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Papers by Diana Bruno

Research paper thumbnail of Relationship Between the Theory of Mind and the Ability to Change of Perspective in Patients with Relapsing-Remitting Multiple Sclerosis (P2.135)

Neurology, Apr 5, 2016

Introduction and Objectives: In recent years, research has reported that at least 65[percnt] of M... more Introduction and Objectives: In recent years, research has reported that at least 65[percnt] of MS patients have cognitive deficits, the most prominent being those associated with frontal lobe. Within these deficits is the ability to infer feelings and thoughts of others (theory of mind). In other research, some authors have suggested that such capacity requires a basic skill that would be the ability to change perspective (a relationship analogous to the relationship between attention and memory). The aim of this study is to evaluate the ability to change perspective in patients with relapsing-remitting multiple sclerosis and determine whether there is any relationship between this and the theory of mind. Methodology: 34 RRMS patients and 39 controls matched for age, sex and educational level were included. Both groups were administered a test designed to assess the ability to change perspective in three domains: personal, temporal and visual. They were also assessed with a battery of tests that included social cognition (Faux-Pass and Eyes). Results: RRMS patients showed significant differences from controls in the performance of the task of changing perspective. Furthermore, this test had significant positive correlations with Theory of Mind. Eyes correlated with different types of changing perspective (personal, temporal and visual) and Faux Pas particularly with changing personal perspective. Conclusion: The findings described in this study demonstrate that there is a relationship between the ability to change perspective (personal, temporal and visual) and the functions associated with the frontal lobe, particularly the theory of mind. Patients diagnosed with RRMS showed difficulties in the performance of these tasks. Disclosure: Dr. Bruno has nothing to disclose. Dr. Pagani Cassara has nothing to disclose. Dr. Sinay has nothing to disclose. Dr. Roca has nothing to disclose.

Research paper thumbnail of Incidental learning throughout life (P3.1-015)

Research paper thumbnail of Discursos sobre formación docente y autobiografía educativa

Anuario Digital de Investigación Educativa, 2010

Research paper thumbnail of Valores normativos para el Test del Hotel en adultos jóvenes de Buenos Aires

Research paper thumbnail of Correction to: Argentinean consensus recommendations for the use of telemedicine in clinical practice in adult people with multiple sclerosis

Research paper thumbnail of Argentinean consensus recommendations for the use of telemedicine in clinical practice in adult people with multiple sclerosis

Neurological Sciences

Background The use of telemedicine has quickly increased during of the COVID-19 pandemic. Given t... more Background The use of telemedicine has quickly increased during of the COVID-19 pandemic. Given that unmet needs and barriers to multiple sclerosis (MS) care have been reported, telemedicine has become an interesting option to the care of these patients. The objective of these consensus recommendations was to elaborate a guideline for the management of people with MS using telemedicine in order to contribute to an effective and high-quality healthcare. Methods A panel of Argentinean neurologist's experts in neuroimmunological diseases and dedicated to the diagnosis, management,and care of MS patients gathered virtually during 2021 and 2022 to conduct a consensus recommendation on the use of telemedicine in clinical practice in adult people with MS. To reach consensus, the methodology of "formal consensus RAND/UCLA Appropriateness method" was used. Results Recommendations were established based on relevant published evidence and expert opinion focusing on definitions, general characteristics and ethical standards, diagnosis of MS, follow-up (evaluation of disability and relapses of MS), identification and treatment of relapses, and finally disease-modifying treatments using telemedicine. Conclusion The recommendations of this consensus would provide a useful guide for the proper use of telemedicine for the assessment, follow-up, management, and treatment of people with MS. We suggest the use of these guidelines to all the Argentine neurologists committed to the care of people with MS.

