Dorota Mańkowska-Wierzbicka - Academia.edu (original) (raw)
Papers by Dorota Mańkowska-Wierzbicka
European Review for Medical and Pharmacological Sciences, Oct 1, 2019
OBJECTIVE Aim of the study was to assess the possible vitamin B1 deficiency in relation to the ex... more OBJECTIVE Aim of the study was to assess the possible vitamin B1 deficiency in relation to the exacerbation of Crohn's disease (CD) in adult patients. PATIENTS AND METHODS Forty-nine Crohn's disease (CD) patients with different disease activity (The Crohn's Disease Activity Index-CDAI) were included in the study. Anthropometrical and biochemical parameters, i.e., high sensitive C-reactive protein, were assessed. The spectrophotometric method was used to measure the transketolase activity (TK) in erythrocytes. The normalized transketolase activity ratio (NTKZ) and the percentage of activation with thiamine pyrophosphate (%TPP) were also evaluated. RESULTS The mean values of BMI were close to cut-off: 18.5 kg/m2, indicating a poor nutritional status in CD patients. The patients with moderate-to-severe active CD had a statistically significant higher value of CDAI and hsCRP concentrations compared to those being in the asymptomatic remission or at the mildly active stage of the disease. The level of NTKZ and %TPP were statistically different between the analyzed groups, showing the deficit of vitamin B1 in the group of moderate-to-severe active CD patients (Mean ± SD; NTKZ: 1.99 ± 0.87 vs. 1.54 ± 0.62 U/g Hb; % of TPP: 0.15 ± 0.78 vs. 54.90 ± 38.80). CONCLUSIONS Vitamin B1 deficiency is part of the Crohn's disease manifestation in moderate-to-severe active patients.
International Journal of Molecular Sciences, Jun 21, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Scientific Reports, 2021
Ulcerative colitis (UC) is a chronic immune-mediated disorder, whose etiology is not fully unders... more Ulcerative colitis (UC) is a chronic immune-mediated disorder, whose etiology is not fully understood and for which no effective treatment is available. Recently, research has focused on the dysbiosis of gut microbiome in UC. However, the results so far remain inconsistent and insufficient to understand the microbial component in UC pathogenesis. In this study, we determine specific changes in the gut microbial profile in Polish UC patients compared to healthy subjects for the first time. Using 16S rRNA gene-based analysis we have described the intestinal microbial community in a group of 20 individuals (10 UC patients and 10 controls). Our results after multiple hypothesis testing correction demonstrated substantially lower gut microbiome diversity in UC cases compared to the controls and considerable differences at the phylum level, as well as among 13 bacterial families and 20 bacterial genera (p < 0.05). UC samples were more abundant in Proteobacteria (8.42%), Actinobacteria ...
Journal of Clinical Medicine
The incidence of food hypersensitivity has increased dramatically over the years not only among c... more The incidence of food hypersensitivity has increased dramatically over the years not only among children but also in adults. Adult patients are usually less suspected of food hypersensitivity symptoms since food allergies are more typical for small children, with a tendency to outgrow the condition. The aim of this article is to increase awareness of hypersensitivity to food symptoms and their diagnosis and treatment possibilities among gastroenterologists and other health care professionals dealing with this type of patient. Symptoms of many gastrointestinal disorders, especially functional, may be driven by different types of mechanisms, and food intolerance or allergy should be considered as a potential cause. This article presents the current understanding of the epidemiology, diagnosis and treatment of immune- and non-immune-mediated food-induced diseases. Diagnosis of food hypersensitivity is based mainly on medical history, different types of sensitivity tests, e.g., hydrogen...
Biomedicines
It is crucial to consider the importance of the microbiome and the gut–lung axis in the context o... more It is crucial to consider the importance of the microbiome and the gut–lung axis in the context of SARS-CoV-2 infection. This pilot study examined the fecal microbial composition of patients with COVID-19 following a 3-month recovery. Using for the first time metagenomic analysis based on all hypervariable regions (V1-V9) of the 16S rRNA gene, we have identified 561 microbial species; however, 17 were specific only for the COVID-19 group (n = 8). The patients’ cohorts revealed significantly greater alpha diversity of the gut microbiota compared to healthy controls (n = 14). This finding has been demonstrated by operational taxonomic units (OTUs) richness (p < 0.001) and Chao1 index (p < 0.01). The abundance of the phylum Verrucomicrobia was 30 times higher in COVID-19 patients compared to healthy subjects. Accordingly, this disproportion was also noted at other taxonomic levels: in the class Verrucomicrobiae, the family Verrucomicrobiaceae, and the genus Akkermansia. Elevated ...
