cell population. In this report we show that a single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the peripheral CD4 cell pool with HAART (P < 0.001). This suggests that collagen-targeted therapies might be of benefit.

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