Research paper thumbnail of Perfil cognitivo de cuatro pacientes con enfermedad renal crónica que acceden a trasplante renal

Introducción: Existen reportes de que la disfunción cognitiva es altamente prevalente en paciente... more Introducción: Existen reportes de que la disfunción cognitiva es altamente prevalente en pacientes con Enfermedad Renal Crónica, generando mayor compromiso en lo que respecta a las funciones ejecutivas, memoria y lenguaje. Objetivo: Comparar el rendimiento cognitivo en cuatro pacientes que acceden a trasplante renal, para describir el perfil cognitivo asociado a la enfermedad renal. Método: Estudio exploratorio descriptivo. Se aplicó una Batería Neuropsicológica integrada por nueve pruebas, la cual fue confeccionada para evaluar diversos dominios cognitivos. La muestra estuvo conformada por 4 personas con diagnóstico de ERC en Estadio 5 (de 18, 40, 62 y 75 años) que acceden a trasplante renal. Resultados: Los sujetos evaluados presentaron un déficit significativo en aquellas pruebas que evalúan, atención, velocidad motora, fluencia verbal semántica, memoria episódica verbal, memoria semántica, memoria operativa en comparación con los valores normativos reportados para su grupo de re...

Research paper thumbnail of Perspective taking deficits and their relationship with theory of mind abilities in patients with relapsing-remitting multiple sclerosis (RRMS)

Applied Neuropsychology: Adult

Research paper thumbnail of La Divulgación Científica: Un Aporte a La Pandemia Por COVID-19

REVISTA CUADERNOS Nueva Serie, Dec 10, 2020

Juan, organizó un ciclo de charlas junto con profesionales de distintas áreas, destinadas a la po... more Juan, organizó un ciclo de charlas junto con profesionales de distintas áreas, destinadas a la población en general a fin de brindar información precisa sobre determinadas temáticas, con un sustento teórico suficiente para reducir el impacto que la pandemia y el aislamiento social han tenido y tienen en la población. La situación actual de pandemia, con el consecuente distanciamiento social como medida primordial para detener el contagio, ha cambiado el mundo de manera rotunda. Gran parte de la población mundial se encuentra en cuarentena o en aislamiento obligatorio, mientras las cifras de contagios y muertes en el mundo aumentan a pesar del alto porcentaje de recuperados. Si bien las medidas de distanciamiento social parecen ser las más efectivas, conllevan costos no solo a nivel económico sino también a nivel de salud mental en los distintos grupos sociales. Numerosos estudios han reportado efectos psicológicos negativos, como síntomas de ansiedad, estrés, depresión e incluso cambios cognitivos.

Research paper thumbnail of Manejo Vehicular y Vejez

REVISTA CUADERNOS Nueva Serie, Dec 9, 2020

Research paper thumbnail of Incidental learning throughout life (P3.1-015)

Research paper thumbnail of Discursos sobre formación docente y autobiografía educativa

Anuario Digital de Investigación Educativa, 2010

Research paper thumbnail of Edited by

The relationship between executive functions and fluid

Research paper thumbnail of Caracterización del impacto en salud mental de la pandemia Covid-19

Research paper thumbnail of Impaired Cardiac Interoception In Patients With Multiple Sclerosis. (P1.116)

Neurology, 2015

Objective: To evaluate the heartbeat evoked potential (HEP) in patients with multiple sclerosis (... more Objective: To evaluate the heartbeat evoked potential (HEP) in patients with multiple sclerosis (MS) and controls. Background: The HEP is a negative modulation between 200 and 400 ms and is associated with the perception of the heartbeat (cardiac interoception). The insular cortex is one of the main areas involved in the processing of bodily signal information and of emotional awareness. Regarding MS, several studies have described atrophy of this area; however, there are no reports about whether interoceptive processing is affected or not in these patients. Methods: Thirty three patients with MS and 40 controls were evaluated with a heartbeat detection (HBD) task during which a high density electroencephalogram (hd-EEG) was registered. The HBD task consisted of one condition where subjects paid attention to an external stimulus (control condition) and a second where they followed their own heartbeats without external help (interoceptive condition). Each condition lasted five minute...

