Dobgima Fonmboh - Academia.edu (original) (raw)
Papers by Dobgima Fonmboh
International Journal of Pathogen Research, Nov 9, 2022
The coronavirus (COVID-19) took the world by storm and triggered intensive research mobilization ... more The coronavirus (COVID-19) took the world by storm and triggered intensive research mobilization and action towards vaccines and drug repurposing. This pandemic triggered an emergence therapy intervention of which the development of new vaccine and drug repurposing were good options that was to be validated by regulatory authorities for potential use for enhancing acquired immunity for the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Prior to the outbreak that led to the global health emergency intervention, an understanding of the viral architecture, pathophysiology and mechanism of action and functions were well established. The global health disaster caused by COVID-19 has generated significant interest globally for research in vaccine discovery and development by many research institutions and Pharmaceutical sectors since 2019. So far, the approval of many clinical trials tested vaccines by the regulatory authorities have led to the need for post approval concerns of efficacy, safety and quality of these approved vaccines. This review paper attempts to explore the vaccines approved for global access to the population discovery and development process, the potential safety implications. An insight into other therapy options such as the convalescence plasma treatment and management for the global COVID-19 pandemic has been reviewed.
Asian Journal of Biotechnology and Bioresource Technology
Agricultural production, agro-industrial food processing, distribution and consumption generate h... more Agricultural production, agro-industrial food processing, distribution and consumption generate high Amounts of varied food by-products and waste which place a heavy burden on the environment and cause losses to the food industry. The most common disposal methods of food wastes are the use of landfills and incineration, which lead to several environmental, social, and economic issues. However, many of these by-products and wastes have been reported to be higher than the final product in terms of nutritional or functional properties, making them potential raw materials for application in the agro-food industry. Together with the recent sustainable development goals of food security, environmental protection, and energy efficiency, these are the key reasons why food waste valorization is necessary. Valorization of food waste within the bio-economy approach offers an economical and environmental opportunity that can serve as a solution to the issues faced with the conventional disposal...
Journal of Advances in Medical and Pharmaceutical Sciences
Once a drug is approved in phase III of clinical trials, pharmacovigilance (PV) becomes very impo... more Once a drug is approved in phase III of clinical trials, pharmacovigilance (PV) becomes very important for the surveillance of drug, vaccine or medical devices. PV constitutes part of the phase IV approval, which involves a study for collecting, detecting, and monitoring adverse events in any population that the drug is used. The adverse events that are reported must be assessed to ascertain the causal effects and prevent or avoid unanticipated side effects on the population. With the advent of the coronavirus disease 2019 (COVID-19) pandemic, vaccination has been the motor for the management of the pandemic, and through intensive health sensitization, more people are vaccinated in a short period leading to greater challenges to the PV taskforce and the PV operating centrers. Global partnerships including the international society of pharmacovigilance (ISOP), the French national agency for medicines and health products safety (ANSM), and a multitude of others are working in synergy ...
