DuŠka Meh - Academia.edu (original) (raw)
Papers by DuŠka Meh
Nervenarzt, Jun 1, 1997
Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögen... more Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögens sowie die elektrophysiologische Untersuchung des autonomen Nervensystems, welche die Funktion der dünnen Nervenfasern (markarme A-delta- und marklose C-Faser) darstellt, wurde bei 44 Patienten mit Symptomen einer sensiblen Neuropathie erfaßt. Routinemäßig wurde auch die klassische Elektromyo- und Elektroneurographie zur Feststellung der Funktion der myelinisierten Nervenfaserntypen durchgeführt. Die quantitative Beurteilung der Sensibilität, die mit der Marstock-Thermode (SOMEDIC Thermotest, Somedic AB Stockholm, Schweden) gemessen wurde, die Analyse des sympathischen Hautreflexes und die Variation des R-R-Intervalls zeigten bei der Feststellung der gestörten Nervenfunktion eine deutlich größere Empfindlichkeit als bei der klassischen elektrophysiologischen Untersuchung. Die isoliert beeinträchtigte Funktion der dünnen Nervenfasern wurde anhand einer Suralisbiopsie morphologisch nachgewiesen.
Der Nervenarzt, 1997
Quantitative assessment of thermal and pain sensitivity (Marstock method on a SOMEDIC Thermotest,... more Quantitative assessment of thermal and pain sensitivity (Marstock method on a SOMEDIC Thermotest, Somedic AB Stockholm, Schweden) was made and the function of autonomic nervous system (sympathetic skin response and R-R interval variation) indicating the function of small nerve fibres (A-delta and C) was determined in 44 patients with symptoms of the presumed sensory neuropathy. The function of the large nerve fibres was evaluated by the classic nerve conduction study. The methods of small nerve fibres evaluation exhibited greater sensitivity as the classic nerve conduction study. The dysfunction of small nerve fibre function was morphologically proved by sural nerve biopsy.
Der Nervenarzt, 1997
Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögen... more Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögens sowie die elektrophysiologische Untersuchung des autonomen Nervensystems, welche die Funktion der dünnen Nervenfasern (markarme A-delta- und marklose C-Faser) darstellt, wurde bei 44 Patienten mit Symptomen einer sensiblen Neuropathie erfaßt. Routinemäßig wurde auch die klassische Elektromyo- und Elektroneurographie zur Feststellung der Funktion der myelinisierten Nervenfaserntypen durchgeführt. Die quantitative Beurteilung der Sensibilität, die mit der Marstock-Thermode (SOMEDIC Thermotest, Somedic AB Stockholm, Schweden) gemessen wurde, die Analyse des sympathischen Hautreflexes und die Variation des R-R-Intervalls zeigten bei der Feststellung der gestörten Nervenfunktion eine deutlich größere Empfindlichkeit als bei der klassischen elektrophysiologischen Untersuchung. Die isoliert beeinträchtigte Funktion der dünnen Nervenfasern wurde anhand einer Suralisbiopsie morphologisch nachgewiesen.
Der Nervenarzt, 1997
Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögen... more Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögens sowie die elektrophysiologische Untersuchung des autonomen Nervensystems, welche die Funktion der dünnen Nervenfasern (markarme A-delta- und marklose C-Faser) darstellt, wurde bei 44 Patienten mit Symptomen einer sensiblen Neuropathie erfaßt. Routinemäßig wurde auch die klassische Elektromyo- und Elektroneurographie zur Feststellung der Funktion der myelinisierten Nervenfaserntypen durchgeführt. Die quantitative Beurteilung der Sensibilität, die mit der Marstock-Thermode (SOMEDIC Thermotest, Somedic AB Stockholm, Schweden) gemessen wurde, die Analyse des sympathischen Hautreflexes und die Variation des R-R-Intervalls zeigten bei der Feststellung der gestörten Nervenfunktion eine deutlich größere Empfindlichkeit als bei der klassischen elektrophysiologischen Untersuchung. Die isoliert beeinträchtigte Funktion der dünnen Nervenfasern wurde anhand einer Suralisbiopsie morphologisch nachgewiesen.