Forum Zaburzeń Metabolicznych, 2021
Nieceliakalna nadwrażliwość na gluten (NCGS) jest ciągle mało poznaną chorobą. Objawy NCGS nakład... more Nieceliakalna nadwrażliwość na gluten (NCGS) jest ciągle mało poznaną chorobą. Objawy NCGS nakładają się na objawy innych chorób glutenozależnych, co dodatkowo utrudnia jednoznaczną diagnostykę. Wyniki badań wykazały, że głównymi wyzwalaczami NCGS są glutem i produkty o dużej zawartości FODMAP. Obecnie w celu złagodzenia objawów NCGS stosuje się dietę niskoglutenową/bezglutenową i low-FODMAP. Z uwagi na brak markerów specyficznych w kierunku NCGS nie zawsze jest to choroba prawidłowo diagnozowana. W celu ogólnej standaryzacji rozpoznania NCGS przyjęto Skalę Oceny Objawów Gastrointestinal Sympton Rating Scale
Postepy higieny i medycyny doswiadczalnej, 2015
The human skin harbours hundreds of species of commensal organisms, collectively known as the ski... more The human skin harbours hundreds of species of commensal organisms, collectively known as the skin microbiota. The composition of the microbiota can be modified by various factors, such as host genotype, diet, antibiotics, hygiene, and pathogen infections, among others. Changes in these factors can cause microbiome disruption known as dysbiosis, leading to the outgrowth of potential pathogenic bacteria or a decrease in the number of beneficial bacteria. Dysbiosis has been implicated in some dermatological diseases. This mini-review aims to discuss the topic of the skin microbiota and its potential effects on various skin diseases.
Endocrine Connections
Dysregulation of thyroid function has known impact on body metabolism, however, data regarding me... more Dysregulation of thyroid function has known impact on body metabolism, however, data regarding metabolic outcome after restoration of thyroid function is limited. Therefore, the aim of the study was to investigate the effect of restoration of euthyroidism on serum visfatin, and its associations with insulin resistance and body composition. This is an observational study with consecutive enrollment. Forty-nine hyperthyroid (median age of 34 years) and 44 hypothyroid women (median age of 46 years) completed the study. Laboratory parameters and body composition analysis were assessed before and after the therapy. In the hyperthyroid group, visfatin concentrations increased (P < 0.0001), while glucose concentrations decreased (P < 0.0001). Total body mass and fat mass in the trunk and limbs significantly increased during the treatment. In the hypothyroid group, significant weight loss resulted from decrease of fat and muscle masses in trunk and limbs. Visfatin serum concentrations...
Annals of Medicine and Surgery, 2021
Introduction and Importance Primary intestinal lymphangiectasia (PIL) is a rare protein-losing ga... more Introduction and Importance Primary intestinal lymphangiectasia (PIL) is a rare protein-losing gastroenteropathy of unknown etiology, characterized by impaired lymphatic vessels drainage. The pathological changes in PIL result in usually localized or diffuse dilatation of intestinal lacteals, leading to leakage of lymphatic fluid rich of proteins, lymphocytes, and immunoglobulins into the intestinal lumen. PIL may be asymptomatic or mildly symptomatic in moderate forms of the disease. In some patients, though, the outcome may be poor or even life-threatening. This case report demonstrates the severity of protein malnutrition, in some cases, and the extent of GI tract affected, requiring to start PN early and the need for its continuation as home parenteral nutrition (HPN). Case presentation We present a case of 39-year-old male with Factor V Leiden deficiency, who presented initially with symptoms of malnutrition and anasarca. The diagnosis was confirmed by histopathological finding...