Journal of Analytical & Pharmaceutical Research, 2020
diabetes mellitus, gonorrhoea, respiratory infections, and mental illnesses. The leaves of F. tho... more diabetes mellitus, gonorrhoea, respiratory infections, and mental illnesses. The leaves of F. thonningii contain various bioactive compounds which include alkaloids, terpenoids, flavonoids, tannins and active proteins, all of which contribute to its curative properties. In vitro and in vivo pharmacological studies revealed that F.thonningii possesses antimicrobial, anti diarrheal, anti helmintic, antioxidant, anti-inflammatory and analgesic properties. Scientific research has validated the ethno medicinal claims that F. thonningii is useful in disease management. However, there is need to continue identifying, isolating and quantifying the active principles and possibly determine the mechanisms underlying the curative properties of its bark. 2 It is in this context that the current study was conducted to investigate phyto chemically screen, evaluate the antioxidant of the stem bark extract on Wistar rats Materials and methods This was an experimental in vitro and in vivo preclinical study on Wistar rats conducted from the 11 November 2016 to the 25th May 2017. The study was done in the Preclinical Animal toxicology and
The intrinsic signatures of Cannabis species to bioaccumulate non-essential harmful heavy metals ... more The intrinsic signatures of Cannabis species to bioaccumulate non-essential harmful heavy metals (HMs) are substantially determined by their high tolerance, weedy propensities, phenotypic plasticity attributes, and pedoclimatic stress adaptation in an ecological niche. The detection trends of HMs contaminants in cannabis products have reshaped the 2027 forecast and beyond for global cannabis trade valued at $57 billion. Consumer base awareness for the cohort of HMs contaminants viz., lead (Pb), mercury (Hg), arsenic (As), chromium (Cr), cadmium (Cd), and radioactive elements, and the associative dissuading effects significantly impact cannabis bioeconomy. On the premise that fiber hemp (Cannabis sativa L.) could be repurposed to diverse non-consumable products, concerns over HMs contamination would not significantly decrease fiber trade, a trend that could impact globally by 2025. The economic trend will depend on acceptable consumer risk, regulatory instruments, and grower's du...
International Journal of Chemical Engineering, 2021
In Cameroon, agrofood waste biomass such as peels of Musa paradisiaca and Musa acuminate is being... more In Cameroon, agrofood waste biomass such as peels of Musa paradisiaca and Musa acuminate is being valorized using various traditional processing methods to produce a traditional functional food salt, potash, locally called nikkih. Nikkih has been reported to have varying physicochemical and functional properties, which negatively affect the quality and stability of food prepared using it. This work aims at evaluating the effect of traditional process methods on the physicochemical and functional properties of nikkih produced from these peels in view of the optimization of the process. The peels were preprocessed using two methods: boiling at 90oC before drying and direct drying of raw samples. All samples were dried and combusted to ash at varying temperatures of 250oC, 300o C, and 350oC and times of 30 min, 60 min, and 90 min. The ash obtained was dissolved in varied volumes of water, filtered to obtain the nikkih. Yellow achu soup was prepared through the dry gum method using wate...
Asian Journal of Biotechnology and Bioresource Technology, 2021
High protein from meat consumption has been associated recently to environmental depletion and he... more High protein from meat consumption has been associated recently to environmental depletion and health related issues despite the important contribution of meat and meat products in diet and growth development. This has motivated debates on a drastic shift from excessive meat consumption amongst stake holders, academics, animal rights activists and environmentalist as informed consumers are pushing food scientist for a more sustainable alternative protein source. Plant proteins are considered a suitable alternative protein. However, the nutritional, functional potential and the form of presentation have shown some technological difficulties which indicates that direct transformation of plant proteins to meat products is less feasible. Though meat alternative research is promising in developed countries, there are technological breakthroughs that have permitted to replace in part or fully certain sensory attributes of meat inspired by the technology behind the ancient east Asian tradi...
Advances in Bioscience and Bioengineering, 2019
Sumerianz Journal of Biotechnology, 2020
The powders of a traditional food (Nyam ngub) and two wild varieties of orchid tubers (Ateehteu a... more The powders of a traditional food (Nyam ngub) and two wild varieties of orchid tubers (Ateehteu and Lamsie) were studied for the chemical composition (proximate and mineral composition) and functional properties (water, oil, ethanol absorption capacities, solubility index and swelling power). The tubers were collected from Kedjom Ketingoh (5o 58’N and 10o 19E) in the Northwest Region of Cameroon from July to September 2017. The Nyam ngub was prepared following the traditional method used by local processors in the field. Nyam ngub and tubers were separately sliced, dried for 96 h at 45 °C, ground and sieved to obtain powders used for the analysis. For 100g DW, the mean crude protein, starch, total sugars, soluble sugars, total lipid, crude fibre, vitamin C, calcium, iron contents and energy values for Ateehteu, Lamsie and Nyam ngub were (1.93; 3.50; 2.59)mg, (6.51; 4.48; 4.26)g, (14.34; 15.07;13.08)g, (1.07; 1.06; 1.05)g, (2.45; 2.93; 2.41)g, (4.02; 5.22; 4.88)g, (8.38; 5.69; 5.93)m...