Der Nervenarzt, 1997
Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögen... more Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögens sowie die elektrophysiologische Untersuchung des autonomen Nervensystems, welche die Funktion der dünnen Nervenfasern (markarme A-delta- und marklose C-Faser) darstellt, wurde bei 44 Patienten mit Symptomen einer sensiblen Neuropathie erfaßt. Routinemäßig wurde auch die klassische Elektromyo- und Elektroneurographie zur Feststellung der Funktion der myelinisierten Nervenfaserntypen durchgeführt. Die quantitative Beurteilung der Sensibilität, die mit der Marstock-Thermode (SOMEDIC Thermotest, Somedic AB Stockholm, Schweden) gemessen wurde, die Analyse des sympathischen Hautreflexes und die Variation des R-R-Intervalls zeigten bei der Feststellung der gestörten Nervenfunktion eine deutlich größere Empfindlichkeit als bei der klassischen elektrophysiologischen Untersuchung. Die isoliert beeinträchtigte Funktion der dünnen Nervenfasern wurde anhand einer Suralisbiopsie morphologisch nachgewiesen.
Journal of Neurology, Neurosurgery & Psychiatry, 2000
Botulinum Toxin in the Treatment of Cerebral Palsy. Edited by werner poewe and jorg wissell. (CD ... more Botulinum Toxin in the Treatment of Cerebral Palsy. Edited by werner poewe and jorg wissell. (CD Rom) Published by Blackwell Science, Austria, 1997. ISBN 3-89412-364-8. It was a pleasure to review this CD Rom. It is certainly a sign of changing times that the book review section now also contains reviews of CD Rom material. This is basically a review of the use of botulinum toxin in the treatment of cerebral palsy built around a meeting held in the Department of Neurology in Innsbruck in May 1997. The CD Rom contains the talks of eight speakers recorded at the time. While listening to the speaker's voice the slides come …
The Clinical Investigator, 1994
Peripheral nervous system complications are rare in patients with primary Sjögren's syndr... more Peripheral nervous system complications are rare in patients with primary Sjögren's syndrome. We investigated a group of six women aged 43-64 years who complained of pain and sensory symptoms. Conventional neurophysiological tests reflecting large nerve fiber function revealed normal motor conduction in all patients, whereas sensory nerve action potentials were absent in two. On the other hand, quantitative thermometry and autonomic nerve function tests indicating small nerve fiber function were more sensitive in the assessment of nerve dysfunction; these showed abnormalities in all cases. Vibrametry showed dysfunctions in four patients. The latter methods possess great sensitivity in discovering sensory disturbances. Neurophysiological assessment of the sensory and autonomic nervous system demonstrating sensory neuropathy contributes to early diagnosis of primary Sjögren's syndrome.
Electromyography and clinical neurophysiology
The psychophysically assessed thermal specific, thermal pain and vibration sensitivities were cor... more The psychophysically assessed thermal specific, thermal pain and vibration sensitivities were correlated to somatosensory evoked potentials in eighteen patients with definite multiple sclerosis. In the psychophysical tests, modality specific stimuli were used. Somatosensory potentials were electrically evoked. The abnormalities of both the temperature and the vibration sensitivity were to same extent related to the somatosensory evoked potentials. Dorsal columns-medial lemnisc and anterolateral-spinothalamic demyelinating lesions were presumed. The psychophysical tests supplement the clinical, laboratory, neuroradiologic and electrophysiological tests. These should be included in the battery of diagnostic tests in multiple sclerosis.