Research paper thumbnail of White and gray matter correlates of executive functions and social cognition impairment in MS (P6.137)

Neurology, 2015

Introduction: Executive Functions (EF) and social cognition (SC) have been shown to be impaired i... more Introduction: Executive Functions (EF) and social cognition (SC) have been shown to be impaired in MS. Previous morphometry studies evidenced atrophy of cortical sites in MS including the insular cortex (IC) and primary somatosensorial cortex (S1) which are crucial hubs of the salience network for bodily sensation and social cognition domains. Objective: Here we evaluate the atrophy of specific nodes of the salience network in MS and relate them to EF and SC deficits. Methods: 20 RRME patients (mean age=40.3; mean EDSS=2) were assessed with neuropsychology tests of EF (Phonological Fluency, Hayling test, INECO-Frontal-screening [IFS] and PASAT) and SC (reading the mind in the eyes, Faux Pas test) and voxel-based morphometry of white matter (WM) and gray matter (GM) of structural magnetic resonance imaging. Results: GM and WM atrophy in patients with MS involved a pattern of frontal, parietal and occipital atrophy. Phonological fluency correlated with atrophy of bilateral S1-IC (r=0....

Research paper thumbnail of Altered neural signatures of interoception in multiple sclerosis

Human brain mapping, Jan 4, 2018

Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals... more Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed to determine whether MS patients present changes in interoception-that is, the monitoring of autonomic bodily information-a process that might be related to various bodily dysfunctions. We performed two studies in 34 relapsing-remitting, early-stage MS patients and 46 controls matched for gender, age, and education. In Study 1, we evaluated the heartbeat-evoked potential (HEP), a cortical signature of interoception, via a 128-channel EEG system during a heartbeat detection task including an exteroceptive and an interoceptive condition. Then, we obtained whole-brain MRI recordings. In Study 2, participants underwent fMRI recordings during two resting-state conditions: mind wandering and interoception. In Study 1, controls exhibited greater HEP modulation during the i...

Research paper thumbnail of Validación argentino-chilena de la versión en español del test Addenbrooke's Cognitive Examination III para el diagnóstico de demencia

Neurología, 2017

NRL-1100; No. of Pages 7 2 D. Bruno et al. Resultados: La versión argentina-chilena del ACE-III p... more NRL-1100; No. of Pages 7 2 D. Bruno et al. Resultados: La versión argentina-chilena del ACE-III presentó una buena consistencia interna (alfa de Cronbach = 0,87). Se hallaron diferencias significativas en los valores totales del ACE-III entre el grupo control y el grupo de demencias (p< 0,05) y entre ambos grupos de demencia (p< 0,05). Con un punto de corte de 86, el 98,6% de los pacientes con DTA, el 83,9% de pacientes con variante conductual de la demencia frontotemporal y el 84,2% de los controles fue correctamente clasificado. Conclusiones: El presente estudio ha demostrado que el ACE-III continúa siendo una herramienta útil para la detección de la disfunción cognitiva en la demencia.

Research paper thumbnail of Impacto de la fatiga y los síntomas anímicos en el funcionamiento cognitivo en pacientes con esclerosis múltiple en brote remisión

Neurología Argentina, 2017

Introducción y objetivos: La fatiga es un síntoma frecuente en esclerosis múltiple (EM) y se acom... more Introducción y objetivos: La fatiga es un síntoma frecuente en esclerosis múltiple (EM) y se acompaña de síntomas anímicos asociados subjetivamente al impacto de la enfermedad en la vida cotidiana. Al menos el 65% de los pacientes con EM presenta déficits ejecutivos. Estudios previos han sugerido que existe relación entre la fatiga y la velocidad de procesamiento de la información, y entre los síntomas anímicos y la atención. Poco se ha indagado sobre cómo estos síntomas impactan en otras funciones ejecutivas como flexibilidad cognitiva, control inhibitorio, capacidad de multitasking y memoria de trabajo. El objetivo del presente estudio fue examinar la relación entre la fatiga y los síntomas anímicos con el rendimiento en diversas pruebas ejecutivas en pacientes con esclerosis múltiple en brote remisión (EMBR). Material y métodos: Se evaluó a 36 pacientes y 42 controles con el BDI-II, un cuestionario de fatiga y una batería neuropsicológica que incluyó pruebas ejecutivas. Resultados: Los pacientes presentaron diferencias significativas con los controles en todas las variables de estudio (fatiga, síntomas anímicos y funcionamiento ejecutivo). Se observó que tanto la fatiga como los síntomas anímicos se correlacionan positivamente con la velocidad de procesamiento, la alternancia atencional, la memoria de trabajo y tareas de multitasking, mientras que solo la fatiga se correlaciona positivamente con el control inhibitorio. Conclusión: Los síntomas de fatiga que presentan los pacientes con EMBR impactan no solo en la velocidad de procesamiento de los pacientes, sino también en otras medidas ejecutivas. Los síntomas anímicos se relacionan con déficits atencionales y con fallas en tareas de multitasking.

