Devesh Tewari - Academia.edu (original) (raw)

Papers by Devesh Tewari

Journal of Essential Oil Bearing Plants, 21(6): 1636-1641, 2018

The species Angelica glauca is found wild in North-Western and eastern Himalayan region from Kash... more The species Angelica glauca is found wild in North-Western and eastern Himalayan region from Kashmir to Uttarakhand at an altitude ranging between 1500-3700 m above mean sea level and reported against various disease conditions. The present study was conducted to investigate the essential oil composition of A. glauca roots from Kumaun Himalaya of Uttarakhand region. Essential oil was isolated from dried roots of A. glauca collected from high altitude region of Uttarakhand by hydro-distillation method and subjected to gas chromatography-mass spectrometry. The main compounds identified were trans-ligustilide followed by (Z)-3-butylidenephthalide, α-phellandrene, β-phellandrene, p-cymene, (-)-spathulenol. It was also found that the essential oil contain highest amount of trans-ligustilide reported from this species so far which is an indicative of the high therapeutic potential of the essential oil due to substantial effects specially neuroprotective effect of the compound. The study concluded that large scale cultivation of roots and production of essential oil of A. glauca can be very beneficial for the upliftment of the rural population of the Himalayan region.

Indian journal of traditional knowledge, 2018

Crocus is one of the highest priced plant materials on the earth and due to its high cost; it is ... more Crocus is one of the highest priced plant materials on the earth and due to its high cost; it is frequently subjected to adulteration of various types. Owing to the importance of this precious commodity, present study on pharmacognostical analysis and chemical fingerprinting of Crocus sativus L. was undertaken. The stigmas of the plant were collected from two different geographical locations of the Himalayan regions having different ecological, climatic and geographical surroundings and evaluated for their specific characteristics. These samples were designated as sample S-1 and S-2. The organoleptic evaluation revealed a specific dark orange brown colour, characteristic odour and bitter taste of both the samples. Powder drug analysis of samples showed the presence of specific cellular structures, viz. abundant oil globules, helical to spiral xylem vessels, pollen grains, fiber and epidermal cells of style showing papillae structures. The preliminary phytochemical screening of samples revealed that sample S-1 was superior in terms of phytochemicals than the sample S-2. These samples were further evaluated by detailed chemical fingerprinting using HPTLC. Chemical fingerprinting showed the presence of 11 and 8 peaks in S-1 and S-2, respectively corresponding to the different phytochemicals and some peaks resembles the main constituents saffranol and crocin in both the samples. The pharmacognostic, physiochemical and phytochemical parameters evaluated in this study would be useful for identification of this highly prized and commonly adulterated plant used in various pharmaceutical and food preparations.

ABSTRACT Objective: The primary aim of the study was to establish the pharmacognostic standards a... more ABSTRACT
Objective: The primary aim of the study was to establish the
pharmacognostic
standards along with nutritional values on the important
medicinal herb Glinus oppositifolius (L.) Aug. DC., commonly known
as Parpata in South India. Material and Methods: Pharmacognostical,
physicochemical, nutritional evaluation along with the TLC profiling and
preliminary phytochemical screening was carried out. Results: Histological
study of different parts of the plant revealed the presence of different
cellular structures viz. stem showed the presence of multi cellular
to unicellular trichomes, collateral vascular bundles, starch grains etc.
Mesophyll of the leaves was embedded with starch grains with clustered
calcium oxalate and prism shaped crystals. Anomocytic stomata
were present on both the epidermis of the leaf. Powder microscopy
exhibited multi cellular trichomes, clustered calcium oxalate, fibres etc.
Physicochemical and histochemical studies revealed the presence of
various secondary metabolites and different minerals within the acceptable
limits. Thin layer chromatographic profiling showed different spots
suggesting the presence of specific phytoconstituents in different extracts.
The plant also revealed good nutritional value with calorific value
of about 245 kcal/100g; Vitamin C 112 mg/100 g and higher amount of
calcium etc. Conclusion: The results are beneficial to establish the quality
control parameters of the plant species and may be served as future
reference for the identification and authentication of the genuine crude
drug and also provide sufficient data to recognize the use of the plant as
dietary suppliment.
Key words: Antidiabetic, Pharmacognosy, Standardization, Thin layer
chromatography,
Powder microscopy, Histochemical studies.
Address for Correspondence:
Dr. Shantha Thirumalai Ramaseshan, Drug Standardization Research
Unit, Research Officer (Botany), National Ayurveda Dietetics Research
Institute, (CCRAS, Ministry
of AYUSH, Govt. of India), Bangalore-560011,
India.
Phone no: 91- 9986365762, Telephone (O): 91-080-26562030
E-mail: shanthatr57@gmail.com
DOI : 10.5530/pj.2016.1.7