Celiac disease affects 1% of the population. Patients with celiac disease, due to atrophy of the ... more Celiac disease affects 1% of the population. Patients with celiac disease, due to atrophy of the intestinal epithelial epithelial atrophy, are at risk of deficiencies in both minerals and vitamins due to decreased intestinal absorption. Among people with celiac disease who do not use a gluten-free diet, the most frequently underestimated parameters are iron, zinc, vitamin B12, B6 and D. In addition, there is a non-invasive, specific and reliable test showing the presence of immunogenic gluten peptides (GIP) in the urine. There is a positive GIP correlation to the amount of gluten consumed. It is an important factor that monitors the reliability of adherence to dietary recommendations excluding gluten. Currently, the only sure method of treating celiac disease is a gluten-free diet, which should be maintained throughout life, but research on new, easier and less absorbing methods is underway. Among the so-called Future methods can include, among others: splitting proline-rich gluten ...
Lack of knowledge about clinical symptoms and celiac disease diagnosis may lead to a significant ... more Lack of knowledge about clinical symptoms and celiac disease diagnosis may lead to a significant delay in diagnosis. There was a definite progress in the diagnostic possibilities of celiac disease. Four gastroenterological organizations such as: the American College of Gastroenterology (ACG), the European Society of Pediatric Gastroenterology, Hepatology and Nutrition, the World Gastroenterological Association and The British Society of Gastroenterology propose the diagnosis of visceral disease based on halotyping, small intestine biopsy and serum antibody determination. In addition, ESPGHAN (European Society of Pediatric Gastroenterology, Hepatology and Nutrition, World Gastroenterological Association) suggests that in young patients a non-invasive diagnostic method may be used, a tTG IgA titer , which is 10 times above the upper limit of normal, endomysial antibodies, and the HLA DQ2 or DQ8 halotype. According to the Oslo definition, the following classification should be used: cl...
Journal of the Medical Sciences, 2016
Aim. The aim of this study was to evaluate diet of patients with IBD, their nutritional status an... more Aim. The aim of this study was to evaluate diet of patients with IBD, their nutritional status and potential differences as compared to diet of healthy persons. Material and methods. The examination included the patients of Internal, Metabolic Diseases and Dietetics Ward and Gastroenterology, Internal Diseases and Human Nutrition Ward of Heliodor Świecicki Clinic in the Poznan University of Medical Sciences in Poznan. The criterion allowing participation into the study involved a diagnosed ulcerative or Crohn’s disease, basing on histopathology and radiological examination. The study was conducted on 50 patients, 25 women and 25 men. The control of group included 50 persons, 30 women and 20 men, potentially healthy and occupationally active. In the study the authors' own questionnaire was used, which contained questions related to diet and evaluating conditions of nutrition, based on the results of anthropometric measurements and selected biochemical parameters. Results. The stu...
Inflammatory bowel diseases are a group of chronic diseases of the digestive tract of unknown ori... more Inflammatory bowel diseases are a group of chronic diseases of the digestive tract of unknown origin. The etiology of IBD is multifactorial and involves interaction between genetic, environmental and immunological factors with oxidative stress being an inherent part of any one of them. Therefore, the redox equilibrium is crucial to maintain cell homeostasis in the gastrointestinal (GI) tract, which is constantly exposed to large numbers of commensal and pathological bacteria. Distortion of this homeostasis and increase in oxidative stress leads to the propagation of inflammation, mucosal injury in the GI tract and is associated with the development and exacerbation of IBD.
Current Opinion in Clinical Nutrition & Metabolic Care
Purpose of review Noncoeliac gluten sensitivity (NCGS) can be suspected after exclusion of coelia... more Purpose of review Noncoeliac gluten sensitivity (NCGS) can be suspected after exclusion of coeliac disease and wheat allergy. However, poorly understood pathogenesis of the NCGS, lack of gold standard for diagnosis and agreement in the definition for the NCGS condition, open the space for future investigation. This review aims to give an overview on the diagnosis and effective diet composition in the treatment of NCGS symptoms. Recent findings It appears that a diet low in fermentable oligo, di, and monosaccharides and polyols (FODMAPs) and gluten-free diet play a prominent role in the strategy of NCGS management. Considering available evidence with respect to diagnostic tools, it is challenging to prepare a standard guideline for NCGS diagnosis and treatment with clear cut-offs for symptom reduction/improvement that could directly be translated into test results. Nutritional support, including the use of pre/probiotics, has to be tailored to the individual situation of NCGS patients. Summary The exclusion of such components of wheat as amylase/trypsin inhibitors, wheat-germ agglutinins, or free of FODMAPs diet can reduce clinical symptoms of NCGS. The further investigation on microbiota changes may strengthen the knowledge in this area, where the major challenge is to develop biomarkers for NCGS investigation.
