Dr.Shafaat Khan - Academia.edu (original) (raw)

Papers by Dr.Shafaat Khan

World Journal of Advanced Research and Reviews

Metabolic syndrome is the most common issue faced by a large population, especially women and old... more Metabolic syndrome is the most common issue faced by a large population, especially women and old aged people. This is not only a clinical issue for the women and adults but also a social concern particularly among children and adolescents in high-income areas. The prevention and Cure are the hottest area of discussion through the years and many recommendations came regarding preventions and treatments as depressing the asprosin hormone level which is a major cause of high appetite and increase sugar level in blood can help in controlling the obesity and few metabolisms, and nutraceuticals discoveries. There are few proposals about adding psychological interventions in treatments, as these people should also be motivated psychologically as these people sometimes these people face social isolation and give up on treatments. In the SARS-COV 2 pandemic the incidences of this syndrome due to restricted movement of people and other factors.

Islamabad carried out a questionnaire survey to explore the use of the Internet and e-mail by pra... more Islamabad carried out a questionnaire survey to explore the use of the Internet and e-mail by practising clinicians in twelve hospitals in Pakistan. Access, views and practices of clinicians were investigated. While access to Internet and email was high, the use of Internet and email by clinicians for their work was not very high. And while many clinicians agreed that the Internet and email has potential value for their work, the likelihood of its use in health care delivery in Pakistan emerged to be low.

Pakistan Journal of Medical and Health Sciences, Feb 5, 2023

Background: Arthroscopic Bankart repair and open Latarjet procedures are the most frequent surgic... more Background: Arthroscopic Bankart repair and open Latarjet procedures are the most frequent surgical treatments for shoulder instability and recurrent shoulder dislocation. Objectives: Therefore, we performed research to assess the clinical outcomes and recurrence rate of instability between both Arthroscopic Bankart repair and open Latarjet techniques. Methods: A cross-sectional study was performed at Lahore General Hospital, Lahore from 2021-23, comprising 74 patients, managed surgically for the condition of recurrent shoulder dislocation. The patients were allocated into two groups viz Group A and B comprising 37 patients in each, who were managed through Arthroscopic Bankart repair and open Latarjet techniques, respectively. Post-operative complications, re-occurrence and success rate were measured in terms of SSV scores. Results: Average age of patients in Arthroscopic Bankart group was 28.34+5.31 years while in open Latarjet group; it was 29.09+6.19 years. 14 (37.83%) patients of Arthroscopic Bankart repair group revealed recurrent shoulder dislocation, while no such complaint was found in the open Latarjet technique. Twenty-seven patients of Arthroscopic Bankart group showed satisfaction with the procedure and 33 out of 37 patients (89.18%) were satisfied with open Latarjet technique. Patients in open Latarjet technique group showed successful recovery of shoulder dislocation and their SSV was 87.91%, while the patients in Arthroscopic Bankart repair group showed less SSV score of 59.76%. Conclusion: Open Latarjet group patients had a greater rate of functional satisfaction, while the arthroscopic Bankart repair group showed a trend for more recurrence. Open Latarjet operation had a higher success rate and patients had a better rate of return to previous top-level sports than Arthroscopic Bankart technique.

Sang-e-Meel Publications eBooks, 1996

Phytomedicine

Background: The development of digital technologies and the evolution of open innovation approach... more Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week "2021 INPST Twitter Networking Event" (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events.

Journal of International Economics, 2021

We study how anticipation to policy changes affects the elasticity of substitution, the most impo... more We study how anticipation to policy changes affects the elasticity of substitution, the most important parameter in international trade. Standard identification of this parameter uses the tariff variation from the Free Trade Agreements (FTA) and assumes that the trade flows equal their consumption. However, FTAs eliminate initial tariffs through announced phaseouts over multiple years. Firms respond to these future policy changes by delaying their purchases until the tariff cut is effective while consuming past purchases held in inventories. These anticipatory dynamics bias the elasticity of substitution as imports diverge from their consumption. We document that around NAFTA's staged tariff reductions, imports experienced sizeable anticipatory slumps followed by liberalization bumps. A trade model with inventories replicates these dynamics and illustrates that consumption of imports provides unbiased estimates of the elasticity of substitution. To overcome the lack of consumption data, we propose an empirical measure of consumed imports, which eliminates the bias in the model simulations. When applied to the data, we find that using import flows instead of consumed imports overestimates the annual elasticity by 68% and the average elasticity of substitution by 16%. The use of consumed imports increases the ratio of long-to short-run response from 2 to 3.5.

