Denise Sharon - Academia.edu (original) (raw)

Papers by Denise Sharon

Sleep medicine reviews, Aug 1, 2024

Sleep Medicine, Feb 1, 2007

Sleep Medicine, Sep 1, 2011

room air versus on oxygen) in central apneas (1.9/hour of sleep vs 0.4, p=0.0008), obstructive/mi... more room air versus on oxygen) in central apneas (1.9/hour of sleep vs 0.4, p=0.0008), obstructive/mixed apneas (7.8/hour of sleep vs 3.0, p=0.0053), hypopnea index (15.3 vs 7.3, p=0.0013), combined apnea/hypopnea index (24.7 vs 11.0, p=0.0001). There was no significant improvement in sleep efficiency (84.7% at baseline vs 81.0% on oxygen, p=0.137). Average SaO2 improved (93% at baseline vs 96% on oxygen, p=0.0392) as did SaO2 nadir (79% at baseline vs 85% on oxygen, p=0.0434). Oxygen use was associated with increased periodic leg movement (PLM) index (12.2 vs 23.4, p=0.005) and PLM arousal index (2.4 vs 6.9, p=003). Conclusion: Low-flow oxygen is effective in reducing central, obstructive and mixed apneas in infants with OSA. Proposed mechanisms include alleviation of hypoxemia-induced hypotonia of the upper airway dilators and improved central ventilatory control. Prospective studies are needed to confirm these findings.

Neurology, Oct 1, 1998

Encouraging initial response of restless legs syndrome to pramipexole Article abstract-Restless l... more Encouraging initial response of restless legs syndrome to pramipexole Article abstract-Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and an urge to move the limbs. Two centers tested a new dopamine agonist, pramipexole, in 23 patients with RLS in a time-limited, open-label, clinical trial. After 4 weeks or more, 19 patients reported significant improvement as assessed by the short International Restless Legs Syndrome Study Group questionnaire (p < 0.0001). These encouraging preliminary results justify larger, controlled trials for pramipexole in patients with RLS.

PubMed, 2000

To address the violence phenomenon in psychiatric institutions towards the staff, to find the cau... more To address the violence phenomenon in psychiatric institutions towards the staff, to find the causes of these phenomena and to examine effective methods that will help to prevent the occurrence and/or confront it. To break the "conspiracy of silence" around the subject matter and to raise the awareness of all personnel in order to formulate a policy of responses to violent incidents and to learn procedures for the management of these complex situations.

Sleep Medicine, Feb 1, 2007

Encyclopedia of Sleep, 2013

Sleep-related movement disorders are common and often underdiagnosed in the elderly. The elderly ... more Sleep-related movement disorders are common and often underdiagnosed in the elderly. The elderly are a poorly defined group, usually assumed to start at the age of 65 years. In this group, clinical application of research data has to take into account the frequent occurrence of comorbidities, of medications, and of possible cognitive deterioration. This article will focus on restless legs syndrome, periodic limb movement disorder, sleep-related leg cramps, and sleep-related bruxism in the elderly.

Sleep Medicine, 2011

room air versus on oxygen) in central apneas (1.9/hour of sleep vs 0.4, p=0.0008), obstructive/mi... more room air versus on oxygen) in central apneas (1.9/hour of sleep vs 0.4, p=0.0008), obstructive/mixed apneas (7.8/hour of sleep vs 3.0, p=0.0053), hypopnea index (15.3 vs 7.3, p=0.0013), combined apnea/hypopnea index (24.7 vs 11.0, p=0.0001). There was no significant improvement in sleep efficiency (84.7% at baseline vs 81.0% on oxygen, p=0.137). Average SaO2 improved (93% at baseline vs 96% on oxygen, p=0.0392) as did SaO2 nadir (79% at baseline vs 85% on oxygen, p=0.0434). Oxygen use was associated with increased periodic leg movement (PLM) index (12.2 vs 23.4, p=0.005) and PLM arousal index (2.4 vs 6.9, p=003). Conclusion: Low-flow oxygen is effective in reducing central, obstructive and mixed apneas in infants with OSA. Proposed mechanisms include alleviation of hypoxemia-induced hypotonia of the upper airway dilators and improved central ventilatory control. Prospective studies are needed to confirm these findings.