There is a phenomenal increase, the world over, in the demand for education and training. The rec... more There is a phenomenal increase, the world over, in the demand for education and training. The recognized fact is that conventional schools, colleges, and universities are failing to cope with the demand. Distance education has been found a viable alternative, but countries burdened with such a demand often start DE systems from scratch. In many cases there is no manpower with relevant training, and it is those people with training in conventional education systems who are prevailed upon to start as best as they can. It is generally accepted that the tertiary hospital- based model of medical education in an urban setting provides limited exposure to the future medical professionals about health needs and infrastructures of the rural areas. Pharmacists play an important and varied role in healthcare, from research and manufacture of medicines to drug dispensation and patient education. The pharmacy profession continues to evolve, as pharmacists are increasingly involved in patient mon...

Human rights are the inherent dignities and freedoms to which we are all entitled as human beings... more Human rights are the inherent dignities and freedoms to which we are all entitled as human beings, wherever we live. As human beings, our health and the health of those we care about is a matter of daily concern. Regardless of our age, gender, socio-economic or ethnic background, we consider our health to be our most basic and essential asset. Health, on the other hand, can keep us from going to school or to work, from attending to our family responsibilities or from participating fully in the activities of our community. The right to health is a fundamental part of our human rights and of our understanding of a life in dignity. The right to the enjoyment of the highest attainable standard of physical and mental health, to give it its full name, is not new. Internationally, it was first articulated in the 1946 Constitution of the World Health Organization whose preamble defined health as “a state of complete physical, mental and social well-being and not merely the absence of diseas...

Sitoplaladi churna is a polyherbal Ayurvedic medicine used for its antitussive activity from an a... more Sitoplaladi churna is a polyherbal Ayurvedic medicine used for its antitussive activity from an ancient time. An attempt was made to develop a formulation to ease the administration of the phytoconstituents responsible for the activity. The sitopaladi churnas of two reputed companies of Ayurvedic medicines were taken and the syrup was made and evaluated. The present study is a primary stage to develop such a formulation which can improve the patient compliance as well as cost effectiveness. Various formulations were formulated and the comparative evaluation of the formulations was carried out to short out the best formulation. All the prepared formulation was evaluated for various parameters such as pH, viscosity, density, Orgnoleptic properties and stability studies. The development of such formulation will mark an important advancement in area of phytopharmaceuticals.

Abstract: Some new 2,5-disubstituted-1,3,4-oxadiazole derivatives of Naproxen were synthesized by... more Abstract: Some new 2,5-disubstituted-1,3,4-oxadiazole derivatives of Naproxen were synthesized by reaction of 2-(6methoxynaphthalen-2-yl) propanehydrazide and various aromatic acids in the presence of phosphorus oxychloride. The structure were verified on the basis of satisfactory analytical and spectral (IR, (1) H NMR, MS) data. The newly synthesized compounds were evaluated for their in-vivo anti-inflammatory and analgesic activities as per standard protocols. Above study showed that some newly synthesized compounds possess significant analgesic and anti-inflammatory activities.

Analytical Chemistry Letters, 2015

To establish the fingerprint profile of Swertia chirayita (Roxb. ex Fleming) Karsten from the hig... more To establish the fingerprint profile of Swertia chirayita (Roxb. ex Fleming) Karsten from the high altitude area of the western Himalaya using high performance thin layer chromatography (HPTLC) technique. Dried and powdered plant material of S. chirayita was successively extracted with petroleum ether, ethyl acetate and methanol in the order of increasing polarity. The extracts so obtained were subjected to qualitative phytochemical screening and based on the presence and/or absence of phytochemical constituents HPTLC fingerprinting analysis of ethyl acetate and methanol extract were carried out using CAMAG HPTLC system. Preliminary phytochemical screening of the extracts showed the presence of alkaloids, terpenoids, phenolics, flavonoids, carbohydrates, glycosides, tannins, saponins and lipids in various extracts. Methanol and ethyl acetate extracts contained the maximum number of phytochemicals. HPTLC phytochemical fingerprinting led to the detection of altogether 21 compounds in ethyl acetate and methanol extracts. However, greater numbers of compounds were detected in methanol extracts as compared to ethyl acetate extract. The chromatographic fingerprinting revealed the presence and variation in the phytochemical constituents with change in the polarity of the solvents. Further studies are required for the quantification of the compounds in various extracts and evaluation of their medicinal activities.