Phytoparasitica, 2020
The fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) is a transbo... more The fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) is a transboundary polyphagous insect pest which preferentially feeds on grain crops. The FAW was responsible for economic damage to maize crops in more than 44 African countries by 2019 accounting for the loss of over US$2–5.5 billion. The parallel cultivation of Bt-maize expressing Cry1Ab protein and indigenous maize varieties in some African countries was aimed to enhance output and mitigate the harmful impact of the Lepidopteran insect below the economic injury level. A total of six maize farms (holding at least 4–20 ha of land) in delocalized geographies of Gauteng province, South Africa were randomly selected and assessed for the impact of FAW during the 2017 outbreak. A biotype of S. frugiperda that significantly destroyed Bt maize and non-Bt maize and exhibited tolerance to pesticides under field conditions is reported. It is observed that, whether maize at the tasseling stage carried the Cry1Ab trait or not, S. frugiperda caused a minimum damage of ~62.6% (P < 0.05, P = 0.0001, |t| = 2.78) and maximum damage of ~83.33% (P < 0.05, P = 0.0001, |t| = 2.78) in farms without refuge strategies. Phylogenetic analysis using the mitochondrial cytochrome oxidase I gene, revealed divergent evolution amongst reported S. frugiperda lineages, the emergence of singleton, and distinct haplotypes within the African continent. It is concluded that S. frugiperda that invaded maize farms in the Gauteng region of South Africa is genetically evolved from those identified in Sao Tome and Principe, and Nigeria, and tolerant to certain insecticides. Thus, the African continent might have been invaded by several routes and distinct haplotypes.
Asian Journal of Research in Medical and Pharmaceutical Sciences, 2020
Introduction: The World Health Organization (WHO) has estimated that about 80% of the world’s pop... more Introduction: The World Health Organization (WHO) has estimated that about 80% of the world’s population rely mostly on traditional medicine. Peptic ulcer disease (PUD) which results from an imbalance between stomach acid-pepsin and mucosal defense barriers is a chronic disease affecting up to 10% of the world’s population and represents 33% of gastroenterology consultations in Cameroon. The people in low medium incomecountries depend mostly on medicinal plants for primary healthcare since they can be accessed quickly and are affordable. Such plant is Ficus thonningii Blume, which is found abundantly in Africa and also in Cameroon. The objective of this study was to phytochemically screened the aqueous fruits extract of Ficus thonningii (AEFFt), and investigate their antiulcer activity. Methods: The aqueous fruits extract was phytochemically screened following standard qualitative methods. Four in vitro tests to characterize antacid properties were carried out. Ulcers were induced u...
World Journal of Microbiology and Biotechnology, 2019
![Research paper thumbnail of {"__content__"=>"Global challenges faced by engineered genes in soybean ( L.) in the twenty-first century.", "i"=>[{"__content__"=>"Bacillus thuringiensis Cry"}, {"__content__"=>"Glycine max"}]}](https://attachments.academia-assets.com/84366249/thumbnails/1.jpg)
](3 Biotech, 2018
The most important insect pests causing severe economic damages to soybean ( L.) production world... more The most important insect pests causing severe economic damages to soybean ( L.) production worldwide are (), (), (), (), (Walker, Noctuidae), (Walker, Noctuidae), (Stoll, Noctuidae), (Smith; Noctuidae), (Hübner, Noctuidae), (Boddie; Noctuidae) and (Hymenoptera,Platygastidae). Despite the success of biotech ()/herbicide tolerance (HT)-soybean in the past decade in terms of output, unforeseen mitigated performances have been observed due to changes in climatic events that favors the emergence of insect resistance. Thus, there is a need to develop hybrids with elaborated gene stacking to avert the upsurge in insect field tolerance to crystal (Cry) toxins in -soybean. This study covers the performance of important commercial transgenic soybean developed to outwit destructive insects. New gene stacking soybean events such as -, - and -soybean (DAS-81419-2, Conkesta™ technology), and MON-87751-7 × MON-87701-2 × MON 87708 × MON 89788 (bearing [], ) are being approved and deployed in field...