Neurology, 1998

Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and a... more Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and an urge to move the limbs. Two centers tested a new dopamine agonist, pramipexole, in 23 patients with RLS in a time-limited, open-label, clinical trial. After 4 weeks or more, 19 patients reported significant improvement as assessed by the short International Restless Legs Syndrome Study Group questionnaire (p < 0.0001). These encouraging preliminary results justify larger, controlled trials for pramipexole in patients with RLS.

CHEST Journal, 2005

INTERLEUKIN 2 INCREASES ALVEOLAR FLUID CLEAR-ANCE IN ISOLATED RAT LUNGS Makoto Sugita MD* Zheng W... more INTERLEUKIN 2 INCREASES ALVEOLAR FLUID CLEAR-ANCE IN ISOLATED RAT LUNGS Makoto Sugita MD* Zheng Wang MD Sumiko Maeda MD Motoyasu Sagawa MD Jin Xu MD Toshishige Shibamoto MD Tsutomu Sakuma MD Kanazawa Medical University, Ishikawa ...

Sleep Medicine, Jun 1, 2013

Sleep Medicine, 2003

Background: There is a need for an easily administered instrument which can be applied to all pat... more Background: There is a need for an easily administered instrument which can be applied to all patients with restless legs syndrome (RLS) to measure disease severity for clinical assessment, research, or therapeutic trials. The pathophysiology of RLS is not clear and no objective measure so far devised can apply to all patients or accurately reflect severity. Moreover, RLS is primarily a subjective disorder. Therefore, a subjective scale is at present the optimal instrument to meet this need. Methods: Twenty centers from six countries participated in an initial reliability and validation study of a rating scale for the severity of RLS designed by the International RLS study group (IRLSSG). A ten-question scale was developed on the basis of repeated expert evaluation of potential items. This scale, the IRLSSG rating scale (IRLS), was administered to 196 RLS patients, most on some medication, and 209 control subjects. Results: The IRLS was found to have high levels of internal consistency, inter-examiner reliability, test-retest reliability over a 2-4 week period, and convergent validity. It also demonstrated criterion validity when tested against the current criterion of a clinical global impression and readily discriminated patient from control groups. The scale was dominated by a single severity factor that explained at least 59% of the pooled item variance. Conclusions: This scale meets performance criteria for a brief, patient completed instrument that can be used to assess RLS severity for purposes of clinical assessment, research, or therapeutic trials. It supports a finding that RLS is a relatively uniform disorder in which the severity of the basic symptoms is strongly related to their impact on the patient's life. In future studies, the IRLS should be tested against objective measures of RLS severity and its sensitivity should be studied as RLS severity is systematically manipulated by therapeutic interventions.

Pediatrics, 2002

Objective. To investigate the effect of low-flow supplemental oxygen (SupOx) on sleep architectur... more Objective. To investigate the effect of low-flow supplemental oxygen (SupOx) on sleep architecture and cardiorespiratory events in asymptomatic preterm infants. Methods. An overnight polysomnographic evaluation was conducted prospectively in 23 premature infants who were born at 30.0 ± 3.2 (standard deviation) weeks’ gestational age and studied at 38.1 ± 4.4 weeks’ postconceptional age. Infants were free of any adverse events, including cardiorespiratory monitor alarms in the nursery for at least 1 week before the study. Infants received room air (RA) or SupOx via nasal cannula at 0.25 L/min. Results. Quiet sleep density was increased during SupOx (33.3 ± 10.8% vs 26.6 ± 10.0% total sleep time [TST] in RA), and a reciprocal decrease in active sleep density was observed (61.5 ± 11.1% vs 68.4 ± 9.9% TST in RA). No differences in sleep efficiency emerged (69.7 ± 10.6% SupOx vs 69.7 ± 8.8% RA). SupOx elicited significant decreases in apnea index (3.8 ± 2.4 events/h vs 11.1 ± 6.4 events/...

Sleep and Movement Disorders, 2013

The online version of this article, along with updated information and services, is located on th... more The online version of this article, along with updated information and services, is located on the World Wide Web at:

Convulsive therapy, 1990

Thirty-two outpatients with a mean age of 68 years were observed in a naturalistic study of outpa... more Thirty-two outpatients with a mean age of 68 years were observed in a naturalistic study of outpatient electroconvulsive therapy (ECT) for the management of recurrent mood disorder. Sixty-nine percent of the patients responded favorably to ECT and were either discharged well from therapy or continue in treatment. A rehospitalization rate of 9% supports the efficacy of this treatment. We find outpatient ECT safe for the long-term management of recurrent depressive illness in elderly patients. The low dropout rate demonstrates that patient acceptance is equal to that of other outpatient treatments.

