Doç. Dr. Metin Ekinci - Academia.edu (original) (raw)

Papers by Doç. Dr. Metin Ekinci

$Research paper thumbnail of Effect of the pre-photorefractive keratectomy Schirmer value on the post-photorefractive keratectomy central epithelial thickness, ocular surface disease index scores, and uncorrected visual acuity$

Purpose: The aim of the present study was to investigate the effect of the pre-photorefractive ke... more Purpose: The aim of the present study was to investigate the effect of the pre-photorefractive keratectomy (PRK) Schirmer value on the post-PRK central epithelial thickness (CET), Ocular surface disease index (OSDI) scores and uncorrected visual acuity (UCVA). Methods: After the exclusion of patients, 106 patients were analyzed (n = 54 for control group; n = 52 for dry eye group). Best corrected visual acuity levels, detailed anterior segment and fundus examinations of the patients, intraocular pressures were recorded. Corneal thickness measurements were performed. Tear film break-up time (BUT) and Schirmer’s tests were applied to all patients. The OSDI questionnaire was administered to all patients at the third month after the operation. The patients were divided into two groups according to the preoperative Schirmer’s value as follows: control group (preoperative Schirmer value over 10 mm) and dry eye group (preoperative Schirmer 1 value between 0–10 mm). After the surgical proced...

Purpose: To evaluate the efficacy of a-lipoic acid (ALA) in reducing scarring after trabeculectom... more Purpose: To evaluate the efficacy of a-lipoic acid (ALA) in reducing scarring after trabeculectomy. Materials and Methods: Eighteen adult New Zealand white rabbits underwent trabeculectomy. During trabeculectomy, thin sponges were placed between the sclera and Tenon’s capsule for 3 minutes, saline solution, mitomycin-C (MMC) and ALA was applied to the control group (CG) (n=6 eyes), MMC group (MMCG) (n=6 eyes), and ALA group (ALAG) (n=6 eyes), respectively. After surgery, topical saline and ALA was applied for 28 days to the control and ALAGs, respectively. Filtrating bleb patency was evaluated by using 0.1 % trepan blue. Hematoxylin and eosin and Masson trichrome staining for toxicity, total cellularity, and col-lagen organization; a-smooth muscle actin immunohistochemistry staining performed for myofibroblast phenotype identification. Results: Clinical evaluation showed that all 6 blebs (100%) of the CG had failed, whereas there were only 2 failures (33%) in the ALAG and no failure...

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Kafkas Universitesi Veteriner Fakultesi Dergisi, 2011

Summary The purpose of this study was to evaluate the effects of the use of the subconjunctival i... more Summary The purpose of this study was to evaluate the effects of the use of the subconjunctival injection of ranibizumab (Lucentis) on angiogenesis in the rabbit cornea. Corneas of 12 New Zealand Rabbits were cauterized with silver nitrate crystal. Animals were divided in two groups: control group (GC) that received 0.02 ml of 0.9% saline solution; group ranibizumab (GR) that received 0.5 mg of ranibizumab subconjunctivally at the 24th h after the lesion was formed. Animals corneas were extracted on the 14th day under general anesthesia. The newly formed vessels digital photographs were obtained and analyzed in a computerized system (google sketch-up program). In the control group, neovascularization covered 64.66%±20.81 (mean±standard deviation [SD]) of the corneal surface, compared with 34.17%±4.53 (mean±SD) in the GR group. When vascular density is compared between treated groups, statistical differences were observed (P<0.002). The results showed an inhibition of angiogenesis...

The Eurasian Journal of Medicine, 2017

Objective: To evaluate the efficacy of phacoemulsification combined with posterior capsulorhexis,... more Objective: To evaluate the efficacy of phacoemulsification combined with posterior capsulorhexis, core vitrectomy and ciliary sulcus intraocular lens (IOL) implantation in patients with Fuchs' heterochromic uveitis (FHU). Materials and Methods: A total of 18 eyes of 18 patients with FHU underwent cataract surgery were included in the study. 18 eyes with FHU underwent posterior capsulorhexis, core vitrectomy and poly (methyl methacrylate) (PMMA) IOL implantation in the ciliary sulcus. Subjects were chosen for this procedure based on an intraoperative vitreous haziness assessment, performed by indirect ophthalmoscopy. Patients with +2 or more vitreous haziness qualified for this procedure. Results: Of the 83 eyes with FHU that underwent cataract surgery, 18 eyes (21.6%) of 18 patients were employed in the study. There were 11 (61.1%) men and 7 (38.9%) women in the study; ages ranged from 23 to 47, with a mean of 32.06 years. Follow-up ranged from 8 months to 49 months. There were no intraoperative complications except for peripheral iris bleeding in 7 eyes. There was no severe intraocular inflammation in any patient postoperatively. All patients had 0.05 or better logMAR visual acuity after corneal suture removal. Glaucoma developed in 2 patients. For the short term period, the main vision threatening problem was suture-induced astigmatism. Conclusion: Cataract surgery combined with posterior capsulorhexis, core vitrectomy and IOL implantation in the ciliary sulcus is safe and leads to good visual outcome due to the removal of the hazy vitreous in patients with FHU.

Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Nov 1, 2011

ABSTRACT The purpose of this study was to evaluate the effects of the use of the subconjunctival ... more ABSTRACT The purpose of this study was to evaluate the effects of the use of the subconjunctival injection of ranibizumab (Lucentis) on angiogenesis in the rabbit cornea. Corneas of 12 New Zealand Rabbits were cauterized with silver nitrate crystal. Animals were divided in two groups: control group (GC) that received 0.02 ml of 0.9% saline solution; group ranibizumab (GR) that received 0.5 mg of ranibizumab subconjunctivally at the 24th h after the lesion was formed. Animals corneas were extracted on the 14th day under general anesthesia. The newly formed vessels digital photographs were obtained and analyzed in a computerized system (google sketch-up program). In the control group, neovascularization covered 64.66%±20.81 (mean±standard deviation [SD]) of the corneal surface, compared with 34.17%±4.53 (mean±SD) in the GR group. When vascular density is compared between treated groups, statistical differences were observed (P<0.002). The results showed an inhibition of angiogenesis when the control group was compared with ranibizumab treated groups. These results suggest that subconjunctival injection of ranibizumab is able to inhibit corneal angiogenesis.

Journal of Veterinary Research, 2016

The aim of this study was to investigate fluorescein use in the diagnosis of bladder ruptures in ... more The aim of this study was to investigate fluorescein use in the diagnosis of bladder ruptures in rabbits as an experimental model.The study was conducted on male New Zealand rabbits divided into a retrograde fluorescein group (n = 8) and an intravenous (IV) fluorescein group (n = 8). Following general anaesthesia, 10 mL of 10% fluorescein dye (sodium fluoresceine powder) was administeredFollowing IV injection of fluorescein dye, the bladder veins were stained green within 10 s and then fluorescein mixed with urine flowed into bladder lumen. The green fluid flow was observed in the abdominal cavity after the perforation of the bladder in both groups.Fluorescein can be used as a marker in diagnosis of bladder ruptures. If there is no bleeding or intestinal content in the abdominal cavity, although a smoky yellow-green image is observed, bladder rupture can be suspected.

Turkiye Klinikleri Journal of Ophthalmology, 2014

Kafkas Journal of Medical Sciences, 2015

A 56 years old male presented with a history of intermittent headache for 10 years and protrusion... more A 56 years old male presented with a history of intermittent headache for 10 years and protrusion in his left eye downwards and outwards the last 3 years. Ophthalmological examination revealed diplopia and restriction in upward gaze. Computed Tomography scan showed a mass originating from left frontal sinus with an extension to the orbit. The mass was excised and histopathological examination revealed that it was compatible with mature type osteoma. In this report, we presented a case including the diagnosis and treatment of a frontal sinus osteoma with an extension into the orbit which is a very rare clinical entity in existing literature.

Clinical Ophthalmology, 2015

Background: To investigate the effects of selective laser trabeculoplasty (SLT) on macular thickn... more Background: To investigate the effects of selective laser trabeculoplasty (SLT) on macular thickness change. Methods: Forty eyes of 40 consecutive patients with uncontrolled primary open-angle glaucoma with medical treatment were included in this prospective study. SLT was performed to the inferior 180°, and macular thickness was measured. Data were collected before SLT, and 1 week and 1 month after SLT. Macular thickness evaluation was performed in five quadrants, the central 1 mm quadrant (fovea = F), the nasal 3 mm quadrant surrounding F (NQ), temporal quadrant, superior quadrant (SQ), and inferior quadrant (IQ). The preoperative and postoperative thicknesses were compared. Results: There was an increase in macular thickness in the NQ, IQ, and SQ on the first week after SLT compared to preoperative measurements. On the other hand, there was no significant increase in the F and temporal quadrant. On the first month after SLT, thickness in the NQ, IQ, and SQ was back to preoperative measurements, and there was no significant change between the preoperative measurements in any quadrant. Conclusion: There was no significant increase in macular thickness shortly after SLT in our study.