Research paper thumbnail of The Utility of the INECO Frontal Screening (IFS) in the Detection of Executive Dysfunction in Patients with Traumatic Brain Injury (TBI) (P07.194)

Neurology, 2012

Several studies have reported that about 65 % of patients with relapsing-remitting multiple scler... more Several studies have reported that about 65 % of patients with relapsing-remitting multiple sclerosis (RRMS) suffer from cognitive impairment, with executive dysfunction being the most frequently described. Even if several executive screening tests have been designed to specifically detect executive deficits, few studies have investigated their ability to tackle such dysfunction particularly in multiple sclerosis (MS). The aim of the present study was to evaluate the sensitivity and specificity of the INECO frontal screening (IFS) in the detection of executive dysfunction in patients with relapsing-remitting MS (RRMS). 54 patients with RRMS were included in the study. 34 presented executive dysfunction while 20 did not. 32 control subjects matched for age, sex, and educational level were also included. All were evaluated with the IFS and with a battery of classical executive tests. A patient was considered to have executive dysfunction if he/she scored a one and a half standard deviation below the control mean in at least one of the classical executive tests. Sensitivity and specificity of the IFS in its ability to detect executive dysfunction in MS was analyzed. Using a cutoff of 25.5 points, sensitivity of the IFS was 73.53 %, and specificity 78.13 % in differentiating controls from MS patients with executive dysfunction. The IFS showed excellent concurrent validity with executive tasks. The IFS can be considered a brief, easy-to-administer, cost-less tool for the detection of executive dysfunction in patients with RRMS.

Research paper thumbnail of Relationship Between the Theory of Mind and the Ability to Change of Perspective in Patients with Relapsing-Remitting Multiple Sclerosis (P2.135)

Neurology, Apr 5, 2016

Introduction and Objectives: In recent years, research has reported that at least 65[percnt] of M... more Introduction and Objectives: In recent years, research has reported that at least 65[percnt] of MS patients have cognitive deficits, the most prominent being those associated with frontal lobe. Within these deficits is the ability to infer feelings and thoughts of others (theory of mind). In other research, some authors have suggested that such capacity requires a basic skill that would be the ability to change perspective (a relationship analogous to the relationship between attention and memory). The aim of this study is to evaluate the ability to change perspective in patients with relapsing-remitting multiple sclerosis and determine whether there is any relationship between this and the theory of mind. Methodology: 34 RRMS patients and 39 controls matched for age, sex and educational level were included. Both groups were administered a test designed to assess the ability to change perspective in three domains: personal, temporal and visual. They were also assessed with a battery of tests that included social cognition (Faux-Pass and Eyes). Results: RRMS patients showed significant differences from controls in the performance of the task of changing perspective. Furthermore, this test had significant positive correlations with Theory of Mind. Eyes correlated with different types of changing perspective (personal, temporal and visual) and Faux Pas particularly with changing personal perspective. Conclusion: The findings described in this study demonstrate that there is a relationship between the ability to change perspective (personal, temporal and visual) and the functions associated with the frontal lobe, particularly the theory of mind. Patients diagnosed with RRMS showed difficulties in the performance of these tasks. Disclosure: Dr. Bruno has nothing to disclose. Dr. Pagani Cassara has nothing to disclose. Dr. Sinay has nothing to disclose. Dr. Roca has nothing to disclose.