Annals of the New York Academy of Sciences, 1994
Scandinavian journal of …, 1995
An morphological confirmation of neurophysiologically assessed small nerve fibre dysfunction in a... more An morphological confirmation of neurophysiologically assessed small nerve fibre dysfunction in a patient with Sjögren's syndrome was sought. Conventional motor and sensory nerve conduction studies were normal, while examination of the thermal specific and thermal pain sensitivity and an autonomic nervous system evaluation showed striking abnormalities. Sural nerve electron microscopy showed almost normally large nerve fibres and abnormalities in unmyelinated nerve fibres or Schwann cells, and verified morphologically the neurophysiologically supposed small nerve fibre involvement.
Zdravniški Vestnik, 2001
Background. Mild to moderate cognitive dysfunction is a frequent complaint of patients with Parki... more Background. Mild to moderate cognitive dysfunction is a frequent complaint of patients with Parkinson’s disease, though the clinical picture of dementia is rarely reported. Methods. The development of cognitive deficits seams to be associated with hypokinesia and rigidy rather than tremor. In our study, auditory ERP were used to confirm cognitive alterations in two groups of non-demented patients with idiopathic Parkinson’s disease. Mini mental test was performed to exclude clinical picture of dementia. Patients were classified according to the Hoehen-Yahr and Webster scale. The Beck depression score in Parkinson’s patient was assessed. Auditory event related potentials were recorded using the »oddball« paradigm. The waves N100, P200, N200 and P300 were recorded and their latencies and amplitudes measured. Results and conclusions. The P300 latencies in both patients group were significantly longer (p < 0.05), than in the control group. P300 latency was longer in non tremor group. There were no significant statistical differences in latencies between the both groups. All patients had normal N100 latency. Significant decline of P300 amplitude was found only in non-tremor group (p < 0.001).
Obzornik zdravstvene nege, 1998
Journal of neurology, 1997
We report three female patients, 43, 47, and 50 years old, with a rare asymmetric form of clinica... more We report three female patients, 43, 47, and 50 years old, with a rare asymmetric form of clinically pure sensory neuropathy associated with primary Sjögren's syndrome. In all three patients glandular involvement was accompanied by peripheral nerve disease. Sensory conduction studies showed completely normal results in two of three patients. Yet assessment of thermal-specific thresholds and thermal pain thresholds, combined with autonomic function tests (sympathetic skin response and R-R interval variation) supported the clinical suspicion of peripheral nerve disorder. Sjögren's syndrome must be considered in asymmetric sensory neuropathies of unknown cause.
Background. Mild to moderate cognitive dysfunction is a frequent complaint of patients with Parki... more Background. Mild to moderate cognitive dysfunction is a frequent complaint of patients with Parkinson’s disease, though the clinical picture of dementia is rarely reported. Methods. The development of cognitive deficits seams to be associated with hypokinesia and rigidy rather than tremor. In our study, auditory ERP were used to confirm cognitive alterations in two groups of non-demented patients with idiopathic Parkinson’s disease. Mini mental test was performed to exclude clinical picture of dementia. Patients were classified according to the Hoehen-Yahr and Webster scale. The Beck depression score in Parkinson’s patient was assessed. Auditory event related potentials were recorded using the »oddball« paradigm. The waves N100, P200, N200 and P300 were recorded and their latencies and amplitudes measured. Results and conclusions. The P300 latencies in both patients group were significantly longer (p < 0.05), than in the control group. P300 latency was longer in non tremor group....
Pain is frequently one of the most disturbing symptoms of multiple sclerosis. It is caused by the... more Pain is frequently one of the most disturbing symptoms of multiple sclerosis. It is caused by the disease process or its consequences, and may be one of the first symptoms of this condition. Trigeminal neuralgia, which is a very painful and often long-lasting problem, may occur at an early stage of the disease. Orbital pain is often caused by optic neuritis. Pain in the extremities, mostly painful cramps in the lower limbs, is almost intractable. It generally affects the most disabled people and is frequently therapy-resistant. The therapy of different pain syndromes is described.