The Open Ophthalmology Journal, 2015

Purpose : To present complications of using fibrin glue in conjunctival-limbal autografting in pt... more Purpose : To present complications of using fibrin glue in conjunctival-limbal autografting in pterygium surgeries other than recurrences and discuss their prevention and management strategies. Materials and Methodology: The charts of all patients who underwent fibrin glue assisted pterygium excision surgery with conjunctival-limbal autograft transplantation from 2010 to 2013 were reviewed. Patients who developed complications except recurrence postoperatively were included in this study. Results : Sixteen (17.39%) of the 92 patients were detected with a complication. Graft dehiscence was diagnosed in 7 (7.6%) patients with 5 of them treated conservatively and 2 patients requiring suturing. Five (5.43%) patients were diagnosed with cyst formation between the graft and conjunctiva or in the graft-removal area; these cysts were primarily excised and no additional problems occurred. Corneal dellen developed in 3 (3.26%) patients and 2 of them regressed after cessation of topical steroi...

Neuro-Ophthalmology, 2015

A 14-year-old boy presented with left ptosis and squint since his childhood. In primary position ... more A 14-year-old boy presented with left ptosis and squint since his childhood. In primary position he had left hypotropia with ptosis (levator function 2 mm). With elevation of the right eye, the left eye depresses and adducts; with depression of the right eye, the left eye elevates and abducts. Forced duction test revealed no restrictive pattern. The synergistic divergence described in the literature was unidirectional and wholly compatible with inferior rectus co-contraction. But this case is bidirectional, and the aberrant upward movement cannot be explained by rectus muscle co-contraction. The two vertical rectus muscles show reciprocal misinnervation, or this effect could be coming from co-contraction of one of the oblique muscles for the movement in one direction.

We report the use of anterior segment optical coherence tomography (ASOCT) in Descemet's membrane... more We report the use of anterior segment optical coherence tomography (ASOCT) in Descemet's membrane detachment (DMD). A patient who developed DMD after uneventful cataract surgery with posterior chamber lens implantation is presented in this case report. At the follow-up examination after cataract surgery, slit-lamp evaluation showed stromal striae, but it was impossible to diagnose the DMD due to the corneal edema. ASOCT imaging of the cornea revealed a DMD, and the patient underwent intracameral air injection to the anterior chamber through the site which was identified as intact by ASOCT. Follow-up ASOCT imaging revealed the reattachment of the Descemet's membrane and reduced corneal thickness. If DMD is suspected in any cases, ASOCT can be useful to document and follow the postsurgical detachment of DMD and also to determine the site, configuration, and extent of the DMD, thus guiding the treatment method and monitoring the treatment outcome.

Araştırmalar / Researches ÖZET Yüksek miyop hastalarda fakoemulsifikasyon ve intraokuler lens imp... more Araştırmalar / Researches ÖZET Yüksek miyop hastalarda fakoemulsifikasyon ve intraokuler lens implantasyonun klinik sonuçları Amaç: Yüksek miyop hastalarda fakoemulsifikasyon ve intraokuler lens implantasyon cerrahisinin klinik sonuçlarının değerlendirilmesi. Gereç ve Yöntem: Bu retrospektif çalışmaya katarakt nedeniyle fakoemulsifikasyon ve intraokuler lens implantasyonu cerrahisi uygulanan, aksiyel uzunluğu 26 mm'den fazla olan 35 hastanın 52 gözü dahil edildi. Katarakt ve yüksek miyopi dışında başka bir okuler patolojisi olan hastalar çalışma kapsamı dışında bırakıldı. Hastalara ait dosyalar taranarak, ameliyat öncesi ve sonrası en iyi düzeltilmiş görme keskinliği (EİDGK), refraksiyon kusurları ve komplikasyonlar kayıt edildi. Bulgular: Çalışmaya alınan hastaların ortalama yaşı 58.06±15.46 yıl (27-80 yıl) ve ortalama takip süresi 8.44±3.62 ay idi. Ortalama preoperatif miyopi-10.94±4.75 diyoptri (D), ortalama aksiyel uzunluğu 28.14±1.72 mm ve ortalama EİDGK 0.84±0.4 logMAR idi. İntraoperatif vitreus kaybı iki hastada (3.85%) saptandı ve bu hastalara, arka kamara lensi sulkusa implante edildi. Periferik retina dejenerasyonları saptanan 8 göze (15.4%) preoperatif profilaktik argon lazer uygulaması yapıldı. Ortalama postoperatif sferik değer-0.26±1.51 D ve ortalama EİDGK 0.24±0.24 logMAR idi. Miyopi değerinde istatistiksel anlamlı düşüş (Wilcoxon testi p<0.001) ve EİDGK değerinde istatistiksel anlamlı artış (Wilcoxon testi p<0.001) saptandı. Sonuç: Yüksek miyop hastalarda fakoemulsifikasyon cerrahisi anatomik ve fonksiyonel olarak başarılı sonuçları ile güvenli ve etkili bir yöntemdir. Detaylı retina muayenesi ve profilaktik uygulanan fotokoagulasyon işlemi retinal komplikasyonların oranının azaltılmasını sağlayabilir.