Journal of Crohn's and Colitis, 2009
SICUS detected additional jejunal/proximal ileum lesions in 7 pts confirmed at radiology and/or W... more SICUS detected additional jejunal/proximal ileum lesions in 7 pts confirmed at radiology and/or WCE or surgery. At SICUS the extension of the proximal and distal SB lesions was 26±22.8 cm and 17±10 cm respectively. Furthermore SICUS detected extraluminal CD findings, namely nodes enlargement and mesenteric involvement, in 21/26 patients. Conclusions: These findings indicate that the non invasive procedure SICUS: 1) has a high accuracy for diagnosing Crohn's lesions of the SB, 2) is comparable to endoscopic, radiological and WCE examination, in detecting presence and site of SB lesions, and 3) furthermore enables to assess the extension of the SB lesions. These findings support the use of non-invasive SICUS as a first choice examination in the diagnostic work up and follow up of CD pediatric patients.
Journal of Crohn's and Colitis, 2009
Gastroenterology, 2009
showed an accuracy of 87,3%, sensitivity of 90,2% and specificity of 83,6% for active disease. Th... more showed an accuracy of 87,3%, sensitivity of 90,2% and specificity of 83,6% for active disease. The pathological signs of the disease showed strong correlation with the CDAI score in MREG (r =0.69). Conclusion: It has been observed that the MRI technique with oral contrast administration is an accurate tool in detecting inflammatory activity. The relatively safe contrast medium and a negligible radiation exposure are the main reasons why MREG should be used as a preferred method for monitoring of patients with Crohn's disease.
European Review for Medical and Pharmacological Sciences, Oct 1, 2019
OBJECTIVE Aim of the study was to assess the possible vitamin B1 deficiency in relation to the ex... more OBJECTIVE Aim of the study was to assess the possible vitamin B1 deficiency in relation to the exacerbation of Crohn's disease (CD) in adult patients. PATIENTS AND METHODS Forty-nine Crohn's disease (CD) patients with different disease activity (The Crohn's Disease Activity Index-CDAI) were included in the study. Anthropometrical and biochemical parameters, i.e., high sensitive C-reactive protein, were assessed. The spectrophotometric method was used to measure the transketolase activity (TK) in erythrocytes. The normalized transketolase activity ratio (NTKZ) and the percentage of activation with thiamine pyrophosphate (%TPP) were also evaluated. RESULTS The mean values of BMI were close to cut-off: 18.5 kg/m2, indicating a poor nutritional status in CD patients. The patients with moderate-to-severe active CD had a statistically significant higher value of CDAI and hsCRP concentrations compared to those being in the asymptomatic remission or at the mildly active stage of the disease. The level of NTKZ and %TPP were statistically different between the analyzed groups, showing the deficit of vitamin B1 in the group of moderate-to-severe active CD patients (Mean ± SD; NTKZ: 1.99 ± 0.87 vs. 1.54 ± 0.62 U/g Hb; % of TPP: 0.15 ± 0.78 vs. 54.90 ± 38.80). CONCLUSIONS Vitamin B1 deficiency is part of the Crohn's disease manifestation in moderate-to-severe active patients.