Topics in Public Health, 2015
Topics in Public Health, 2015
Asian Journal of Research in Medical and Pharmaceutical Sciences, 2020
Herbal plants are very important in traditional community use and enrich our plant biodiversity a... more Herbal plants are very important in traditional community use and enrich our plant biodiversity and conservation. Natural products are vital substances of traditional knowledge systems in complementary and alternative medicine, nutraceutical, food supplements, and pharmaceutical bioactive metabolites of new chemical entities. Bioactive secondary metabolites from herbal plants of different forms are main sources and provide major opportunities for drug active pharmaceuticals due to the diverse flora and fauna biodiversity that produces the necessary available chemical diversity. There has been an increasing popularity in phytochemical research within the high through put (HTS) screening programs in search of lead. Phytochemicals of herbal extracts for traditional uses contain various types of bioactive metabolites of pharmaceutical and pharmacotherapeutic nature, and many phytomedicines for different therapeutic areas have been derived from herbal products. This paper is aimed at giv...
Journal of Complementary and Alternative Medical Research
Introduction: Liver or hepatic disease refers to different conditions that affect the liver. Chro... more Introduction: Liver or hepatic disease refers to different conditions that affect the liver. Chronic alcohol consumption is one of the most frequent causes of liver disease and accounts for about 55% of liver cirrhosis deaths recorded in Cameroon in 2020. Standard accessible treatments focus on end-stage liver disease with safety and efficacy obstacles. We have a research gap in Cameroon to understand the alternative use of natural products as treatment with a long traditional history of safe use. Curcuma longa has long been a source of traditional and modern medicine. It is commonly used in Cameroon as a spice and herbal product with some level of activity against various forms of liver disease. Objective: To phytochemically screen for bioactive metabolites and evaluate the hepatoprotective activity of the aqueous extract of Curcuma longaon alcohol-induced toxicity in Wistar rats. Methods: Phytochemical screening was carried out on the aqueous extract obtainedfrom maceration of pla...
Journal of Complementary and Alternative Medical Research
The causative etiology of the viral pneumonia outbreak in the Wuhan province of China of December... more The causative etiology of the viral pneumonia outbreak in the Wuhan province of China of December 2019 initially identified as “novel-Coronavirus-2019” and today called “Corona Virus Disease-2019 has been identified as “severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)”. Tireless efforts have therefore been invested to elaborate a treatment and/ or vaccine though with much controversy due to the lack of proper mastery of the structure, mode of action, mutation, recombination and transmission mechanism of the virus. Numerous public health measures have thus been imposed to slow down the rate of invasion and/or transmission (regular hand washing, face mask wearing, quarantine as well as method of diagnosis and symptomatic treatment) and now a convinent and acceptable treatment protocol and/ or vaccine. With the difficulties encountered in the development of an effective and efficient control and / or preventive towards the virus even in the western world, countries in sub-S...
Journal of Advances in Medicine and Medical Research
The popularity of doping in competitive sports is relevant for all those involved in sports, part... more The popularity of doping in competitive sports is relevant for all those involved in sports, particularly for evaluating anti-doping policy measures. However, there is a gap of information that addresses this subject so far. As a consequence, the prevalence of doping in competitive sports in resource limited countries is unknown. Even though it is challenging to uncover the exact prevalence of herbal products with prohibited activity such as doping, various methods put in place by world antidoping agency (WADA) have now been adopted to uncover parts of this particular problem, and enables the circumvention to some extend the issues of honesty, definition problems and the limits of pharmacological evidence. It is evident that current doping control test results can show a distinct underestimation of true doping prevalence in low middle income countries (LMIC). Nowadays, doping is a critical issue at international levels of sporting competitions. Athletes’ use of herbal supplements ha...