Research paper thumbnail of Incidental learning throughout life (P3.1-015)

Research paper thumbnail of Discursos sobre formación docente y autobiografía educativa

Anuario Digital de Investigación Educativa, 2010

Research paper thumbnail of Valores normativos para el Test del Hotel en adultos jóvenes de Buenos Aires

Research paper thumbnail of Correction to: Argentinean consensus recommendations for the use of telemedicine in clinical practice in adult people with multiple sclerosis

Research paper thumbnail of Argentinean consensus recommendations for the use of telemedicine in clinical practice in adult people with multiple sclerosis

Neurological Sciences

Background The use of telemedicine has quickly increased during of the COVID-19 pandemic. Given t... more Background The use of telemedicine has quickly increased during of the COVID-19 pandemic. Given that unmet needs and barriers to multiple sclerosis (MS) care have been reported, telemedicine has become an interesting option to the care of these patients. The objective of these consensus recommendations was to elaborate a guideline for the management of people with MS using telemedicine in order to contribute to an effective and high-quality healthcare. Methods A panel of Argentinean neurologist's experts in neuroimmunological diseases and dedicated to the diagnosis, management,and care of MS patients gathered virtually during 2021 and 2022 to conduct a consensus recommendation on the use of telemedicine in clinical practice in adult people with MS. To reach consensus, the methodology of "formal consensus RAND/UCLA Appropriateness method" was used. Results Recommendations were established based on relevant published evidence and expert opinion focusing on definitions, general characteristics and ethical standards, diagnosis of MS, follow-up (evaluation of disability and relapses of MS), identification and treatment of relapses, and finally disease-modifying treatments using telemedicine. Conclusion The recommendations of this consensus would provide a useful guide for the proper use of telemedicine for the assessment, follow-up, management, and treatment of people with MS. We suggest the use of these guidelines to all the Argentine neurologists committed to the care of people with MS.

Research paper thumbnail of Perfil cognitivo de cuatro pacientes con enfermedad renal crónica que acceden a trasplante renal

Introducción: Existen reportes de que la disfunción cognitiva es altamente prevalente en paciente... more Introducción: Existen reportes de que la disfunción cognitiva es altamente prevalente en pacientes con Enfermedad Renal Crónica, generando mayor compromiso en lo que respecta a las funciones ejecutivas, memoria y lenguaje. Objetivo: Comparar el rendimiento cognitivo en cuatro pacientes que acceden a trasplante renal, para describir el perfil cognitivo asociado a la enfermedad renal. Método: Estudio exploratorio descriptivo. Se aplicó una Batería Neuropsicológica integrada por nueve pruebas, la cual fue confeccionada para evaluar diversos dominios cognitivos. La muestra estuvo conformada por 4 personas con diagnóstico de ERC en Estadio 5 (de 18, 40, 62 y 75 años) que acceden a trasplante renal. Resultados: Los sujetos evaluados presentaron un déficit significativo en aquellas pruebas que evalúan, atención, velocidad motora, fluencia verbal semántica, memoria episódica verbal, memoria semántica, memoria operativa en comparación con los valores normativos reportados para su grupo de re...

Research paper thumbnail of Perspective taking deficits and their relationship with theory of mind abilities in patients with relapsing-remitting multiple sclerosis (RRMS)

Applied Neuropsychology: Adult

Research paper thumbnail of La Divulgación Científica: Un Aporte a La Pandemia Por COVID-19

REVISTA CUADERNOS Nueva Serie, Dec 10, 2020

Juan, organizó un ciclo de charlas junto con profesionales de distintas áreas, destinadas a la po... more Juan, organizó un ciclo de charlas junto con profesionales de distintas áreas, destinadas a la población en general a fin de brindar información precisa sobre determinadas temáticas, con un sustento teórico suficiente para reducir el impacto que la pandemia y el aislamiento social han tenido y tienen en la población. La situación actual de pandemia, con el consecuente distanciamiento social como medida primordial para detener el contagio, ha cambiado el mundo de manera rotunda. Gran parte de la población mundial se encuentra en cuarentena o en aislamiento obligatorio, mientras las cifras de contagios y muertes en el mundo aumentan a pesar del alto porcentaje de recuperados. Si bien las medidas de distanciamiento social parecen ser las más efectivas, conllevan costos no solo a nivel económico sino también a nivel de salud mental en los distintos grupos sociales. Numerosos estudios han reportado efectos psicológicos negativos, como síntomas de ansiedad, estrés, depresión e incluso cambios cognitivos.