Muscle & Nerve, 1996
ABSTRACT
Nervenarzt, Jun 1, 1997
Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögen... more Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögens sowie die elektrophysiologische Untersuchung des autonomen Nervensystems, welche die Funktion der dünnen Nervenfasern (markarme A-delta- und marklose C-Faser) darstellt, wurde bei 44 Patienten mit Symptomen einer sensiblen Neuropathie erfaßt. Routinemäßig wurde auch die klassische Elektromyo- und Elektroneurographie zur Feststellung der Funktion der myelinisierten Nervenfaserntypen durchgeführt. Die quantitative Beurteilung der Sensibilität, die mit der Marstock-Thermode (SOMEDIC Thermotest, Somedic AB Stockholm, Schweden) gemessen wurde, die Analyse des sympathischen Hautreflexes und die Variation des R-R-Intervalls zeigten bei der Feststellung der gestörten Nervenfunktion eine deutlich größere Empfindlichkeit als bei der klassischen elektrophysiologischen Untersuchung. Die isoliert beeinträchtigte Funktion der dünnen Nervenfasern wurde anhand einer Suralisbiopsie morphologisch nachgewiesen.
Der Nervenarzt, 1997
Quantitative assessment of thermal and pain sensitivity (Marstock method on a SOMEDIC Thermotest,... more Quantitative assessment of thermal and pain sensitivity (Marstock method on a SOMEDIC Thermotest, Somedic AB Stockholm, Schweden) was made and the function of autonomic nervous system (sympathetic skin response and R-R interval variation) indicating the function of small nerve fibres (A-delta and C) was determined in 44 patients with symptoms of the presumed sensory neuropathy. The function of the large nerve fibres was evaluated by the classic nerve conduction study. The methods of small nerve fibres evaluation exhibited greater sensitivity as the classic nerve conduction study. The dysfunction of small nerve fibre function was morphologically proved by sural nerve biopsy.
Der Nervenarzt, 1997
Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögen... more Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögens sowie die elektrophysiologische Untersuchung des autonomen Nervensystems, welche die Funktion der dünnen Nervenfasern (markarme A-delta- und marklose C-Faser) darstellt, wurde bei 44 Patienten mit Symptomen einer sensiblen Neuropathie erfaßt. Routinemäßig wurde auch die klassische Elektromyo- und Elektroneurographie zur Feststellung der Funktion der myelinisierten Nervenfaserntypen durchgeführt. Die quantitative Beurteilung der Sensibilität, die mit der Marstock-Thermode (SOMEDIC Thermotest, Somedic AB Stockholm, Schweden) gemessen wurde, die Analyse des sympathischen Hautreflexes und die Variation des R-R-Intervalls zeigten bei der Feststellung der gestörten Nervenfunktion eine deutlich größere Empfindlichkeit als bei der klassischen elektrophysiologischen Untersuchung. Die isoliert beeinträchtigte Funktion der dünnen Nervenfasern wurde anhand einer Suralisbiopsie morphologisch nachgewiesen.
Der Nervenarzt, 1997
Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögen... more Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögens sowie die elektrophysiologische Untersuchung des autonomen Nervensystems, welche die Funktion der dünnen Nervenfasern (markarme A-delta- und marklose C-Faser) darstellt, wurde bei 44 Patienten mit Symptomen einer sensiblen Neuropathie erfaßt. Routinemäßig wurde auch die klassische Elektromyo- und Elektroneurographie zur Feststellung der Funktion der myelinisierten Nervenfaserntypen durchgeführt. Die quantitative Beurteilung der Sensibilität, die mit der Marstock-Thermode (SOMEDIC Thermotest, Somedic AB Stockholm, Schweden) gemessen wurde, die Analyse des sympathischen Hautreflexes und die Variation des R-R-Intervalls zeigten bei der Feststellung der gestörten Nervenfunktion eine deutlich größere Empfindlichkeit als bei der klassischen elektrophysiologischen Untersuchung. Die isoliert beeinträchtigte Funktion der dünnen Nervenfasern wurde anhand einer Suralisbiopsie morphologisch nachgewiesen.