International Journal of Molecular Sciences, Jun 21, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Scientific Reports, 2021
Ulcerative colitis (UC) is a chronic immune-mediated disorder, whose etiology is not fully unders... more Ulcerative colitis (UC) is a chronic immune-mediated disorder, whose etiology is not fully understood and for which no effective treatment is available. Recently, research has focused on the dysbiosis of gut microbiome in UC. However, the results so far remain inconsistent and insufficient to understand the microbial component in UC pathogenesis. In this study, we determine specific changes in the gut microbial profile in Polish UC patients compared to healthy subjects for the first time. Using 16S rRNA gene-based analysis we have described the intestinal microbial community in a group of 20 individuals (10 UC patients and 10 controls). Our results after multiple hypothesis testing correction demonstrated substantially lower gut microbiome diversity in UC cases compared to the controls and considerable differences at the phylum level, as well as among 13 bacterial families and 20 bacterial genera (p < 0.05). UC samples were more abundant in Proteobacteria (8.42%), Actinobacteria ...
Journal of Clinical Medicine
The incidence of food hypersensitivity has increased dramatically over the years not only among c... more The incidence of food hypersensitivity has increased dramatically over the years not only among children but also in adults. Adult patients are usually less suspected of food hypersensitivity symptoms since food allergies are more typical for small children, with a tendency to outgrow the condition. The aim of this article is to increase awareness of hypersensitivity to food symptoms and their diagnosis and treatment possibilities among gastroenterologists and other health care professionals dealing with this type of patient. Symptoms of many gastrointestinal disorders, especially functional, may be driven by different types of mechanisms, and food intolerance or allergy should be considered as a potential cause. This article presents the current understanding of the epidemiology, diagnosis and treatment of immune- and non-immune-mediated food-induced diseases. Diagnosis of food hypersensitivity is based mainly on medical history, different types of sensitivity tests, e.g., hydrogen...
Biomedicines
It is crucial to consider the importance of the microbiome and the gut–lung axis in the context o... more It is crucial to consider the importance of the microbiome and the gut–lung axis in the context of SARS-CoV-2 infection. This pilot study examined the fecal microbial composition of patients with COVID-19 following a 3-month recovery. Using for the first time metagenomic analysis based on all hypervariable regions (V1-V9) of the 16S rRNA gene, we have identified 561 microbial species; however, 17 were specific only for the COVID-19 group (n = 8). The patients’ cohorts revealed significantly greater alpha diversity of the gut microbiota compared to healthy controls (n = 14). This finding has been demonstrated by operational taxonomic units (OTUs) richness (p < 0.001) and Chao1 index (p < 0.01). The abundance of the phylum Verrucomicrobia was 30 times higher in COVID-19 patients compared to healthy subjects. Accordingly, this disproportion was also noted at other taxonomic levels: in the class Verrucomicrobiae, the family Verrucomicrobiaceae, and the genus Akkermansia. Elevated ...
Forum Zaburzeń Metabolicznych, 2021
Nieceliakalna nadwrażliwość na gluten (NCGS) jest ciągle mało poznaną chorobą. Objawy NCGS nakład... more Nieceliakalna nadwrażliwość na gluten (NCGS) jest ciągle mało poznaną chorobą. Objawy NCGS nakładają się na objawy innych chorób glutenozależnych, co dodatkowo utrudnia jednoznaczną diagnostykę. Wyniki badań wykazały, że głównymi wyzwalaczami NCGS są glutem i produkty o dużej zawartości FODMAP. Obecnie w celu złagodzenia objawów NCGS stosuje się dietę niskoglutenową/bezglutenową i low-FODMAP. Z uwagi na brak markerów specyficznych w kierunku NCGS nie zawsze jest to choroba prawidłowo diagnozowana. W celu ogólnej standaryzacji rozpoznania NCGS przyjęto Skalę Oceny Objawów Gastrointestinal Sympton Rating Scale
Postepy higieny i medycyny doswiadczalnej, 2015
The human skin harbours hundreds of species of commensal organisms, collectively known as the ski... more The human skin harbours hundreds of species of commensal organisms, collectively known as the skin microbiota. The composition of the microbiota can be modified by various factors, such as host genotype, diet, antibiotics, hygiene, and pathogen infections, among others. Changes in these factors can cause microbiome disruption known as dysbiosis, leading to the outgrowth of potential pathogenic bacteria or a decrease in the number of beneficial bacteria. Dysbiosis has been implicated in some dermatological diseases. This mini-review aims to discuss the topic of the skin microbiota and its potential effects on various skin diseases.