Sleep medicine reviews, Aug 1, 2024

Sleep Medicine, Feb 1, 2007

Sleep Medicine, Sep 1, 2011

room air versus on oxygen) in central apneas (1.9/hour of sleep vs 0.4, p=0.0008), obstructive/mi... more room air versus on oxygen) in central apneas (1.9/hour of sleep vs 0.4, p=0.0008), obstructive/mixed apneas (7.8/hour of sleep vs 3.0, p=0.0053), hypopnea index (15.3 vs 7.3, p=0.0013), combined apnea/hypopnea index (24.7 vs 11.0, p=0.0001). There was no significant improvement in sleep efficiency (84.7% at baseline vs 81.0% on oxygen, p=0.137). Average SaO2 improved (93% at baseline vs 96% on oxygen, p=0.0392) as did SaO2 nadir (79% at baseline vs 85% on oxygen, p=0.0434). Oxygen use was associated with increased periodic leg movement (PLM) index (12.2 vs 23.4, p=0.005) and PLM arousal index (2.4 vs 6.9, p=003). Conclusion: Low-flow oxygen is effective in reducing central, obstructive and mixed apneas in infants with OSA. Proposed mechanisms include alleviation of hypoxemia-induced hypotonia of the upper airway dilators and improved central ventilatory control. Prospective studies are needed to confirm these findings.

Neurology, Oct 1, 1998

Encouraging initial response of restless legs syndrome to pramipexole Article abstract-Restless l... more Encouraging initial response of restless legs syndrome to pramipexole Article abstract-Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and an urge to move the limbs. Two centers tested a new dopamine agonist, pramipexole, in 23 patients with RLS in a time-limited, open-label, clinical trial. After 4 weeks or more, 19 patients reported significant improvement as assessed by the short International Restless Legs Syndrome Study Group questionnaire (p < 0.0001). These encouraging preliminary results justify larger, controlled trials for pramipexole in patients with RLS.

PubMed, 2000

To address the violence phenomenon in psychiatric institutions towards the staff, to find the cau... more To address the violence phenomenon in psychiatric institutions towards the staff, to find the causes of these phenomena and to examine effective methods that will help to prevent the occurrence and/or confront it. To break the "conspiracy of silence" around the subject matter and to raise the awareness of all personnel in order to formulate a policy of responses to violent incidents and to learn procedures for the management of these complex situations.

Sleep Medicine, Feb 1, 2007

Encyclopedia of Sleep, 2013

Sleep-related movement disorders are common and often underdiagnosed in the elderly. The elderly ... more Sleep-related movement disorders are common and often underdiagnosed in the elderly. The elderly are a poorly defined group, usually assumed to start at the age of 65 years. In this group, clinical application of research data has to take into account the frequent occurrence of comorbidities, of medications, and of possible cognitive deterioration. This article will focus on restless legs syndrome, periodic limb movement disorder, sleep-related leg cramps, and sleep-related bruxism in the elderly.

Sleep Medicine, 2011

room air versus on oxygen) in central apneas (1.9/hour of sleep vs 0.4, p=0.0008), obstructive/mi... more room air versus on oxygen) in central apneas (1.9/hour of sleep vs 0.4, p=0.0008), obstructive/mixed apneas (7.8/hour of sleep vs 3.0, p=0.0053), hypopnea index (15.3 vs 7.3, p=0.0013), combined apnea/hypopnea index (24.7 vs 11.0, p=0.0001). There was no significant improvement in sleep efficiency (84.7% at baseline vs 81.0% on oxygen, p=0.137). Average SaO2 improved (93% at baseline vs 96% on oxygen, p=0.0392) as did SaO2 nadir (79% at baseline vs 85% on oxygen, p=0.0434). Oxygen use was associated with increased periodic leg movement (PLM) index (12.2 vs 23.4, p=0.005) and PLM arousal index (2.4 vs 6.9, p=003). Conclusion: Low-flow oxygen is effective in reducing central, obstructive and mixed apneas in infants with OSA. Proposed mechanisms include alleviation of hypoxemia-induced hypotonia of the upper airway dilators and improved central ventilatory control. Prospective studies are needed to confirm these findings.

Neurology, 1998

Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and a... more Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and an urge to move the limbs. Two centers tested a new dopamine agonist, pramipexole, in 23 patients with RLS in a time-limited, open-label, clinical trial. After 4 weeks or more, 19 patients reported significant improvement as assessed by the short International Restless Legs Syndrome Study Group questionnaire (p < 0.0001). These encouraging preliminary results justify larger, controlled trials for pramipexole in patients with RLS.