International Journal of Pathogen Research, Nov 9, 2022
The coronavirus (COVID-19) took the world by storm and triggered intensive research mobilization ... more The coronavirus (COVID-19) took the world by storm and triggered intensive research mobilization and action towards vaccines and drug repurposing. This pandemic triggered an emergence therapy intervention of which the development of new vaccine and drug repurposing were good options that was to be validated by regulatory authorities for potential use for enhancing acquired immunity for the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Prior to the outbreak that led to the global health emergency intervention, an understanding of the viral architecture, pathophysiology and mechanism of action and functions were well established. The global health disaster caused by COVID-19 has generated significant interest globally for research in vaccine discovery and development by many research institutions and Pharmaceutical sectors since 2019. So far, the approval of many clinical trials tested vaccines by the regulatory authorities have led to the need for post approval concerns of efficacy, safety and quality of these approved vaccines. This review paper attempts to explore the vaccines approved for global access to the population discovery and development process, the potential safety implications. An insight into other therapy options such as the convalescence plasma treatment and management for the global COVID-19 pandemic has been reviewed.
Asian Journal of Biotechnology and Bioresource Technology
Agricultural production, agro-industrial food processing, distribution and consumption generate h... more Agricultural production, agro-industrial food processing, distribution and consumption generate high Amounts of varied food by-products and waste which place a heavy burden on the environment and cause losses to the food industry. The most common disposal methods of food wastes are the use of landfills and incineration, which lead to several environmental, social, and economic issues. However, many of these by-products and wastes have been reported to be higher than the final product in terms of nutritional or functional properties, making them potential raw materials for application in the agro-food industry. Together with the recent sustainable development goals of food security, environmental protection, and energy efficiency, these are the key reasons why food waste valorization is necessary. Valorization of food waste within the bio-economy approach offers an economical and environmental opportunity that can serve as a solution to the issues faced with the conventional disposal...
Journal of Advances in Medical and Pharmaceutical Sciences
Once a drug is approved in phase III of clinical trials, pharmacovigilance (PV) becomes very impo... more Once a drug is approved in phase III of clinical trials, pharmacovigilance (PV) becomes very important for the surveillance of drug, vaccine or medical devices. PV constitutes part of the phase IV approval, which involves a study for collecting, detecting, and monitoring adverse events in any population that the drug is used. The adverse events that are reported must be assessed to ascertain the causal effects and prevent or avoid unanticipated side effects on the population. With the advent of the coronavirus disease 2019 (COVID-19) pandemic, vaccination has been the motor for the management of the pandemic, and through intensive health sensitization, more people are vaccinated in a short period leading to greater challenges to the PV taskforce and the PV operating centrers. Global partnerships including the international society of pharmacovigilance (ISOP), the French national agency for medicines and health products safety (ANSM), and a multitude of others are working in synergy ...