Research paper thumbnail of Manejo Vehicular y Vejez

REVISTA CUADERNOS Nueva Serie, Dec 9, 2020

Research paper thumbnail of Incidental learning throughout life (P3.1-015)

Research paper thumbnail of Discursos sobre formación docente y autobiografía educativa

Anuario Digital de Investigación Educativa, 2010

Research paper thumbnail of Edited by

The relationship between executive functions and fluid

Research paper thumbnail of Caracterización del impacto en salud mental de la pandemia Covid-19

Research paper thumbnail of Impaired Cardiac Interoception In Patients With Multiple Sclerosis. (P1.116)

Neurology, 2015

Objective: To evaluate the heartbeat evoked potential (HEP) in patients with multiple sclerosis (... more Objective: To evaluate the heartbeat evoked potential (HEP) in patients with multiple sclerosis (MS) and controls. Background: The HEP is a negative modulation between 200 and 400 ms and is associated with the perception of the heartbeat (cardiac interoception). The insular cortex is one of the main areas involved in the processing of bodily signal information and of emotional awareness. Regarding MS, several studies have described atrophy of this area; however, there are no reports about whether interoceptive processing is affected or not in these patients. Methods: Thirty three patients with MS and 40 controls were evaluated with a heartbeat detection (HBD) task during which a high density electroencephalogram (hd-EEG) was registered. The HBD task consisted of one condition where subjects paid attention to an external stimulus (control condition) and a second where they followed their own heartbeats without external help (interoceptive condition). Each condition lasted five minute...

Research paper thumbnail of White and gray matter correlates of executive functions and social cognition impairment in MS (P6.137)

Neurology, 2015

Introduction: Executive Functions (EF) and social cognition (SC) have been shown to be impaired i... more Introduction: Executive Functions (EF) and social cognition (SC) have been shown to be impaired in MS. Previous morphometry studies evidenced atrophy of cortical sites in MS including the insular cortex (IC) and primary somatosensorial cortex (S1) which are crucial hubs of the salience network for bodily sensation and social cognition domains. Objective: Here we evaluate the atrophy of specific nodes of the salience network in MS and relate them to EF and SC deficits. Methods: 20 RRME patients (mean age=40.3; mean EDSS=2) were assessed with neuropsychology tests of EF (Phonological Fluency, Hayling test, INECO-Frontal-screening [IFS] and PASAT) and SC (reading the mind in the eyes, Faux Pas test) and voxel-based morphometry of white matter (WM) and gray matter (GM) of structural magnetic resonance imaging. Results: GM and WM atrophy in patients with MS involved a pattern of frontal, parietal and occipital atrophy. Phonological fluency correlated with atrophy of bilateral S1-IC (r=0....

Research paper thumbnail of Altered neural signatures of interoception in multiple sclerosis

Human brain mapping, Jan 4, 2018

Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals... more Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed to determine whether MS patients present changes in interoception-that is, the monitoring of autonomic bodily information-a process that might be related to various bodily dysfunctions. We performed two studies in 34 relapsing-remitting, early-stage MS patients and 46 controls matched for gender, age, and education. In Study 1, we evaluated the heartbeat-evoked potential (HEP), a cortical signature of interoception, via a 128-channel EEG system during a heartbeat detection task including an exteroceptive and an interoceptive condition. Then, we obtained whole-brain MRI recordings. In Study 2, participants underwent fMRI recordings during two resting-state conditions: mind wandering and interoception. In Study 1, controls exhibited greater HEP modulation during the i...