CHEST Journal, 2005

INTERLEUKIN 2 INCREASES ALVEOLAR FLUID CLEAR-ANCE IN ISOLATED RAT LUNGS Makoto Sugita MD* Zheng W... more INTERLEUKIN 2 INCREASES ALVEOLAR FLUID CLEAR-ANCE IN ISOLATED RAT LUNGS Makoto Sugita MD* Zheng Wang MD Sumiko Maeda MD Motoyasu Sagawa MD Jin Xu MD Toshishige Shibamoto MD Tsutomu Sakuma MD Kanazawa Medical University, Ishikawa ...

Sleep Medicine, Jun 1, 2013

Sleep Medicine, 2003

Background: There is a need for an easily administered instrument which can be applied to all pat... more Background: There is a need for an easily administered instrument which can be applied to all patients with restless legs syndrome (RLS) to measure disease severity for clinical assessment, research, or therapeutic trials. The pathophysiology of RLS is not clear and no objective measure so far devised can apply to all patients or accurately reflect severity. Moreover, RLS is primarily a subjective disorder. Therefore, a subjective scale is at present the optimal instrument to meet this need. Methods: Twenty centers from six countries participated in an initial reliability and validation study of a rating scale for the severity of RLS designed by the International RLS study group (IRLSSG). A ten-question scale was developed on the basis of repeated expert evaluation of potential items. This scale, the IRLSSG rating scale (IRLS), was administered to 196 RLS patients, most on some medication, and 209 control subjects. Results: The IRLS was found to have high levels of internal consistency, inter-examiner reliability, test-retest reliability over a 2-4 week period, and convergent validity. It also demonstrated criterion validity when tested against the current criterion of a clinical global impression and readily discriminated patient from control groups. The scale was dominated by a single severity factor that explained at least 59% of the pooled item variance. Conclusions: This scale meets performance criteria for a brief, patient completed instrument that can be used to assess RLS severity for purposes of clinical assessment, research, or therapeutic trials. It supports a finding that RLS is a relatively uniform disorder in which the severity of the basic symptoms is strongly related to their impact on the patient's life. In future studies, the IRLS should be tested against objective measures of RLS severity and its sensitivity should be studied as RLS severity is systematically manipulated by therapeutic interventions.

Pediatrics, 2002

Objective. To investigate the effect of low-flow supplemental oxygen (SupOx) on sleep architectur... more Objective. To investigate the effect of low-flow supplemental oxygen (SupOx) on sleep architecture and cardiorespiratory events in asymptomatic preterm infants. Methods. An overnight polysomnographic evaluation was conducted prospectively in 23 premature infants who were born at 30.0 ± 3.2 (standard deviation) weeks’ gestational age and studied at 38.1 ± 4.4 weeks’ postconceptional age. Infants were free of any adverse events, including cardiorespiratory monitor alarms in the nursery for at least 1 week before the study. Infants received room air (RA) or SupOx via nasal cannula at 0.25 L/min. Results. Quiet sleep density was increased during SupOx (33.3 ± 10.8% vs 26.6 ± 10.0% total sleep time [TST] in RA), and a reciprocal decrease in active sleep density was observed (61.5 ± 11.1% vs 68.4 ± 9.9% TST in RA). No differences in sleep efficiency emerged (69.7 ± 10.6% SupOx vs 69.7 ± 8.8% RA). SupOx elicited significant decreases in apnea index (3.8 ± 2.4 events/h vs 11.1 ± 6.4 events/...

Sleep and Movement Disorders, 2013

The online version of this article, along with updated information and services, is located on th... more The online version of this article, along with updated information and services, is located on the World Wide Web at:

Convulsive therapy, 1990

Thirty-two outpatients with a mean age of 68 years were observed in a naturalistic study of outpa... more Thirty-two outpatients with a mean age of 68 years were observed in a naturalistic study of outpatient electroconvulsive therapy (ECT) for the management of recurrent mood disorder. Sixty-nine percent of the patients responded favorably to ECT and were either discharged well from therapy or continue in treatment. A rehospitalization rate of 9% supports the efficacy of this treatment. We find outpatient ECT safe for the long-term management of recurrent depressive illness in elderly patients. The low dropout rate demonstrates that patient acceptance is equal to that of other outpatient treatments.