Pharmacognosy Journal, 2015

ABSTRACT Objective: The primary aim of the study was to establish the pharmacognostic standards a... more ABSTRACT Objective: The primary aim of the study was to establish the pharmacognostic standards along with nutritional values on the important medicinal herb Glinus oppositifolius (L.) Aug. DC., commonly known as Parpata in South India. Material and Methods: Pharmacognostical, physicochemical, nutritional evaluation along with the TLC profiling and preliminary phytochemical screening was carried out. Results: Histological study of different parts of the plant revealed the presence of different cellular structures viz. stem showed the presence of multi cellular to unicellular trichomes, collateral vascular bundles, starch grains etc. Mesophyll of the leaves was embedded with starch grains with clustered calcium oxalate and prism shaped crystals. Anomocytic stomata were present on both the epidermis of the leaf. Powder microscopy exhibited multi cellular trichomes, clustered calcium oxalate, fibres etc. Physicochemical and histochemical studies revealed the presence of various secondary metabolites and different minerals within the acceptable limits. Thin layer chromatographic profiling showed different spots suggesting the presence of specific phytoconstituents in different extracts. The plant also revealed good nutritional value with calorific value of about 245 kcal/100g; Vitamin C 112 mg/100 g and higher amount of calcium etc. Conclusion: The results are beneficial to establish the quality control parameters of the plant species and may be served as future reference for the identification and authentication of the genuine crude drug and also provide sufficient data to recognize the use of the plant as dietary suppliment. Key words: Antidiabetic, Pharmacognosy, Standardization, Thin layer chromatography, Powder microscopy, Histochemical studies. Address for Correspondence: Dr. Shantha Thirumalai Ramaseshan, Drug Standardization Research Unit, Research Officer (Botany), National Ayurveda Dietetics Research Institute, (CCRAS, Ministry of AYUSH, Govt. of India), Bangalore-560011, India. Phone no: 91- 9986365762, Telephone (O): 91-080-26562030 E-mail: shanthatr57@gmail.com DOI : 10.5530/pj.2016.1.7

International Journal of Pharmacognosy and Phytochemical Research, Oct 10, 2013

Elaeocarpus sphaericus (Rudraksha) is a broad leaved tree, belonging to family Elaeocarpaceae fou... more Elaeocarpus sphaericus (Rudraksha) is a broad leaved tree, belonging to family Elaeocarpaceae found in tropical & subtropical areas. Traditionally rudraksha is used for the treatment of various ailments like stress, anxiety, depression, nerve pain, epilepsy migraine and lack of concentration etc. In India the tree occupies the regions ranging from the Gangetic plains to the foothills of the great Himalaya. The investigation was carried out to study the pharmacognostical characteristics of the plant material. Rudraksha is a large evergreen, drought tolerant, perennial broad leaved tree; the stem is cylindrical with a dirty white and coarse textured bark. Morphology of the entire plant has been studied with pharmacognostical, & histological parameters which can possibly help to differentiate the drug from its other species/varieties.

Journal of Biologically Active Products from Nature, 2015

WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

The high end of medical science is the preservation of health and it can be attained in two ways,... more The high end of medical science is the preservation of health and it can be attained in two ways, first of all by eradicating the diseases, which may invade the body; secondly by due observation of such rules as would keep away the diseases. These rules are no less important than the treatment of diseases and method of cure. The prerequisites to attain this include wholesome diet, conservation of environment, congenial social and cultural atmosphere. Diet (ahara) is an essential factor for the maintenance of life. Though the science of nutrition at the present times evolved as an elaborate and organized subject of study, contemporary perspective mull over gross components of diet like carbohydrates, fats, proteins, minerals, water etc. While Ayurveda –the ancient science of life emphasizes on diversified aspects of dietetics and nutrition viz. quality, quantity, processing methods, rationale of combination of food articles, emotional aspects, nature of the consumer, geographical & e...