Endocrine Connections
Dysregulation of thyroid function has known impact on body metabolism, however, data regarding me... more Dysregulation of thyroid function has known impact on body metabolism, however, data regarding metabolic outcome after restoration of thyroid function is limited. Therefore, the aim of the study was to investigate the effect of restoration of euthyroidism on serum visfatin, and its associations with insulin resistance and body composition. This is an observational study with consecutive enrollment. Forty-nine hyperthyroid (median age of 34 years) and 44 hypothyroid women (median age of 46 years) completed the study. Laboratory parameters and body composition analysis were assessed before and after the therapy. In the hyperthyroid group, visfatin concentrations increased (P < 0.0001), while glucose concentrations decreased (P < 0.0001). Total body mass and fat mass in the trunk and limbs significantly increased during the treatment. In the hypothyroid group, significant weight loss resulted from decrease of fat and muscle masses in trunk and limbs. Visfatin serum concentrations...
Annals of Medicine and Surgery, 2021
Introduction and Importance Primary intestinal lymphangiectasia (PIL) is a rare protein-losing ga... more Introduction and Importance Primary intestinal lymphangiectasia (PIL) is a rare protein-losing gastroenteropathy of unknown etiology, characterized by impaired lymphatic vessels drainage. The pathological changes in PIL result in usually localized or diffuse dilatation of intestinal lacteals, leading to leakage of lymphatic fluid rich of proteins, lymphocytes, and immunoglobulins into the intestinal lumen. PIL may be asymptomatic or mildly symptomatic in moderate forms of the disease. In some patients, though, the outcome may be poor or even life-threatening. This case report demonstrates the severity of protein malnutrition, in some cases, and the extent of GI tract affected, requiring to start PN early and the need for its continuation as home parenteral nutrition (HPN). Case presentation We present a case of 39-year-old male with Factor V Leiden deficiency, who presented initially with symptoms of malnutrition and anasarca. The diagnosis was confirmed by histopathological finding...
Celiac disease affects 1% of the population. Patients with celiac disease, due to atrophy of the ... more Celiac disease affects 1% of the population. Patients with celiac disease, due to atrophy of the intestinal epithelial epithelial atrophy, are at risk of deficiencies in both minerals and vitamins due to decreased intestinal absorption. Among people with celiac disease who do not use a gluten-free diet, the most frequently underestimated parameters are iron, zinc, vitamin B12, B6 and D. In addition, there is a non-invasive, specific and reliable test showing the presence of immunogenic gluten peptides (GIP) in the urine. There is a positive GIP correlation to the amount of gluten consumed. It is an important factor that monitors the reliability of adherence to dietary recommendations excluding gluten. Currently, the only sure method of treating celiac disease is a gluten-free diet, which should be maintained throughout life, but research on new, easier and less absorbing methods is underway. Among the so-called Future methods can include, among others: splitting proline-rich gluten ...
Lack of knowledge about clinical symptoms and celiac disease diagnosis may lead to a significant ... more Lack of knowledge about clinical symptoms and celiac disease diagnosis may lead to a significant delay in diagnosis. There was a definite progress in the diagnostic possibilities of celiac disease. Four gastroenterological organizations such as: the American College of Gastroenterology (ACG), the European Society of Pediatric Gastroenterology, Hepatology and Nutrition, the World Gastroenterological Association and The British Society of Gastroenterology propose the diagnosis of visceral disease based on halotyping, small intestine biopsy and serum antibody determination. In addition, ESPGHAN (European Society of Pediatric Gastroenterology, Hepatology and Nutrition, World Gastroenterological Association) suggests that in young patients a non-invasive diagnostic method may be used, a tTG IgA titer , which is 10 times above the upper limit of normal, endomysial antibodies, and the HLA DQ2 or DQ8 halotype. According to the Oslo definition, the following classification should be used: cl...