Journal of Analytical & Pharmaceutical Research, 2020
diabetes mellitus, gonorrhoea, respiratory infections, and mental illnesses. The leaves of F. tho... more diabetes mellitus, gonorrhoea, respiratory infections, and mental illnesses. The leaves of F. thonningii contain various bioactive compounds which include alkaloids, terpenoids, flavonoids, tannins and active proteins, all of which contribute to its curative properties. In vitro and in vivo pharmacological studies revealed that F.thonningii possesses antimicrobial, anti diarrheal, anti helmintic, antioxidant, anti-inflammatory and analgesic properties. Scientific research has validated the ethno medicinal claims that F. thonningii is useful in disease management. However, there is need to continue identifying, isolating and quantifying the active principles and possibly determine the mechanisms underlying the curative properties of its bark. 2 It is in this context that the current study was conducted to investigate phyto chemically screen, evaluate the antioxidant of the stem bark extract on Wistar rats Materials and methods This was an experimental in vitro and in vivo preclinical study on Wistar rats conducted from the 11 November 2016 to the 25th May 2017. The study was done in the Preclinical Animal toxicology and
The intrinsic signatures of Cannabis species to bioaccumulate non-essential harmful heavy metals ... more The intrinsic signatures of Cannabis species to bioaccumulate non-essential harmful heavy metals (HMs) are substantially determined by their high tolerance, weedy propensities, phenotypic plasticity attributes, and pedoclimatic stress adaptation in an ecological niche. The detection trends of HMs contaminants in cannabis products have reshaped the 2027 forecast and beyond for global cannabis trade valued at $57 billion. Consumer base awareness for the cohort of HMs contaminants viz., lead (Pb), mercury (Hg), arsenic (As), chromium (Cr), cadmium (Cd), and radioactive elements, and the associative dissuading effects significantly impact cannabis bioeconomy. On the premise that fiber hemp (Cannabis sativa L.) could be repurposed to diverse non-consumable products, concerns over HMs contamination would not significantly decrease fiber trade, a trend that could impact globally by 2025. The economic trend will depend on acceptable consumer risk, regulatory instruments, and grower's du...
International Journal of Chemical Engineering, 2021
In Cameroon, agrofood waste biomass such as peels of Musa paradisiaca and Musa acuminate is being... more In Cameroon, agrofood waste biomass such as peels of Musa paradisiaca and Musa acuminate is being valorized using various traditional processing methods to produce a traditional functional food salt, potash, locally called nikkih. Nikkih has been reported to have varying physicochemical and functional properties, which negatively affect the quality and stability of food prepared using it. This work aims at evaluating the effect of traditional process methods on the physicochemical and functional properties of nikkih produced from these peels in view of the optimization of the process. The peels were preprocessed using two methods: boiling at 90oC before drying and direct drying of raw samples. All samples were dried and combusted to ash at varying temperatures of 250oC, 300o C, and 350oC and times of 30 min, 60 min, and 90 min. The ash obtained was dissolved in varied volumes of water, filtered to obtain the nikkih. Yellow achu soup was prepared through the dry gum method using wate...
Asian Journal of Biotechnology and Bioresource Technology, 2021
High protein from meat consumption has been associated recently to environmental depletion and he... more High protein from meat consumption has been associated recently to environmental depletion and health related issues despite the important contribution of meat and meat products in diet and growth development. This has motivated debates on a drastic shift from excessive meat consumption amongst stake holders, academics, animal rights activists and environmentalist as informed consumers are pushing food scientist for a more sustainable alternative protein source. Plant proteins are considered a suitable alternative protein. However, the nutritional, functional potential and the form of presentation have shown some technological difficulties which indicates that direct transformation of plant proteins to meat products is less feasible. Though meat alternative research is promising in developed countries, there are technological breakthroughs that have permitted to replace in part or fully certain sensory attributes of meat inspired by the technology behind the ancient east Asian tradi...
Advances in Bioscience and Bioengineering, 2019
Sumerianz Journal of Biotechnology, 2020
The powders of a traditional food (Nyam ngub) and two wild varieties of orchid tubers (Ateehteu a... more The powders of a traditional food (Nyam ngub) and two wild varieties of orchid tubers (Ateehteu and Lamsie) were studied for the chemical composition (proximate and mineral composition) and functional properties (water, oil, ethanol absorption capacities, solubility index and swelling power). The tubers were collected from Kedjom Ketingoh (5o 58’N and 10o 19E) in the Northwest Region of Cameroon from July to September 2017. The Nyam ngub was prepared following the traditional method used by local processors in the field. Nyam ngub and tubers were separately sliced, dried for 96 h at 45 °C, ground and sieved to obtain powders used for the analysis. For 100g DW, the mean crude protein, starch, total sugars, soluble sugars, total lipid, crude fibre, vitamin C, calcium, iron contents and energy values for Ateehteu, Lamsie and Nyam ngub were (1.93; 3.50; 2.59)mg, (6.51; 4.48; 4.26)g, (14.34; 15.07;13.08)g, (1.07; 1.06; 1.05)g, (2.45; 2.93; 2.41)g, (4.02; 5.22; 4.88)g, (8.38; 5.69; 5.93)m...