Journal of Natural Products, 2019

During chronic inflammation, neutrophils acting locally as effector cells not only activate antib... more During chronic inflammation, neutrophils acting locally as effector cells not only activate antibacterial defense but also promote the inflammatory response. Interleukin 8 (IL-8), the main cytokine produced by activated neutrophils, positively correlates with the severity of respiratory tract diseases. By screening European plants traditionally used for treating respiratory tract diseases, we found that extracts of aerial parts of Eupatorium cannabinum inhibit IL-8 release from neutrophils. Using bioassay-guided fractionation, we identified five sesquiterpene lactones, eupatoriopicrin (1), 5′-deoxyeupatoriopicrin (2), hiyodorilactone A (3), 3-hydroxy-5′-O-acetyleupatoriopicrin = hiyodorilactone D (4), and hiyodorilactone B (5), that efficiently (IC 50 < 1 μM) inhibited IL-8 and TNF-α release in lipopolysaccharide (LPS)-stimulated human neutrophils. Moreover, all these sesquiterpene lactones suppressed the adhesion of human neutrophils to an endothelial monolayer by downregulating the expression of the β2 integrin CD11b/CD18 on the neutrophil surface. Furthermore, eupatoriopicrin efficiently suppressed LPSinduced phosphorylation of p38 MAPK and ERK and attenuated neutrophil infiltration in the thioglycolate-induced peritonitis model in mice. Altogether, these results demonstrate the potential of the sesquiterpene lactone eupatoriopicrin as a lead substance for targeting inflammation.

Rheumatology, 2003

Primary synovial non-Hodgkin's lymphoma in association with ankylosing spondylitis Rheumatology K... more Primary synovial non-Hodgkin's lymphoma in association with ankylosing spondylitis Rheumatology Key message Always bear in mind differential causes for a swollen joint even in an inflammatory joint disease, as important but rare causes may be missed.

Scientific Reports, 2017

Cellular senescence is characterized by a permanent cell-cycle arrest and a pro-inflammatory secr... more Cellular senescence is characterized by a permanent cell-cycle arrest and a pro-inflammatory secretory phenotype, and can be induced by a variety of stimuli, including ionizing radiation, oxidative stress, and inflammation. In endothelial cells, this phenomenon might contribute to vascular disease. Plasma levels of the inflammatory cytokine tumor necrosis factor alpha (TNFα) are increased in age-related and chronic conditions such as atherosclerosis, rheumatoid arthritis, psoriasis, and Crohn’s disease. Although TNFα is a known activator of the central inflammatory mediator NF-κB, and can induce the intracellular generation of reactive oxygen species (ROS), the question whether TNFα can induce senescence has not been answered conclusively. Here, we investigated the effect of prolonged TNFα exposure on the fate of endothelial cells and found that such treatment induced premature senescence. Induction of endothelial senescence was prevented by the anti-oxidant N-acetyl cysteine, as we...

International Journal of Advanced Computer Science, Mar 19, 2012

This paper develops the conceptual framework of barriers faced by the decision makers and managem... more This paper develops the conceptual framework of barriers faced by the decision makers and management personnel of health sector. The main theme of this paper is to give a clear understanding about the adaption barriers of health technology faced by developing societies. The information about barriers would be useful for policy makers to decide about the particular technology. So that they can fulfill the defined mission of their organizations. Developing a conceptual framework is the first step in building organizational capacity. Information technology in health sector is spreading globally. Use of health information technology is offering evidence-based practice to endorse health and human prosperity. Globalization of health information system is inevitable for establishment and promotion of healthcare sector in developing societies. Present health systems in developing societies are inadequate to meet the needs of the population. Health sector of developing societies is facing a lot of barriers in establishment and promotion of health information system. These barriers include lack of infrastructure, cost, technical sophistications, lack of skilled human resources and lack of e- readiness of medical professionals. In this paper authors conducted a survey of hospitals in Pakistan to identify and categorized adaption barriers in health information technology. Existing health system should be transformed by using HIT to improve health status of population by eliminating barriers identified in this paper.

International Journal of Agriculture and Biology

Fishes usually have low levels of acid secretion in the gut as compared to mammals. Inclusion of ... more Fishes usually have low levels of acid secretion in the gut as compared to mammals. Inclusion of organic acids in their diet reduces the pH in the gut. This lowering of pH increases the phytate hydrolysis, kills the pathogens, decreases the rate of gastric emptying and improves mineralization and nutrient absorption. Among the organic acids, citric acid (CA) has been used extensively for diet acidification due to its unique flavor and high buffering capacity. It has great potential to replace fish meal (up to 70%) with plant based protein sources. Being a strong chelator of calcium and phosphorus, CA enhances the phytate hydrolysis. It improves the bioavailability of minerals by solubilizing the bones and competing with other chelators. It also increases the endogenous as well as exogenous phytases efficiency by providing an optimum pH in gut. Besides, it acts as antimicrobial agent and stimulates feeding in fish. Purpose of this review is to appraise the applications of citric acid...