Der Nervenarzt, 1997
Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögen... more Zusammenfassung Die quantitative Bestimmung des Temperatur- und Schmerzempfindlichkeitsvermögens sowie die elektrophysiologische Untersuchung des autonomen Nervensystems, welche die Funktion der dünnen Nervenfasern (markarme A-delta- und marklose C-Faser) darstellt, wurde bei 44 Patienten mit Symptomen einer sensiblen Neuropathie erfaßt. Routinemäßig wurde auch die klassische Elektromyo- und Elektroneurographie zur Feststellung der Funktion der myelinisierten Nervenfaserntypen durchgeführt. Die quantitative Beurteilung der Sensibilität, die mit der Marstock-Thermode (SOMEDIC Thermotest, Somedic AB Stockholm, Schweden) gemessen wurde, die Analyse des sympathischen Hautreflexes und die Variation des R-R-Intervalls zeigten bei der Feststellung der gestörten Nervenfunktion eine deutlich größere Empfindlichkeit als bei der klassischen elektrophysiologischen Untersuchung. Die isoliert beeinträchtigte Funktion der dünnen Nervenfasern wurde anhand einer Suralisbiopsie morphologisch nachgewiesen.
Journal of Neurology, Neurosurgery & Psychiatry, 2000
Botulinum Toxin in the Treatment of Cerebral Palsy. Edited by werner poewe and jorg wissell. (CD ... more Botulinum Toxin in the Treatment of Cerebral Palsy. Edited by werner poewe and jorg wissell. (CD Rom) Published by Blackwell Science, Austria, 1997. ISBN 3-89412-364-8. It was a pleasure to review this CD Rom. It is certainly a sign of changing times that the book review section now also contains reviews of CD Rom material. This is basically a review of the use of botulinum toxin in the treatment of cerebral palsy built around a meeting held in the Department of Neurology in Innsbruck in May 1997. The CD Rom contains the talks of eight speakers recorded at the time. While listening to the speaker's voice the slides come …
The Clinical Investigator, 1994
Peripheral nervous system complications are rare in patients with primary Sjögren's syndr... more Peripheral nervous system complications are rare in patients with primary Sjögren's syndrome. We investigated a group of six women aged 43-64 years who complained of pain and sensory symptoms. Conventional neurophysiological tests reflecting large nerve fiber function revealed normal motor conduction in all patients, whereas sensory nerve action potentials were absent in two. On the other hand, quantitative thermometry and autonomic nerve function tests indicating small nerve fiber function were more sensitive in the assessment of nerve dysfunction; these showed abnormalities in all cases. Vibrametry showed dysfunctions in four patients. The latter methods possess great sensitivity in discovering sensory disturbances. Neurophysiological assessment of the sensory and autonomic nervous system demonstrating sensory neuropathy contributes to early diagnosis of primary Sjögren's syndrome.
Electromyography and clinical neurophysiology
The psychophysically assessed thermal specific, thermal pain and vibration sensitivities were cor... more The psychophysically assessed thermal specific, thermal pain and vibration sensitivities were correlated to somatosensory evoked potentials in eighteen patients with definite multiple sclerosis. In the psychophysical tests, modality specific stimuli were used. Somatosensory potentials were electrically evoked. The abnormalities of both the temperature and the vibration sensitivity were to same extent related to the somatosensory evoked potentials. Dorsal columns-medial lemnisc and anterolateral-spinothalamic demyelinating lesions were presumed. The psychophysical tests supplement the clinical, laboratory, neuroradiologic and electrophysiological tests. These should be included in the battery of diagnostic tests in multiple sclerosis.