Phytoparasitica, 2020
The fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) is a transbo... more The fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) is a transboundary polyphagous insect pest which preferentially feeds on grain crops. The FAW was responsible for economic damage to maize crops in more than 44 African countries by 2019 accounting for the loss of over US$2–5.5 billion. The parallel cultivation of Bt-maize expressing Cry1Ab protein and indigenous maize varieties in some African countries was aimed to enhance output and mitigate the harmful impact of the Lepidopteran insect below the economic injury level. A total of six maize farms (holding at least 4–20 ha of land) in delocalized geographies of Gauteng province, South Africa were randomly selected and assessed for the impact of FAW during the 2017 outbreak. A biotype of S. frugiperda that significantly destroyed Bt maize and non-Bt maize and exhibited tolerance to pesticides under field conditions is reported. It is observed that, whether maize at the tasseling stage carried the Cry1Ab trait or not, S. frugiperda caused a minimum damage of ~62.6% (P < 0.05, P = 0.0001, |t| = 2.78) and maximum damage of ~83.33% (P < 0.05, P = 0.0001, |t| = 2.78) in farms without refuge strategies. Phylogenetic analysis using the mitochondrial cytochrome oxidase I gene, revealed divergent evolution amongst reported S. frugiperda lineages, the emergence of singleton, and distinct haplotypes within the African continent. It is concluded that S. frugiperda that invaded maize farms in the Gauteng region of South Africa is genetically evolved from those identified in Sao Tome and Principe, and Nigeria, and tolerant to certain insecticides. Thus, the African continent might have been invaded by several routes and distinct haplotypes.
Asian Journal of Research in Medical and Pharmaceutical Sciences, 2020
Introduction: The World Health Organization (WHO) has estimated that about 80% of the world’s pop... more Introduction: The World Health Organization (WHO) has estimated that about 80% of the world’s population rely mostly on traditional medicine. Peptic ulcer disease (PUD) which results from an imbalance between stomach acid-pepsin and mucosal defense barriers is a chronic disease affecting up to 10% of the world’s population and represents 33% of gastroenterology consultations in Cameroon. The people in low medium incomecountries depend mostly on medicinal plants for primary healthcare since they can be accessed quickly and are affordable. Such plant is Ficus thonningii Blume, which is found abundantly in Africa and also in Cameroon. The objective of this study was to phytochemically screened the aqueous fruits extract of Ficus thonningii (AEFFt), and investigate their antiulcer activity. Methods: The aqueous fruits extract was phytochemically screened following standard qualitative methods. Four in vitro tests to characterize antacid properties were carried out. Ulcers were induced u...
World Journal of Microbiology and Biotechnology, 2019
3 Biotech, 2018
The most important insect pests causing severe economic damages to soybean ( L.) production world... more The most important insect pests causing severe economic damages to soybean ( L.) production worldwide are (), (), (), (), (Walker, Noctuidae), (Walker, Noctuidae), (Stoll, Noctuidae), (Smith; Noctuidae), (Hübner, Noctuidae), (Boddie; Noctuidae) and (Hymenoptera,Platygastidae). Despite the success of biotech ()/herbicide tolerance (HT)-soybean in the past decade in terms of output, unforeseen mitigated performances have been observed due to changes in climatic events that favors the emergence of insect resistance. Thus, there is a need to develop hybrids with elaborated gene stacking to avert the upsurge in insect field tolerance to crystal (Cry) toxins in -soybean. This study covers the performance of important commercial transgenic soybean developed to outwit destructive insects. New gene stacking soybean events such as -, - and -soybean (DAS-81419-2, Conkesta™ technology), and MON-87751-7 × MON-87701-2 × MON 87708 × MON 89788 (bearing [], ) are being approved and deployed in field...