Journal of the Medical Sciences, 2016
Aim. The aim of this study was to evaluate diet of patients with IBD, their nutritional status an... more Aim. The aim of this study was to evaluate diet of patients with IBD, their nutritional status and potential differences as compared to diet of healthy persons. Material and methods. The examination included the patients of Internal, Metabolic Diseases and Dietetics Ward and Gastroenterology, Internal Diseases and Human Nutrition Ward of Heliodor Świecicki Clinic in the Poznan University of Medical Sciences in Poznan. The criterion allowing participation into the study involved a diagnosed ulcerative or Crohn’s disease, basing on histopathology and radiological examination. The study was conducted on 50 patients, 25 women and 25 men. The control of group included 50 persons, 30 women and 20 men, potentially healthy and occupationally active. In the study the authors' own questionnaire was used, which contained questions related to diet and evaluating conditions of nutrition, based on the results of anthropometric measurements and selected biochemical parameters. Results. The stu...
Inflammatory bowel diseases are a group of chronic diseases of the digestive tract of unknown ori... more Inflammatory bowel diseases are a group of chronic diseases of the digestive tract of unknown origin. The etiology of IBD is multifactorial and involves interaction between genetic, environmental and immunological factors with oxidative stress being an inherent part of any one of them. Therefore, the redox equilibrium is crucial to maintain cell homeostasis in the gastrointestinal (GI) tract, which is constantly exposed to large numbers of commensal and pathological bacteria. Distortion of this homeostasis and increase in oxidative stress leads to the propagation of inflammation, mucosal injury in the GI tract and is associated with the development and exacerbation of IBD.
Current Opinion in Clinical Nutrition & Metabolic Care
Purpose of review Noncoeliac gluten sensitivity (NCGS) can be suspected after exclusion of coelia... more Purpose of review Noncoeliac gluten sensitivity (NCGS) can be suspected after exclusion of coeliac disease and wheat allergy. However, poorly understood pathogenesis of the NCGS, lack of gold standard for diagnosis and agreement in the definition for the NCGS condition, open the space for future investigation. This review aims to give an overview on the diagnosis and effective diet composition in the treatment of NCGS symptoms. Recent findings It appears that a diet low in fermentable oligo, di, and monosaccharides and polyols (FODMAPs) and gluten-free diet play a prominent role in the strategy of NCGS management. Considering available evidence with respect to diagnostic tools, it is challenging to prepare a standard guideline for NCGS diagnosis and treatment with clear cut-offs for symptom reduction/improvement that could directly be translated into test results. Nutritional support, including the use of pre/probiotics, has to be tailored to the individual situation of NCGS patients. Summary The exclusion of such components of wheat as amylase/trypsin inhibitors, wheat-germ agglutinins, or free of FODMAPs diet can reduce clinical symptoms of NCGS. The further investigation on microbiota changes may strengthen the knowledge in this area, where the major challenge is to develop biomarkers for NCGS investigation.
Journal of Crohn's and Colitis, 2009
SICUS detected additional jejunal/proximal ileum lesions in 7 pts confirmed at radiology and/or W... more SICUS detected additional jejunal/proximal ileum lesions in 7 pts confirmed at radiology and/or WCE or surgery. At SICUS the extension of the proximal and distal SB lesions was 26±22.8 cm and 17±10 cm respectively. Furthermore SICUS detected extraluminal CD findings, namely nodes enlargement and mesenteric involvement, in 21/26 patients. Conclusions: These findings indicate that the non invasive procedure SICUS: 1) has a high accuracy for diagnosing Crohn's lesions of the SB, 2) is comparable to endoscopic, radiological and WCE examination, in detecting presence and site of SB lesions, and 3) furthermore enables to assess the extension of the SB lesions. These findings support the use of non-invasive SICUS as a first choice examination in the diagnostic work up and follow up of CD pediatric patients.
Journal of Crohn's and Colitis, 2009
Gastroenterology, 2009
showed an accuracy of 87,3%, sensitivity of 90,2% and specificity of 83,6% for active disease. Th... more showed an accuracy of 87,3%, sensitivity of 90,2% and specificity of 83,6% for active disease. The pathological signs of the disease showed strong correlation with the CDAI score in MREG (r =0.69). Conclusion: It has been observed that the MRI technique with oral contrast administration is an accurate tool in detecting inflammatory activity. The relatively safe contrast medium and a negligible radiation exposure are the main reasons why MREG should be used as a preferred method for monitoring of patients with Crohn's disease.