Research paper thumbnail of Validación argentino-chilena de la versión en español del test Addenbrooke's Cognitive Examination III para el diagnóstico de demencia

Neurología, 2017

NRL-1100; No. of Pages 7 2 D. Bruno et al. Resultados: La versión argentina-chilena del ACE-III p... more NRL-1100; No. of Pages 7 2 D. Bruno et al. Resultados: La versión argentina-chilena del ACE-III presentó una buena consistencia interna (alfa de Cronbach = 0,87). Se hallaron diferencias significativas en los valores totales del ACE-III entre el grupo control y el grupo de demencias (p< 0,05) y entre ambos grupos de demencia (p< 0,05). Con un punto de corte de 86, el 98,6% de los pacientes con DTA, el 83,9% de pacientes con variante conductual de la demencia frontotemporal y el 84,2% de los controles fue correctamente clasificado. Conclusiones: El presente estudio ha demostrado que el ACE-III continúa siendo una herramienta útil para la detección de la disfunción cognitiva en la demencia.

Research paper thumbnail of Impacto de la fatiga y los síntomas anímicos en el funcionamiento cognitivo en pacientes con esclerosis múltiple en brote remisión

Neurología Argentina, 2017

Introducción y objetivos: La fatiga es un síntoma frecuente en esclerosis múltiple (EM) y se acom... more Introducción y objetivos: La fatiga es un síntoma frecuente en esclerosis múltiple (EM) y se acompaña de síntomas anímicos asociados subjetivamente al impacto de la enfermedad en la vida cotidiana. Al menos el 65% de los pacientes con EM presenta déficits ejecutivos. Estudios previos han sugerido que existe relación entre la fatiga y la velocidad de procesamiento de la información, y entre los síntomas anímicos y la atención. Poco se ha indagado sobre cómo estos síntomas impactan en otras funciones ejecutivas como flexibilidad cognitiva, control inhibitorio, capacidad de multitasking y memoria de trabajo. El objetivo del presente estudio fue examinar la relación entre la fatiga y los síntomas anímicos con el rendimiento en diversas pruebas ejecutivas en pacientes con esclerosis múltiple en brote remisión (EMBR). Material y métodos: Se evaluó a 36 pacientes y 42 controles con el BDI-II, un cuestionario de fatiga y una batería neuropsicológica que incluyó pruebas ejecutivas. Resultados: Los pacientes presentaron diferencias significativas con los controles en todas las variables de estudio (fatiga, síntomas anímicos y funcionamiento ejecutivo). Se observó que tanto la fatiga como los síntomas anímicos se correlacionan positivamente con la velocidad de procesamiento, la alternancia atencional, la memoria de trabajo y tareas de multitasking, mientras que solo la fatiga se correlaciona positivamente con el control inhibitorio. Conclusión: Los síntomas de fatiga que presentan los pacientes con EMBR impactan no solo en la velocidad de procesamiento de los pacientes, sino también en otras medidas ejecutivas. Los síntomas anímicos se relacionan con déficits atencionales y con fallas en tareas de multitasking.

Research paper thumbnail of The Utility of the INECO Frontal Screening (IFS) in the Detection of Executive Dysfunction in Patients with Traumatic Brain Injury (TBI) (P07.194)

Neurology, 2012

Several studies have reported that about 65 % of patients with relapsing-remitting multiple scler... more Several studies have reported that about 65 % of patients with relapsing-remitting multiple sclerosis (RRMS) suffer from cognitive impairment, with executive dysfunction being the most frequently described. Even if several executive screening tests have been designed to specifically detect executive deficits, few studies have investigated their ability to tackle such dysfunction particularly in multiple sclerosis (MS). The aim of the present study was to evaluate the sensitivity and specificity of the INECO frontal screening (IFS) in the detection of executive dysfunction in patients with relapsing-remitting MS (RRMS). 54 patients with RRMS were included in the study. 34 presented executive dysfunction while 20 did not. 32 control subjects matched for age, sex, and educational level were also included. All were evaluated with the IFS and with a battery of classical executive tests. A patient was considered to have executive dysfunction if he/she scored a one and a half standard deviation below the control mean in at least one of the classical executive tests. Sensitivity and specificity of the IFS in its ability to detect executive dysfunction in MS was analyzed. Using a cutoff of 25.5 points, sensitivity of the IFS was 73.53 %, and specificity 78.13 % in differentiating controls from MS patients with executive dysfunction. The IFS showed excellent concurrent validity with executive tasks. The IFS can be considered a brief, easy-to-administer, cost-less tool for the detection of executive dysfunction in patients with RRMS.