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2006

Cleft palate (with or without cleft lip) occurs in about 1: 750-1: 2000 births in different socie... more Cleft palate (with or without cleft lip) occurs in about 1: 750-1: 2000 births in different societies in the world. Cleft palate individuals have a greater incidence of hearing loss than the general population. The primary cause of the ear problem in cleft patients is eustachian tube dysfunction. The cause for which is abnormal insertion of levator veli palatini and tensor veli palatini muscles into the posterior margin of the hard palate and the palatal aponeurosis and associated muscular hypoplasia.

Toxicology and Industrial Health, 2011

Chromium (Cr), being an excellent tanning agent, is widely used in the leather industry and tanne... more Chromium (Cr), being an excellent tanning agent, is widely used in the leather industry and tannery workers (TW) are exposed to it either in the form of inorganic Cr(III) compounds or Cr bound to proteins (leather dust) in the process of leather production. During the present study, the effect of Cr on the hematological indices in TW was evaluated. In this study, hematological indices of 92 male TW aged 20—60 years were compared with 79 control males who hardly had a chance of exposure to chromium. Both groups were subdivided into four age groups with an interval of 10: group A, 20—29 years; group B, 30—39 years; group C, 40—49 years; group D, 50—60 years. Total erythrocyte count (TEC) was significantly lower (p < 0.05) in TW of age group A, B and C than control subjects. Packed cell volume (PCV) was significantly higher (p < 0.05) in TW of age group B while mean corpuscular hemoglobin (MCH) was significantly lower (p < 0.05) in TW of age group D. Within the TW, MCH was sig...

Carbohydrate Polymers, 2009

In this study, three kinds of chitooligosaccharides (COS) with different substitution groups, inc... more In this study, three kinds of chitooligosaccharides (COS) with different substitution groups, including aminoethyl (AE), dimethylaminoethyl (DMEM) and diethylaminoethyl (DEAE) groups, were evaluated for their inhibitory activities against cholinesterase (acetylcholinesterase and butyrylcholinesterase). These COS derivatives were synthesized and their structures were characterized as AE-COS, DMAE-COS and DEAE-COS, respectively; the structures were elucidated via spectroscopic techniques (1H NMR). Of these, DMAE-

Endocrine Abstracts, 2015

NeuroImage, 2009

93 F-AM Modulating rt-fMRI neurofeedback interfaces via craving and control in chronic smokers, S... more 93 F-AM Modulating rt-fMRI neurofeedback interfaces via craving and control in chronic smokers, SM LaConte,

Journal of Thrombosis and Haemostasis, 2013

Organs intended for transplantation are generally stored in the cold for better preservation of t... more Organs intended for transplantation are generally stored in the cold for better preservation of their function. However, following transplantation and reperfusion, the microvasculature of transplanted organs often proves to be activated. Extensive leukocyte adhesion and microthrombus formation contribute to failure of the transplanted organ. In this study we analyzed cold-induced changes to the activation status of cultured endothelial cells, possibly contributing to organ failure. We exposed human umbilical vein endothelial cells (HUVECs) to temperatures below 37 °C (mostly to 8 °C) for 30 min and upon rewarming to 37 °C kept incubating them for up to 24 h. We also in vivo locally exposed mice to cold. The exposure to low temperatures induced, in HUVECs, expression of the prothrombotic factors plasminogen activator inhibitor-1 (PAI-1) and tissue factor (TF) and of the inflammatory adhesion molecules, E-selectin, intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Furthermore, upon rewarming for 30 min, we detected activation of the inflammatory NF-κB pathway, as measured by transient NF-κB translocation to the nucleus and IκBα degradation. Using butylated hydroxytoluene (BHT), a scavenger of reactive oxygen species (ROS), we further demonstrated that cold-induced NF-κB activation depends on ROS production. Local exposure to cold also, in vivo, induced ROS production and ICAM-1 expression and resulted in leukocyte infiltration. Our results point to a causative link between ROS production and NF-κB activation, suppression of which had been shown to be beneficial during hypothermic storage and subsequent rewarming of organs for transplantation.

The thesis focuses on the design and implementation of a control scheme for a photolithography pr... more The thesis focuses on the design and implementation of a control scheme for a photolithography process. The process requires a tight control to maintain a desired gate critical dimension (CD). The control approach, which is currently in use in most semiconductor facilities is based on operator experience and does not provide satisfactory control on the CD variation. Implementation of an automatic feedback control system in the industry has been difficult because the CD cannot be measured in real-time but only after the process has been completed. In this thesis, a neural network (NN) is used to predict CD based on the input parameters using historical data that are collected at a manufacturing facility. Using neural networks an inverse model of the process is designed and cascaded with the process model to form the feed forward controller. A feedback CD controller that provides a tighter control in the CD variation is obtained by connecting a fuzzy controller in the feedback loop