Journal of Science, Technology and Management, 7(4): 277-283, Dec 2014

Global resurgence of interest in herbal medicine coupled with increased market demand and resourc... more Global resurgence of interest in herbal medicine coupled with increased market demand and resource crisis have led to the use of adulterated and spurious raw material in drug production. Purity of the plant material is the prerequisite for the safety and efficacy of plant derived medicine. Hence, validation of plant drugs is now considered one of the top priority researches in the area of phytomedicine. Observation of strict quality control measures is essential at every steps of drug production involving authentication of raw material and refinement of processing techniques for production of reliable and safe medicines suitable for human consumption and meeting the quality norms of the world market. Phytochemical standardization considered to be a reliable tool for verification of identity of raw materials for ensuring the purity and efficacy of plant derived medicines. Approaches towards ascertaining quality, safety and efficacy of herbal medicine are discussed in this paper.

International Journal of Science and Research, 4(1): 1357-1360, Jan 2015

The study presented was aimed to investigate the effect of different pre-treatments of Agave sisa... more The study presented was aimed to investigate the effect of different pre-treatments of Agave sisalana leaves on yield, physicochemical and anatomical characteristics of fibre. A. sisalana leaves were treated with acid, alkali and biomaterial. Fibres obtained through different pre-treatment conditions were examined for their physicochemical and anatomical characteristics. Results indicated a notable influence of the three treatments on yield and physical properties of fibres. Total yield (%) and number of fibre per leave was recorded from the biomaterial treated leaves followed by alkali treated leaves. Physical properties including fibre length and fibre diameter were also maximum for the fibres obtained from biomaterial treated leaves. Results of solubility and other chemical examination of fibres from all the treatments were same. Microscopic study of fibre indicated their cellular structure and needle shape with sharp apex and lumen. The study thus established the biomaterial pretreatment as an ecofrienly, efficient and productive way for extraction of sisal fibre.

The use of plants as sources of medicines are human substance has been in vogue since antiquity. ... more The use of plants as sources of medicines are human substance has been in vogue since antiquity. Large numbers of plants are utilized in various systems of medicine practiced in India and local health traditions for the treatment of human diseases since time immemorial. Among the plants known for medicinal value, the plants of genus Ocimum belonging to family Lamiaceae are very important for their therapeutic potentials. Tulsi is the legendary 'Incomparable one' of India, is one of the holiest and most cherished of the many healing and healthy giving herbs of the orient. Traditionally, Tulsi is taken in many forms: as an herbal tea, dried powder, fresh leaf, or mixed with Honey or Ghee. For centuries, the dried leaves of Tulsi have been mixed with stored grains to repel insects. Many research and studies suggest that Tulsi may be a COX-2 inhibitor, like many modern painkillers, due to its significant amount of eugenol. The chemical composition of Tulsi is highly complex, con...

In recent years natural fibres are considered as an environment-friendly strengthening agent to r... more In recent years natural fibres are considered as an environment-friendly strengthening agent to replace asbestos and fiberglass in composite materials for various uses including the automobile industry. Agave sisalana Perrine ex Engelm, Family: Agavaceae (Asparagaceae) commonly known as Sisal is one of the major fibre yielding plants apart from jute. Sisal fibre finds immense economical importance because of its strength, durability, flexibility, affinity for dyestuffs and resistance to deterioration. The plant is widely distributed in the Uttarakhand, however, its fiber is still put to traditional uses like making twine, rope and general cordage to limited extent in low-cost paper, dartboards, buffing cloth, mattresses, handicrafts, etc. due to the lack of efficient method for extraction of quality fibre. Traditionally, fibre is extracted by decortication process, where leaves are crushed and beaten by a rotating wheel set with blunt knives which result in breakage of fibre and con...