Annals of the New York Academy of Sciences, 1994
Scandinavian journal of …, 1995
An morphological confirmation of neurophysiologically assessed small nerve fibre dysfunction in a... more An morphological confirmation of neurophysiologically assessed small nerve fibre dysfunction in a patient with Sjögren's syndrome was sought. Conventional motor and sensory nerve conduction studies were normal, while examination of the thermal specific and thermal pain sensitivity and an autonomic nervous system evaluation showed striking abnormalities. Sural nerve electron microscopy showed almost normally large nerve fibres and abnormalities in unmyelinated nerve fibres or Schwann cells, and verified morphologically the neurophysiologically supposed small nerve fibre involvement.
Zdravniški Vestnik, 2001
Background. Mild to moderate cognitive dysfunction is a frequent complaint of patients with Parki... more Background. Mild to moderate cognitive dysfunction is a frequent complaint of patients with Parkinson’s disease, though the clinical picture of dementia is rarely reported. Methods. The development of cognitive deficits seams to be associated with hypokinesia and rigidy rather than tremor. In our study, auditory ERP were used to confirm cognitive alterations in two groups of non-demented patients with idiopathic Parkinson’s disease. Mini mental test was performed to exclude clinical picture of dementia. Patients were classified according to the Hoehen-Yahr and Webster scale. The Beck depression score in Parkinson’s patient was assessed. Auditory event related potentials were recorded using the »oddball« paradigm. The waves N100, P200, N200 and P300 were recorded and their latencies and amplitudes measured. Results and conclusions. The P300 latencies in both patients group were significantly longer (p < 0.05), than in the control group. P300 latency was longer in non tremor group. There were no significant statistical differences in latencies between the both groups. All patients had normal N100 latency. Significant decline of P300 amplitude was found only in non-tremor group (p < 0.001).
Obzornik zdravstvene nege, 1998
Journal of neurology, 1997
We report three female patients, 43, 47, and 50 years old, with a rare asymmetric form of clinica... more We report three female patients, 43, 47, and 50 years old, with a rare asymmetric form of clinically pure sensory neuropathy associated with primary Sjögren's syndrome. In all three patients glandular involvement was accompanied by peripheral nerve disease. Sensory conduction studies showed completely normal results in two of three patients. Yet assessment of thermal-specific thresholds and thermal pain thresholds, combined with autonomic function tests (sympathetic skin response and R-R interval variation) supported the clinical suspicion of peripheral nerve disorder. Sjögren's syndrome must be considered in asymmetric sensory neuropathies of unknown cause.
Background. Mild to moderate cognitive dysfunction is a frequent complaint of patients with Parki... more Background. Mild to moderate cognitive dysfunction is a frequent complaint of patients with Parkinson’s disease, though the clinical picture of dementia is rarely reported. Methods. The development of cognitive deficits seams to be associated with hypokinesia and rigidy rather than tremor. In our study, auditory ERP were used to confirm cognitive alterations in two groups of non-demented patients with idiopathic Parkinson’s disease. Mini mental test was performed to exclude clinical picture of dementia. Patients were classified according to the Hoehen-Yahr and Webster scale. The Beck depression score in Parkinson’s patient was assessed. Auditory event related potentials were recorded using the »oddball« paradigm. The waves N100, P200, N200 and P300 were recorded and their latencies and amplitudes measured. Results and conclusions. The P300 latencies in both patients group were significantly longer (p < 0.05), than in the control group. P300 latency was longer in non tremor group....
Pain is frequently one of the most disturbing symptoms of multiple sclerosis. It is caused by the... more Pain is frequently one of the most disturbing symptoms of multiple sclerosis. It is caused by the disease process or its consequences, and may be one of the first symptoms of this condition. Trigeminal neuralgia, which is a very painful and often long-lasting problem, may occur at an early stage of the disease. Orbital pain is often caused by optic neuritis. Pain in the extremities, mostly painful cramps in the lower limbs, is almost intractable. It generally affects the most disabled people and is frequently therapy-resistant. The therapy of different pain syndromes is described.
Muscle & Nerve, 1996
ABSTRACT