Topics in Public Health, 2015
Topics in Public Health, 2015
Asian Journal of Research in Medical and Pharmaceutical Sciences, 2020
Herbal plants are very important in traditional community use and enrich our plant biodiversity a... more Herbal plants are very important in traditional community use and enrich our plant biodiversity and conservation. Natural products are vital substances of traditional knowledge systems in complementary and alternative medicine, nutraceutical, food supplements, and pharmaceutical bioactive metabolites of new chemical entities. Bioactive secondary metabolites from herbal plants of different forms are main sources and provide major opportunities for drug active pharmaceuticals due to the diverse flora and fauna biodiversity that produces the necessary available chemical diversity. There has been an increasing popularity in phytochemical research within the high through put (HTS) screening programs in search of lead. Phytochemicals of herbal extracts for traditional uses contain various types of bioactive metabolites of pharmaceutical and pharmacotherapeutic nature, and many phytomedicines for different therapeutic areas have been derived from herbal products. This paper is aimed at giv...
Journal of Complementary and Alternative Medical Research
Introduction: Liver or hepatic disease refers to different conditions that affect the liver. Chro... more Introduction: Liver or hepatic disease refers to different conditions that affect the liver. Chronic alcohol consumption is one of the most frequent causes of liver disease and accounts for about 55% of liver cirrhosis deaths recorded in Cameroon in 2020. Standard accessible treatments focus on end-stage liver disease with safety and efficacy obstacles. We have a research gap in Cameroon to understand the alternative use of natural products as treatment with a long traditional history of safe use. Curcuma longa has long been a source of traditional and modern medicine. It is commonly used in Cameroon as a spice and herbal product with some level of activity against various forms of liver disease. Objective: To phytochemically screen for bioactive metabolites and evaluate the hepatoprotective activity of the aqueous extract of Curcuma longaon alcohol-induced toxicity in Wistar rats. Methods: Phytochemical screening was carried out on the aqueous extract obtainedfrom maceration of pla...
Journal of Complementary and Alternative Medical Research
The causative etiology of the viral pneumonia outbreak in the Wuhan province of China of December... more The causative etiology of the viral pneumonia outbreak in the Wuhan province of China of December 2019 initially identified as “novel-Coronavirus-2019” and today called “Corona Virus Disease-2019 has been identified as “severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)”. Tireless efforts have therefore been invested to elaborate a treatment and/ or vaccine though with much controversy due to the lack of proper mastery of the structure, mode of action, mutation, recombination and transmission mechanism of the virus. Numerous public health measures have thus been imposed to slow down the rate of invasion and/or transmission (regular hand washing, face mask wearing, quarantine as well as method of diagnosis and symptomatic treatment) and now a convinent and acceptable treatment protocol and/ or vaccine. With the difficulties encountered in the development of an effective and efficient control and / or preventive towards the virus even in the western world, countries in sub-S...
Journal of Advances in Medicine and Medical Research
The popularity of doping in competitive sports is relevant for all those involved in sports, part... more The popularity of doping in competitive sports is relevant for all those involved in sports, particularly for evaluating anti-doping policy measures. However, there is a gap of information that addresses this subject so far. As a consequence, the prevalence of doping in competitive sports in resource limited countries is unknown. Even though it is challenging to uncover the exact prevalence of herbal products with prohibited activity such as doping, various methods put in place by world antidoping agency (WADA) have now been adopted to uncover parts of this particular problem, and enables the circumvention to some extend the issues of honesty, definition problems and the limits of pharmacological evidence. It is evident that current doping control test results can show a distinct underestimation of true doping prevalence in low middle income countries (LMIC). Nowadays, doping is a critical issue at international levels of sporting competitions. Athletes’ use of herbal supplements ha...