Present investigation was carried out to elucidate the medicinally important herbs and their role... more Present investigation was carried out to elucidate the medicinally important herbs and their role in the healthcare of villagers living in Roorkee area of Hridwar, Uttarakhand. The ethno botanical survey was conducted to document plant remedies used for the treatment of various diseases in six randomly selected area of the Roorkee region. A total number of 24 medicinal plants belonging to 20 families are found on which 11 trees, 7 herbs and 6 shrubs. It was found that local communities of the area have rich tradition of using natural plant resources and various plants are used for various ailments. This high number of medicinal plants recorded perhaps indicated the high biodiversity of the area. Roorkee is on the banks of the Ganges canal and close to the foothills of Himalayas the soil of the area is good for the cultivation of various agricultural and medicinal products. The cultivation of medicinal plants in the rural areas of Roorkee can also improve the socioeconomic conditions...

Journal of Essential Oil Bearing Plants, 21(6): 1636-1641, 2018

Indian journal of traditional knowledge, 2018

Analytical Chemistry Letters, 2015

Pharmacognosy Journal, 2015

ABSTRACT Objective: The primary aim of the study was to establish the pharmacognostic standards a... more ABSTRACT Objective: The primary aim of the study was to establish the pharmacognostic standards along with nutritional values on the important medicinal herb Glinus oppositifolius (L.) Aug. DC., commonly known as Parpata in South India. Material and Methods: Pharmacognostical, physicochemical, nutritional evaluation along with the TLC profiling and preliminary phytochemical screening was carried out. Results: Histological study of different parts of the plant revealed the presence of different cellular structures viz. stem showed the presence of multi cellular to unicellular trichomes, collateral vascular bundles, starch grains etc. Mesophyll of the leaves was embedded with starch grains with clustered calcium oxalate and prism shaped crystals. Anomocytic stomata were present on both the epidermis of the leaf. Powder microscopy exhibited multi cellular trichomes, clustered calcium oxalate, fibres etc. Physicochemical and histochemical studies revealed the presence of various secondary metabolites and different minerals within the acceptable limits. Thin layer chromatographic profiling showed different spots suggesting the presence of specific phytoconstituents in different extracts. The plant also revealed good nutritional value with calorific value of about 245 kcal/100g; Vitamin C 112 mg/100 g and higher amount of calcium etc. Conclusion: The results are beneficial to establish the quality control parameters of the plant species and may be served as future reference for the identification and authentication of the genuine crude drug and also provide sufficient data to recognize the use of the plant as dietary suppliment. Key words: Antidiabetic, Pharmacognosy, Standardization, Thin layer chromatography, Powder microscopy, Histochemical studies. Address for Correspondence: Dr. Shantha Thirumalai Ramaseshan, Drug Standardization Research Unit, Research Officer (Botany), National Ayurveda Dietetics Research Institute, (CCRAS, Ministry of AYUSH, Govt. of India), Bangalore-560011, India. Phone no: 91- 9986365762, Telephone (O): 91-080-26562030 E-mail: shanthatr57@gmail.com DOI : 10.5530/pj.2016.1.7

International Journal of Pharmacognosy and Phytochemical Research, Oct 10, 2013

Journal of Biologically Active Products from Nature, 2015

WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Journal of Science, Technology and Management, 7(4): 277-283, Dec 2014

International Journal of Science and Research, 4(1): 1357-1360, Jan 2015

Conference Abstract Book

Fibre extraction and its allied activities like processing and making value added products are pr... more Fibre extraction and its allied activities like processing and making value added products are proven sources of employment and income generation. However, use of Sisal (Agave sisalana) fibre is limited to making twine, rope and cordage, handicrafts and to some extent used in low-cost paper, dartboards, buffing cloth, mattresses, etc. owing to cumbersome extraction method though it can be extensively applied to high-end industrial products like corrugated polyester sheets, fabrics, speciality paper, filters, geotextiles, wall coverings, etc. Conventionally, Sisal fiber is extracted by decorticator, which apart from being highly unsafe does not provide good quality fibers. The mechanical process also results in considerable damage to the fibre and consequent low yield. Extracting fibre through retting of sisal leaves is time consuming, water intensive, unhygienic and eco-unfriendly. Chemical methods used worldwide are also not conducive as the large amount of chemical used for pretreatment are unsafe to the environment, thus have the problem of disposal. In view of all these facts, an easy and eco-friendly method has been developed for Sisal fiber extraction through biological pre-treatment of leaves. The paper discusses about a simplistic and ecofriendly process for good quality fibre from Sisal Leaves.