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

The purpose of this study was to evaluate the effects of the use of the subconjunctival injection... more The purpose of this study was to evaluate the effects of the use of the subconjunctival injection of ranibizumab (Lucentis) on angiogenesis in the rabbit cornea. Corneas of 12 New Zealand Rabbits were cauterized with silver nitrate crystal. Animals were divided in two groups: control group (GC) that received 0.02 ml of 0.9% saline solution; group ranibizumab (GR) that received 0.5 mg of ranibizumab subconjunctivally at the 24th h after the lesion was formed. Animals corneas were extracted on the 14th day under general anesthesia. The newly formed vessels digital photographs were obtained and analyzed in a computerized system (google sketch-up program). In the control group, neovascularization covered 64.66%±20.81 (mean±standard deviation [SD]) of the corneal surface, compared with 34.17%±4.53 (mean±SD) in the GR group. When vascular density is compared between treated groups, statistical differences were observed (P<0.002). The results showed an inhibition of angiogenesis when th...

Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy, 2015

International Journal of Research in Medical Sciences, 2015

the eye, pain, and sensitivity to light. The most common cause of hyphema is ocular trauma, usual... more the eye, pain, and sensitivity to light. The most common cause of hyphema is ocular trauma, usually a blunt or lacerating one. Other causes of hyphema include intraocular surgery, eye infections caused by herpes virus, cancer of the eye, artificial lens implants and blood clotting problems such as hemophilia, sickle cell anemia and von Willebrand disease. Hyphema may also occur spontaneously in conditions such as rubeosis iridis, juvenile xanthogranuloma, myotonic dystrophy and iris melanoma. The purpose of this case report is to point to the management of hyphema which occurs after administration of mydriatic drugs.

Current eye research, Jan 10, 2015

The aim of this study is to investigate the effect of 200 mg caffeine on subfoveal choroidal thic... more The aim of this study is to investigate the effect of 200 mg caffeine on subfoveal choroidal thickness (CT) in the macular area as measured by enhanced depth imaging optical coherence tomography (EDI-OCT) in healthy subjects. Fifty healthy individuals (study group) and 50 healthy individuals (control group) were enrolled in study. In the study group, participants received a 200 mg caffeine capsule and the control group consisted of subjects who received plasebo capsule. The subfoveal CT was measured by EDI-OCT before the caffeine intake and at 30 min, 1 h, 2 h, 3 h, 4 h and 6 h following caffeine intake. SFCT after caffeine intake was significantly decreased at 30 min, 1 h, 2 h, 3 h and 4 h compared to the baseline measurement, while the difference between baseline and 6 h was not statistically significant in the study group. There were no significant differences between the baseline and the other measurement times in the control group (p > 0.05). The thinning of CT begins about ...

Medical science monitor : international medical journal of experimental and clinical research, 2014

The aim f this study was to evaluate the effect of capsular tension ring implantation during cata... more The aim f this study was to evaluate the effect of capsular tension ring implantation during cataract surgery on the incidence of neodymium: YAG (Nd: YAG) laser posterior capsulotomy in myopic (axial length [AL] ≥25.00 mm) eyes. MATERIAL/METHODS In this retrospective study, the records of the cases of 117 myopic patients who underwent cataract surgery between January 2004 and January 2011 were reviewed. A total of 153 eyes with an axial length of 25 mm or higher were included in the study with consideration of exclusion criteria mentioned below. Eyes were grouped by presence or lack of capsular tension ring (CTR+ and CTR-, respectively). The study included 153 eyes from 107 myopic patients. Hydrophilic acrylic IOL and capsular tension ring (CTR) were implanted in 78 eyes (CTR+ group), and 75 eyes received only the hydrophilic acrylic IOL (CTR- group). Six eyes (7.6%) in CTR+ and 16 eyes (21.3%) in CTR- required Nd: YAG laser capsulotomy within 7 years. The difference between the 2 g...